Matla a taurine a feta monahano oa hau !!!

Haufinyane tjena, lipatlisiso tse mabapi le taurine li phatlalalitsoe likoranteng tse tharo tse holimo Science, Cell, le Nature. Lithuto tsena li senotse mesebetsi e mecha ea taurine - e thibelang botsofali, e ntlafatsa phello ea kalafo ea mofets'e, le ho thibela botenya.

Ka June 2023, bafuputsi ba National Institute of Immunology in India, Columbia University e United States, le litsi tse ling ba ile ba hatisa lipampiri koranteng e ka sehloohong ea thuto ea machaba ea Science. Boithuto bona bo fana ka maikutlo a hore khaello ea taurine ke mokhanni oa botsofali. Ho tlatselletsa taurine ho ka liehisa botsofali ba li-nematode, litoeba le litšoene, hape ho ka lelefatsa bophelo bo botle ba litoeba tsa lilemo tse mahareng ka 12%. Lintlha: Saense: Matla a fetang monahano oa hau! Taurine e ka boela ea khutlisa botsofali le ho lelefatsa bophelo?

Ka Mmesa 2024, Moprofesa Zhao Xiaodi, Motlatsi oa Moprofesa Lu Yuanyuan, Moprofesa Nie Yongzhan, le Moprofesa Wang Xin oa Sepetlele sa Xijing sa Univesithi ea Bone ea Sesole ea Bongaka ba ile ba hatisa lipampiri koranteng ea maemo a holimo ea thuto ea machaba ea Cell. Phuputso ena e fumane hore lisele tsa tumor li qothisana lehlokoa le lisele tsa CD8 + T bakeng sa taurine ka ho fetelletsa taurine transporter SLC6A6, e bakang lefu la T cell le mokhathala, e leng se lebisang ho phonyoha ha 'mele oa ho itšireletsa mafung, kahoo ho khothalletsa tsoelo-pele ea hlahala le ho khutla hape, ha ho tlatsetsa Taurine ho ka tsosolosa lisele tsa CD8 + T tse khathetseng. le ho ntlafatsa katleho ea kalafo ea mofetše.

Ka Phato 7, 2024, sehlopha sa Jonathan Z. Long oa Univesithi ea Stanford (Dr. Wei Wei ke sengoli sa pele) se ile sa hatisa pampiri ea lipatlisiso e bitsoang: PTER ke N-acetyl taurine hydrolase e laolang ho fepa le ho nona haholo sehlopheng se phahameng sa thuto ea machaba. koranta ea Tlhaho.

Phuputso ena e sibollotse N-acetyl taurine hydrolase ea pele ho liphoofolo tse anyesang, PTER, mme e netefalitse karolo ea bohlokoa ea N-acetyl taurine ho fokotsa ho ja lijo le ho thibela botenya. Nakong e tlang, hoa khoneha ho hlahisa li-inhibitors tse matla le tse khethiloeng tsa PTER bakeng sa phekolo ea botenya.

Taurine e fumanoa haholo liseleng tsa mammalian le lijong tse ngata 'me e fumaneha haholo-holo ka har'a lisele tse monate tse kang pelo, mahlo, boko le mesifa. Taurine e 'nile ea hlalosoa e na le mesebetsi ea pleiotropic cellular le physiological, haholo-holo tabeng ea metabolic homeostasis. Phokotso ea liphatsa tsa lefutso maemong a taurine e lebisa ho atrophy ea mesifa, ho fokotseha ha matla a boikoetliso, le ho se sebetse ha mitochondrial liseleng tse ngata. Tlatsetso ea taurine e fokotsa khatello ea maikutlo ea mitochondrial redox, e ntlafatsa bokhoni ba boikoetliso, 'me e hatella boima ba' mele.

Biochemistry le enzymology ea taurine metabolism li hohetse thahasello e kholo ea lipatlisiso. Tseleng ea endogenous taurine biosynthetic, cysteine ​​​​e fetoloa ke cysteine ​​​​dioxygenase (CDO) le cysteine ​​​​sulfinate decarboxylase (CSAD) ho hlahisa hypotaurine, eo hamorao e leng Oxidation ka flavin monooxygenase 1 (FMO1) e hlahisa taurine. Ntle le moo, cysteine ​​​​e ka hlahisa hypotaurine ka tsela e 'ngoe ea cysteamine le cysteamine dioxygenase (ADO). Tlas'a taurine ka boeona ho na le metabolite ea bobeli ea taurine, ho kenyelletsa taurocholate, tauramidine, le N-acetyl taurine. Enzyme e le 'ngoe feela e tsejoang ho susumetsa litsela tsena tse tlase ke BAAT, e kopanyang taurine le bile acyl-CoA ho hlahisa taurocholate le letsoai le leng la bile. Ntle le BAAT, boitsebahatso ba limolek'hule tsa li-enzyme tse ling tse lipakeng tsa taurine metabolism ea bobeli ha bo so tsejoe.

N-acetyltaurine (N-acetyl taurine) ke metabolite ea bobeli ea taurine e khahlisang empa e sa ithutoa hantle. Maemo a N-acetyl taurine marong a baeloji a laoloa ka matla ke ho ferekana ha 'mele ho hoholo ho eketsang taurine le/kapa acetate flux, ho kenyelletsa boikoetliso ba mamello, ho noa joala, le tlatsetso ea taurine ea phepo. Ho feta moo, N-acetyltaurine e na le sebopeho sa lik'hemik'hale tse ts'oanang le limolek'hule tsa matšoao ho kenyelletsa neurotransmitter acetylcholine le ketane e telele ea N-fatty acyltaurine e laolang tsoekere ea mali, e fana ka maikutlo a hore e kanna ea sebetsa joalo ka pontšo ea metabolite Sehlahisoa se sebetsa. Leha ho le joalo, biosynthesis, degradation, le mesebetsi e ka bang teng ea N-acetyl taurine li ntse li sa hlaka.

Phuputsong ena ea morao-rao, sehlopha sa lipatlisiso se supile PTER, enzyme ea khutsana e sa tsejoeng, e le phoofolo e ka sehloohong ea mammalian N-acetyl taurine hydrolase. In vitro, recombinant PTER e bonts'itse mofuta o moqotetsane oa substrate le meeli e meholo. Ho N-acetyl taurine, e entsoe ka hydrolyzed ho taurine le acetate.

Ho hula mofuta oa Pter ho litoeba ho fella ka tahlehelo e felletseng ea ts'ebetso ea N-acetyl taurine hydrolytic liseleng le keketseho ea sistimi ea litaba tsa N-acetyl taurine liseleng tse fapaneng.

Sebaka sa PTER sa motho se amahanngoa le 'mele oa boima ba' mele (BMI). Sehlopha sa lipatlisiso se ile sa boela sa fumana hore kamora ho khothaletsoa ka maemo a ntseng a eketseha a taurine, litoeba tsa Pter knockout li bonts'itse ho ja lijo tse fokotsehileng mme li hanana le botenya bo bakoang ke lijo. le ho ntlafatsa glucose homeostasis. Keketso ea N-acetyl taurine ho feta litoeba tsa mofuta o hlaha le eona e fokolitse ho ja lijo le boima ba 'mele ka mokhoa o itšetlehileng ka GFRAL.

Lintlha tsena li beha PTER sebakeng sa mantlha sa enzyme node ea taurine secondary metabolism mme e senola karolo ea PTER le N-acetyl taurine taolong ea boima ba 'mele le botsitso ba matla.

Ka kakaretso, thuto ena e sibollotse acetyl taurine hydrolase ea pele ho liphoofolo tse anyesang, PTER, mme e netefalitse karolo ea bohlokoa ea acetyl taurine ho fokotsa ho ja lijo le ho thibela botenya. Nakong e tlang, ho lebeletsoe hore ho tla ntlafatsoa li-inhibitors tse matla le tse khethiloeng tsa PTER bakeng sa phekolo ea botenya.