Lisebelisoa tse sireletsehileng tsa mitophagy le lisebelisoa tse ncha tse thibelang botsofali-Urolithin A

Nalane eaurolithin A (UA)e ka lateloa ho tloha 2005. Ke metabolite ea likokoana-hloko tsa mala 'me e ke ke ea tlatsetsoa ka ho toba ka mekhoa ea lijo. Leha ho le joalo, selelekela sa eona sa ellagitannins se na le litholoana tse ngata tse fapaneng tse kang likharenate le fragole.

Karolo ea urolithin A

Ka la 25 March, 2016, phuputso e kholo makasineng ea "Nature Medicine" e ile ea lebisa tlhokomelo ea bamameli mabapi le kamano ea eona le ho lieha ho tsofala ha batho. Ho tloha ha ho sibolloa ka 2016 hore UA e khona ho lelefatsa nako ea bophelo ba C. elegans, UA e 'nile ea sebelisoa maemong ohle (lisele tsa hematopoietic stem, lisele tsa letlalo, boko (litho), tsamaiso ea' mele ea ho itšireletsa mafung, nako ea bophelo ba motho ka mong) le mefuta e sa tšoaneng. (C. elegans, melanogaster Liphello tse thibelang botsofali li bontšitsoe ka matla ho lintsintsi tsa litholoana, litoeba le batho.

(1) Ho thibela botsofali le ho ntlafatsa ts'ebetso ea mesifa
Teko ea kliniki e sa reroang e hatisitsoeng ho JAMA Network Open, koranta e ka tlaase ea Journal of the American Medical Association, e bontšitse hore ho batho ba hōlileng kapa batho ba nang le bothata ba ho falla ka lebaka la ho kula, li-supplement tsa UA li ka thusa ho ntlafatsa bophelo bo botle ba mesifa le ho etsa boikoetliso bo hlokahalang.

(2) Thusa ho ntlafatsa bokhoni ba anti-tumor ea immunotherapy
Ka 2022, sehlopha sa lipatlisiso sa Florian R. Greten se tsoang Setsing sa Georg-Speyer-Haus sa Tumor Biology le Experimental Therapeutics Jeremane se ile sa fumana hore UA e ka kenya mitophagy liseleng tsa T, ea khothalletsa ho lokolloa ha PGAM5, ea kenya tšebetsong tsela ea pontšo ea Wnt, le khothalletsa lisele tsa stem tsa T memori. sebopeho, ka tsela eo ho khothalletsa ho itšireletsa khahlanong le hlahala.

(3) Ho khutlisa botsofali ba lisele tsa stem tsa hematopoietic le sesole sa 'mele
Phuputsong ea 2023, Univesithi ea Lausanne e Switzerland e ile ea ithuta phello ea eona tsamaisong ea mali ka ho lumella litoeba tse likhoeli tse 18 ho ja lijo tse nang le urolithin A bakeng sa likhoeli tsa 4 le ho hlahloba liphetoho liseleng tsa bona tsa mali khoeli le khoeli. Tšusumetso.
Liphetho li bonts'itse hore lijo tsa UA li ekelitse palo ea lisele tsa mali le lisele tsa lymphoid progenitor, le ho fokotsa palo ea lisele tsa erythroid. Ho fumanoa hona ho fana ka maikutlo a hore lijo tsena li ka fetola liphetoho tse ling tsamaisong ea hematopoietic e amanang le botsofali.

(4) Phello e khahlanong le ho ruruha
Ts'ebetso e khahlanong le ho ruruha ea UA e matla haholo 'me e ka thibela haholo mefuta e sa tšoaneng e tloaelehileng ea ho ruruha e kang TNF-α. Ke ka lebaka lena UA e nkang karolo liphekolong tse fapaneng tsa ho ruruha ho kenyelletsa boko, mafura, pelo, mala le sebete. E ka imolla ho ruruha liseleng tse fapaneng.

(5) Neuroprotection
Litsebi tse ling li tiisitse hore UA e ka thibela tsela ea apoptosis e amanang le mitochondria le ho laola tsela ea pontšo ea p-38 MAPK, kahoo e thibela apoptosis e bakoang ke khatello ea kelello ea oxidative. Mohlala, UA e ka ntlafatsa sekhahla sa ho phela ha li-neurone tse hlohlelletsoang ke khatello ea oxidative mme e na le ts'ebetso e ntle ea ts'ireletso ea methapo.

(6) Phello ea mafura
UA e ka ama metabolism ea lipid ea cellular le lipogenesis. Liphuputso li bontšitse hore UA e ka etsa hore ho sebelisoe mafura a sootho le ho soothoa ha mafura a masoeu, ha e ntse e thibela ho bokellana ha mafura ho bakoang ke lijo.

(7) Ntlafatsa botenya
UA e ka boela ea fokotsa ho bokellana ha mafura ka har'a li-adipocyte le liseleng tsa sebete tse hlahisitsoeng ka har'a vitro le ho eketsa oxidation ea mafura. E ka fetola T4 e sa sebetseng hantle ho thyroxine hore e be T3 e sebetsang haholoanyane, e matlafatsa sekhahla sa metabolism le tlhahiso ea mocheso ka pontšo ea thyroxine. , ka hona e phetha karolo ea ho laola botenya.

(8) Sireletsa mahlo
The mitophagy inducer UA e ka fokotsa khatello ea oxidative ho retina ea khale; e fokotsa boemo ba cytosolic cGAS mme e fokotsa ts'ebetso ea lisele tsa glial ho retina ea khale.

(9) Tlhokomelo ea letlalo
Har'a tsohle tse fumanoeng metabolite ea mala a mammalian, UA e na le ts'ebetso e matla ka ho fetisisa ea antioxidant, ea bobeli feela ho proanthocyanidin oligomers, catechins, epicatechin le 3,4-dihydroxyphenylacetic acid. ema.

Urolithin A maemo a kopo

Ka 2018, UA e khethiloe ke Tsamaiso ea Lijo le Lithethefatsi ea US e le ntho e jeoang "ka kakaretso e nkoa e bolokehile" mme e ka ekeletsoa ho li-protein shakes, lino tse nchafatsang lijo, oatmeal hang-hang, li-protein tsa phepo e nepahetseng le lino tsa lebese (ho fihla ho 500 mg). /serving) ), yoghurt ea Greek, yogurt e nang le protheine e ngata le liprotheine tsa lebese (ho fihla ho 1000 mg / ho sebeletsa).

UA e ka boela ea ekeletsoa lihlahisoa tsa tlhokomelo ea letlalo, ho kenyelletsa le litlolo tsa motšehare, litlolo tsa bosiu le metsoako ea serum, e etselitsoeng ho ntlafatsa metsi a letlalo le ho fokotsa wrinkles haholo, ho ntlafatsa letlalo la letlalo ho tsoa ka hare, le ho loantša ka katleho matšoao a bonahalang a botsofali. , ho thusa letlalo ho lula le le monyenyane.

Mokhoa oa tlhahiso ea Urolithin A

(1) Mokhoa oa ho belisa
Tlhahiso ea khoebo ea UA e finyelloa pele ka theknoloji ea ho belisoa, eo haholo-holo e lomositsoeng ho tloha makhapetleng a kharenate 'me e na le urolithin A e fetang 10%.
(2) Mokhoa oa ho kopanya lik'hemik'hale
Ka boqapi bo tsoelang pele le nts'etsopele ea lipatlisiso, motsoako oa lik'hemik'hale ke mokhoa oa bohlokoa oa tlhahiso ea indasteri ea urolithin A. Suzhou Myland Pharm ke tlatsetso e ncha ea mahlale a bophelo, k'hamphani ea maiketsetso le lits'ebeletso tsa tlhahiso e ka fanang ka urolithin A ea boleng bo holimo. phofo e tala.