Ha ho tluoa tabeng ea ho boloka bophelo bo botle, ho bohlokoa ho nahana ka likarolo tsohle tsa bophelo bo botle le phepo e nepahetseng. Ho kenyelletsa tlatsetso ea evodiamine morerong oa hau oa bophelo bo botle le phepo e nepahetseng e ka ba mokhoa o motle oa ho ts'ehetsa bophelo bo botle le boiketlo ba hau ka kakaretso. Hore na o batla ho laola boima ba 'mele, ho tšehetsa tšilo ea lijo e phetseng hantle, kapa ho matlafatsa ts'ebetso ea pelo, evodiamine e ka thusa. Evodiamine ke motsoako oa tlhaho o fumanoang litholoana tsa sefate sa Evodia. E 'nile ea sebelisoa meriana ea setso ea Machaena ka lilemo tse makholo' me e tsebahala ka melemo ea eona ea bophelo bo botle.
Evodiamine e khetholloa e le alkaloid ea bioactive 'me e fumanoa litholoana tsa semela sa Evodiamine. Sena se bolela hore e na le bokhoni ba ho sebelisana le mekhoa e fapaneng ea likokoana-hloko 'meleng. Motsoako ona o ithutoe ka litlamorao tse ka bang teng ho metabolism, taolo ea boima ba 'mele, le bophelo bo botle ka kakaretso. Meriana ea setso ea Sechaena, evodiamine e sebelisoa ho tšehetsa tšilo ea lijo, ho kokobetsa bohloko, le ho khothalletsa ho leka-lekana ha matla. Lipatlisisong tsa morao-rao, evodiamine e 'nile ea ithutoa ka bokhoni ba eona e le thermogenic, ho bolelang hore e ka' na ea e-ba le bokhoni ba ho eketsa tlhahiso ea 'mele ea mocheso le litšenyehelo tsa matla.
Liphuputso tse ling li fana ka maikutlo a hore evodiamine e ka 'na ea e-ba le bokhoni ba ho eketsa lebelo la metabolism' meleng, e leng se bakang litšenyehelo tse ngata tsa lik'halori le ho lahleheloa ke boima ba 'mele. Ho phaella moo, evodiamine e 'nile ea ithutoa ka bokhoni ba eona ba ho khothalletsa ho soothoa ha lisele tse tšoeu tsa adipose, tse ka' nang tsa e-ba le liphello tsa ho ntlafatsa bophelo bo botle ba metabolism le ho fokotsa kotsi ea mafu a amanang le botenya.
Hoa tsebahala hore ho ruruha le khatello ea oxidative li phetha karolo ea ho nts'etsapele mafu a sa tšoaneng a sa foleng, kahoo metsoako e khonang ho loantša mekhoa ena e na le thahasello e kholo ho bafuputsi le litsebi tsa bophelo bo botle. Lipatlisiso tse ling li fana ka maikutlo a hore evodiamine e ka ba le bokhoni ba ho fokotsa ho ruruha le ho sireletsa khahlanong le tšenyo ea oxidative, e ka 'nang ea e-ba le liphello tsa ho tšehetsa bophelo bo botle le bophelo bo botle ka kakaretso.
Hajoale, evodiamine e fumaneha haholo e le tlatsetso ea lijo, e nang le letoto la melemo ea bophelo bo botle bakeng sa 'mele oa motho.
Evodiamine e fumanoe e fana ka liphello tsa eona ka litsela tse ngata tsa limolek'hule. E 'ngoe ea mekhoa ea bohlokoa ea ts'ebetso ea evodiamine ke bokhoni ba eona ba ho kenya liteishene tsa nakoana tsa receptor tse ka bang vanilloid 1 (TRPV1). TRPV1 ke receptor e amehang bohlokong le ho utloa mocheso, 'me ho sebelisoa ha eona ka evodiamine ho bontšitsoe ho susumetsa thermogenesis le ho eketsa litšenyehelo tsa matla. Phello ena ea thermogenic ea evodiamine e ka tlatsetsa ho thepa ea eona e khahlanong le botenya, e leng se etsang hore e be sepheo sa ho ntlafatsa mekhoa ea ho fokotsa boima ba 'mele.
Ho phaella liphellong tsa eona ho TRPV1, evodiamine e fumanoe e fetola lipakane tse ling tsa molek'hule, ho akarelletsa le adenosine monophosphate-activated protein kinase (AMPK) le peroxisome proliferator-activated receptor gamma (PPARγ). AMPK ke molaoli ea ka sehloohong oa homeostasis ea matla a cellular, 'me ts'ebetso ea eona ka evodiamine e khothalletsa ho kenngoa ha tsoekere le mafura a acid oxidation, kahoo e ntlafatsa kutloisiso ea insulin le bophelo bo botle ba metabolism. Ka lehlakoreng le leng, ts'ebetso ea PPARγ ka evodiamine e ka laola polelo ea liphatsa tsa lefutso tse amehang ho metabolism ea lipid le adipogenesis, e leng se tlatsetsang ho phello ea eona e khahlanong le botenya.
Ho phaella moo, evodiamine e bontšitsoe ho bontša thepa e khahlanong le ho ruruha ka ho thibela pontšo ea nuclear factor kappa B (NF-κB). NF-κB ke molaoli oa mantlha oa likarabo tsa ho ruruha, 'me ho senyeha ha eona ho amahanngoa le mefuta e sa tšoaneng ea mafu a sa foleng. Ka ho thibela ts'ebetso ea NF-κB, evodiamine e ka fokotsa tlhahiso ea bakena-lipakeng ba nang le ts'oaetso le ho fokotsa ts'ebetso ea ho ruruha, e fana ka maikutlo a karolo ea eona ea phekolo ea phekolo ea phekolo ea mafu a ho ruruha.
Ho feta moo, litlamorao tsa anticancer tsa evodiamine li hlahisoa ke bokhoni ba eona ba ho susumetsa apoptosis le ho thibela ho ata meleng e fapaneng ea lisele tsa mofetše. Sena se nahanoa hore se etsahala ka taolo ea litsela tse ngata tsa lipontšo tse amehang ho pholoheng le ho hōla ha lisele, ho akarelletsa le mitogen-activated protein kinase (MAPK) le phosphoinositide 3-kinase (PI3K)/Akt pathways. Ho phaella moo, evodiamine e bontšitsoe ho thibela polelo ea matrix metalloproteinases (MMPs), li-enzyme tse amehang tlhaselong ea hlahala le metastasis.
1.E thusa ho theola boima ba 'mele le ho fokotsa metabolism
Senotlolo sa ho thusa evodiamine ka ho theola boima ba 'mele ke ho eketsa thermogenesis' meleng. Thermogenesis ke mokhoa oo 'mele o hlahisang mocheso le ho chesa lik'hilojule. Ka ho susumetsa thermogenesis, evodiamine e ka thusa ho matlafatsa metabolism le ho khothalletsa ho chesa mafura. Sena se bolela hore o chesa lik'hilojule tse ngata ho pholletsa le letsatsi, esita le ha u phomotse, e leng se lebisang ho lahleheloa ke boima ba 'mele ka nako.
Ntle le litlamorao tsa eona ho thermogenesis, evodiamine e kanna ea ba le litlamorao ho metabolism ea mafura. Lipatlisiso li bontša hore evodiamine e ka thusa ho eketsa ho senyeha ha mafura le ho thibela ho thehoa ha lisele tse ncha tsa mafura. Sena se bolela hore ha se thuse feela ho chesa mabenkele a mafura a teng, hape se thibela ho bokella mafura a macha, ho nolofalletsa ho boloka boima ba 'mele ka nako e telele.
Ho phaella moo, evodiamine e bontšitsoe hore e na le liphello tse ka thibelang takatso ea lijo. Ka ho fokotsa tlala le ho eketsa maikutlo a ho tlala, evodiamine e ka u thusa ho ja lik'hilojule tse fokolang, ho etsa hore ho be bonolo ho khomarela lijo tsa hau le ho finyella lipakane tsa hau tsa ho theola boima ba 'mele. Ho phaella moo, lipatlisiso tse ling li fana ka maikutlo a hore evodiamine e ka boela ea e-ba le thepa e khahlanong le ho ruruha le ea antioxidant, e ka thusang bophelo bo botle le boiketlo ka kakaretso nakong ea ho theola boima ba 'mele.
2.E thusa ho fokotsa ho ruruha
Evodiamine e tsoa ho tholoana ea semela sa Evodia rutaecarpa, se 'nileng sa sebelisoa meriana ea setso ea Machaena ho phekola maloetse a sa tšoaneng ka lilemo tse makholo. Patlisiso ka evodiamine e bonts'a hore e thibela tlhahiso ea limolek'hule tsa ho ruruha 'meleng, joalo ka li-cytokine le prostaglandin. Sena se thusa ho fokotsa maemo a kakaretso a ho ruruha 'meleng, kahoo ho fokotsa bohloko le matšoao a mang a amanang le ho ruruha ho sa foleng.
Phuputso e phatlalalitsoeng ho Journal of Ethnopharmacology e fumane hore evodiamine e na le liphello tse kholo tse khahlanong le ho ruruha ho litoeba tse nang le ho ruruha ho bakoang. Bafuputsi ba ile ba etsa qeto ea hore evodiamine e ka ba phekolo e sebetsang ea tlhaho bakeng sa mafu a ho ruruha. Phuputso e 'ngoe koranteng ea Phytomedicine e fumane hore evodiamine e na le litlamorao tse matla tse thibelang ho ruruha litloaelong tsa lisele, e fana ka maikutlo a hore e kanna ea ba kalafo e sebetsang ea ho ruruha bathong.
3.E thusa bophelo bo botle ba pelo
Evodiamine e bontšitsoe hore e na le thepa ea vasodilatory, e bolelang hore e ka thusa ho phomola le ho atolosa methapo ea mali, kahoo e ntlafatsa phallo ea mali. Sena se molemo haholo ho batho ba nang le khatello e phahameng ea mali, kaha se ka thusa ho fokotsa mosebetsi oa pelo le ho fokotsa kotsi ea mathata a kang stroke kapa lefu la pelo.
Ho phaella moo, evodiamine e 'nile ea ithutoa ka bokhoni ba eona ba ho fokotsa ho ruruha le khatello ea oxidative, tseo ka bobeli li amanang haholo le nts'etsopele ea lefu la pelo. Ka ho fokotsa likotsi tsena, evodiamine e ka thusa ho sireletsa pelo le methapo ea mali ho senyeha le ho se sebetseng hantle. Evodiamine e fumanoe e na le li-antiplatelet le li-antithrombotic effects, ho bolelang hore e ka thusa ho thibela mali hore a se ke a thehoa. Maqeba a mali a ka sitisa phallo ea mali 'me a lebisa liketsahalong tse tebileng tsa pelo, kahoo bokhoni ba evodiamine ba ho thibela ho thehoa ha lesela bo ka ba le phello e kholo bophelong bo botle ba pelo.
4.Ho Tšehetsa Bophelo bo Botle ba Gastrointestinal
Lipatlisiso li fana ka maikutlo a hore evodiamine e ka ba le liphello tse 'maloa tse molemo tsamaisong ea gastrointestinal. E na le thepa ea anti-inflammatory le antioxidant e thusang ho sireletsa mala le mala a mala ho tsoa tšenyo e bakoang ke li-radicals tsa mahala le ho ruruha. Ho phaella moo, evodiamine e 'nile ea bontšoa hore e na le liphello tse thibelang likokoana-hloko' me e ka thusa ho khothalletsa ho leka-lekana ha libaktheria tsa mala le ho fokotsa kotsi ea mafu a ka mpeng.
Ho phaella moo, ho fumanoe hore evodiamine e na le thepa ea ho thibela seso, e thusang ho fokotsa kotsi ea liso tsa ka mpeng le mafu a mang a mala. Ka ho khothalletsa botšepehi ba lesela la mucosal le ho thibela secretion ea acid e feteletseng, evodiamine e ka thusa ho sireletsa mpa le mala ho senya le ho teneha.
5.Melemo e meng ea bophelo bo botle
Evodiamine e na le bokhoni ba ho laola maemo a tsoekere ea mali. Tekanyo e phahameng ea tsoekere maling e ka baka mathata a mangata a bophelo bo botle, ho kenyelletsa lefu la tsoekere le lefu la pelo. Lipatlisiso li bontša hore evodiamine e ka thusa ho ntlafatsa kutloisiso ea insulin le ho laola maemo a tsoekere ea mali, e leng se etsang hore e be sesebelisoa sa bohlokoa ho mang kapa mang ea batlang ho boloka maemo a tsoekere a mali a phetseng hantle.
Ntle le bokhoni ba eona ba ho laola maemo a tsoekere ea mali, evodiamine e boetse e fumanoe e fokotsa maemo a k'holeseterole. Maemo a phahameng a k'holeseterole a eketsa kotsi ea lefu la pelo le stroke, kahoo ho fumana mekhoa ea tlhaho ea ho theola k'holeseterole ea hau ho bohlokoa ho boloka bophelo bo botle ba hau ka kakaretso. Evodiamine e bontšitsoe ho fokotsa maemo a LDL k'holeseterole ("cholesterol e mpe") ha e ntse e eketsa maemo a k'holeseterole ea HDL (eo hape e bitsoang "molemo" cholesterol).
Ho feta moo, evodiamine e fumanoe e eketsa maemo a matla ka kakaretso. Lefatšeng la kajeno le potlakileng, batho ba bangata ba loantšana le matla a fokolang le mokhathala. Evodiamine e bontšitsoe ho eketsa metabolism le tšebeliso ea matla, ka tsela eo ka tlhaho e matlafatsa maemo a matla. Sena se molemo haholo ho baatlelete kapa mang kapa mang ea batlang ho ntlafatsa matla le matla a bona ka kakaretso.
Ha u bapisa li-supplement tsa evodiamine, ntho ea pele eo u lokelang ho nahana ka eona ke mohloli oa evodiamine. Ho bohlokoa ho khetha tlatsetso e sebelisang boleng ba boleng bo holimo, bo hloekileng ba evodiamine bo tsoang mohloling o tsebahalang. Batla lihlahisoa tse lekiloeng ke motho oa boraro 'me li na le lengolo la tlhahlobo ho netefatsa bohloeki le potency.
Ntho e 'ngoe ea bohlokoa e lokelang ho nahanoa ke tekanyo ea evodiamine ka tlatsetso. Tekanyetso e khothaletsoang ea evodiamine e ka fapana ho latela motho le lipheo tsa bona tsa bophelo bo botle. Li-supplement tse ling li ka 'na tsa e-ba le evodiamine e phahameng kapa e tlaase, kahoo ho bohlokoa ho khetha e finyellang litlhoko le likhetho tsa hau.
Ho phaella ho dikahare tsa evodiamine, ho bohlokoa ho nahana ka metsoako e meng ea tlatsetso ea hau. Li-supplement tse ling tsa evodiamine li ka 'na tsa e-ba le lisebelisoa tse ling, tse kang pepere e ntšo kapa e ntšo ea tee e tala.
Ho feta moo, mofuta oa tlatsetso ke mohopolo o mong oa bohlokoa. Li-supplement tsa Evodiamine li fumaneha ka mefuta e fapaneng, ho kenyelletsa capsules, powders, le tinctures. Khetha mofuta o bonolo le o bonolo ho o kenyelletsa bophelong ba hau ba letsatsi le letsatsi. Ka mohlala, haeba u na le bothata ba ho metsa matlapa, phofo e ka ba khetho e molemo ho uena.
Hape ke habohlokoa ho nahana ka boleng ha u khetha tlatsetso ea evodiamine. Batla moetsi oa sechaba ea nang le nalane ea ho hlahisa li-supplement tsa boleng bo holimo le litlhahlobo tse ntle tsa bareki. Batlisisa mekhoa ea tlhahiso ea mofuta le mehato ea taolo ea boleng ho netefatsa hore o fumana sehlahisoa se bolokehileng le se tšepahalang.
Qetellong, ha u khetha tlatsetso ea evodiamine, nahana ka lipakane tsa hau tsa bophelo bo botle le mathata leha e le afe a itseng a bophelo bo botle. Batho ba bang ba ka 'na ba thahasella evodiamine bakeng sa ho laola boima ba' mele, ha ba bang ba ka 'na ba batla ho tšehetsa bophelo bo botle ba tšilo ea lijo kapa bophelo bo botle ka kakaretso. Hape, buisana le setsebi sa tlhokomelo ea bophelo pele u qala mokhoa leha e le ofe o mocha oa tlatsetso, haholo-holo haeba u e-na le boemo bo teng ba bophelo bo botle kapa u noa meriana.
Suzhou Myland Pharm & Nutrition Inc. esale e sebetsa khoebong ea tlatsetso ea phepo e nepahetseng ho tloha ka 1992. Ke k'hamphani ea pele naheng ea China ho nts'etsapele le ho rekisa sekhechana sa peo ea morara.
Ka boiphihlelo ba lilemo tse 30 'me e khannoa ke theknoloji e phahameng le leano le ntlafalitsoeng la R&D, k'hamphani e thehile lihlahisoa tse ngata tsa tlholisano mme ea fetoha tlatsetso e ncha ea mahlale a bophelo, ho kopanya tloaelo le khamphani ea lits'ebeletso tsa tlhahiso.
Ntle le moo, khamphani hape ke moetsi ea ngolisitsoeng ke FDA, e netefatsang bophelo bo botle ba batho ka boleng bo tsitsitseng le kholo e tsitsitseng. Lisebelisoa tsa k'hamphani tsa R&D le lisebelisoa tsa tlhahiso le lisebelisoa tsa tlhahlobo ke tsa sejoale-joale ebile li na le mesebetsi e mengata, 'me li khona ho hlahisa lik'hemik'hale ka sekala sa milligram ho isa ho tone ho latela litekanyetso tsa ISO 9001 le mekhoa ea tlhahiso ea GMP.
P: Evodiamine ke eng?
A: Evodiamine ke motsoako oa tlhaho o fumanoang litholoana tsa semela sa Evodia rutaecarpa, E 'nile ea sebelisoa meriana ea setso ea Sechaena ka lilemo tse makholo' me e tsebahala ka melemo ea eona ea bophelo bo botle.
P: Melemo e ka bang teng ea li-supplement tsa evodiamine ke efe?
A: Li-supplement tsa Evodiamine ho lumeloa hore li na le melemo e mengata ea bophelo bo botle, ho kenyelletsa le ts'ehetso ea ho laola boima ba 'mele, metabolism, le bophelo bo botle ka kakaretso. Ho feta moo, li ka ba le li-anti-inflammatory le antioxidant properties.
P: Ke lokela ho kenyelletsa li-supplement tsa evodiamine joang morerong oa ka oa bophelo bo botle le phepo e nepahetseng?
K: Pele o kenyelletsa tlatsetso efe kapa efe e ncha moralong oa hau oa bophelo bo botle le phepo e nepahetseng, ho bohlokoa ho buisana le setsebi sa tlhokomelo ea bophelo. Li ka u thusa ho fumana tekanyo e nepahetseng le ho lekola litšebelisano leha e le life tse ka bang teng le meriana e meng kapa li-supplement tseo u ka 'nang ua li noa.
P: Na ho na le litla-morao tse ka bang teng tsa li-supplement tsa evodiamine?
A: Le hoja li-supplement tsa evodiamine hangata li nkoa li sireletsehile ho batho ba bangata ha li nooa ka tekanyo e nepahetseng, batho ba bang ba ka 'na ba e-ba le litla-morao tse kang ho halefa kapa ho teneha. Ke habohlokoa ho latela tekanyo e khothalletsoang le ho shebella karabelo ea 'mele oa hau ho tlatsetso.
P: Na ho na le mehato eo u lokelang ho e ela hloko ha u noa li-supplement tsa evodiamine?
A: Haeba u imme, u anyesa, kapa u e-na le maemo leha e le afe a bophelo bo botle, ho bohlokoa ho bua le setsebi sa tlhokomelo ea bophelo pele u nka li-supplement tsa evodiamine. Ho feta moo, ho bohlokoa ho reka li-supplement ho tsoa mohloling o tsebahalang ho netefatsa boleng le polokeho.
Boitlhotlhollo: Sengoloa sena ke sa tlhaiso-leseling e akaretsang feela 'me ha ea lokela ho nkuoa e le keletso efe kapa efe ea bongaka. Tse ling tsa litaba tsa poso ea blog li tsoa Marang-rang mme ha se setsebi. Sebaka sena sa marang-rang se na le boikarabello ba ho hlophisa, ho hlophisa le ho hlophisa lingoliloeng. Sepheo sa ho fetisa boitsebiso bo bongata ha se bolele hore u lumellana le maikutlo a eona kapa u tiisa bonnete ba litaba tsa eona. Kamehla buisana le setsebi sa tlhokomelo ea bophelo pele u sebelisa li-supplement leha e le life kapa u etsa liphetoho tsamaisong ea tlhokomelo ea bophelo.
Nako ea poso: Feb-02-2024
