Glycerylphosphocholine e ka Matlafatsa Boko ba Hao Joang?

Glycerylphosphocholine (GPC, e tsejoang hape e le L-alpha-glycerylphosphorylcholine kapa alphacholine)ke mohloli oa tlhaho oa choline o fumanoang lijong tse sa tšoaneng (ho akarelletsa le lebese la matsoele) le liseleng tsohle tsa batho E na le li-choline tse nyenyane. GPC ke molek'hule e qhibilihang ka metsing e bontšitsoeng e le mohloli o matla oa choline ea kliniki ho feta choline kapa phosphatidylcholine (PC) ho tloha lijong kapa li-supplement.

GPC e tsamaisoang ka molomo e kenngoa hantle 'me e phunyeletse ka har'a li-enterocyte ho glycerol-1-phosphate le choline. Ka mor'a ho noa GPC, litekanyetso tsa choline ka plasma li ile tsa phahama ka potlako 'me tsa lula li phahame ka lihora tsa 10. Bophahamo bo phahameng ba plasma ea choline bo hlohlelletsa ho tsamaisoa ha eona hantle ho pholletsa le mokoallo oa mali le boko. Sena se eketsa mabenkele a choline ka har'a li-neuron, moo e sebelisetsoang ho kopanya PC le acetylcholine.

Ka mokhoa o hlophisitsoeng, α-GPC ke motsoako oa choline o kopantsoeng le molek'hule ea glycerol ka sehlopha sa phosphate, 'me ke choline e nang le phospholipid. Litaba tsa choline li phahame haholo, li nka hoo e ka bang 40%, e bolelang hore 1000 mg ea α-GPC e ka hlahisa hoo e ka bang 400 mg ea choline ea mahala.

Choline ke limatlafatsi tsa bohlokoa tse fumanoang lihlahisoa tsa lebese le mahe a thusang lisele ho boloka lera la tsona. Choline ka boeona e boetse e hlokahala ho etsa acetylcholine. Le hoja alpha-GPC le li-choline tse ling tse kang phosphatidylcholine le lecithin li ka khothalletsa tlhahiso ea acetylcholine, alpha-GPC e hlile e phahametse hobane lipids eo e fanang ka eona e hlile e etsa hore ho be bonolo hore lisele li monye, ​​Ho feta 90% ea phosphatidylcholine e kenngoa ke lijana tsa lymphatic. , ha α-GPC e atisa ho kenngoa ke mothapo oa portal, kahoo ho monya ho matla ho phahame, kahoo ho khothalletsa tlhahiso ea acetylcholine ka katleho. Acetylcholine ke neurotransmitter e bapalang karolo ea bohlokoa ho laola tšebetso ea boko le taolo ea mesifa. Le hoja re ka ja choline ka lijo, palo ea acetylcholine e fokotseha ka lilemo.

Melemo ea GPC e Thehiloeng Lipatlisisong

Mosebetsi oa boko

• E ntlafatsa mohopolo, mohopolo le nako ea ho itšoara ho batho ba baholo le ba banyenyane
• E khothalletsa tlhahiso le ho lokolloa ha acetylcholine (ACh) ho tloha ho li-neurone mohlomong le lisele tse ling.
• E ka lefella ho fokotseha ha ACh ho bakoang ke botsofali, khaello ea estrogen (ho khaotsa ho ilela khoeli, mohlomong le tšebeliso ea lithibela-kemolo tsa molomo)
• Ntlafatsa mekhoa ea EEG
• E eketsa tlhahiso ea dopamine, serotonin le GABA18.
• Ntlafatsa mosebetsi oa mitochondrial nakong ea khatello ea kelello ea ischemia / oxidative
• E hanana le ho fokotseha ho amanang le lilemo tsa lisele tsa boko le linomoro tsa ACh receptor, tšebetso ea mesifa le tlhahiso ea lihomone tsa kholo.
• Khothaletsa tlhahiso ea li-hormone tsa kholo ho bacha le batho ba baholo
• E eketsa oxidation ea mafura, matla a mesifa le nako ea ho itšoara, mohlomong ho ntlafatsa ho leka-lekana, haholo-holo ho batho ba baholo.

Ho lokisa Boko le Tšehetso ea Alzheimer's/Dementia

• E ntlafatsa ho hlaphoheloa ha boko ka mor'a ho otloa ke setorouku, kotsi e bohloko ea boko, le anesthesia (pele le ka mor'a ho buuoa).
• Lokisa lisele tse thibelang mali bokong tse sentsoeng ke khatello ea mali
• E ntlafatsa temoho le boitšoaro ba sechaba ho lefu la Alzheimer, vascular/senile dementia, le lefu la Parkinson.
• Fokotsa ho honyela ha molumo oa boko ho tšoana le lefu la Alzheimer
• E ka ba molemo ho mafu a hlokang ho lokisoa ha myelin le Duchenne muscular dystrophy Mesebetsi ea Choline ho metabolism ea batho le GPC.

Lintho tse ikhethang e le mohloli o matla oa choline, mohaho oa mohaho oa acetylcholine le ntho e susumetsang tlhahiso ea eona le ho hlahisa.

• Acetylcholine ke neurotransmitter bokong le transducer signal libakeng tse ling 'meleng, bohlokoa bakeng sa ho honyela ha mesifa, letlalo la letlalo, motility ea gastrointestinal, le mesebetsi e meng ea lisele. Ho fapana le choline / PC e fanoeng ka lijo kapa tlatsetso, tlatsetso ea GPC e bontšitsoe hore e na le phello e matla e susumetsang ho kopanngoa ha ACh le ho lokolloa ha lisele tsa cholinergic.

Tlatsetso ea GPC e fella ka pontšo e ntlafetseng ea cholinergic ho li-neuron le lisele tse ling tse ka hlahisang acetylcholine. Sena se molemo ka ho khetheha ha palo le ts'ebetso e sebetsang ea li-neuron tsa cholinergic li fokotseha ka lebaka la botsofali bo tloaelehileng kapa mekhoa e sa tšoaneng ea ho senyeha. Tlatsetso ka GPC e na le monyetla oa ho lefa ka mokhoa o itseng oa ho senyeha hona hobane e baka ho phahama ka potlako ho choline ea plasma, e nang le phello e matla ea substrate ho li-enzyme le lipalangoang litseleng tsena.

Mohaho oa phosphatidylcholine (PC)

• PC ke ea phospholipids 'me ke karolo ea bohlokoa ea lisele tsa lisele le li-membrane tsa mitochondrial. Bokhoni ba tlatsetso ea GPC ho thusa ho hlaphoheloa ke stroke, hammoho le ho hanyetsa ho fokotseha ho amanang le lilemo ho palo ea li-receptor tsa ACh liseleng tsa methapo kapa boko, ke bopaki bo eketsehileng ba tlatsetso ea eona ho boloka lera la neuronal ka PC synthesis.

Ho thehoa ha sphingomyelin

• Sphingomyelin ke karolo ea sheath ea myelin e koahelang le ho thibela methapo ea kutlo le methapo. Ka hona, tlatsetso ea GPC e ka 'na ea e-ba molemo boemong leha e le bofe ka tlhokahalo e eketsehileng ea ho lokisoa ha myelin, joalo ka neuropathy, multiple sclerosis, le maemo a mang a amanang le ho senyeha ha maikutlo le ho itšireletsa ha lisele tsa methapo. Ho tsamaisa mafura ka hare le ka ntle ho lisele

• PC ea hlokahala bakeng sa ho kopanya le ho hlahisa likaroloana tsa VLDL. Li-triglycerides li tloha sebeteng ka har'a likaroloana tsa VLDL, e leng se hlalosang hore na ke hobane'ng ha khaello ea choline e eketsa kotsi ea lefu la sebete sa mafura. PC e ka fumanoa mehloling ea lijo kapa li-supplement; leha ho le joalo, PC bakeng sa phospholipids le lipoprotein ha e fumanehe ka kotloloho ho tsoa ho PC e kentsoeng kapa e entsoeng esale pele. E entsoe ho tsoa ho li-precursors tse fapaneng tsa choline (ho kenyeletsoa le GPC), ka hona ho kenya PC ha se mokhoa o sebetsang ka ho fetesisa oa ho eketsa letamo la 'mele la PC.
Tšehetsa sperm motility

• GPC ke ntlha e ka sehloohong ea ho khomarela DHA (docosahexaenoic acid), ho etsa PC-DHA. DHA-PC complex e sebelisoa mefuteng ea lisele tse sebetsang haholo tse kang lisele tse bonang khanya ea retina le lisele tsa peō ea botona. DHA-PC e eketsa mokelikeli oa membrane, o bohlokoa bakeng sa ts'ebetso e phetseng hantle ea peō. Peō ea botona e na le likhahla tse phahameng tsa GPC; Lisele tsa epididymal tse hlaolelang li-sperm cell li ntšoa letamong la GPC ebe li kopanya PC-DHA. Maemo a tlase a GPC le PC-DHA ka har'a peō ea botona a ka eketsa kotsi ea ho fokotsa ho tsamaea ha peō.

Papiso ea GPC le Acetyl-L-Carnitine (ALCAR)

• Phuputsong ea bakuli ba nang le lefu la Alzheimer's e tsoetseng pele, GPC e entse hore ho be le lintlafatso tse kholo ho li-parameter tse ngata tsa neuropsychological bapisoa le ALCAR. Le hoja metsoako ka bobeli e tšehetsa keketseho ea acetylcholine, ho ka nahanoa hore ho ka ba le phello ea synergistic pakeng tsa ho tlatsetsa metsoako e 'meli, kaha GPC e fana ka choline ha ALCAR e fana ka karolo ea acetyl bakeng sa motsoako oa acetylcholine.

Tšebelisano e ka bang teng lipakeng tsa GPC le lithethefatsi. GPC supplementation ha e nahane hore e kena-kenana le meriana leha e le efe e etselitsoeng ho ntlafatsa mosebetsi oa boko. Ha e le hantle, ka lebaka la melemo ea eona litseleng tsa cholinergic le ho ntlafatsa ts'ebetso ea lisele tsa neuronal, e ka 'na ea ntlafatsa melemo ea bona. GPC e ka 'na ea ntlafatsa liphello tsa acetylcholinesterase AChE inhibitors hobane e ka eketsa bongata ba ACh ka har'a synaptic cleft, athe lithethefatsi tsena li liehisa ho senyeha ha eona.

Ho phaella moo, ho ea ka lithuto tsa liphoofolo, GPC e ka ntlafatsa tlhahiso ea dopamine, serotonin, kapa GABA bokong, 'me GPC e ka ntlafatsa liphello tsa reuptake inhibitors tsa li-neurotransmitters tsena.

Suzhou Myland Pharm & Nutrition Inc.ke moetsi ea ngolisitsoeng ke FDA ea fanang ka phofo ea boleng bo holimo le e hloekileng ea Alpha GPC.

Ho Suzhou Myland Pharm re ikemiselitse ho fana ka lihlahisoa tsa boleng bo holimo ka litheko tse ntle. Alpha GPC ea rona ea phofo e lekoa ka matla bakeng sa bohloeki le potency, ho netefatsa hore u fumana tlatsetso ea boleng bo phahameng eo u ka e tšepang. Hore na o batla ho ts'ehetsa bophelo bo botle ba cellular, ho matlafatsa sesole sa hau sa 'mele kapa ho ntlafatsa bophelo bo botle ka kakaretso, phofo ea rona ea Alpha GPC ke khetho e phethahetseng.

Ka boiphihlelo ba lilemo tse 30 'me e susumetsoa ke thekenoloji e phahameng le maano a R&D a ntlafalitsoeng haholo, Suzhou Myland Pharm e hlahisitse lihlahisoa tse ngata tsa tlholisano mme e fetohile tlatsetso e ncha ea mahlale a bophelo, ho kopanya tloaelo le k'hamphani ea lits'ebeletso tsa tlhahiso.

Ntle le moo, Suzhou Myland Pharm hape ke moetsi ea ngolisitsoeng ke FDA. Lisebelisoa tsa R&D tsa k'hamphani, lisebelisoa tsa tlhahiso, le lisebelisoa tsa tlhahlobo ke tsa sejoale-joale ebile li na le mesebetsi e mengata, 'me li ka hlahisa lik'hemik'hale ho tloha ho limiligrama ho isa ho lithane ka tekanyo,' me li lumellana le litekanyetso tsa ISO 9001 le litlhaloso tsa tlhahiso ea GMP.