Lebitso la saense la NAD ke nicotinamide adenine dinucleotide. NAD+ e teng seleng e 'ngoe le e 'ngoe ea 'mele ea rona. Ke metabolite ea bohlokoa le coenzyme mekhoeng e fapaneng ea metabolic. E kenella le ho kenya letsoho lits'ebetsong tse fapaneng tsa baeloji. Li-enzyme tse fetang 300 li itšetlehile ka NAD+ Ho sebetsa. Leha ho le joalo, boemo ba litaba tsa NAD+ ha bo eme. Ha re ntse re tsofala, litaba tsa NAD + liseleng li tla fokotseha. Haholo-holo ka mor'a lilemo tsa 30, boemo ba NAD + bo tla theoha haholo, bo lebisang ho fokotseha ha mesebetsi e mengata 'me kahoo ho bontša matšoao a botsofali. Nicotinamide riboside chloride ke mofuta oa vithamine B3. Nicotinamide riboside chloride e ka fetoloa NAD+ (nicotinamide adenine dinucleotide). Ke e 'ngoe ea li-precursors tsa NAD+ tse ithutoang haholo. E kenngoa habonolo ke 'mele le ho e sebelisa. Liphuputso tse ngata li bonts'itse hore ho tlatselletsa NRC ho ka eketsa maemo a NAD +, e leng se ka tlisang melemo ho metabolic, pelo le methapo ea methapo. Hangata e sebelisoa e le tlatsetso ea lijo ho khothalletsa bophelo bo botle le boiketlo ka kakaretso.
Nicotinamide riboside chloride (NRC) ke ntho e nkiloeng ho vithamine B3 le ntho e ncha ea bioactive. E entsoe ka molek'hule ea tsoekere ea ribose le karolo ea vithamine B3 nicotinamide (eo hape e tsejoang e le nicotinic acid kapa vithamine B3). E ka jeoa ka ho ja nama, tlhapi, lijo-thollo le lijo tse ling kapa ka li-supplement tsa NRC.
Nicotinamide ribose chloride e ka fetoloa NAD+ (nicotinamide adenine dinucleotide) 'me ea sebetsa ka har'a lisele. NAD + ke coenzyme ea bohlokoa ea intracellular e kenyang letsoho mekhoeng e sa tšoaneng ea lik'hemik'hale tsa lisele, ho kenyelletsa tlhahiso ea matla, ho lokisoa ha DNA, ho ata ha lisele, joalo-joalo Nakong ea botsofali ba 'mele oa motho, litaba tsa NAD + li fokotseha butle-butle. Nicotinamide riboside chloride supplementation e ka eketsa boemo ba NAD +, e lebelletsoeng ho liehisa ho hlaha ha botsofali ba lisele le mafu a amanang.
Patlisiso ka nicotinamide riboside chloride e bonts'itse hore e na le mesebetsi e mengata ea tlhaho, joalo ka:
Ntlafatsa metabolism ea matla, eketsa mamello le ts'ebetso ea boikoetliso;
Ntlafatsa ts'ebetso ea methapo le mohopolo;
Ntlafatsa ts'ebetso ea sesole sa 'mele.
Ka kakaretso, nicotinamide riboside chloride ke motsoako o ts'episang haholo oa phepo o nang le tebello e pharalletseng ea ts'ebeliso.
Ntle le moo, nicotinamide ribose chloride e boetse e sebelisoa haholo lipatlisisong tsa mahlale. E le ntho ea pele ea NAD+, e ka sebelisoa ho ithuta biosynthesis le litsela tsa metabolic tsa NAD+ le litaba tse ling tse amanang le tsona. Ka nako e ts'oanang, nicotinamide riboside chloride e boetse e sebelisoa e le motsoako oa lihlahisoa tsa bophelo bo botle le litlolo ho khothaletsa bophelo bo botle ba lisele le ho fokotsa botsofali ba letlalo.
Botsofali ke taba ea ka ho sa feleng bakeng sa batho. Ho latela lipatlisiso tsa bo-ramahlale, botsofali ba lisele bo amana haufi-ufi le phokotso ea litaba tsa nicotinamide adenine dinucleotide (NAD). NAD ke sehokelo sa bohlokoa metabolism le tokiso ea lisele 'meleng oa motho. E ke ke ea liehisa botsofali feela, empa hape e boloka matla a lisele le ho boloka bophelo bo botle ba 'mele le ba kelello. empa. Ha re ntse re tsofala, maemo a NAD 'meleng ea rona a theoha ka potlako le ka potlako, mme a ka ba a theoha ho feta halofo ea lilemo tse pakeng tsa 40 le 80.
Ho na le enzyme ea bohlokoa haholo 'meleng ea rona, e leng karolo ea mantlha ea metabolism ea matla a cellular. Ke ea bohlokoa hakae? Hoo e ka bang lits'ebetso tsohle tse bolokang ts'ebetso e tloaelehileng ea 'mele, joalo ka metabolism, tokiso, le ho itšireletsa mafung, li hloka ho kenya letsoho ha enzyme ena. Ha maemo a enzyme ena a fokotseha, matšoao a mangata le maloetse a amanang le botsofali a ka hlaha, joalo ka mafu a metabolism, ho fokola ha 'mele oa ho itšireletsa mafung, ho fokotseha ha kelello, joalo-joalo Enzyme ena ea bohlokoa e na le lebitso le lelelele: nicotinamide adenine dinucleotide, kapa NAD +.
Ka bokhutšoanyane, phokotso ea NAD + 'meleng e bolela ho tsofala. Joale, na re ka tlatselletsa NAD + 'meleng ho lieha ho tsofala? Haeba o tlatselletsa NAD + ka kotloloho, 'mele oa motho o ke ke oa khona ho o amohela,' me o tla ba le litlamorao tse mpe. Ka hona, batho ba ile ba lebisa tlhokomelo ea bona ho ntho ea pele ea NAD +: nicotinamide ribose chloride (NRC).
Nicotinamide riboside chloride ke mofuta oa vithamine B3 le e 'ngoe ea li-precursor tsa NAD+ tse ithutoang ka ho fetesisa. E monyela habonolo le ho sebelisoa ke 'mele. Liphuputso tse ngata li bonts'itse hore tlatsetso ea NR e ka eketsa maemo a NAD +, e leng se ka tlisang melemo ho metabolic, pelo le methapo ea methapo.
Lentsoe "khahlanong le botsofali" le fumana rap e mpe. Ho utloahala eka re leka ho emisa ntho e seng e ntse e tsoela pele, kapa ha re khone ho amohela likarolo tsa rona tseo re lokelang ho li rata. Empa 'nete ke hore liphetoho tsa metabolism li etsahala ka tlas'a letlalo pele re bona liphello tsa botsofali. Ho khetha ho talima bophelo ba rōna ho tsoa botebong ba ka ntle e ka 'na ea e-ba sona seo re se hlokang ho ntlafatsa tsela eo re tsofalang ka eona.
Ha e le hantle, e 'ngoe ea matšoao a botsofali ke mokhoa o tsejoang e le "ho se sebetse ha mitochondrial," lentsoe le bolelang tahlehelo e akaretsang ea matla le bokhoni ba lisele tsa rona ka nako. Sena e ka ba le leng la mabaka a etsang hore re tsofala. Haeba mitochondria e le pelong ea botsofali ba rona, ho bohlokoa ho etsa lipatlisiso ka mekhoa eohle e ka khonehang ea ho li boloka li sebetsa nako e telele kamoo ho ka khonehang.
Ithute ka mitochondria.
Ka har’a sele e ’ngoe le e ’ngoe ho na le lithoana tsena tse nyenyane, tse nang le sebōpeho se sa tloaelehang tse bitsoang mitochondria—“matla a matla a sele.” Litho tsena tse nyane li na le boikarabello ba ho hlahisa karolo ea 90% ea matla ao 'mele ea rona e e hlokang. Mitochondria ke lebaka leo ka lona re leng teng kajeno re le liphoofolo tse rarahaneng ho e-na le libaktheria.
Hase kamehla re tsebang hore na mitochondria e bohlokoa hakae bophelong ba rona. Mokhoa oa bohlokoa oa ho boloka mitochondria ea hau e phetse hantle ke molek'hule e bitsoang NAD+ (nicotinamide adenine dinucleotide). Ka tlhaho lisele tsa rona li hlahisa NAD+ 'me re e sebelisa re sa khaotse letsatsi lohle.
Hape rea tseba hore phepelo ea rona ea NAD+ ea fokotseha ha re ntse re tsofala. Hang ha bafuputsi ba elelloa hore NAD + e kanna ea tšoara senotlolo sa ho boloka lisele tsa rona li phetse hantle, ba ile ba qhekella ho fumana mokhoa oa ho e sebelisa hamolemo.
Bafuputsi ba se ba ntse ba tseba hore livithamini tse peli li qala ts'ebetso ea lik'hemik'hale ea ho eketsa NAD +: niacin le niacinamide. Tsena li ile tsa sibolloa ka bo-1930 ho phekola pellagra, khaello e ka 'nang ea bolaea ea vithamine B3.
Niacin e ne e tla tsoela pele ho ba kalafo ea cholesterol e phahameng lilemong tsa bo-1950. Leha ho le joalo, ho fumanoe hore ho ja litekanyo tse phahameng tsa niacin ka linako tse ling ho ka baka ho khoehla ha letlalo ho khopisang le ho sa boheheng.
Niacinamide ha e bake ho phatloha ha letlalo mme ho ka thoe e ka fana ka melemo e mengata e ts'oanang, empa e thibela ts'ebetso ea liprotheine tsa bohlokoa tse ntlafatsang lisele tse bitsoang li-sirtuins. Niacinamide kapa niacin ha lia ka tsa sebetsa joalo ka ha bafuputsi ba ne ba tšepile.
Leha livithamini tsena tse peli e le li-precursor tsa NAD +, ha se tharollo e nepahetseng. Ka lebaka la litlamorao tse mpe tsa niacin le katleho e lekantsoeng ea nicotinamide, bafuputsi ba ntse ba sena tlatsetso e lekaneng ea vithamine ho eketsa maemo a NAD+.
Ho sibolloa ha nicotinamide riboside.
Mofuta o mong oa vithamine B3 o bitsoang nicotinamide riboside o ile oa fumanoa ka tomoso ka bo-1940. Empa e bile ho fihlela mathoasong a lilemo tsa bo-2000 moo bo-rasaense ba ileng ba qala ho bona bokhoni ba vithamine ena ea boraro, B3, eseng feela ho eketsa NAD + empa hape le ho ntlafatsa bophelo bo botle ba batho. Ka 2004, sehlopha sa lipatlisiso sa Dartmouth College se ile sa fumana hore nicotinamide riboside, joalo ka moena oa eona oa vithamine B3, ke selelekela sa NAD+.
Sehlopha sa lipatlisiso se etelletsoeng pele ke Dr. Charles Brenner se fumane hore nicotinamide riboside e ekelitse NAD + litoeba, 'me litoeba li ile tsa fumana melemo e mengata ea bophelo bo botle ka lebaka leo.
Litoeba li bontšitse ntho e 'ngoe le e' ngoe ho tloha ho tsoekere e ntlafetseng ea mali le maemo a k'holeseterole ho fokotsa tšenyo ea methapo le ho hanyetsa boima ba 'mele. Dr. Charles Brenner o fumane liphello tsena e le tse khothatsang hoo a ileng a nka mohato o latelang ho utloisisa se boleloang ke nicotinamide riboside bakeng sa bophelo bo botle ba motho.
Ka 2014, Dr. Brenner e bile motho oa pele oa ho nka nicotinamide riboside e le tlatsetso. Liphello le tsona lia khothatsa. Mofuta ona o sa tsejoeng oa vithamine B3 o ile oa eketsa maemo a hae a NAD+ haholo ka mokhoa o sireletsehileng, kapele, ntle le litla-morao tse mpe.
Nicotinamide riboside e sebelisa tsela e ikhethang ho hlahisa NAD+ eo ho seng vithamine B3 e 'ngoe e e sebelisang.
Nicotinamide riboside e ka boela ea kenya tšebetsong liprotheine tse khothalletsang liprotheine tse sirtuin. Ha re ntse re tsofala, li-sirtuin tsena li sebetsa nako e eketsehileng ho thusa lisele hore li lule li le matla.
Ho lula u phetse hantle ha u ntse u hōla ha ho mohla ho tla ba bonolo joaloka vithamine e le 'ngoe, leha e le e ts'episang joalo ka nicotinamide riboside. Ho na le lithuto tse fetang 100 tse etsang lipatlisiso tsa nicotinamide riboside, tseo bongata ba tsona li bonts'ang hore maemo a NAD+ a ntseng a eketseha a amahanngoa le bophelo bo botle ba metabolic le mesifa ho litoeba. Lipatlisiso tse ling li ntse li tsoela pele ho utloisisa karolo ea NAD+ ho ts'ehetsa mathata a mang a bophelo bo amanang le lilemo, ho kenyelletsa le ho fokotseha ha tšebetso ea sebete, boima ba 'mele, maemo a insulin le ts'ebetso ea boko ho litoeba.
NAD ke eng?
NAD+ ke coenzyme I, e leng coenzyme e fetisang li-protons (ka nepo, li-ion tsa hydrogen) mme e nka karolo mesebetsing e mengata ea fisioloji joalo ka metabolism ea cellular, synthesis ea matla, le tokiso ea DNA. NAD+ ke limatlafatsi tse hlokahalang bakeng sa ts'ebetso ea protheine ea Sirtuin, e bitsoang "longevity factor" ke bo-ramahlale. Haholo-holo, e ka boloka bolelele ba li-telomere tsa bohlokoa, ea liehisa mokhoa oa ho tsofala le ho lelefatsa nako ea bophelo.
NAD+ e ka boela ea khothaletsa tokiso ea liphatsa tsa lefutso le ho liehisa botsofali ba lisele. NAD + e khothalletsa nchafatso ea lisele le ho hanela mafu a sesole sa 'mele. NAD+ e ntlafatsa botsitso ba chromosome mme e fokotsa kotsi ea mofets'e.
Ke metsoalle ea hlooho ea khomo ea li-enzyme, e thusang ho besa "mochini oa cellular" o hlahisang matla a hlokahalang bakeng sa ts'ebetso e 'ngoe le e' ngoe e kholo 'meleng oa hau maemong a cellular.
Hobaneng NAD+ e le bohlokoa?
Ka lebaka la karolo ea eona ea bohlokoa tlhahisong ea matla a cellular, khaello ea NAD + 'meleng oa hau e etsa hore mesebetsi e mengata ea' mele e se be le thuso. Ntle le NAD, matšoafo a hau a ke ke a khona ho nka oksijene, pelo ea hau e ke ke ea khona ho pompa mali, 'me li-synapse tsa boko ba hau li ke ke tsa tuka.
NAD+ e boetse e thusa ho khothaletsa tokiso ea DNA le ho laola ts'ebetso ea lisele ka ho sebetsa ka li-sirtuin le poly(ADP-ribose) polymerases (PARPs), tse bohlokoa ho laola likarabo tsa cellular ho mahlapa a kang ho ja ho feta tekano, ho noa joala, ho sitisoa ke boroko, le mekhoa ea ho lula fatše. Li-enzyme.
NAD+ le botsofali
Lipatlisiso tse entsoeng ka 2012 ke sehlopha sa Lefapha la Pharmacology Univesithing ea New South Wales li bontšitse hore NAD metabolism e amahanngoa le lilemo. Boithuto bo bonts'a hore maemo a NAD + liseleng tsa letlalo la motho a theoha ho fihla ho 50% lipakeng tsa lilemo tse 40 le 60, le hore ho fokotseha ha NAD + ho ka bapala karolo ea bohlokoa ts'ebetsong ea botsofali.
"Ho ile ha bonoa likamano tse matla lipakeng tsa maemo a NAD + le lilemo ho banna le basali," bafuputsi ba boletse pampiring.
Ho feta moo, NAD e kenya letsoho phefutsong ea cellular, haholo ho mitochondria, mme e kenya letsoho ho bophelo bo botle ba mitochondrial. Ho na le thahasello e matla ea saense mabapi le ho kenya letsoho ha NAD ho se sebetse ha mitochondrial, e 'ngoe ea matšoao a botsofali.
Lilemong tsa morao tjena, lipatlisiso li tsepamisitse maikutlo ho utloisiseng karolo ea NAD ho sebetsana le ho fokotseha ha ts'ebetso e amanang le lilemo.
Nicotinamide Ribose Chloride e eketsa maemo a NAD +.
NR ke selelekela sa NAD, ho bolelang hore ke "sebaka sa moaho" seo limolek'hule tsa NAD + li entsoeng ka sona. E ile ea sibolloa ka 2004 e le selelekela sa vithamine ho NAD+, e etsa hore e be e 'ngoe ea likhatelopele tsa morao-rao lipatlisisong tsa NAD+.
NR ke vithamine ea tlhaho le mofuta o mocha oa vithamine B3, empa tšebeliso ea eona e le tlatsetso e anngoe hampe ke "botsofali bo botle". E sebetsa haholo ho eketsa NAD, e e etsa hore e be e 'ngoe ea litšebetso tse thabisang ka ho fetisisa litharollong tsa botsofali tse phetseng hantle.
NR e ka eketsa maemo a NAD + ka katleho. Teko ea bongaka e phatlalalitsoeng ho Scientific Reports e bonts'itse hore e eketsehile NAD+ ka 50% kamora libeke tse peli ho e nka.
Leha tlatsetso ea NR e netefalitsoe hore e eketsa maemo a NAD +, tlatsetso ea NAD + joalo ka motsoako o ikemetseng ha e sebetse joalo.
NAD+ ke molek'hule e kholo haholo 'me ha e khone ho kena liseleng ka kotloloho. Ho e-na le hoo, 'mele oa hao o lokela ho o arola likotoana tse nyenyane pele o ka tšela lera la sele. Likarolo tsena li kopantsoe hape ka har'a betri.
Nicotinamide riboside (NR) le nicotinamide riboside chloride (NRC) ke mefuta ka bobeli ea vithamine B3, e tsejoang hape e le niacin. Vithamine B3 ke limatlafatsi tse bohlokoa tse bapalang karolo ea bohlokoa mesebetsing e fapaneng ea 'mele, ho kenyelletsa tlhahiso ea matla, tokiso ea DNA le metabolism ea lisele. Ka bobeli NR le NRC ke li-precursors tsa nicotinamide adenine dinucleotide (NAD+), coenzyme e amehang lits'ebetsong tse fapaneng tsa tlhaho, joalo ka ho laola tlhahiso ea matla a cellular le ho tšehetsa tokiso ea DNA.
Nicotinamide riboside (NR) ke mofuta oa vithamine B3 e fumaneng tlhokomelo bakeng sa thepa ea eona e ka thibelang botsofali le ho matlafatsa matla. Ke motsoako oa tlhaho o fumanehang ka bongata lijong tse ling, empa hape o fumaneha e le tlatsetso ea lijo. NR e tsejoa ka bokhoni ba eona ba ho eketsa maemo a NAD + 'meleng, e leng eona e ka ts'ehetsang ts'ebetso ea mitochondrial, ea ntlafatsa tlhahiso ea matla a cellular, mme e ka fana ka ts'ireletso khahlano le ho fokotseha ho amanang le botsofali.
Nicotinamide riboside chloride (NRC), ka lehlakoreng le leng, ke mofuta oa letsoai oa NR 'me o sebelisoa hangata lihlopheng tsa lijo. Ho eketsa chloride ho NR ho hlahisa NRC, eo ho lumeloang hore e matlafatsa botsitso le bioavailability ea motsoako. Sena se bolela hore NRC e kanna ea ba le ho monya le ts'ebeliso e ntle 'meleng ho feta NR feela mme e kanna ea ba le phello e hlakileng haholoanyane maemong a NAD + le ts'ebetso ea cellular.
E 'ngoe ea phapang e ka sehloohong pakeng tsa NR le NRC ke sebopeho sa bona sa lik'hemik'hale. NR ke mofuta oa motheo oa motsoako ona, athe NRC ke phetolelo e fetotsoeng e nang le chloride e eketsehileng. Phetoho ena e reretsoe ho eketsa ho qhibiliha ha motsoako le bioavailability, ho nolofalletsa 'mele ho o monya le ho o sebelisa.
Mabapi le melemo ea bona ea bophelo bo botle, ho nahanoa hore NR le NRC li na le liphello tse tšoanang ka lebaka la bokhoni ba tsona ba ho eketsehaNAD+maemo. Liphello tsena li ka kenyelletsa ts'ebetso e ntlafetseng ea mitochondrial, matla a matla a metabolism, le tšehetso e ka bang teng bakeng sa bophelo bo botle ba lisele. Leha ho le joalo, ho sebelisa NRC ka tlatsetso ho ka tlisa molemo o eketsehileng oa ho monya le ho sebelisoa hamolemo, ho ka fellang ka melemo e hlakileng haholoanyane ha e bapisoa le ho sebelisa NR feela.
1. Ntlafatsa tlhahiso ea matla a cellular
E 'ngoe ea melemo e hlokomelehang eanicotinamide riboside chloride ke karolo ea eona ho matlafatsa tlhahiso ea matla a liselefouno. NR ke selelekela sa nicotinamide adenine dinucleotide (NAD+), coenzyme e bapalang karolo tlhahisong ea adenosine triphosphate (ATP), chelete ea mantlha ea matla ea sele. karolo ea bohlokoa. Ha re ntse re tsofala, maemo a NAD + a fokotseha, a fella ka ho fokotseha ha tlhahiso ea matla a cellular. Ka ho tlatsana le NR, ho lumeloa hore maemo a NAD + a ka tlatsoa, ka hona a ts'ehetsa metabolism ea matla a cellular.
2. Mosebetsi oa Mitochondrial le nako ea bophelo
Mitochondria ke matla a matla a sele, a ikarabellang bakeng sa ho hlahisa matla le ho laola mekhoa ea lisele. Patlisiso e bonts'a hore Nicotinamide Riboside Chloride e ka ts'ehetsa ts'ebetso ea mitochondrial ka ho khothaletsa biogenesis ea mitochondria e ncha le ho eketsa ts'ebetso ea bona. Sena se na le litlamorao bakeng sa bophelo ka kakaretso le botsofali bo phetseng hantle, kaha mitochondria e sebetsang hantle e bohlokoa bakeng sa ho boloka bophelo bo botle ba cellular le botsitso.
3. Bophelo bo botle ba metabolism le taolo ea boima ba 'mele
NAD+ ke coenzyme, kapa molek'hule ea kenyelletso, e amehang liketsong tse ngata tsa tlhaho. Boithuto ba morao-rao bo fumane hore tlatsetso ea nicotinamide ribose e ka susumetsa metabolism ea NAD+ ho batho ba baholo ba phetseng hantle ba lilemo tse mahareng le ba baholo. Hase feela hore li-supplement tsa NR li mamelloa hantle ke barupeluoa, li ka 'na tsa thusa ho fokotsa khatello ea mali le ho satalla ha methapo. Khaello ea NAD+ ke sesosa se tloaelehileng sa botsofali le mafu a mangata, 'me lipatlisiso li bonts'a hore ho khutlisa maemo a NAD+ ho na le boleng bo botle ba kalafo le phepo e nepahetseng.
Ka ho eketsa maemo a NAD +, nicotinamide ribose e ruisa molemo taolong ea metabolic, mehloli ea matla, motsoako oa DNA, le mesebetsi e meng ea 'mele.
Ho feta moo, liphuputso li bonts'itse hore tlatsetso ea NR e ka ntlafatsa kutloisiso ea insulin, ea fokotsa ho ruruha, le ho ntlafatsa maemo a metabolism. Litlamorao tsena li ka ba molemo haholo ho batho ba batlang ho laola boima ba bona le ho ts'ehetsa bophelo bo botle ba metabolic.
4. Ts'ebetso ea kelello le bophelo bo botle ba boko
Joalo ka selelekela sa NAD +, nicotinamide ribose e sireletsa lisele tsa boko khatellong ea oxidative, e ka lebisang ho mafu a boko a amanang le lilemo. Ka har'a lisele tsa boko, NAD+ e thusa ho laola tlhahiso ea PGC-1-alpha, protheine e bonahalang e thusa ho sireletsa lisele khatellong ea oxidative le ho se sebetse ha mitochondrial.
Bafuputsi ba fumane hore ho litoeba, ho fokotseha ha NAD + ho phetha karolo ea bohlokoa ho neuroinflammation, tšenyo ea DNA, le ho senyeha ha neuronal ho lefu la Alzheimer. Hape thutong ea tube-test, nicotinamide riboside e matlafalitse maemo a NAD+ mme ea ntlafatsa haholo ts'ebetso ea mitochondrial liseleng tsa stem tsa bakuli ba lefu la Parkinson.
Lipatlisiso tse ntseng li hlaha li boetse li supa melemo e ka bang teng ea kelello ea nicotinamide riboside chloride. NAD+ e kenya letsoho lits'ebetsong tse fapaneng tse amanang le bophelo bo botle ba boko, ho kenyeletsoa lets'oao la neuronal, tokiso ea DNA, le ho tlosoa ha liprotheine tse senyehileng. Ka ho ts'ehetsa maemo a NAD+, NR e ka thusa ho boloka ts'ebetso ea kelello le ho thibela ho theoha ha kelello ho amanang le lilemo.
5. Ts'ebetso ea Liatleletiki le Pholiso
Phuputso ea 2019 e phatlalalitsoeng ho European Journal of Nutrient Impurities e fumane hore ho sebelisa nicotinamide ribose tlatsetso ho ntlafalitse tsebo ea 'mele le ho fokotsa khatello ea oxidative ho batho ba baholo.
Bafuputsi ba fihletse qeto ea hore tlatsetso ea NR e ne e le molemo ho batho ba haelloang ke NAD +, ba hlalosa hore na hobaneng e ne e sebetsa ho batho ba baholo ho feta batho ba baholo ba banyenyane.
Baatlelete le batho ba chesehelang boikoetliso ba 'mele ba ka thabela ho tseba hore nicotinamide riboside chloride e ka ama ts'ebetso ea liatleletiki le ho hlaphoheloa hantle. NAD+ e bapala karolo ea bohlokoa ho laola lits'ebetso tsa cellular tse amehang tlhahisong ea matla le ts'ebetso ea mesifa. Ka ho ts'ehetsa maemo a NAD+, NR e ka ntlafatsa mamello, ea ntlafatsa ho hlaphoheloa ha mesifa, le ho ntlafatsa ts'ebetso ea liatleletiki ka kakaretso.
Boleng le Bohloeki
Ha u reka phofo ea nicotinamide riboside chloride, boleng le bohloeki e tlameha ho ba tsona tse tlang pele bophelong ba hau. Batla lihlahisoa tse entsoeng ke lik'hamphani tse hlomphehang le batho ba boraro ba lekiloeng bakeng sa bohloeki le potency. Ha e le hantle, lihlahisoa ha lia lokela ho ba le litšila le li-filler ho netefatsa hore u fumana tlatsetso ea boleng bo holimo e fanang ka melemo e reriloeng.
Tekanyo le tšebeliso
Pele o kenyelletsa phofo ea nicotinamide riboside chloride kemisong ea hau ea letsatsi le letsatsi, ho bohlokoa ho utloisisa litekanyetso tse nepahetseng le litataiso tsa ts'ebeliso. Ke habohlokoa ho qala ka tekanyo e tlaase 'me butle-butle e eketsehe ha ho hlokahala, kaha litekanyetso tse phahameng ha li hlile li lekana le liphello tse molemo' me li ka baka liphello tse mpe. Ho feta moo, ka kopo nahana ka ho buisana le setsebi sa tlhokomelo ea bophelo ho fumana hore na tekanyo e nepahetseng bakeng sa lipakane le litlhoko tsa hau tsa bophelo bo botle ke efe.
Melemo le mehopolo e ka bang teng
Nicotinamide Riboside Chloride Powder hangata e hlahisoa ka melemo ea eona e ka bang teng, ho kenyelletsa ho ts'ehetsa maemo a matla, ts'ebetso ea mitochondrial, le bophelo bo botle ba liselefouno. Lipatlisiso li bontša hore e ka 'na ea e-ba le tšusumetso botsofaling le mafu a amanang le lilemo.
Tšireletseho le litemoso
Joalo ka tlatsetso efe kapa efe, ho bohlokoa ho beha polokeho pele le ho utloisisa litemoso tse ka bang teng. Leha nicotinamide riboside chloride ka kakaretso e mamelloa hantle, batho ba bang ba ka ba le litlamorao tse bobebe, joalo ka ho se phele hantle ka mpeng. Ho phaella moo, haeba u e-na le maemo leha e le afe a bophelo bo botle kapa u noa meriana, etsa bonnete ba hore u buisana le setsebi sa tlhokomelo ea bophelo pele u sebelisa tlatsetso ena ho netefatsa hore e bolokehile ebile e loketse boemo ba hau.
Khetha morekisi ea tšepahalang
Ha u reka Nicotinamide Riboside Chloride Powder, ho bohlokoa ho khetha mofani oa thepa ea tsebahalang ea etelletsang pele boleng, pepeneneng le khotsofalo ea bareki. Batla lik'hamphani tse fanang ka lintlha tse mabapi le lits'ebetso tsa tsona tsa tlhahiso, ho fumana le tlhahlobo ea motho oa boraro. Ntle le moo, nahana ka ho bala maikutlo a bareki le ho batla likhothaletso ho tsoa mehloling e tšepahalang ho netefatsa hore o reka ho tsoa ho morekisi ea tšepahalang le ea tšepahalang.
Suzhou Myland Pharm & Nutrition Inc. esale e sebetsa khoebong ea tlatsetso ea phepo e nepahetseng ho tloha ka 1992. Ke k'hamphani ea pele naheng ea China ho nts'etsapele le ho rekisa sekhechana sa peo ea morara.
Ka boiphihlelo ba lilemo tse 30 'me e khannoa ke theknoloji e phahameng le leano le ntlafalitsoeng la R&D, k'hamphani e thehile lihlahisoa tse ngata tsa tlholisano mme ea fetoha tlatsetso e ncha ea mahlale a bophelo, ho kopanya tloaelo le khamphani ea lits'ebeletso tsa tlhahiso.
Ho feta moo, Suzhou Myland Pharm & Nutrition Inc. hape ke moetsi ea ngolisitsoeng ke FDA. Lisebelisoa tsa R&D tsa k'hamphani, lisebelisoa tsa tlhahiso, le lisebelisoa tsa tlhahlobo ke tsa sejoale-joale ebile li sebetsa ka bongata mme li ka hlahisa lik'hemik'hale ho tloha ho limiligrama ho isa ho lithane ka sekala, 'me li latela litekanyetso tsa ISO 9001 le litlhaloso tsa tlhahiso ea GMP.
P: Nicotinamide riboside chloride phofo ke eng?
A: Nicotinamide Riboside Chloride Powder ke mofuta oa vithamine B3 e ithutoang bakeng sa bokhoni ba eona ba ho tšehetsa tlhahiso ea matla a cellular le metabolism. Hangata e sebelisoa e le tlatsetso ea lijo ho khothalletsa bophelo bo botle le boiketlo ka kakaretso.
P: Melemo e ka bang teng ea nicotinamide riboside chloride powder ke efe?
A: Melemo e meng e ka bang teng ea Nicotinamide Riboside Chloride Powder e kenyelletsa ho ts'ehetsa ts'ebetso ea mitochondrial, ho khothaletsa botsofali bo botle, le ho matlafatsa mamello le ts'ebetso ea 'mele. E ka boela ea thusa ho ts'ehetsa ts'ebetso ea kelello le bophelo bo botle ba cellular.
P: Nka reka phofo ea nicotinamide riboside chloride hokae?
A: Nicotinamide Riboside Chloride powder e fumaneha ho tsoa ho barekisi ba fapaneng le mabenkeleng a marang-rang. Ha u reka tlatsetso ena, ke habohlokoa ho khetha mohloli o hlomphehang ho netefatsa boleng le polokeho.
Boitlhotlhollo: Sengoloa sena ke sa tlhaiso-leseling e akaretsang feela 'me ha ea lokela ho nkuoa e le keletso efe kapa efe ea bongaka. Tse ling tsa litaba tsa poso ea blog li tsoa Marang-rang mme ha se setsebi. Sebaka sena sa marang-rang se na le boikarabello ba ho hlophisa, ho hlophisa le ho hlophisa lingoliloeng. Sepheo sa ho fetisa boitsebiso bo bongata ha se bolele hore u lumellana le maikutlo a eona kapa u tiisa bonnete ba litaba tsa eona. Kamehla buisana le setsebi sa tlhokomelo ea bophelo pele u sebelisa li-supplement leha e le life kapa u etsa liphetoho tsamaisong ea tlhokomelo ea bophelo.
Nako ea poso: Aug-14-2024
