Li-deazaflavin, li-analogue tsa maiketsetso tsa riboflavin, li fetoha libapali tsa bohlokoa ho catalysis ea enzymatic le karabelo ea redox. Sebopeho sa bona se ikhethang le thepa ea redox e ba etsa li-cofactors tse loketseng bakeng sa li-enzyme tse fapaneng bakeng sa phetisetso ea elektronike e sebetsang hantle le ts'ebetso ea catalytic. e na le ts'episo e kholo lefapheng la pharmacology. Bokhoni ba eona ba ho ba antioxidant le taolo ea metabolism ea cellular bo bula mekhoa e mecha ea ho etsa lipatlisiso le ho kenella kalafong.
Deazaflavin, e nkiloeng ho riboflavin le analogue ea bohlokoa ea flavin ea tlhaho, e na le litšobotsi tse ikhethang tse hohetseng tlhokomelo ea bafuputsi mafapheng a fapaneng a lipatlisiso. Deazaflavin, eo hape e tsejoang e le 7,8-dimethyl-8-hydroxy-5-deazariboflavin, e rehelletsoe ka athomo ea 7 ea naetrojene ea riboflavin ea isoalloxazine e nkeloa sebaka ke athomo ea khabone.
Phetoho ena ea sebopeho e e khetholla ho molekane oa eona oa riboflavin mme e e fa litšobotsi tse ikhethang tsa lik'hemik'hale. Ka sebopeho sa eona se ikhethileng, deazaflavin e bapala karolo ea bohlokoa lits'ebetsong tse ngata tsa tlhaho.
Deazaflavin ke motsoako o mosehla oa lamunu o nang le mokhoa oa molek'hule oa C16H13N3O2, o khetholloang ke sehlopha sa phenolic hydroxyl sebakeng sa 8.
E 'ngoe ea mesebetsi e hlahelletseng ea deazaflavin ke ho nka karolo ho biosynthesis ea cofactor F420, e teng ho libaktheria tse ling, archaea le eukaryote e tlase. E le sesebelisoa sa bohlokoa sa elektronike, F420 e na le karolo ho karabelo ea redox mme ka potlako e fetisetsa lielektrone lipakeng tsa li-enzyme. Ho ba teng ha deazaflavin ho bohlokoa bakeng sa mohato oa ho qetela oa F420 synthesis, ho fetolela riboflavin ho F420 le ho eketsa mesebetsi ea eona e mengata ea likokoana-hloko.
Melemo e ka bang teng ea deazaflavin:
●thibela lefu
●E Matlafatsa Tlhahiso ea Matla a Mehala
●Antioxidant le anti-inflammatory properties
●E Khothalletsa Bophelo bo Botle ba Boko le Mosebetsi
●ts'ehetso ea sesole sa 'mele
1. Khahlanong le botsofali/ Botsofali
5-Desaflavin phofo ke motsoako o matla o thibelang botsofali o ntseng o tsebahala indastering ea bophelo bo botle le bophelo bo botle. E tsebahala ka ho matlafatsa tlhahiso ea 'mele ea NAD+, acoenzymee bapalang karolo ea bohlokoa ho metabolism ea matla le ho lokisoa ha lisele.
2. Thibela mafu
Li-deazaflavin li bapala karolo ea bohlokoa ts'ebetsong ea erythropoiesis. E thusa ho boloka sebopeho se tloaelehileng le mosebetsi oa lisele tse khubelu tsa mali le ho thibela maloetse a amanang le mali a kang phokolo ea mali.
3. E Matlafatsa Tlhahiso ea Matla a Lisele
E 'ngoe ea mekhoa e ka sehloohong eo deazaflavin e fanang ka melemo ea eona ea bophelo bo botle ke ka ho ntlafatsa tlhahiso ea matla a cellular. Joalo ka riboflavin, deazaflavin e sebetsa joalo ka coenzyme ea bohlokoa metabolism ea cellular. Ka ho kenya letsoho ketane ea lipalangoang tsa elektronike le liketso tse ling tsa enzymatic, deazaflavin e khothalletsa tlhahiso e nepahetseng ea matla, e netefatsa hore lisele li sebetsa hantle. Thepa ena ha e thuse feela ho loantša mokhathala, empa e boetse e tšehetsa matla le bophelo bo botle ka kakaretso.
4. Antioxidant le anti-inflammatory properties
Liphuputso li bonts'itse hore deazaflavin e na le thepa e matla ea antioxidant e bapalang karolo ea bohlokoa ho fokotsa khatello ea oxidative le ho loants'a litlamorao tse kotsi tsa li-radicals mahala 'meleng. Khatello ea oxidative e amana haufi-ufi le mafu a fapaneng a sa foleng, ho kenyelletsa lefu la pelo, lefu la neurodegenerative le mofets'e. Bokhoni ba mahala ba deazaflavin bo ka thusang ho sireletsa 'mele ho mafu ana le ho thusa ho phela nako e telele.
Ho feta moo, lipatlisiso tse ncha li bontša hore Deazaflavin e na le thepa e khahlanong le ho ruruha. Ho ruruha ho sa foleng ke sesosa se bakang mathata a mangata a bophelo bo botle. Ka ho fetola karabelo ea ho ruruha, deazaflavin e ka thusa ho phekola le ho thibela mafu a kang ramatiki, asthma le mafu a autoimmune.
5. E Khothalletsa Bophelo bo Botle ba Boko le Mosebetsi
Litlamorao tse ka bang teng tsa "neuroprotective" tsa deazaflavin le tsona li khahla bafuputsi ba ithutang ka temoho le bophelo bo botle ba boko. Mafu a neurodegenerative a kang lefu la Alzheimer le Parkinson a fetohile mathata a maholo a bophelo lefatšeng ka bophara. Bokhoni ba li-deazaflavins ho ntlafatsa tlhahiso ea matla a cellular hammoho le li-antioxidant le anti-inflammatory li etsa hore e be batho ba tšepisang bakeng sa ho fokotsa litlamorao tse mpe tsa mafu ana.
Ntle le moo, lipatlisiso tsa pele li fana ka maikutlo a hore Deazaflavin e ka ts'ehetsa mohopolo le ts'ebetso ea kelello, e etsa hore e be molekane ea ka bang teng ho loants'a ho fokotseha ha kelello ho amanang le lilemo le ho ntlafatsa bophelo bo botle ba boko. Leha ho le joalo, lipatlisiso tse felletseng lia hlokahala ho utloisisa ka botlalo boholo ba litlamorao tsa deazaflavin ho bophelo bo botle ba boko.
6. Tšehetso ea Ts'ireletso ea 'mele
Masole a rona a 'mele ke tšireletso ea 'mele ea rona khahlanong le tšoaetso le mafu. Karolo ea deazaflavin e le coenzyme ea bohlokoa liketsong tse fapaneng tsa enzymatic e boetse e fetela tšebetsong ea sesole sa 'mele. Ho tšehetsa karabelo e matla ea 'mele ea ho itšireletsa mafung ho bohlokoa ho boloka bophelo bo botle le ho thibela maloetse. Ka ho khothaletsa tlhahiso ea matla le bophelo bo botle ba lisele, li-deazaflavin li ka bapala karolo ea bohlokoa ho ts'ehetsa ts'ebetso ea 'mele ea ho itšireletsa mafung le ho matlafatsa matla a' mele ea rona ho loants'a likokoana-hloko.
Deazaflavin ke limatlafatsi tsa bohlokoa tse bapalang karolo ea bohlokoa lits'ebetsong tse fapaneng tsa 'mele. Tse latelang ke tse ling tsa litlamorao le matšoao a khaello ea deazaflavin:
Mathata a letlalo le lera la mucous: Khaello ea Deazaflavin e ka lebisa ho nts'etsopele ea mafu a letlalo a kang dermatitis, melomo e omeletseng kapa e phatlohileng, le 'metso o bohloko. Libaka tse amehileng tsa letlalo li ka 'na tsa omella, tsa hlaba kapa tsa ruruha.
Mathata a mahlo: Maemong a boima, khaello ea deazaflavin e ka baka mathata a amanang le mahlo a kang photosensitivity le pono e lerootho.
Khaello ea mali: Deazaflavin e bohlokoa bakeng sa tlhahiso ea lisele tse khubelu tsa mali. Ho haella ha eona ho ka lebisa ho phokolo ea mali, e khetholloang ke lisele tse khubelu tsa mali tse fokolang le ho fokotseha ha matla a ho tsamaisa oksijene, e leng se lebisang mokhathala, bofokoli le ho hema ka thata.
Mathata a bophelo bo botle ba molomo le molomo: Ho haella ha Deazaflavins ho ka lebisa ho nts'etsopele ea mathata a bophelo bo botle ba molomo joalo ka glossitis (ho ruruha ha leleme), melomo e phatlohileng, le liso tsa molomo.
Matšoao a Neurologic: Le hoja ho haella ha deazaflavin ho sa tloaelehang ho ka ama tsamaiso ea methapo, ho baka matšoao a neurologic a kang ho senyeha ha kelello, pherekano le tšenyo ea methapo.
Deazaflavin ke mofuta o fetotsoeng ka lik'hemik'hale oa riboflavin (eo hape e tsejoang e levithamine B2）. E sebelisoa e le cofactor bakeng sa li-enzyme tse fapaneng ho biotechnology le lits'ebetso tsa baeloji ea limolek'hule. Litaelo tse akaretsang tsa ho sebelisa deazaflavin ke tsena:
Etsa bonnete ba hore u na le litharollo tsa stock tsa boleng bo holimo tse fumanehang pele u sebelisa deazaflavin. Hangata Desaflavin e fumaneha ka phofo kapa ka sebōpeho se tiileng, kahoo ho ka 'na ha hlokahala hore u e qhibilihe ka har'a motsoako o loketseng, joalo ka metsi kapa tharollo e nang le buffered. Haeba e le teng, latela litaelo tsa moetsi bakeng sa ho theha bocha.
Li-deazaflavin li na le kutloelo-bohloko ho khanya, mocheso le oxidation. Ka hona, ke habohlokoa ho boloka tharollo sebakeng se lefifi, se pholileng le ho se sireletsa ho tloha nako e telele moeeng. Nahana ka ho tlosa tharollo ea setoko ka likaroloana tse nyane tse ka lahloang ho fokotsa ho senyeha.
Motsoako o khethehileng oa deazaflavin o hlokahalang o ka fapana ho latela enzyme kapa karabelo e ithutoang. Ho kgothaletswa ho shebana le lingoliloeng kapa ho buisana le setsebi sa ts'ebeliso e lakatsehang ho fumana sebaka se loketseng sa mahloriso.
Li-deazaflavins hangata li sebelisoa ka ho li kenyelletsa motsoakong oa karabelo kapa litsamaiso tsa tlhahlobo ea enzymatic. Linako tsa ho incubation li ka fapana ho latela protocol e khethehileng ea liteko. Latela litaelo tsa moetsi kapa sheba lingoliloeng tse amehang bakeng sa linako le maemo a nepahetseng a ho elisa.
Ho bohlokoa ho kenyelletsa likarabo tse nepahetseng tsa taolo kapa lihlopha tsa taolo ntle le deazaflavin moralong oa liteko. Litaolo tsena li tla u thusa ho khetholla litlamorao tse bakoang ke deazaflavin ho tsoa linthong tse ling tsamaisong ea hau.
Ngola maemo a liteko, litebello, 'me liphetho ka mokhoa o ngotsoeng hantle. Sekaseka ka hloko le ho hlalosa lintlha tse fumanoeng litekong, u bapisa liphetho le litsamaiso tse nepahetseng.
Hlokomela hore tsena ke litataiso tse akaretsang 'me tšebeliso e ikhethileng le liprothokholi li ka fapana ho ipapisitse le tlhahlobo ea hau e ikhethileng le ts'ebeliso e reriloeng. Etsa bonnete ba hore u sheba lingoliloeng tse amehang kapa u batle keletso ho setsebi lefapheng la hau bakeng sa litaelo tse nepahetseng ka ho fetisisa bakeng sa teko e itseng.
Tšireletseho ea deazaflavin
Ha ho nahanoa ka polokeho ea deazaflavin, ho bohlokoa ho hlokomela hore motsoako o entsoe liteko tse matla tsa pele ho kliniki le liphoofolo ho fumana chefo ea eona le litlamorao tse ka bang teng. Lithuto tsena li tlalehile hore ha ho chefo e bonoang e matla kapa e sa foleng, e totobatsang boemo ba polokeho ea komporo ka kakaretso. Leha ho le joalo, ho bohlokoa ho etsa liteko tse ling tsa kliniki ho lekola polokeho ea eona ho batho.
litla-morao tsa deazaflavin:
Le hoja liphuputso tsa preclinical li so tlalehe litla-morao tsa deazaflavin, ho bohlokoa ho ba hlokolosi mabapi le tšebeliso ea eona. Joalo ka motsoako ofe kapa ofe, liteko tse ling tsa kliniki lia hlokahala ho lekola polokeho ea eona ho batho le ho khetholla litla-morao tse ka bang teng kapa litšebelisano tsa lithethefatsi. Tekanyetso e nepahetseng, tsamaiso le tlhokomelo ea mokuli e tla ba senotlolo sa ho netefatsa tšebeliso ea eona e bolokehileng.
Q: Ho nka nako e kae hore deazaflavin e sebetse?
A: Liphello tsa Calcium deazaflavin li ka fapana ho itšetlehile ka motho ka mong, litekanyetso, le mokhoa oa tsamaiso. Leha ho le joalo, ka tloaelo, ho lumeloa hore deazaflavin e ka nka kae kapa kae ho tloha metsotso e seng mekae ho ea ho lihora tse 'maloa ho qala ho sebetsa. Ho khothalletsoa ho buisana le setsebi sa tlhokomelo ea bophelo kapa ho latela litaelo tse fanoeng ke moetsi bakeng sa tlhahisoleseding e tobileng ea hore na ho nka nako e kae hore motsoako ona o sebetse.
Boitlhotlhollo: Sengoliloeng sena ke sa merero ea tlhahisoleseling feela mme ha sea lokela ho nkuoa e le keletso ea bongaka. Kamehla buisana le setsebi sa tlhokomelo ea bophelo pele u sebelisa li-supplement kapa ho fetola mokhoa oa hau oa tlhokomelo ea bophelo.
Nako ea poso: Jul-10-2023
