Salidroside: Ho utolla lekunutu la thepa ea antioxidant ea Rhodiola rosea

Salidroside ke antioxidant ea tlhaho e sireletsang lisele tsa methapo ka ho senya ROS le ho thibela apoptosis ea lisele.

Intracellular calcium overload ke e 'ngoe ea lisosa tse kholo tsa neuronal apoptosis. Rhodiola rosea extract le salidroside e ka fokotsa ho eketseha ha maemo a khalsiamo a intracellular a bakoang ke khatello ea oxidative le ho sireletsa lisele tsa cortical tsa motho ho tloha glutamate. Salidroside e ka thibela lipopolysaccharide-induced microglial activation, e thibela tlhahiso ea NO, e thibela mosebetsi oa inducible nitric oxide synthase (iNOS), le ho fokotsa maemo a TNF-α le IL-1β, IL-6.

Salidroside e thibela NADPH oxidase 2/ROS/mitogen-activated protein kinase (MAPK) le regulator ea karabelo ea ntshetsopele le tšenyo ea DNA 1 (REDD1)/mammalian target of rapamycin (mTOR)/p70 ribosome Protheine S6 kinase signaling pathway activate the AMP-based protein kinase / silent information regulator 1, RAS homologous gene setho sa lelapa A/MAPK le PI3K/Akt litsela tsa lipontšo.

1. Salidroside e hanyetsa tšenyo e sa lefelloeng 'me e sireletsa' mele

'Mele o ka hlahisa palo e itseng ea li-radicals tsa mahala tsa endogenous nakong ea ts'ebetso e tloaelehileng ea fisioloji, mme tekanyo e itseng ea fisioloji ea li-radicals tsa mahala ea hlokahala ho boloka mesebetsi e tloaelehileng ea' mele ea 'mele. Ho boetse ho na le sistimi ea mahala ea "radical scavenging" 'meleng ho tlosa li-radicals tsa mahala tse fetang litekanyetso tsa 'mele e le hore li se ke tsa senya bophelo ba' mele.

Leha ho le joalo, tlas'a tšusumetso ea lintlha tse ling tse khethehileng tsa tikoloho, li-radicals tsa mahala tsa 'mele li tla ba tse feteletseng' me li fete tekanyo ea mahala ea "radical scavenging" ea tsamaiso, e leng se bakang ho se leka-lekane tsamaisong ea 'mele ea tlhahiso ea oksijene ea mahala, e lebisang ho bokelleng ha li-radicals tsa mahala tsa oksijene. 'meleng, kahoo e baka tšenyo ea lera la sele. tshenyo.

Lipatlisiso li bonts'a hore tikoloho ea hypoxic tlas'a maemo a sehlabeng e ka baka ho se leka-lekane ho metabolism ea mahala ea oksijene, ho bokella li-radicals tsa mahala tsa intracellular le ho eketsa lihlahisoa tsa lipid peroxidation. Liphuputso li bontšitse hore salidroside e ka sireletsa lisele tsa 'mele ka ho senya li-radicals tsa mahala' meleng.

2. Salidroside e hanyetsa hypoxia ho boloka botsitso ba ts'ebetso ea mitochondrial

Hoo e ka bang 80-90% ea oksijene ea intracellular e sebelisoa bakeng sa oxidation ea likokoana-hloko ho mitochondria ho hlahisa ATP le ho theha mefuta e sebetsang ea oksijene ea ROS ho boloka mesebetsi e tloaelehileng ea bophelo ba lisele. Ke 10-20% feela ea oksijene e lokolohileng ka ntle ho mitochondria bakeng sa biosynthesis, degradation, biotransformation (detoxification), joalo-joalo Mosebetsi oa phefumoloho oa Mitochondrial o ntlafatsoa ka hypoxia e bonolo kapa qalong ea hypoxia, e bonahatsoang e le karabelo ea matšeliso. tsamaiso ea 'mele ea ho hema.

Hypoxia e matla e tla qala ka ho ama oksijene ea kantle ea mitochondria le mathata a ts'ebetso ea metabolism ea 'mele, e fokotse tlhahiso ea li-neurotransmitters, le ho fokolisa bokhoni ba biotransformation, ka hona e ama ts'ebetso ea lisele le litho. Liphuputso li bontšitse hore salidroside e ka sireletsa tlhokomelo ea mosebetsi oa mitochondrial ka ho fokotsa litaba tsa ROS ka mitochondria ea sele, ho eketsa ts'ebetso ea SOD, le ho eketsa palo ea mitochondria.

3. Tšireletso ea myocardial ea salidroside

Liphuputso li bontšitse hore tsamaiso ea pelo ke eona tsamaiso e ka sehloohong e fetolang tikoloho ea hypoxic. Tikoloho ea hypoxic e tla etsa hore metabolism ea 'mele e fokotsehe le ho haella ha matla a phepelo ea matla, e leng se lebisang matšoao a kang hypoxia, ischemia, le apoptosis ea lisele tsa myocardial. Liphuputso li bontšitse hore salidroside e ka ntlafatsa ts'ebetso ea pelo le ho ntlafatsa microcirculation ka ho atolosa methapo ea mali le methapo ea mali, ho ntlafatsa phallo ea mali ea myocardial, ho fetola hemodynamics ea pelo, ho fokotsa boima ba pelo, le ho fokotsa tšenyo ea methapo ea pelo.
Ka bokhutšoanyane, salidroside e ka sebetsa tsamaisong ea pelo ka mekhoa e mengata, litsela, le lipakane, ho sireletsa apoptosis ea lisele tsa myocardial tse bakoang ke lisosa tse ngata, le ho ntlafatsa boemo ba 'mele oa ischemia le hypoxia. Sebakeng sa hypoxic, ho kenella ha Rhodiola rosea ho bohlokoa haholo ho sireletsa lisele le litho tsa 'mele le ho boloka botsitso ba mesebetsi ea lisele. E phetha karolo ea bohlokoa ho thibeleng le ho kokobetsa ho kula ka bophahamo.
Boemo ba hona joale ba tlhahiso ea salidroside

1) Haholo-holo itšetlehe ka ho ntšoa ha limela

Rhodiola rosea ke thepa e tala easalidroside.Joalo ka mofuta oa semela sa herbaceous se sa feleng, Rhodiola rosea e hola haholo libakeng tse nang le serame se phahameng, anoxia, ho omella, le phapang e kholo ea mocheso lipakeng tsa mots'eare le bosiu sebakeng sa bophahamo ba limithara tse 1600-4000. Ke se seng sa limela tse hlaha tsa sehlabeng. China ke e 'ngoe ea libaka tse ka sehloohong tse hlahisang Rhodiola rosea lefatšeng, empa mekhoa ea ho phela ea Rhodiola rosea e ikhethile haholo. Hase feela hore ho thata ho lema ka mokhoa oa maiketsetso, empa lihlahisoa tsa mefuta e sa tšoaneng ea hlaha li tlaase haholo. Lekhalo la selemo le selemo la tlhokeho ea Rhodiola rosea le ka holimo ho lithane tse 2,200.

2) Kemiso ea lik'hemik'hale le ho belisoa ha likokoana-hloko

Ka lebaka la lihlahisoa tse tlaase le litšenyehelo tse phahameng tsa tlhahiso ea limela, ntle le mekhoa ea tlhaho ea tlhaho, mekhoa ea tlhahiso ea salidroside e boetse e kenyelletsa mekhoa ea ho kopanya lik'hemik'hale, mekhoa ea ho belisoa ha likokoana-hloko, joalo-joalo Har'a bona, ha theknoloji e ntse e tsoela pele ho hōla, ho belisoa ha likokoana-hloko ho fetohile ntho e tloaelehileng. tsela ea tekheniki bakeng sa nts'etsopele ea lipatlisiso le tlhahiso ea salidroside. Hajoale, Suzhou Mailun e fihletse liphetho tsa lipatlisiso le nts'etsopele mme e fihletse kholo ea indasteri.