Ho hlahloba Urolithin A le B: Bokamoso ba ho Theola boima ba 'mele le Tlatsetso ea Bophelo bo Botle

Lilemong tsa morao tjena, leseli le fetohile urolithins, haholo-holo urolithin A le B, e le metsoako e tšepisang e nkiloeng ho metabolism ea polyphenols e fumanoang likharenate le litholoana tse ling. Li-metabolite tsena li hapile tlhokomelo bakeng sa melemo ea tsona ea bophelo bo botle, ho kenyelletsa ho theola boima ba 'mele, thepa e thibelang botsofali, le bophelo bo botle ka kakaretso.

Ho utloisisa Urolithins: A le B

Urolithins ke metabolite e hlahisoang ke libaktheria tsa mala ha li pshatla ellagitannins, mofuta oa polyphenol o fumanoang litholoana tse fapaneng, haholo-holo likharenate. Har'a mefuta e fapaneng ea urolithin, urolithin A (UA) leurolithin B (UB) ke tsona tse ithutoang ka ho fetisisa.

Urolithin A e 'nile ea amahanngoa le melemo e mengata ea bophelo bo botle, ho kenyelletsa le ts'ebetso e ntlafetseng ea mitochondrial, bophelo bo botle ba mesifa, le liphello tse ka 'nang tsa e-ba khahlanong le ho ruruha. Lipatlisiso li fana ka maikutlo a hore UA e ka bapala karolo ea ho khothalletsa autophagy, mokhoa o thusang 'mele ho ntša lisele tse senyehileng le ho tsosolosa tse ncha. Bokhoni bona ba ho tsosolosa bo ipiletsa ka ho khetheha ho ba batlang ho boloka boima ba mesifa le matla a kakaretso ha ba ntse ba tsofala.

Urolithin B ka lehlakoreng le leng, ha e ithutoe haholo empa ho lumeloa hore e na le melemo ea eona ea bophelo bo botle. Liphuputso tse ling li bontša hore UB e ka boela ea tšehetsa mosebetsi oa mitochondrial le ho bontša thepa ea antioxidant, le hoja liphello tsa eona li sa ngoloa hantle joaloka tsa UA.

Urolithin A le ho fokotsa boima ba 'mele

E 'ngoe ea libaka tse thabisang ka ho fetisisa tsa lipatlisiso tse potolohileng urolithin A ke karolo e ka bang teng ea ho theola boima ba' mele. Liphuputso tse 'maloa li bontšitse hore UA e ka thusa ho laola metabolism le ho khothalletsa tahlehelo ea mafura. Mohlala, phuputso e hatisitsoeng koranteng ea *Nature* e fumane seourolithin Ae ka ntlafatsa bokhoni ba 'mele ba ho chesa mafura ka ho ntlafatsa ts'ebetso ea mitochondrial. Sena se bohlokoa haholo kaha bophelo bo botle ba mitochondrial bo bohlokoa bakeng sa tlhahiso ea matla le metabolism.

Ho feta moo, urolithin A e bonts'itsoe ho susumetsa microbiome ea mala hantle. Microbiome e phetseng hantle ea mala e bohlokoa bakeng sa tšilo ea lijo le metabolism e sebetsang, 'me e ka bapala karolo ea bohlokoa taolong ea boima ba' mele. Ka ho khothaletsa tikoloho e leka-lekaneng ea mala, UA e ka thusa batho ka bomong ho fihlela lipheo tsa bona tsa ho theola boima ba 'mele ka katleho.

Lisebelisoa tse Hloekileng tsa Urolithin A

Ka thahasello e ntseng e hola ea urolithin A, lik'hamphani tse ngata li se li qalile ho fana ka lisebelisoa tse hloekileng tsa urolithin A. Li-supplement tsena li rekisoa e le mokhoa oa ho sebelisa melemo ea motsoako ona ntle le ho hloka ho ja likharenate tse ngata kapa lijo tse ling tse nang le ellagitannin.

Ha ho nahanoa ka tlatsetso e hloekileng ea urolithin A, ho bohlokoa ho batla lihlahisoa tse tšehelitsoeng ke lipatlisiso tsa mahlale mme li entsoe liteko tse matla tsa bohloeki le katleho. Li-supplement tsa boleng bo holimo li lokela ho ba le tekanyo e tloaelehileng ea urolithin A ho netefatsa hore basebelisi ba fumana melemo e reriloeng.

Lisebelisoa tse Molemohali tsa Urolithin A Marakeng

Ha tlhoko ea li-supplement tsa urolithin A e ntse e hola, lihlahisoa tse 'maloa li hlahile e le baetapele 'marakeng. Mona ke tse ling tsa li-supplement tsa urolithin A tse fumanehang hajoale:

1. Kharenate Extract e nang le Urolithin A: Mefuta e meng e fana ka lisebelisoa tsa kharenate tse kenyelletsang urolithin A e le motsoako oa bohlokoa. Lihlahisoa tsena li fana ka melemo ea litholoana le metabolite ea eona.

2. Myland Nutraceuticals Urolithin A: Letšoao lena le fana ka tlatsetso e hloekileng ea urolithin A e se nang li-additives le li-fillers, e leng se etsang hore e be khetho e ntle ho ba batlang mokhoa o otlolohileng oa ho tlatsetsa.

Qetello

Urolithin A le B li emela sebaka se khahlang sa lipatlisiso se nang le litlamorao tse kholo tsa bophelo bo botle le bophelo bo botle. Le hoja urolithin A e bontša tšepiso ea ho tšehetsa tahlehelo ea boima ba 'mele le bophelo bo botle ka kakaretso, urolithin B e ka boela ea kenya letsoho melemong ena, le hoja e le ka tekanyo e fokolang. Ha mahlale a potolohileng metsoako ena a ntse a tsoela pele ho fetoha, ho tla ba joalo le likhetho tse fumanehang bakeng sa bareki ba batlang ho ntlafatsa bophelo ba bona ka tlatsetso.

Bakeng sa ba nang le thahasello ea ho hlahloba melemo e ka bang teng ea urolithin A, ho bohlokoa ho khetha lisebelisoa tsa boleng bo holimo tse tšehetsoeng ke lipatlisiso. Joalo ka mehla, batho ba lokela ho buisana le litsebi tsa tlhokomelo ea bophelo pele ba qala mofuta ofe kapa ofe o mocha oa tlatsetso, haholo haeba ba na le maemo a bophelo bo botle kapa ba noa meriana e meng.

Ka kakaretso, urolithin A le B ha li na ho bua feela ka indasteri ea tlatsetso ea bophelo bo botle; li emela moeli o mocha oa kutloisiso ea rona ea hore na metsoako ea tlhaho e ka tšehetsa tahlehelo ea boima ba 'mele, bophelo bo botle ba lisele, le bophelo bo botle ka kakaretso. Ha lipatlisiso li ntse li tsoela pele, re ka fumana lits'ebetso tse khahlisang le ho feta tsa metabolite tsena tse matla lilemong tse tlang.