A na u ntse u batla mokhoa oa ho khothaletsa bophelo bo botle le boiketlo ba hau ka kakaretso?Calcium alpha-ketoglutarate supplements ke khetho ea hau e ntle ka ho fetisisa.Calcium alpha-ketoglutarate ke motsoako o bapalang karolo ea bohlokoa tlhahisong ea matla ea 'mele le metabolism.Hape ke motsoako oa bohlokoa oa ho boloka masapo a matla le a phetseng hantle, e leng se etsang hore e be limatlafatsi tsa bohlokoa bakeng sa bophelo bo botle ka kakaretso.Ka ho kenyelletsa li-supplement tsa calcium alpha ketoglutarate tšebetsong ea hau ea letsatsi le letsatsi, u ka fumana melemo e mengata ea bophelo bo botle e ntlafatsang maikutlo a hau a bophelo bo botle.
Ka-AKGke motsoako oa mineral calcium le molek'hule ea alpha-ketoglutarate.Alpha-ketoglutarate ke ntho ea bohlokoa tšebetsong ea 'mele ea tlhahiso ea matla, haholo-holo potolohong ea asiti ea tricarboxylic, moo e leng bohlokoa bakeng sa tlhahiso ea adenosine triphosphate (ATP), mohloli oa matla oa' mele.
Ho phaella moo, Ca-AKG e sebetsa e le metabolite ea potoloho ea Kreb le α-ketoglutarate e hlahisoa ha lisele li senya limolek'hule tsa lijo bakeng sa matla.Joale e phalla ka hare le pakeng tsa lisele, e nolofalletsa mekhoa e mengata ea ho boloka bophelo le mekhoa ea lipontšo.E bile e phetha karolo ea ho hlahisa liphatsa tsa lefutso, e sebetsa e le mokhoa oa taolo o bonahalang o thibela liphoso tsa ho ngoloa ha DNA tse atisang ho lebisa mafung a kang kankere.
Ha motho a fihla lilemong tse itseng, boemo ba tlhaho ba α-ketoglutarate 'meleng bo fokotseha,' me ho fokotseha hona ho amana le mokhoa oa ho tsofala.
Har'a bona, α-ketoglutarate ke α-keto acid e phethang karolo ea bohlokoa mefuteng e fapaneng ea mekhoa ea motheo ea likokoana-hloko.Ho feta moo, alpha-ketoglutarate le eona ke k'hemik'hale e sa feleng, ho bolelang hore e hlahisoa ke 'mele.E ke ke ea fumanoa ka lijo, empa liphuputso tse ling li fana ka maikutlo a hore e ka bolokoa ka ho itima lijo le lijo tsa ketogenic.E bonahala e na le bonyane mekhoa e mene ea bohlokoa ea ts'ebetso.Tsena li kenyelletsa ho boloka metabolism e phetseng hantle, ho khothaletsa phetisetso ea li-amino acid tsa bohlokoa, ho sireletsa DNA le ho hatella ho ruruha ho sa foleng.Ho sa le joalo, calcium ke diminerale ea bohlokoa e phethang karolo ea bohlokoa mesebetsing e mengata ea 'mele, ho kenyelletsa ho honyela ha mesifa, ho fetisoa ha methapo ea kutlo le bophelo bo botle ba masapo.
Li-supplement tsa Ca-AKG ke motsoako oa calcium le alpha-ketoglutarate tse fanang ka melemo e mengata e ka bang teng, ho kenyelletsa le ts'ebetso e ntlafalitsoeng ea liatleletiki, kholo ea mesifa, le ts'ehetso ea bophelo bo botle ka kakaretso.
Alpha-ketoglutarateke molek'hule e bapalang karolo ea bohlokoa ho metabolism ea cellular.Ke motsoako oa tlhaho o fumanoang 'meleng hape o fumaneha e le tlatsetso ea lijo.
Ho araba potso ena, ke habohlokoa ho utloisisa mekhoa e ka sehloohong ea botsofali.Botsofali ke mokhoa o rarahaneng o kenyelletsang mefuta e mengata ea lintho tse phelang le tikoloho.E 'ngoe ea lintho tse susumetsang botsofali ke ho bokella tšenyo ea lisele le ho se sebetse ha nako ka nako.Sena se ka lebisa ho fokotseha ha ts'ebetso ea lisele tse fapaneng le litho tsa 'mele, qetellong ho lebisa matšoao a botsofali a kang wrinkles, ho fokotseha ha matla a matla le ho ba le ts'oaetso e eketsehileng ea mafu.
Lipatlisiso li fana ka maikutlo a hore alpha-ketoglutarate e ka ba le monyetla oa ho fetola liphetoho tse ling tse amanang le lilemo.Phuputso e phatlalalitsoeng koranteng ea Cell Metabolism e fumane hore ho tlatselletsa lijo tsa litoeba tse tsofetseng ka alpha-ketoglutarate ho hlahisitse litlamorao tse ngata tse molemo.Tsena li kenyelletsa ts'ebetso e ntlafetseng ea 'mele, ho eketseha ha nako e telele, le ho fokotsa matšoao a botsofali sebeteng le mesifa ea masapo.
Bafuputsi ba fumane hape hore tlatsetso ea alpha-ketoglutarate e bakile liphetoho ts'ebetsong ea liphatsa tsa lefutso tse amehang tlhahisong ea matla le metabolism.Sena se fana ka maikutlo a hore alpha-ketoglutarate e ka khona ho nchafatsa lisele tse tsofetseng ka ho ntlafatsa bokhoni ba eona ba ho hlahisa matla le ho lokisa tšenyo.
Ntle le litlamorao tsa eona ho metabolism, alpha-ketoglutarate e bonts'itsoe hore e na le mefuta e meng ea melemo.Ka mohlala, ke selelekela sa tlhahiso ea collagen, karolo ea bohlokoa ea letlalo le lisele tse ling tse sebetsang.Sena se bolela hore alpha-ketoglutarate e ka thusa ho boloka sebopeho le ts'ebetso ea letlalo, ho thusa ho khothaletsa ponahalo ea bocha.
Calcium ke diminerale ea bohlokoa e bapalang karolo ea bohlokoa lits'ebetsong tse ngata tsa tlhaho 'meleng.E 'ngoe ea mesebetsi ea eona e sa tsejoeng haholo ke phello ea eona ho alpha-ketoglutarate, karolo ea bohlokoa ea potoloho ea citric acid.
Taba ea pele, ho bohlokoa ho utloisisa seo alpha-ketoglutarate e se etsang 'meleng.Alpha-ketoglutarate ke motsoako o bohareng oa potoloho ea citric acid (eo hape e tsejoang e le Krebs cycle) 'me e ikarabella bakeng sa ho hlahisa matla ka mokhoa oa adenosine triphosphate (ATP).Potoloho ena e etsahala ka har'a mitochondria ea sele 'me e bohlokoa bakeng sa metabolism ea lik'habohaedreite, mafura le liprotheine.Alpha-ketoglutarate e kenya letsoho liketsong tse 'maloa tsa bohlokoa tsa biochemical potolohong ea citric acid, ho kenyelletsa le phetoho ea isocitrate ho succinyl-CoA.
Lipatlisiso li bontša hore li-ion tsa khalsiamo li bapala karolo ea bohlokoa ho laola tšebetso ea li-enzyme tse amehang potolohong ea citric acid, ho kenyelletsa le tse sebelisanang le alpha-ketoglutarate.Haholo-holo, calcium ions e laola ts'ebetso ea alpha-ketoglutarate dehydrogenase, e susumetsang phetoho ea alpha-ketoglutarate ho succinyl-CoA.Sena se bolela hore boteng ba khalsiamo bo ama sekhahla sa metabolism ea α-ketoglutarate potolohong ea citric acid.
Ho feta moo, khalsiamo e fumanoe e ama maemo a alpha-ketoglutarate 'meleng.Liphuputso li bonts'itse hore ho eketseha ha maemo a calcium a intracellular ho lebisa ho fokotseha ha likhahla tsa alpha-ketoglutarate, ha ho fokotseha ha maemo a calcium ho na le phello e fapaneng.Sena se totobatsa kamano e rarahaneng pakeng tsa calcium le alpha-ketoglutarate, le kamoo ho fetoha ha maemo a calcium ho amang metabolism ea motsoako ona oa bohlokoa.
Litholoana tsa calcium ho alpha-ketoglutarate li fetela ka nģ'ane ho potoloho ea citric acid.Alpha-ketoglutarate e boetse e le selelekela sa motsoako oa glutamate, neurotransmitter ea bohlokoa tsamaisong ea methapo e bohareng.Ho ile ha fumanoa pontšo ea calcium ho laola mosebetsi oa li-enzyme tse amehang tlhahisong ea glutamate ho tloha ho alpha-ketoglutarate.Sena se bontša phello e tebileng ea calcium hoα-ketoglutarate metabolism, ho kenyelletsa le karolo ea eona ho phetiso ea methapo ea kutlo.
1.Ho thibela botsofali
Ca-AKG e bontšitsoe hore e na le liphello tse ka 'nang tsa e-ba khahlanong le botsofali boemong ba lisele tsa cellular.Phuputso e 'ngoe e fumane hore ho tlatsetsa ka Ca-AKG ho lebisitse ho eketseha ha mosebetsi oa mitochondria, matla a lisele, a fokotsehang ka lilemo.Ka ho tšehetsa mosebetsi oa mitochondrial, Ca-AKG e ka thusa ho ntlafatsa bophelo bo botle ba lisele le ho hlaphoheloa, tse ka 'nang tsa e-ba le liphello tse tebileng bophelong ba kakaretso le mafu a amanang le botsofali.
Ntle le moo, pampiri ea 2019 e phatlalalitsoeng koranteng e hlahlobiloeng ke lithaka Aging e bonts'itse hore alpha-ketoglutarate e ka lelefatsa nako ea bophelo ea li-nematode (tse tsejoang hape e le liboko) le hore motsoako o ka fokotsa ts'ebetso ea tsela ea mTOR.MTOR inhibition e amahanngoa le melemo e mengata ea bophelo bo botle.Haholo-holo, thibelo ea mTOR e bonahala e khothalletsa nako e telele ea sele le ho fokotsa kotsi ea mafu a amanang le lilemo ka ho eketsa autophagy.
2.E laola Matla le Metabolism
E 'ngoe ea litsela tsa bohlokoa tseo Ca-AKG e amang matla le metabolism ke ka karolo ea eona potolohong ea citric acid.Modikologo ono o na le boikarabelo jwa go fetola dikotla tse di mo dijong tse di jaaka dikhabohaetereite, mafura le diporoteine gore e nne adenosine triphosphate (ATP), e leng motswedi o mogolo wa maatla a mmele.Alpha-ketoglutarate ke karolo ea bohlokoa ea potoloho ena kaha e nka karolo liketsong tse 'maloa tsa bohlokoa tsa metabolism.Ka ho fa 'mele mohloli oa alpha-ketoglutarate ka mokhoa oa Ca-AKG, ho nahanoa hore batho ka bomong ba ka khona ho tšehetsa mekhoa ea bona ea tlhahiso ea matla, e leng monyetla oa ho ntlafatsa maemo a matla ka kakaretso le metabolism.
Ho feta moo, lipatlisiso li fana ka maikutlo a hore Ca-AKG e kanna ea ba le thepa ea antioxidant, e ka ts'ehetsang karolo ea eona ho laola matla le metabolism.Khatello ea oxidative e etsahala ha ho e-na le ho se leka-lekane pakeng tsa tlhahiso ea li-radicals tsa mahala le matla a 'mele a ho hanela liphello tsa tsona tse kotsi,' me li amahanngoa le mefuta e mengata ea mathata a bophelo bo botle, ho kenyelletsa le mathata a metabolism.Ka ho sebetsa joalo ka antioxidant, Ca-AKG e ka thusa ho fokotsa khatello ea oxidative, ka hona ho khothaletsa tlhahiso e sebetsang ea matla le metabolism.
3.Healthy Weight Tahlehelo le Tsamaiso
Ca-AKG ke mofuta oa letsoai oa alpha-ketoglutarate, karolo ea bohlokoa ea potoloho ea citric acid (eo hape e tsejoang e le potoloho ea Krebs).Potoloho ena e bohlokoa bakeng sa tlhahiso ea adenosine triphosphate (ATP), mohloli oa matla oa lisele tsa rona.Ntle le karolo ea eona tlhahisong ea matla, alpha-ketoglutarate e boetse e bapala karolo ea bohlokoa ho metabolism ea amino acid.
Liphuputso tse ling li fana ka maikutlo a hore Ca-AKG le eona e ka ba le phello e ntle ho kutloisiso ea insulin.Insulin ke hormone e bapalang karolo ea bohlokoa ho laola maemo a tsoekere ea mali le ho boloka matla 'meleng.Ka ho tšehetsa kutloisiso ea insulin, Ca-AKG e ka thusa batho ka bomong ho laola maemo a tsoekere ea mali hamolemo le ho fokotsa kotsi ea ho nona.
Phuputso ea liphoofolo e hatisitsoeng koranteng ea Aging Cell e bontša hore alpha-ketoglutarate e ka fokotsa boima ba 'mele le ho ntlafatsa maemo a itseng a botenya le mafu.Lintlha tse ka sehloohong tse nkiloeng li kenyelletsa:
● mafura a tlaase
● Ntlafatsa ho mamella tsoekere
● Keketseho ea mafura a sootho (mafura)
4.E laola Matla le Metabolism
Calcium alpha-ketoglutarate e ntlafatsa tlhahiso ea matla boemong ba lisele.Ka ho ts'ehetsa potoloho ea Krebs, Ca-AKG e thusa ho ntlafatsa phetoho ea limatlafatsi ho ATP, mohloli oa matla oa lisele tsa rona.
Ho feta moo, calcium alpha ketoglutarate e bontšitsoe ho ts'ehetsa metabolism e phetseng hantle.Metabolism e bolela lits'ebetso tsa lik'hemik'hale tse bolokang bophelo tse etsahalang 'meleng ea rona, mme metabolism e sebetsang hantle e bohlokoa bakeng sa tlhahiso ea matla, kholo le tokiso.Ca-AKG e thusa ho laola metabolism ka ho khothaletsa tšebeliso e nepahetseng ea lik'habohaedreite, mafura le liprotheine, e leng mehloli ea mantlha ea matla a lisele.
Ntle le karolo ea eona tlhahisong ea matla le taolong ea metabolic, calcium alpha-ketoglutarate e boetse e na le thepa ea antioxidant.E le antioxidant, Ca-AKG e thusa ho fokotsa li-radicals tsa mahala tse kotsi, tse ka senyang lisele le ho kenya letsoho maemong a fapaneng ho kenyelletsa khatello ea oxidative, ho ruruha le botsofali.Ka ho fokotsa tšenyo ea oxidative, calcium alpha-ketoglutarate e tšehetsa bophelo bo botle ba lisele le mosebetsi.
E 'ngoe ea lintlha tsa bohlokoa tseo u ka li nahanang ha u khetha tlatsetso ea Ca-AKG ke boleng ba sehlahisoa.Batla li-supplement tse entsoeng ke moetsi ea tsebahalang ea latelang mekhoa e metle ea tlhahiso (GMP) mme ke motho oa boraro ea lekiloeng bakeng sa bohloeki le matla.Sena se tla etsa bonnete ba hore o fumana sehlahisoa sa boleng bo holimo se se nang litšila 'me se kopana le likopo tsa lileibole.
E 'ngoe ea bohlokoa eo u lokelang ho e ela hloko ha u khetha tlatsetso ea Ca-AKG ke mofuta oa tlatsetso.Ca-AKG e fumaneha ka mefuta ea phofo le capsule, e 'ngoe le e' ngoe e na le melemo le mathata a eona.Li-supplement tsa phofo hangata li monngoa habonolo ke 'mele' me li ka kopanngoa le lino kapa li-smoothie hore li sebelisoe habonolo.Ka lehlakoreng le leng, li-capsules li bonolo ebile li bonolo ho li jara.Ha u khetha foromo ea tlatsetso e molemong oa hau, nahana ka mokhoa oa hau oa bophelo le likhetho tsa hau.
Ntle le boleng le sebopeho, ho bohlokoa hape ho nahana ka lethal dose le mahloriso a Ca-AKG ka tlatsetsong.Batla lihlahisoa tse fanang ka tekanyo e lekaneng ea Ca-AKG ho fihlela litlhoko tsa hau ka bomong.Ho bohlokoa hape ho nahana ka bongata ba Ca-AKG tlatsetsong - likhakanyo tse phahameng li ka hloka litekanyetso tse nyane, tse ka bang bonolo ho batho ba bang.
Ho feta moo, ho bohlokoa ho nahana ka lisebelisoa tse ling tsa litlatsetso tsa Ca-AKG.Li-supplement tse ling li ka ba le li-filler, li-preservative kapa li-allergen tseo u ka ratang ho li qoba.Haeba u na le allergy kapa lithibelo tsa lijo, batla li-supplement tse nang le lisebelisoa tse fokolang tse kentsoeng 'me u se na li-allergen tse tloaelehileng.
Qetellong, nahana ka litšenyehelo le boleng ba tlatsetso ea Ca-AKG.Le hoja ho ka 'na ha e-ba tekong ea ho khetha khetho e theko e tlaase, ho bohlokoa ho nahana ka boleng ba kakaretso ea tlatsetso.Fumana sehlahisoa se fanang ka foromo ea boleng bo holimo, e matla ka theko e tlase.Nahana ka litšenyehelo tsa ho sebeletsa le boleng ba kakaretso ea tlatsetso ho latela boleng ba eona, sebopeho, litekanyetso le lisebelisoa tse ling.
Litlhaloso tsa likarolo tsa Suzhou Myland Pharm & Nutrition Inc.esale e sebetsa khoebong ea tlatsetso ea phepo e nepahetseng ho tloha ka 1992. Ke k'hamphani ea pele naheng ea China ho hlahisa le ho etsa khoebo moqomo oa peo ea morara.
Ka boiphihlelo ba lilemo tse 30 'me e khannoa ke theknoloji e phahameng le leano le ntlafalitsoeng la R&D, k'hamphani e thehile lihlahisoa tse ngata tsa tlholisano mme ea fetoha tlatsetso e ncha ea mahlale a bophelo, ho kopanya tloaelo le khamphani ea lits'ebeletso tsa tlhahiso.
Ntle le moo, khamphani hape ke moetsi ea ngolisitsoeng ke FDA, e netefatsang bophelo bo botle ba batho ka boleng bo tsitsitseng le kholo e tsitsitseng.Lisebelisoa tsa k'hamphani tsa R&D le lisebelisoa tsa tlhahiso le lisebelisoa tsa tlhahlobo ke tsa sejoale-joale ebile li na le mesebetsi e mengata, 'me li khona ho hlahisa lik'hemik'hale ka sekala sa milligram ho isa ho tone ho latela litekanyetso tsa ISO 9001 le mekhoa ea tlhahiso ea GMP.
P: Calcium Alpha Ketoglutarate ke eng?
A: Calcium Alpha Ketoglutarate ke tlatsetso e kopanyang khalsiamo le alpha ketoglutaric acid, e leng motsoako o phethang karolo ea bohlokoa tlhahisong ea matla le metabolism ea limatlafatsi 'meleng.
P: Melemo ea ho nka li-supplement tsa Calcium Alpha Ketoglutarate ke efe?
A: Li-supplement tsa Calcium Alpha Ketoglutarate li bontšitsoe ho tšehetsa bophelo bo botle ba masapo, ho ntlafatsa ts'ebetso ea mesifa, ho ntlafatsa mamello ea boikoetliso, le ho khothalletsa bophelo bo botle le bophelo bo botle ka kakaretso.
P: Na lisebelisoa tsa Calcium Alpha Ketoglutarate li ka thusa baatlelete le batho ba chesehelang boikoetliso ba 'mele?
A: E, li-supplement tsa Calcium Alpha Ketoglutarate li ka ntlafatsa ts'ebetso ea boikoetliso le mamello ka ho ntlafatsa tlhahiso ea matla le metabolism ea limatlafatsi 'meleng.
Boitlhotlhollo: Sengoloa sena ke sa tlhaiso-leseling e akaretsang feela 'me ha ea lokela ho nkuoa e le keletso efe kapa efe ea bongaka.Tse ling tsa litaba tsa poso ea blog li tsoa Marang-rang mme ha se setsebi.Sebaka sena sa marang-rang se na le boikarabello ba ho hlophisa, ho hlophisa le ho hlophisa lingoliloeng.Sepheo sa ho fetisa boitsebiso bo bongata ha se bolele hore u lumellana le maikutlo a eona kapa u tiisa bonnete ba litaba tsa eona.Kamehla buisana le setsebi sa tlhokomelo ea bophelo pele u sebelisa li-supplement leha e le life kapa u etsa liphetoho tsamaisong ea tlhokomelo ea bophelo.
Nako ea poso: Feb-22-2024
