Lilemong tsa morao tjena, spermidine trihydrochloride e fumane tlhokomelo bakeng sa melemo ea eona ea bophelo bo botle, ho kenyelletsa le bokhoni ba eona ba ho khothalletsa bophelo bo botle ba lisele, ho ntlafatsa mosebetsi oa pelo, le ho ntlafatsa bophelo bo botle ka kakaretso. Ha batho ba bangata ba ntse ba thahasella ho kenyelletsa spermidine bophelong ba bona ba letsatsi le leng le le leng, 'maraka oa li-supplement tsa spermidine trihydrochloride o ntse o tsoela pele ho hola, ho etsa hore ho khetha sehlahisoa se nepahetseng ho be thata le ho feta. Ka ho ipha nako ea ho etsa lipatlisiso le ho khetha sehlahisoa sa boleng bo phahameng, u ka eketsa melemo e ka bang teng ea spermidine le ho tšehetsa bophelo bo botle le bophelo bo botle ba hau ka kakaretso.
Spermidine ke motsoako oa tlhaho le polyamine e ka khomarelang mefuta e sa tšoaneng ea limolek'hule 'me e phetha karolo ea bohlokoa mesebetsing e mengata ea lisele, tse kang ho boloka botsitso ba DNA, ho kopitsa DNA ho RNA, le ho thibela ho shoa ha sele. E boetse e fana ka maikutlo a hore polyamine e sebetsa ka mokhoa o ts'oanang le lintlha tsa kholo nakong ea karohano ea lisele. Ke ka lebaka leo putrescine le spermidine li leng bohlokoa bakeng sa kholo le ts'ebetso ea lisele tse phetseng hantle. Spermidine Trihydrochloride ke mofuta oa trihydrochloride oa spermidine 'me hangata o fumaneha ka capsule kapa foromo ea phofo.
Spermidine e hlaha ka tlhaho lijong tse fapa-fapaneng 'me hangata e tsoa mehloling ea tlhaho e kang kokoana-hloko ea koro kapa linaoa tsa soya. E na le karolo ea bohlokoa kholong ea lisele le ho phela 'me e na le mefuta e mengata ea melemo ea bophelo bo botle. Ho fumana spermidine e lekaneng ho tsoa lijong tsa hau feela ho ka ba phephetso bophelong, 'me spermidine trihydrochloride, mofuta o tsitsitseng oa spermidine, e tlatsa lekhalo. Li-supplement tsa Spermidine Trihydrochloride li bonts'a ts'episo e kholo ea ho khothaletsa bophelo bo botle ba cellular, bophelo bo botle ba pelo, bophelo bo botle ba boko le bophelo bo bolelele.
Spermidine ke polyamine ea tlhaho e fumanehang hoo e batlang e le linthong tsohle tse phelang, ho kenyelletsa limela, liphoofolo le likokoana-hloko. E ameha mefuteng e mengata ea mekhoa ea likokoana-hloko, ho kenyelletsa le ho hōla ha lisele, ho ata le ho phela. Spermidine e ka susumetsa autophagy, mokhoa oa ho tsosolosoa ha lisele, ka tsela ea TOR kinase. Spermidine trihydrochloride ke mofuta oa trihydrochloride oa spermidine. E 'ngoe ea mekhoa ea eona ea bohlokoa ea ketso ke bokhoni ba eona ba ho laola autophagy. Autophagy ke mokhoa oa tlhaho oa 'mele oa ho tlosa organelles le liprotheine tse senyehileng. Autophagy e phetha karolo ea bohlokoa liseleng. E etsahala ka tlhaho liseleng kaha e laola metabolism ea lisele. Ho feta moo, autophagy e bapala karolo ea bohlokoa ho bolokeng cellular homeostasis mme e amahanngoa le mafu a fapaneng a amanang le lilemo. Autophagy e boetse e leka-lekanya limatlafatsi nakong ea khatello ea kelello ea cellular 'me ka hona e ka potlakisoa ka ho itima lijo kapa ka lik'halori tsa thibelo ea mimetics (CRMs) tse kang spermidine, tse etsisang liphello tsa ho itima lijo 'meleng. Spermidine trihydrochloride e bonts'itsoe ho ntlafatsa autophagy, ka hona e thusa ho thibela ho theoha ho amanang le lilemo le ho lelefatsa bophelo.
Ho feta moo, spermidine trihydrochloride e fumanoe e fana ka litlamorao tsa eona ka ho fetola litsela tse fapaneng tsa matšoao 'meleng. Ho bontšitsoe ho kenya tšebetsong tsela ea AMPK, e phethang karolo ea bohlokoa ho metabolism ea matla 'me e kentse letsoho taolong ea nako ea bophelo le mafu a amanang le lilemo. Ho phaella moo, spermidine trihydrochloride e thibela tsela ea mTOR e amehang khōlong ea lisele le ho ata. Ho senyeha ha tsela ea mTOR ho 'nile ha ameha mafu a sa tšoaneng a amanang le lilemo,' me ka ho thibela tsela ena, spermidine trihydrochloride e ka thusa ho thibela maloetse ana. Ntle le liphello tsa eona lits'ebetsong tsa lisele, spermidine trihydrochloride e bontšitsoe hore e na le liphello tse molemo ho bophelo bo botle ba pelo.
1.Sebopeho sa lik'hemik'hale
Spermidine ke motsoako oa tlhaho oa polyamine o fumanehang liseleng tsohle tse phelang. E na le liathomo tse 'nè tsa carbon, liathomo tse robeli tsa hydrogen, le lihlopha tse tharo tsa amine. Spermidine trihydrochloride, ka lehlakoreng le leng, ke mofuta oa trihydrochloride oa spermidine, e bolelang hore e na le limolek'hule tse tharo tsa hydrochloric acid. Phapang ena ea sebopeho sa lik'hemik'hale e ama ho qhibiliha, botsitso le bioavailability ea motsoako. Bakeng sa tšebeliso ea laboratori. Ho kenyelletsa sehlopha sa hydrochloride ho spermidine ho eketsa ho qhibiliha ha eona metsing, ho etsa hore ho be bonolo ho e sebelisa sebakeng sa laboratori. Phetoho ena e lumella litekanyo tse nepahetseng haholoanyane le taolo e betere ho litlhophiso tsa liteko.
2.Mabaka a kopo
Spermidine le spermidine trihydrochloride li na le ts'ebeliso e ts'oanang ho lipatlisiso, meriana le tlhokomelo ea letlalo. Spermidine e ntse e ithutoa bakeng sa karolo ea eona e ka 'nang ea e-ba teng ho nts'etsopele ea autophagy, mokhoa oa cellular o thusang ho tlosa likarolo tse senyehileng le ho boloka bophelo bo botle ba lisele. E boetse e ntse e ithutoa ka thepa ea eona ea methapo ea kutlo, ea pelo le ea ho thibela ho ruruha 'me hangata e sebelisoa lijong tsa lijo le lihlahisoa tsa tlhokomelo ea letlalo. Spermidine trihydrochloride, ka lehlakoreng le leng, e sebelisoa hangata litlhophisong tsa laboratori bakeng sa setso sa lisele le liteko tsa baeloji ea limolek'hule. Sebopeho sa eona sa letsoai se etsa hore e tsitse le ho ba bonolo ho sebetsana le likopo tsa lipatlisiso.
3.Melemo ea bophelo bo botle
Ka bobeli spermidine le spermidine trihydrochloride li na le melemo e mengata ea bophelo bo botle. Lipatlisiso li bonts'a hore tlatsetso ea spermidine e ka etsa hore motho a se ke a hlola a e-ba teng, a ntlafatsa ts'ebetso ea mitochondrial, 'me a ntlafatse ho hlaphoheloa ha cellular ho tsoa khatellong ea maikutlo. Liphuputso li bontšitse hore tlatsetso ea spermidine e ntlafatsa ts'ebetso ea lisele le ho lelefatsa bophelo ba mefuta e fapaneng ea lintho tse phelang, ho kenyelletsa le tomoso, lintsintsi tsa litholoana le litoeba. Litlamorao tsena li ka e thusa ho khothaletsa bophelo bo bolelele le ho fokotsa kotsi ea mafu a amanang le lilemo joalo ka lefu la pelo, mafu a neurodegenerative le mofets'e. Spermidine trihydrochloride, le hoja e sebelisoa haholo-holo litlhophisong tsa lipatlisiso, e ka fana ka melemo e tšoanang ea bophelo bo botle haeba e hlophisitsoe hantle hore e sebelisoe ke batho.
4.Boteng ba bophelo
Phapang e 'ngoe e kholo lipakeng tsa spermidine le spermidine trihydrochloride ke bioavailability ea tsona. Spermidine trihydrochloride, joalo ka mofuta oa letsoai, e ka ba le thepa e fapaneng ea pharmacokinetic ha e bapisoa le spermidine ea mahala. Ho eketsoa ha limolek'hule tsa hydrochloric acid ho ka ama ho monya, ho ajoa, metabolism le ho tsoa ha metsoako 'meleng.
1. Ntlafatsa temoho
Liphuputso tse ngata li bontšitse hore motsoako ona o ka ba le liphello tsa neuroprotective mme o ka thusa ho thibela ho fokotseha ho amanang le lilemo. Phuputsong e phatlalalitsoeng koranteng ea Cell Reports, bafuputsi ba fumane hore Spermidine trihydrochloride supplementation e ntlafalitse ts'ebetso ea kelello ho litoeba tse tsofetseng. Boithuto bona bo fana ka maikutlo a hore Spermidine trihydrochloride e ka thusa ho ntlafatsa mohopolo le ho ithuta mme e kanna ea sebelisoa e le ts'ebetso ea kalafo bakeng sa phokotso ea kelello e amanang le lilemo ho batho.
Ho feta moo, spermidine trihydrochloride e bontšitsoe hore e na le melemo e ka bang teng ho mafu a neurodegenerative joalo ka mafu a Alzheimer's le Parkinson. Phuputsong e phatlalalitsoeng koranteng ea Nature Medicine, bafuputsi ba fumane hore Spermidine trihydrochloride supplementation e fokotsa ho bokellana ha liprotheine tse senyehileng bokong le ho ntlafatsa ts'ebetso ea motlakase ka mokhoa oa mouse oa lefu la Parkinson. Liphuputso tsena li fana ka maikutlo a hore spermidine trihydrochloride e ka ba le monyetla oa ho liehisa tsoelo-pele ea mafu a neurodegenerative mme e ka ba sebaka se ts'episang bakeng sa lipatlisiso tse ling.
Ho phaella liphellong tsa eona tse ka 'nang tsa e-ba le methapo ea kutlo, spermidine trihydrochloride e bontšitsoe hore e na le thepa e khahlanong le ho ruruha le ea antioxidant, e ka tlatsetsang ka ho eketsehileng melemo ea eona ea kutloisiso. Ho ruruha ho sa feleng le khatello ea oxidative li amahanngoa le ho fokotseha ha kelello, 'me metsoako e hanyetsanang le mekhoa ena e ka thusa ho sireletsa ts'ebetso ea kelello. Ka hona, bokhoni ba Spermidine trihydrochloride ba ho fokotsa ho ruruha le tšenyo ea oxidative e ka bapala karolo ea melemo ea eona ea kelello.
2. Tšireletso ea methapo
Spermidine trihydrochloride e bontšitsoe hore e na le thepa e matla ea methapo ea kutlo, e etsa hore e be mokhethoa bakeng sa thibelo ea mafu a neurodegenerative a kang lefu la Alzheimer le lefu la Parkinson. Neuroprotection e bolela ho sireletsa sebopeho le tšebetso ea li-neurone tsa boko, tse bohlokoa bakeng sa ho boloka ts'ebetso ea kelello le bophelo bo botle ba boko.
E 'ngoe ea litsela tseo spermidine trihydrochloride e fanang ka liphello tsa eona tsa neuroprotective ke ka bokhoni ba eona ba ho ntlafatsa autophagy, ts'ebetso ea cellular e phethang karolo ea bohlokoa ho hlakola likarolo tse senyehileng kapa tse sa sebetseng ka har'a lisele. Autophagy e bohlokoa bakeng sa ho boloka bophelo bo botle ba neuronal le ts'ebetso, mme ho senyeha ha ts'ebetso ena ho amahanngoa le nts'etsopele ea mafu a neurodegenerative. Spermidine trihydrochloride e bontšitsoe ho khothaletsa autophagy, e thusa ho hlakola boko ba liprotheine tse chefo le lintho tse ling tse kotsi tse tlatsetsang ho senyeha ha methapo ea kutlo.
Ntle le ho khothalletsa autophagy, spermidine trihydrochloride e fumanoe e na le li-antioxidant le anti-inflammatory properties, tse bohlokoa ho sireletsa boko tšenyo e bakoang ke khatello ea oxidative le ho ruruha. Khatello ea oxidative le ho ruruha ke likarolo tse tloaelehileng tsa mafu a neurodegenerative, mme ho fokotsa lits'ebetso tsena ho ka thusa ho liehisa tsoelo-pele ea mafu ana.
Liphuputso tse 'maloa li fane ka bopaki bakeng sa liphello tsa neuroprotective tsa spermidine trihydrochloride. Mohlala, phuputso e phatlalalitsoeng ho Journal of Neuroscience e bonts'itse hore kalafo ka spermidine trihydrochloride e ntlafalitse ts'ebetso ea kelello le ho fokotsa neuropathology mokhoeng oa toeba oa lefu la Alzheimer's. Ka mokhoa o ts'oanang, phuputso e 'ngoe e phatlalalitsoeng ho Journal of Neurochemistry e fumane hore spermidine trihydrochloride e sirelelitse li-neurone tšenyo e chefo le ho ntlafatsa ts'ebetso ea motlakase mokhoeng oa toeba oa lefu la Parkinson.
3. Ntlafatsa bophelo bo botle ba pelo
Spermidine trihydrochloride e ruisa bophelo bo botle ba pelo haholo-holo ka bokhoni ba eona ba ho khothaletsa autophagy, ts'ebetso ea 'mele ea ho tlosa lisele tse senyehileng kapa tse sa sebetseng le ho nchafatsa lisele tse ncha tse phetseng hantle. Sena se bohlokoa bakeng sa pelo hobane se ka thusa ho thibela ho bokellana ha plaque methapong ea mali le ho fokotsa kotsi ea lefu la pelo. Ho feta moo, spermidine trihydrochloride e bontšitsoe hore e na le thepa e khahlanong le ho ruruha le antioxidant, e thusang ho sireletsa pelo khatellong ea oxidative le ho ruruha, tseo ka bobeli e leng mabaka a kotsi bakeng sa lefu la pelo. Lipatlisiso li boetse li fana ka maikutlo a hore spermidine trihydrochloride e ka ba le phello e ntle khatellong ea mali le maemo a k'holeseterole, e ts'ehetsang karolo ea eona e ka bang teng molemong oa bophelo bo botle ba pelo.
Joale, o kenyelletsa Spermidine Trihydrochloride joang lijong tsa hau ho ts'ehetsa bophelo bo botle ba pelo ea hau? Joalokaha ho boletsoe pejana, lijo tse ling li na le spermidine trihydrochloride e ngata, ho akarelletsa le linaoa tsa soya, lijo-thollo le likhoaeane. Ka ho kenyelletsa lijo tsena khafetsa lijong tsa hau, ka tlhaho u ka eketsa ho ja motsoako ona o molemo. Leha ho le joalo, ke habohlokoa ho hlokomela hore palo ea spermidine trihydrochloride lijong e ka fapana, 'me ho ka' na ha e-ba thata ho ja chelete e lekaneng ka lijo feela. Mona ke moo tlatsetso e ka bang molemo, haholo-holo ho ba lakatsang ho ts'ehetsa bophelo bo botle ba pelo kapa ho ba le maemo a itseng a kotsi a lefu la pelo.
4. Khothalletsa metabolism
Phuputso e phatlalalitsoeng koranteng ea Cell Metabolism e fumane hore tlatsetso ea spermidine e ntlafalitse ts'ebetso ea metabolism ho litoeba. Bafuputsi ba hlokometse keketseho ea metabolism ea matla mme ba fumana hore tlatsetso ea spermidine e ntlafalitse kutloisiso ea insulin le mamello ea tsoekere. Liphuputso tsena li fana ka maikutlo a hore spermidine trihydrochloride e ka bapala karolo ho ntlafatsa metabolism le bophelo bo botle ba metabolism.
Phuputso e 'ngoe e boetse e fumane hore tlatsetso ea spermidine e na le liphello tse molemo ho metabolism. Bafuputsi ba hlokometse hore spermidine e khothalletsa ts'ebetso ea mitochondrial le biogenesis, tse bohlokoa bakeng sa tlhahiso ea matla le metabolism.
Spermidine trihydrochloride e ka ama metabolism ka mekhoa e mengata. Mokhoa o mong o ka bang teng ke bokhoni ba eona ba ho laola autophagy, ts'ebetso ea cellular e bapalang karolo ea bohlokoa ho boloka metabolism ea homeostasis. Autophagy e thusa ho hlakola li-organelle le liprotheine tse senyehileng e le hore lisele li tsebe ho sebetsa hantle. Spermidine e bontšitsoe ho kenya tšebetsong autophagy, e ka tlatsetsang liphellong tsa eona ho metabolism.
Haeba u batla ho ntlafatsa bophelo bo botle ba hau ka kakaretso, u ka fumana spermidine trihydrochloride supplementation e le khetho e ka bang teng. Spermidine ke motsoako oa tlhaho o fumanoang lijong tse itseng tse fumaneng tlhokomelo bakeng sa thepa ea eona e khahlanong le botsofali le ho khothalletsa bophelo bo botle. Mona ke lintlha tse ling tsa bohlokoa tseo u ka li nahanang ha u khetha tlatsetso ea spermidine trihydrochloride:
1. Boleng le Bohloeki: Ha ho tluoa tabeng ea tlatsetso, boleng le bohloeki ke tsa bohlokoa. Batla lihlahisoa tse entsoeng ka lisebelisoa tsa boleng bo phahameng 'me li lekoa ka matla ho netefatsa bohloeki le matla. Khetha mefuta e tsebahalang e nang le mekhoa e hlakileng ea ho fumana le ho etsa tlhahiso.
2. Spermidine Trihydrochloride Content: Likahare tsa spermidine ka li-supplement li fapana ho tloha sehlahisoa ho ea ho sehlahisoa. Ke habohlokoa ho khetha tlatsetso e fanang ka tekanyo e sebetsang ea spermidine ho fumana melemo ea eona. Batla lihlahisoa tse hlalosang ka ho hlaka litaba tsa spermidine ha u sebeletsa leiboleng.
3. Tlhahiso: Nahana ka foromo ea tlatsetso ea hau. Spermidine trihydrochloride supplements e fumaneha ka mefuta e sa tšoaneng e kang capsules le phofo. Khetha foromo e loketseng hore u nke le e lumellanang le mokhoa oa hau oa bophelo.
4. Lisebelisoa tse ling: Lisebelisoa tse ling tsa Spermidine trihydrochloride li ka 'na tsa e-ba le lisebelisoa tse ling tse ntlafatsang katleho ea tsona, tse kang livithamine, li-antioxidants, kapa metsoako e meng ea tlhaho. Nahana hore na u batla tlatsetso ea spermidine u le mong, kapa e kenyelletsang lisebelisoa tse ling bakeng sa melemo e meng.
5. Theko le Bohlokoa: Le hoja theko e sa lokela ho ba eona feela ntho e etsang qeto, theko ea tlatsetso e lokela ho nkoa e amana le boleng le boleng ba eona. Bapisa likhetho tse fapaneng 'me u hlahlobe boleng ba kakaretso boo u bo fumanang bakeng sa letsete la hau.
6. Ikopanye le setsebi sa tlhokomelo ea bophelo: Haeba u na le maemo a itseng a bophelo bo botle kapa u noa meriana, ke habohlokoa hore u buisane le setsebi sa tlhokomelo ea bophelo pele u qala mokhoa leha e le ofe o mocha oa tlatsetso. Ba ka fana ka tataiso ea motho ka mong mme ba netefatsa hore li-supplement li bolokehile ebile li nepahetse bakeng sa hau.
Suzhou Myland Pharm & Nutrition Inc. esale e sebetsa khoebong ea tlatsetso ea phepo e nepahetseng ho tloha ka 1992. Ke k'hamphani ea pele naheng ea China ho nts'etsapele le ho rekisa sekhechana sa peo ea morara.
Ka boiphihlelo ba lilemo tse 30 'me e khannoa ke theknoloji e phahameng le leano le ntlafalitsoeng la R&D, k'hamphani e thehile lihlahisoa tse ngata tsa tlholisano mme ea fetoha tlatsetso e ncha ea mahlale a bophelo, ho kopanya tloaelo le khamphani ea lits'ebeletso tsa tlhahiso.
Ntle le moo, khamphani hape ke moetsi ea ngolisitsoeng ke FDA, e netefatsang bophelo bo botle ba batho ka boleng bo tsitsitseng le kholo e tsitsitseng. Lisebelisoa tsa k'hamphani tsa R&D le lisebelisoa tsa tlhahiso le lisebelisoa tsa tlhahlobo ke tsa sejoale-joale ebile li na le mesebetsi e mengata, 'me li khona ho hlahisa lik'hemik'hale ka sekala sa milligram ho isa ho tone ho latela litekanyetso tsa ISO 9001 le mekhoa ea tlhahiso ea GMP.
P: Spermidine Trihydrochloride ke eng?
A: Spermidine Trihydrochloride ke motsoako oa tlhaho oa polyamine o fumanoang lijong tse sa tšoaneng tse kang kokoana-hloko ea koro, linaoa tsa soya le li-mushroom. E 'nile ea ithutoa ka melemo ea eona ea bophelo bo botle ho tšehetsa bophelo bo botle ba lisele le ho khothalletsa bophelo bo bolelele.
P: Nka khetha tlatsetso e ntle ka ho fetisisa ea Spermidine Trihydrochloride joang?
A: Ha u khetha tlatsetso ea Spermidine Trihydrochloride, ke habohlokoa ho batla letšoao le nang le botumo bo botle le sebelisang lisebelisoa tsa boleng bo phahameng 'me le lekoa bakeng sa bohloeki le potency. Ho boetse ho khothaletsoa ho buisana le setsebi sa tlhokomelo ea bophelo pele u qala mofuta ofe kapa ofe o mocha oa tlatsetso.
P: Melemo e ka bang teng ea ho nka li-supplement tsa Spermidine Trihydrochloride ke life?
A: Li-supplement tsa Spermidine Trihydrochloride li 'nile tsa ithutoa bakeng sa melemo ea tsona e ka' nang ea e-ba ho tšehetsa bophelo bo botle ba lisele, ho khothalletsa autophagy (mokhoa oa tlhaho oa 'mele oa ho tlosa litšila tsa cellular), le monyetla oa ho lelefatsa bophelo. Leha ho le joalo, ho hlokahala lipatlisiso tse eketsehileng ho utloisisa ka botlalo melemo ea nako e telele le likotsi tse ka 'nang tsa e-ba teng tsa Spermidine Trihydrochloride supplementation.
Boitlhotlhollo: Sengoloa sena ke sa tlhaiso-leseling e akaretsang feela 'me ha ea lokela ho nkuoa e le keletso efe kapa efe ea bongaka. Tse ling tsa litaba tsa poso ea blog li tsoa Marang-rang mme ha se setsebi. Sebaka sena sa marang-rang se na le boikarabello ba ho hlophisa, ho hlophisa le ho hlophisa lingoliloeng. Sepheo sa ho fetisa boitsebiso bo bongata ha se bolele hore u lumellana le maikutlo a eona kapa u tiisa bonnete ba litaba tsa eona. Kamehla buisana le setsebi sa tlhokomelo ea bophelo pele u sebelisa li-supplement leha e le life kapa u etsa liphetoho tsamaisong ea tlhokomelo ea bophelo.
Nako ea poso: Jan-29-2024
