Na u nahana ho eketsa acetyl zingerone tlatsetsong ea hau ea letsatsi le letsatsi? Ka likhetho tse ngata 'marakeng, ho ka ba boima ho khetha e lumellanang le litlhoko tsa hau. Acetyl zingerone ke motsoako o matla oa antioxidant le o khahlanong le ho ruruha o nang le melemo e mengata ea bophelo bo botle, ho kenyeletsa ho laola boima ba 'mele, ho thibela botsofali le bophelo bo botle ka kakaretso. Ho u thusa ho etsa qeto e nepahetseng, mona ke lintlha tsa bohlokoa tseo u ka li nahanang ha u khetha tlatsetso e nepahetseng ea acetyl zingerone.
Acetyl zingerone, eo hape e tsejoang e le 4-(acetoxy) -3-methoxybenzaldehyde, ke motsoako oa motsoako oa tlhaho zingerone ka ginger. E tsebahala ka thepa ea eona ea antioxidant, anti-inflammatory le anti-cancer, acetyl zingerone ke mofuta o fetotsoeng oa zingiberone. Ka sebopeho sa eona se ikhethang sa lik'hemik'hale le thepa e matla, acetyl zingerone e hohela tlhokomelo bakeng sa melemo ea eona ea bophelo bo botle.
Har'a tsona, zingerone ke e 'ngoe ea likarolo tsa antioxidant tsa ginger mme e ithutoe bakeng sa thepa e fapaneng ho litoeba le batho. Hoa thahasellisa hore ebe ginger e ncha e fumanoe e na le tekanyo e phahameng ea motsoako o bitsoang zingerone, o fetoloang zingerone ha o omisitsoe kapa o phehiloe. Gingerone e na le sebopeho se tšoanang le curcumin, e ba fa liphello tse tšoanang tsa meriana. Acetyl zingerone e na le sehlopha se ekelitsoeng sa acetyl, se fanang ka acetyl zingerone matla a eketsehileng a scavenging, chelating, le ho tsitsisa. Acetyl zingerone e etselitsoe ho fokotsa mefuta ea bohlokoa ea UVR e bakoang ke oksijene ea mahala (ROS), mefuta e seng ea oksijene e matla, le li-nucleophile tse matla.
Acetyl zingerone e na le thepa e latelang:
●E le antioxidant e nang le lipheo tse ngata
● Fokotsa tšenyo ea mafura, protheine le DNA
● Fokotsa maikutlo a ho ruruha
● Ntlafatsa matrix a extracellular le ho thibela ho senyeha ha collagen
● Ho ipapisitsoe le lingaka ho ntlafatsa matšoao a photoaging
Acetyl zingeroneke motsoako oa bioactive o fumanoang ginger. E tsebahala ka thepa ea eona ea antioxidant le e khahlanong le ho ruruha, e etsang hore e be motsoako o tummeng oa meriana ea setso le li-supplement tsa morao-rao tsa bophelo bo botle.
Na acetyl zingerone ke ea tlhaho kapa ea maiketsetso? Karabo e mabapi le mokhoa oa ho e etsa. Acetyl zingerone e ka fumanoa ka tlhaho le ka maiketsetso.
Acetyl zingerone ea tlhaho e fumanoa motso oa ginger ka mokhoa oa ho ntša le ho hloekisa. Sena se kenyelletsa ho arola motsoako ho tloha semela sa ginger le ho se hloekisa ho fumana mofuta o hloekileng oa acetyl zingerone. Ts'ebetso ena ea tlhaho ea tlhaho e tiisa hore metsoako e boloka thepa ea eona ea pele 'me ha e na li-additives tsa maiketsetso kapa liphetoho.
Synthetic acetyl zingerone, ka lehlakoreng le leng, e ka hlahisoa ka motsoako oa lik'hemik'hale sebakeng sa laboratori. Sena se kenyelletsa ho sebelisa lik'hemik'hale le mekhoa ea ho etsa metsoako ntle le ho itšetleha ka mehloli ea tlhaho e kang ginger. Synthetic acetyl zingerone e kanna ea sebetsa e le mokhoa o sa sebetseng hantle ho fapana le lisebelisoa tsa tlhaho bakeng sa ho sebelisoa indastering ea meriana le ea lijo.
1. Antioxidant thepa
Mitochondria e tsejoa e le mohloli oa matla oa lisele kaha li fana ka matla a hlokahalang bakeng sa lits'ebetso tse fapaneng. Kahoo, DNA ea mitochondrial e kenyelletsa lits'ebetso tse ngata tsa bohlokoa tsa biochemical letlalong. Leha e fumana tšenyo e tšoanang ea DNA joalo ka nyutlelie ea DNA, ha e na mefuta e felletseng ea mekhoa ea tokiso ea DNA e sebetsang khubung. Bafuputsi ba bang ba hlahisitse oache ea mitochondrial ea botsofali ho ipapisitsoe le ho bokellana ha ts'enyo ena ea oxidative, haholo e bakiloeng ke ROS.
Ho feta moo, ha letlalo la rona le pepesehetse mahlaseli a UV, ho hlahisoa mefuta e kotsi ea oksijene ea mahala (ROS). Li-radicals tsena tsa mahala li ka senya liprotheine, DNA le likarolo tse ling tsa cellular letlalong. Keketseho ena ea ROS e lebisa ho eketseha ha enzyme ea MMP-1, e senyang collagen, e lebisang ho ponahalo ea wrinkles.
Li-antioxidants li thusa ho sireletsa 'mele khatellong ea oxidative, e ka bakang tšenyo ea lisele le ho baka mathata a fapaneng a bophelo bo botle. Acetyl zingerone e bontšitsoe hore e senya li-radicals tsa mahala le ho fokotsa tšenyo ea oxidative, e leng se etsang hore e be tlatsetso ea bohlokoa bophelong ba bophelo bo botle.
2. Phello e khahlanong le ho ruruha
Ho ruruha ke karabelo ea tlhaho ea 'mele ho tsoa kotsi kapa tšoaetso, empa ho ruruha ho sa foleng ho ka lebisa ho nts'etsopele ea mafu a sa foleng a kang lefu la pelo, lefu la tsoekere le kankere. Lipatlisiso li fumane hore acetyl zingerone e na le thepa e khahlanong le ho ruruha 'me e ka thusa ho fokotsa ho ruruha le ho tšehetsa bophelo bo botle ka kakaretso. Acetyl zingerone e boetse e laola letšoao la Notch le ERK1 / 2 (ho laola likarabo tsa baktheria) le ho fokotsa matšoao a TGF-B (ho ruruha). E fokolitse polelo ea liphatsa tsa lefutso tse hlahisitsoeng nakong ea phapang ea KC. Phello ena e kanna ea amahanngoa le ho thibela phetiso ea mofuta oa AP-1. Acetyl zingerone e boetse e hlahisitse likarabo tse ngata tsa retinoid le ho thibela phapang ea KC ho ntlafatsa phenotype ea KC e ntseng e eketseha.
3. Tšehetso e ka bang teng ea ho laola boima ba 'mele
Liphuputso tse ling li fana ka maikutlo a hore acetyl zingerone e ka ba le melemo e ka bang teng bakeng sa taolo ea boima ba 'mele. Ho fumanoe hore e laola metabolism ea lipid le lipogenesis, e ka bang le litlamorao ho ts'ehetsa taolo e phetseng hantle ea boima ba 'mele. Le hoja lipatlisiso tse eketsehileng li hlokahala sebakeng sena, liphetho tsa pele lia tšepisa.
4. Phello e khahlanong le botsofali
Acetyl zingeronee fumanoe e ama extracellular matrix (ECM) homeostasis, e khothalletsang ho tsosolosoa ha de novo synthesis ea likarolo tsa matrix. Matrix ke pokello ea liprotheine le likarolo tse ling tse khothaletsang, tse laolang, le ho theha EMC. Li na le boikarabello ba ho boloka letlalo le le boreleli le le se nang mats'obetso. Acetyl zingerone e sebetsa e le motsoako o thibelang botsofali ka litsela tse latelang:
● Eketsa matrix (collagen, proteoglycan, le ECM) ho fana ka letlalo la bacha
● Fokotsa matrix metalloproteinase (MMP) le ho theola collagen
● Ho fokotsa botsofali ba fibroblast, ho tsosolosa tlhahiso ea collagen le ho bebofatsa letlalo la letlalo.
●E hatella li-biomarker tse thibelang ho ruruha tse amang tlhahiso ea collagen, botšepehi ba ECM, le ho ba le mebala ea letlalo.
● Khothalletsa matrix synthesis
5. Peroxidation ea lipid
Ka mor'a hore letlalo le hlahisoe ke leseli la ultraviolet, tlhahiso ea ROS e baka ho senyeha ha oxidative ea glycerophospholipids, sphingolipids (e kang ceramides), unsaturated fatty acids le k'holeseterole. Sena se bolela hore lipids tsa intercellular tsa mokoallo oa mongobo li senngoa ke ho pepeseha ha UV. Lihlahisoa tsa lipid peroxidation li tsejoa e le chefo, mutagenic, esita le carcinogenic. Peroxidation ea lipid e ka thibeloa ka ho sebelisa li-antioxidants tse itseng tse thibelang ts'ebetso ena. Acetyl zingerone e bontšitsoe ho thibela lipid peroxidation mme e bapisoa le resveratrol ka bokhoni ba eona ba ho thibela lipid peroxidation.
6. Thibela ROS e bakoang ke khanya e putsoa le tšilafalo
Liphuputso li fumane hore mahlaseli a UV a etsa karolo ea 50% feela ea kakaretso ea ROS letlalong, athe 50% e 'ngoe e bakoa ke khanya e bonahalang. Esita le setlolo se sireletsang letsatsi ka ho fetisisa se koahela halofo feela ea tšenyo e bakiloeng ke letsatsi. Ntle le ts'enyo e tsoang letsatsing, li-particle tse tsoang tšilafalong ea litoropo li 'nile tsa amahanngoa le hyperpigmentation le ho thehoa ha wrinkles. Acetyl zingerone e bontšitsoe ho fokotsa khanya e putsoa- le keketseho e bakoang ke lerōle ea litoropong ho ROS ka mokhoa o itšetlehileng ka lethal dose.
Bohloeki le boleng
Bohloeki le boleng e lokela ho ba lintlha tsa hau tse phahameng ha u khetha tlatsetso ea acetyl zingerone. Batla lihlahisoa tse entsoeng ka boleng bo holimo, bo hloekileng ba oli ea ginger ea acetyl. Ho bohlokoa ho khetha li-supplement tse lekiloeng ke li-labs tsa motho oa boraro bakeng sa bohloeki le matla ho netefatsa hore u fumana sehlahisoa sa boleng bo holimo se se nang litšila kapa li-filler.
Bioavailability
Bioavailability e bolela bokhoni ba 'mele ba ho monya le ho sebelisa ntho. Ha u khetha tlatsetso ea acetyl zingerone, khetha foromo e nang le bioavailability e phahameng ho netefatsa hore 'mele oa hau o ka monya hantle le ho rua molemo ho motsoako. Ka mohlala, oli ea ginger ea liposomal acetyl e bontšitsoe hore e na le bioavailability e phahameng ha e bapisoa le mefuta e tloaelehileng ea li-supplement, e leng se etsang hore e be khetho e babatsehang bakeng sa ho eketsa melemo ea eona.
Tekanyo le ho tsepamisa maikutlo
Tekanyo le khatello ea li-acetyl zingerone supplements li ka fapana haholo har'a lihlahisoa tse fapaneng. Ho bohlokoa ho nahana ka matla a tlatsetso le litekanyetso tse khothaletsoang ho netefatsa hore o fumana palo e sebetsang ea acetyl zingerone. Batla tlatsetso e fanang ka litekanyetso tse loketseng tsa acetyl zingerone ho fumana melemo ea eona e felletseng.
Recipe le lisebelisoa tse eketsehileng
Ho phaella ho acetyl zingerone, li-supplement tse ling li ka 'na tsa e-na le lisebelisoa tse ling tse ntlafatsang liphello tsa tsona kapa tsa fana ka melemo ea tlatsetso. Ka mohlala, mekhoa e meng e ka kenyelletsa li-antioxidants tse ling kapa limatlafatsi tse sebetsang ka mokhoa o ts'oanang le acetyl zingerone ho tšehetsa bophelo bo botle le bophelo bo botle ka kakaretso. Ha u khetha tlatsetso e nang le lisebelisoa tse ling, nahana ka lipakane tsa hau tsa bophelo bo botle le lintho tseo u li ratang.
Botumo le Maikutlo
Pele o reka, iphe nako ea ho etsa lipatlisiso ka setumo sa mofuta le ho bala maikutlo a bareki. Batla khampani e nang le botumo bo botle e nang le tlaleho ea ho hlahisa lisebelisoa tsa boleng bo phahameng le maikutlo a nepahetseng a bareki. Litlhahlobo tsa ho bala li ka fana ka lintlha tsa bohlokoa mabapi le katleho le phihlelo ea kakaretso ea ho sebelisa tlatsetso e itseng ea acetyl zingerone.
Theko khahlano le boleng
Le hoja theko ha ea lokela ho ba eona feela ntho e etsang qeto, ke habohlokoa ho nahana ka boleng ba kakaretso ea tlatsetso. Bapisa theko ka ho sebeletsa le kakaretso ea acetyl zingerone ho fumana hore na sehlahisoa se sebetsa hantle hakae. Hopola hore theko e holimo e ka bonts'a boleng le katleho ea tlatsetso, kahoo beha boleng pele ho theko e tlase.
Netefaletso ea boleng
Boleng e lokela ho ba ntho ea bohlokoa ka ho fetisisa ha u reka phofo ea acetyl zingerone. Batla bahlahisi ba khomarelang mehato e tiileng ea ho laola boleng 'me ba na le litifikeiti tse tšehetsang bohloeki le matla a lihlahisoa tsa bona. Bahlahisi ba ka tšeptjoang ba tla ba pepeneneng mabapi le mekhoa ea bona ea tlhahiso le ho fana ka litokomane ho netefatsa boleng ba phofo ea bona ea acetyl zingerone.
Botumo le Rxperience
Batlisisa ka botumo le boiphihlelo ba bahlahisi ba ka bang teng indastering. Baetsi ba nang le rekoto e netefalitsoeng le boiphihlelo ba lilemo ba na le monyetla oa ho fana ka lihlahisoa tse tsitsitseng le tse tšepahalang. Batla maikutlo a bareki, bopaki, le litifikeiti tsa indasteri ho lekanya botumo ba moetsi le botšepehi ba hae.
Bokhoni ba Tlhahiso
Nahana ka bokhoni ba tlhahiso ea moetsi ho netefatsa hore ba ka fihlela litlhoko tsa hau tsa phepelo. Moetsi ea tšepahalang o lokela ho ba le bokhoni ba ho phahamisa tlhahiso ho latela litlhoko tsa hau ntle le ho sekisetsa boleng. Botsa ka lisebelisoa tsa bona tsa tlhahiso, lisebelisoa le bokhoni ba ho lekola bokhoni ba bona ba ho phethahatsa odara ea hau ka nako.
Latela melao
Ho bohlokoa ho sebetsa le bahlahisi ba khomarelang melao le litekanyetso tsa indasteri. Netefatsa hore bahlahisi ba latela Mekhoa e Metle ea Tlhahiso (GMP) le litataiso tse ling tse amehang ho netefatsa polokeho le boleng ba lihlahisoa tsa bona. Ho lumellana le litlhoko tsa taolo ho bontša boitlamo ba moetsi ho hlahisa phofo ea acetylsingerone e finyellang litekanyetso tsa indasteri.
Ponaletso le puisano
Puisano e bulehileng le ponaletso ke matšoao a bohlokoa a moetsi ea tšepahalang. Batla bahlahisi ba arabelang lipotso tsa hau, ba fane ka lintlha tse qaqileng ka lihlahisoa tsa bona, 'me ba ikemiselitse ho rarolla mathata afe kapa afe ao u ka bang le' ona. Baetsi ba tšepahalang ba tla pepenene mabapi le lits'ebetso tsa bona, ho fumana thepa e tala, le liteko life kapa life tse etsoang ke batho ba bang lihlahisoa tsa bona.
Myland Pharm & Nutrition Inc e ntse e sebetsa khoebong ea tlatsetso ea phepo e nepahetseng ho tloha ka 1992. Ke k'hamphani ea pele Chaena ho nts'etsapele le ho rekisa sekhechana sa peo ea morara.
Ka boiphihlelo ba lilemo tse 30 'me e khannoa ke theknoloji e phahameng le leano le ntlafalitsoeng la R&D, k'hamphani e thehile lihlahisoa tse ngata tsa tlholisano mme ea fetoha tlatsetso e ncha ea mahlale a bophelo, ho kopanya tloaelo le khamphani ea lits'ebeletso tsa tlhahiso.
Ntle le moo, Myland Pharm & Nutrition Inc hape ke moetsi ea ngolisitsoeng ke FDA. Lisebelisoa tsa R&D tsa k'hamphani, lisebelisoa tsa tlhahiso, le lisebelisoa tsa tlhahlobo ke tsa sejoale-joale ebile li na le mesebetsi e mengata, 'me li ka hlahisa lik'hemik'hale ho tloha ho limiligrama ho isa ho lithane ka tekanyo,' me li lumellana le litekanyetso tsa ISO 9001 le litlhaloso tsa tlhahiso ea GMP.
P: Ke lintlha life tsa bohlokoa tseo u ka li nahanang ha u khetha moetsi oa phofo ea Acetyl Zingerone?
A: Ha u khetha moetsi oa phofo ea Acetyl Zingerone, nahana ka lintlha tse kang botumo ba k'hamphani, ho khomarela litekanyetso tsa boleng, litifikeiti, boleng ba sehlahisoa, le boitlamo ba ho etsa lipatlisiso le nts'etsopele.
P: Nka hlahloba botumo ba moetsi oa phofo oa Acetyl Zingerone joang?
A: Lekola botumo ba moetsi ka ho hlahloba bopaki ba bareki, ho hlahloba litifikeiti tsa indasteri, le ho hlahloba tlaleho ea bona ea ho fana ka phofo ea Acetyl Zingerone ea boleng bo phahameng, e sireletsehileng le e lumellanang le likhoebo tse ling.
P: Ke li-certification kapa litekanyetso life tseo ke lokelang ho li batla ho moetsi oa phofo oa Acetyl Zingerone?
A: Batla bahlahisi ba khomarelang Mekhoa e Metle ea Tlhahiso (GMP), ba na le litifikeiti tsa bohloeki le matla, 'me ba latele melao ea tsamaiso bakeng sa tlhahiso ea phofo ea Acetyl Zingerone.
P: Ke mefuta efe ea lihlahisoa e lokelang ho fanoa ke moetsi oa phofo ea Acetyl Zingerone?
A: Moetsi oa phofo ea Acetyl Zingerone ea nang le botumo bo botle o lokela ho fana ka mefuta e sa tšoaneng ea phofo ea Acetyl Zingerone ea boleng bo phahameng, e hloekileng le e tšehetsoeng ke saense, ho etsa bonnete ba hore e finyella litlhoko tsa liindasteri le likopo tse sa tšoaneng.
Boitlhotlhollo: Sengoloa sena ke sa tlhaiso-leseling e akaretsang feela 'me ha ea lokela ho nkuoa e le keletso efe kapa efe ea bongaka. Tse ling tsa litaba tsa poso ea blog li tsoa Marang-rang mme ha se setsebi. Sebaka sena sa marang-rang se na le boikarabello ba ho hlophisa, ho hlophisa le ho hlophisa lingoliloeng. Sepheo sa ho fetisa boitsebiso bo bongata ha se bolele hore u lumellana le maikutlo a eona kapa u tiisa bonnete ba litaba tsa eona. Kamehla buisana le setsebi sa tlhokomelo ea bophelo pele u sebelisa li-supplement leha e le life kapa u etsa liphetoho tsamaisong ea tlhokomelo ea bophelo.
Nako ea poso: May-29-2024
