Taurine ke acid ea bohlokoa ea limatlafatsi tse nyane le aminosulfonic e ngata. E ajoa haholo liseleng le lithong tse fapaneng 'meleng. Haholo-holo e teng boemong ba mahala mokelikeling oa interstitial le mokelikeling oa ka hare ho sele. Hobane e ne e le teng ka lekhetlo la pele ho E reheletsoe ka mor'a hore e fumanoe ka har'a bile ea ox. Taurine e eketsoa lino tse tloaelehileng tse sebetsang ho tlatsa matla le ho ntlafatsa mokhathala.
Haufinyane tjena, lipatlisiso mabapi le taurine li phatlalalitsoe likoranteng tse tharo tse holimo tsa Science, Cell, and Nature. Lithuto tsena li senotse mesebetsi e mecha ea taurine - ho thibela botsofali, ho ntlafatsa phello ea kalafo ea mofetše, le ho thibela botenya.
Ka Phuptjane 2023, bafuputsi ba tsoang Setsing sa Naha sa Immunology India, Univesithing ea Columbia United States, le litsi tse ling ba ile ba phatlalatsa lipampiri koranteng e holimo ea machaba ea thuto ea Science. Phuputso e bontša hore khaello ea taurine ke sesosa sa botsofali. Ho eketsa taurine ho ka liehisa botsofali ba nematode, litoeba le litšoene, 'me ho ka eketsa bophelo bo botle ba litoeba tse lilemong tse mahareng ka 12%. Lintlha: Saense: Matla a fetang monahano oa hau! Taurine e ka boela ea khutlisetsa botsofali morao le ho atolosa bophelo?
Ka Mmesa 2024, Moprofesa Zhao Xiaodi, Moprofesa ea Kopaneng Lu Yuanyuan, Moprofesa Nie Yongzhan, le Moprofesa Wang Xin ba tsoang Sepetleleng sa Xijing sa Univesithi ea Bongaka ea Sesole sa Bone ba phatlalalitse lipampiri koranteng e holimo ea machaba ea thuto ea Cell. Phuputso ena e fumane hore lisele tsa hlahala li qothisana lehlokoa le lisele tsa CD8+ T bakeng sa taurine ka ho eketsa haholo taurine transporter SLC6A6, e bakang lefu la lisele tsa T le mokhathala, e leng se lebisang ho phonyoheng ha sesole sa 'mele sa hlahala, ka hona se khothalletsa tsoelo-pele ea hlahala le ho khutla ha eona, ha ho tlatsa Taurine ho ka tsosolosa lisele tsa CD8+ T tse khathetseng le ho ntlafatsa katleho ea kalafo ea mofetše.
Ka la 7 Phato, 2024, sehlopha sa Jonathan Z. Long oa Univesithi ea Stanford (Dr. Wei Wei ke mongoli oa pele) se phatlalalitse pampiri ea lipatlisiso e nang le sehlooho se reng: PTER ke N-acetyl taurine hydrolase e laolang ho fepa le botenya koranteng e ka sehloohong ea machaba ea thuto ea Nature.
Phuputso ena e sibolotse N-acetyl taurine hydrolase ea pele ho liphoofolo tse anyesang, PTER, 'me e tiisitse karolo ea bohlokoa ea N-acetyl taurine ho fokotseng lijo tse jeoang le ho thibela botenya. Nakong e tlang, ho ka khoneha ho hlahisa li-inhibitor tsa PTER tse matla le tse khethiloeng bakeng sa kalafo ea botenya.
Taurine e fumaneha haholo liseleng tsa liphoofolo tse anyesang le lijong tse ngata 'me e fumanoa haholo-holo liseleng tse hlasimollang tse kang pelo, mahlo, boko le mesifa. Taurine e hlalositsoe e na le mesebetsi ea sele le ea 'mele e matla, haholo-holo moelelong oa homeostasis ea metabolic. Ho fokotseha ha liphatsa tsa lefutso maemong a taurine ho lebisa ho fokotseheng ha mesifa, ho fokotseha ha bokhoni ba boikoetliso, le ho se sebetse hantle ha mitochondrial liseleng tse ngata. Tlatsetso ea taurine e fokotsa khatello ea redox ea mitochondrial, e ntlafatsa bokhoni ba boikoetliso, 'me e hatella boima ba' mele.
Biochemistry le enzymology ea metabolism ea taurine li hohetse thahasello e kholo ea lipatlisiso. Tseleng ea taurine biosynthetic ea tlhaho, cysteine e hlahisoa ke cysteine dioxygenase (CDO) le cysteine sulfinate decarboxylase (CSAD) ho hlahisa hypotaurine, e leng seo hamorao Oxidation ke flavin monooxygenase 1 (FMO1) e hlahisang taurine. Ho phaella moo, cysteine e ka hlahisa hypotaurine ka tsela e 'ngoe ea cysteamine le cysteamine dioxygenase (ADO). Tlas'a taurine ka boeona ho na le li-metabolite tse 'maloa tsa taurine tsa bobeli, ho kenyeletsoa taurocholate, tauramidine, le N-acetyl taurine. Enzyme feela e tsejoang ho susumetsa litsela tsena tse ka tlase ke BAAT, e kopanyang taurine le bile acyl-CoA ho hlahisa taurocholate le letsoai le leng la bile. Ntle le BAAT, boitsebiso ba limolek'hule ba lienzyme tse ling tse sebetsanang le metabolism ea taurine ea bobeli ha bo so fumanoe.
N-acetyltaurine (N-acetyl taurine) ke metabolite ea bobeli ea taurine e khahlisang haholo empa e sa ithutiloe hantle. Maemo a N-acetyl taurine marong a baeloji a laoloa ka matla ke litšitiso tse ngata tsa 'mele tse eketsang taurine le/kapa phallo ea acetate, ho kenyeletsoa boikoetliso ba mamello, tšebeliso ea joala, le tlatsetso ea taurine ea phepo e nepahetseng. Ho feta moo, N-acetyltaurine e na le ho tšoana ha sebopeho sa lik'hemik'hale le limolek'hule tsa lipontšo ho kenyeletsoa neurotransmitter acetylcholine le acyltaurine e telele ea N-fatty e laolang tsoekere maling, e leng se bontšang hore e ka boela ea sebetsa e le metabolite ea lets'oao Sehlahisoa sea sebetsa. Leha ho le joalo, biosynthesis, ho senyeha, le mesebetsi e ka bang teng ea N-acetyl taurine ha e so hlaka.
Phuputsong ena ea morao-rao, sehlopha sa lipatlisiso se hlwaile PTER, enzyme e sa tsejoeng e nang le ts'ebetso e sa tsejoeng, e le N-acetyl taurine hydrolase e kholo ea liphoofolo tse anyesang. Ka hare ho 'mele, PTER e kopantsoeng e bontšitse mefuta e menyenyane ea substrate le mefokolo e meholo. Ka hare ho N-acetyl taurine, e haelloa ke hydrolyzed ho ba taurine le acetate.
Ho ntsha jini ya Pter ho ditoeba ho fella ka tahlehelo e felletseng ya ts'ebetso ya hydrolytic ya N-acetyl taurine dinamaleng le keketseho ya kakaretso ya dikahare tsa N-acetyl taurine dinamaleng tse fapaneng.
Sebaka sa PTER sa motho se amahanngoa le index ea boima ba 'mele (BMI). Sehlopha sa lipatlisiso se fumane hape hore kamora ho hlasimolloa ka maemo a eketsehileng a taurine, litoeba tsa Pter knockout li bontšitse ho fokotseha ha lijo 'me li ne li hanela botenya bo bakoang ke lijo. le ho ntlafala ha glucose homeostasis. Ho eketsoa ha N-acetyl taurine ho litoeba tsa mofuta oa naha tse nonneng le hona ho fokolitse ho ja lijo le boima ba 'mele ka tsela e itšetlehileng ka GFRAL.
Lintlha tsena li beha PTER sebakeng sa mantlha sa enzyme ea metabolism ea taurine 'me li senola mesebetsi ea PTER le N-acetyl taurine taolong ea boima ba' mele le ho leka-lekana ha matla.
Ka kakaretso, phuputso ena e sibolotse acetyl taurine hydrolase ea pele ho liphoofolo tse anyesang, PTER, 'me e tiisitse karolo ea bohlokoa ea acetyl taurine ho fokotseng ho ja lijo le ho thibela botenya. Nakong e tlang, ho lebelletsoe hore lithibela-mafu tse matla le tse khethileng tsa PTER li tla hlahisoa bakeng sa kalafo ea botenya.
Tlhokomeliso: Sengoloa sena ke sa tlhahisoleseding e akaretsang feela mme ha sea lokela ho nkuwa e le keletso efe kapa efe ya bongaka. Tse ding tsa tlhahisoleseding ya poso ya blog di tswa Inthaneteng mme ha se tsa botsebi. Webosaete ena e ikarabella feela bakeng sa ho hlophisa, ho hlophisa le ho hlophisa dihlooho. Morero wa ho fetisa tlhahisoleseding e eketsehileng ha o bolele hore o dumellana le maikutlo a yona kapa o tiisa bonnete ba dikahare tsa yona. Kamehla buisana le setsebi sa tlhokomelo ya bophelo pele o sebedisa ditlatsetso dife kapa dife kapa o etsa diphetoho tsamaisong ya hao ya tlhokomelo ya bophelo.
Nako ea poso: Phato-12-2024
