Na u batla ho ntlafatsa ts'ebetso ea kelello, ho ntlafatsa mohopolo, le ho khothaletsa bophelo bo botle ba boko? Haeba ho joalo, u ka 'na ua pepesehela Aniracetam, motsoako oa nootropic oo e leng oa lelapa la racemate. E tsebahala ka bokhoni ba eona ba ho ntlafatsa ts'ebetso ea kelello, ho matlafatsa mohopolo, le ho khothaletsa bophelo bo botle ba boko ka kakaretso.
Li-racetams ke sehlopha sa metsoako ea maiketsetso e fumaneng botumo e le lisebelisoa tsa ho tseba kapa li-nootropics, 'me metsoako ena e na le sebopeho se tšoanang sa lik'hemik'hale se bitsoang 2-pyrrolidone core. Aniracetam ke e 'ngoe ea metsoako e joalo.
Aniracetam ke setho sa lelapa la piracetam 'me e qalile ho etsoa ka bo-1970. Ke motsoako oa ampakin, ho bolelang hore o fetola tšebetso ea li-receptor tse ling tsa neurotransmitter bokong. Aniracetam e 'nile ea ithutoa ka bokhoni ba eona ba ho ntlafatsa ts'ebetso ea kelello, ho ntlafatsa mohopolo, le ho fokotsa ho tšoenyeha.
Aniracetam e arolelana motheo o tšoanang oa 2-pyrrolidone o fumanoang ho li-racemates tse ling, empa o na le lesale le eketsehileng la anisoyl le moiety ea N-anisinoyl-GABA. Liphapang tsena tsa sebopeho li kenya letsoho ho thepa ea eona e ikhethang 'me e etsa hore e be lipophilic (mafura a qhibilihang) ho feta li-racemates tse ling. Ka hona, Aniracetam e sebetsa ka potlako mme e matla le ho feta.
Karolo ea Dopamine mosebetsing oa kelello
Dopamine ke neurotransmitter e bapalang karolo ea bohlokoa mesebetsing e fapaneng ea kelello. Hangata e bitsoa "ikutloa monate" neurotransmitter ka lebaka la ho kenya letsoho moputsong oa boko le litsela tsa menyaka. Dopamine e boetse e kenya letsoho khothatsong, tlhokomelong le taolong ea makoloi, e leng bohlokoa bakeng sa ts'ebetso ea kelello ka kakaretso.
Ho se leka-lekane ha maemo a dopamine ho amahanngoa le mathata a fapaneng a kelello le a methapo, ho kenyelletsa le bothata ba ho se tsotelle (ADHD), lefu la Parkinson le schizophrenia. Ka hona, ho na le thahasello e kholo ea hore na Aniracetam e ama maemo a dopamine joang le ts'ebetso e ka bang teng ea kelello.
Liphello tse ka bang teng tsa Aniracetam ho dopamine
Phuputso e phatlalalitsoeng koranteng ea Pharmacology, Biochemistry le Behavior e fumane hore aniracetam e ekelitse tokollo ea dopamine ka har'a prefrontal cortex ea likhoto, e fana ka maikutlo a litlamorao tsa eona ho dopamine neurotransmission.
Ho phaella moo, Aniracetam e bontšitsoe ho fetola mosebetsi oa li-receptor tsa dopamine bokong. Li-receptor tsa Dopamine ke liprotheine tse holim'a li-neuron tse tlamang dopamine le ho hokahanya litlamorao tsa eona. Ka ho ama tšebetso ea li-receptor tsena, Aniracetam e ka ama ka tsela e sa tobang pontšo ea dopamine le neurotransmission.
Ho utloisisa ka botlalo melemo eaaniracetam,ho bohlokoa ho utloisisa hore na e sebelisana joang le boko le ho ama ts'ebetso ea kelello. Mokhoa oa ts'ebetso oa Aniracetam haholo-holo o kenyelletsa ho feto-fetoha ha li-neurotransmitter receptors, tse phethang karolo ea bohlokoa likarolong tse sa tšoaneng tsa ts'ebetso ea kelello.
Acetylcholine - Aniracetam e ka ntlafatsa kutloisiso e akaretsang ka ho ntlafatsa mosebetsi oa tsamaiso eohle ea acetylcholine, e nang le karolo ea bohlokoa mohopolong, nako ea tlhokomelo, lebelo la ho ithuta, le mekhoa e meng ea kutloisiso. Liphuputso tsa liphoofolo li bontša hore e sebetsa ka ho tlama li-receptor tsa acetylcholine, ho thibela ho fokotseha ha li-receptor, le ho khothalletsa ho lokolloa ha synaptic ea acetylcholine.
Dopamine le Serotonin - Aniracetam e bontšitsoe ho eketsa maemo a dopamine le serotonin bokong, e tsejoang ho imolla ho tepella maikutlong, ho matlafatsa matla le ho fokotsa matšoenyeho. Ka ho tlama ho dopamine le li-receptor tsa serotonin, Aniracetam e thibela ho senyeha ha li-neurotransmitters tsena tsa bohlokoa le ho tsosolosa maemo a nepahetseng a bobeli, ho etsa hore e be mokhoa o atlehang oa ho ntlafatsa maikutlo le ho tšoenyeha.
Phetiso ea Glutamate - Aniracetam e ka ba le phello e ikhethang ho ntlafatsa mohopolo le polokelo ea tlhahisoleseling hobane e ntlafatsa phetiso ea glutamate. Ka ho tlama le ho susumetsa AMPA le li-receptor tsa kainate, li-receptor tsa glutamate tse amanang haufi-ufi le polokelo ea boitsebiso le ho hlahisa mehopolo e mecha, Aniracetam e ka ntlafatsa neuroplasticity ka kakaretso le matla a nako e telele haholo-holo.
Neurotransmitter Regulation
Aniracetam e sebetsa lits'ebetsong tse peli tse kholo tsa neurotransmitter bokong: litsamaiso tsa glutamate le acetylcholine. Acetylcholine ke neurotransmitter e 'ngoe ea bohlokoa e amehang ho ithuteng, ho hopola le ho ela hloko. Ka ho ntlafatsa ts'ebetso ea cholinergic, Aniracetam e ka ntlafatsa lits'ebetso tsa kelello tse kang ho theha mohopolo le ho boloka, hammoho le tlhokomelo le mahloriso.
Ncetylcholine
neurotransmitter ena ea bohlokoa e thusa ho ntlafatsa bokhoni ba rona ba kelello. E khothalletsa ho lokolloa ha synaptic ho pholletsa le tsamaiso ea ACh 'meleng. Aniracetam e tlama ho li-receptor tsena mme ha e thibele feela ho thibela, empa hape e khothalletsa ho lokolloa. ACh e bohlokoa bakeng sa mesebetsi e mengata ea kelello, ho kenyelletsa le ho ithuta, ho hopola, ho tsepamisa mohopolo le ho kopanya mekhoa ena ea kelello.
Bokhoni ba ho laola polasetiki ea synaptic
Synaptic plasticity ke bokhoni ba li-synapses ho matlafatsa kapa ho fokolisa ka mor'a nako ho arabela mosebetsing. Ka ho ntlafatsa polasetiki ea synaptic, Aniracetam e ka ntlafatsa ts'ebetso ea kelello ka ho khothalletsa ho thehoa ha likhokahano tse ncha tsa neural le ho khothalletsa ho kopanya mohopolo.
Serotonin
Aniracetam e boetse e khothalletsa le ho laola mosebetsi oa hormone ea rona e thabisang serotonin. Sena se tla phahamisa maikutlo a hau, ho eketsa boitšepo ba hau, ho fokotsa matšoenyeho a hau, le ho eketsa maemo a matla a kelello. Serotonin e bohlokoa bokong, boroko, mohopolo, phokotso ea khatello ea maikutlo le lits'ebetso tse ling tsa bohlokoa tsa methapo.
Dopamine
Ena ke hormone ea rona ea boikemisetso. Ena ke thabo ea rona, kotsi le moputso oa neurotransmitter ea bohareng. E thusa ho laola maikutlo a rona, metsamao ea 'mele le maikutlo. Aniracetam e tlama ho serotonin le dopamine neurotransmitters ho thibela ho senyeha ha bona ka potlako, e leng ho thusang ho laola maikutlo le liketso tsa rona.
Ntlafatsa mohopolo le mohopolo
Bokhoni ba Aniracetam ba ho eketsa ts'ebetso ea li-receptor tsa AMPA le ho matlafatsa pontšo ea acetylcholine ho nahanoa hore e tla tlatsetsa liphellong tsa eona tse matlafatsang mohopolo. Liphuputso tsa liphoofolo li bontša hore Aniracetam e ka ntlafatsa mohopolo oa nako e khutšoanyane le oa nako e telele le ho khothalletsa mokhoa oa ho kopanya mohopolo. Liphuputso tsa batho li boetse li tlalehile ntlafatso ea ts'ebetso ea mohopolo ka mor'a tlatsetso ea aniracetam, haholo-holo ho batho ba nang le bokooa ba kelello.
Ntle le litlamorao tsa eona mohopolong, Aniracetam e bontšitsoe ho ntlafatsa ho ithuta le ts'ebetso ea kelello ka kakaretso. Liphuputso tsa liphoofolo li bontšitse hore Aniracetam e ka ntlafatsa ts'ebetso ea kelello mesebetsing e fapaneng ea ho ithuta, ha lithuto tsa batho li tlalehile ntlafatso ea ho tsepamisa maikutlo, tlhokomelo le ts'ebetso ea tlhahisoleseding.
Ka ho fetola li-receptor tsa glutamate bokong, Aniracetam e khothalletsa ho tsepamisa maikutlo ho tsitsitseng le ho hlaka kelellong. Sena se molemo haholo ho batho ba batlang ho eketsa tlhahiso le ho tsepamisa maikutlo, ebang ke mosebetsing, sekolong kapa mesebetsing ea boqapi.
Matlafatsa maikutlo a hau le ho fokotsa maemo a ho tšoenyeha:
Boholo ba piracetam ha bo hlile ha bo phahamise maikutlo a hau, empa Aniracetam e ka phahamisa maikutlo le maemo a tlase a ho tšoenyeha, haholo-holo matšoenyeho a sechaba. E ka u fa matla 'me ea etsa hore u ikutloe u susumelletsehile ebile u tsepamisitse maikutlo ha u ntse u theola maemo a khatello ea maikutlo le ho fokotsa ho fetoha ha maikutlo.
Thibela ho fokotseha ha kelello
Liphello tsa Aniracetam ho li-neurotransmitter systems, haholo-holo ntlafatso ea glutamate le pontšo ea acetylcholine, e ka thusa ho sireletsa boko ho fokotseha ha kelello ho amanang le lilemo. Lipatlisiso li bonts'a hore e na le monyetla oa ho ntlafatsa mohopolo le ts'ebetso ea kelello ho batho ba nang le bokooa bo bobebe le lefu la Alzheimer's. Le hoja lipatlisiso tse ling li hlokahala, liphuputso tsena li fana ka maikutlo a hore Aniracetam e ka ba sesebelisoa se molemo ho thibela le ho phekola ho fokotseha ha kelello.
Phello e khahlanong le ho tšoenyeha
Aniracetam e bontšitsoe hore e na le thepa ea anxiolytic (anti-anxiety) lithutong tsa liphoofolo le batho. Bokhoni ba eona ba ho fetola litsamaiso tsa li-neurotransmitter, haholo-holo litsamaiso tsa glutamate le acetylcholine, li ka tlatsetsa litlamorao tsena. Hangata basebelisi ba tlaleha maikutlo a fokotsehileng a khatello ea maikutlo le matšoenyeho le maikutlo a eketsehileng a ho phomola le ho phela hantle.
Lintho tsa neuroprotective
Lipatlisiso li bontša hore Aniracetam e ka tšehetsa bophelo bo botle ba boko ka ho khothalletsa tlhahiso ea boko bo entsoeng ke neurotrophic factor (BDNF), protheine e phethang karolo ea bohlokoa ho holeng ha neuron le ho phela. Ka ho tšehetsa tlhokomelo ea lisele tsa boko le ho tsosolosoa, Aniracetam e ka kenya letsoho ho bophelo bo botle ba boko ba nako e telele le ho hlaphoheloa.
Tšehetsa bophelo bo botle ba boko
Thepa ea Aniracetam ea "neuroprotective" e ka boela ea tšehetsa bophelo bo botle ba boko ka ho khothalletsa kholo ea neuronal, synaptic plasticity, le ho boloka maemo a bophelo bo botle ba li-neurotransmitter. Lintlha tsena li bohlokoa bakeng sa ts'ebetso e nepahetseng ea boko 'me li ka thusa ho sireletsa khahlanong le litlamorao tse mpe tsa khatello ea maikutlo, botsofali le mafu a neurodegenerative.
Liphello tsaaniracetam e ka khonamatlafatsoa ke lintho tse sebelisanang le li-receptor tsa boko kapa li-neurotransmitters tse tšoanang. Mona ke tse ling tsa lintho tse ka ntlafatsang aniracetam:
1. Lisebelisoa tsa Cholinergic: Aniracetam e sebetsa ka karolo e itseng ka ho ama tsamaiso ea cholinergic bokong⁴. Lisebelisoa tse eketsang maemo a acetylcholine, tse kang CDP Choline kapa Alpha GPC, li ka ntlafatsa liphello tsa Aniracetam.
2. Dopaminergic le serotonergic substances: Aniracetam e ka boela ea sebelisana le tsamaiso ea dopaminergic le serotonergic. Ka hona, lintho tse amang litsamaiso tsena tsa li-neurotransmitter li ka baka aniracetam.
3. AMPA receptor modulator: Aniracetam e tlama ho li-receptor tsa glutamate tsa AMPA. Ka hona, lintho tse ling tse fetolang li-receptor tsena ka sebele li ka khona ho matlafatsa litlamorao tsa aniracetam.
Aniracetam e tsejoa ka bokhoni ba eona ba ho ntlafatsa mohopolo, mahloriso le maikutlo, leha ho le joalo, ka likhetho tse ngata 'marakeng, ho fumana sehlahisoa se setle ka ho fetisisa sa Aniracetam e ka ba mosebetsi o boima. Joale ke lintlha life tsa bohlokoa tseo u ka li nahanang ha u khetha tlatsetso e ntle ka ho fetisisa ea Aniracetam bakeng sa litlhoko tsa hau?
1. Boleng le Bohloeki: Boleng le bohloeki ke tsa bohlokoa ka ho fetisisa ha u khetha Aniracetam. Batla barekisi ba tšepahalang ba khomarelang litekanyetso tse thata tsa taolo ea boleng le ho fana ka tlhahlobo ea motho oa boraro ho netefatsa bohloeki le matla a lihlahisoa tsa bona. Ho khetha mohloli o ka tšeptjoang le o ka tšeptjoang ho tla u fa khotso ea kelello le kholiseho ka katleho ea sehlahisoa.
2. Foromo ea litekanyetso le litekanyetso: Aniracetam e fumaneha ka mefuta e sa tšoaneng ea litekanyetso, ho akarelletsa le capsules le phofo. Nahana ka lintho tseo u li ratang le ho ba bonolo ha u khetha foromo e lumellanang hantle le mokhoa oa hau oa bophelo. Hape, ela hloko litlhahiso tsa litekanyetso tsa sehlahisoa le potency. Hoa hlokahala ho qala ka tekanyo e tlaase le ho eketsa butle-butle tekanyo ha ho hlokahala, ha u ntse u buisana le setsebi sa tlhokomelo ea bophelo ho fumana hore na tekanyo e lumellana le litlhoko tsa hau ka bomong.
3. Ponaletso le Botumo: Mofani ea ka tšeptjoang oa Aniracetam o tla ba pepeneneng mabapi le ho fumana, lits'ebetso tsa tlhahiso, le boleng ba motsoako. Batla lihlahisoa tse nang le botumo bo botle le maikutlo a nepahetseng a bareki, kaha sena se ka bontša hore ba ikemiselitse ho hlahisa lihlahisoa tsa boleng bo phahameng le tšebeletso e ntle ea bareki.
4. Boleng ba chelete: Le hoja theko e sa lokela ho ba eona feela ntho e etsang qeto, ke habohlokoa ho hlahloba boleng ba chelete ha u reka Aniracetam. Bapisa litjeo ka ho fana ka mefuta eohle ea lihlahisoa 'me u nahane ka melemo efe kapa efe e eketsehileng, joalo ka litheolelo tsa molumo, likhetho tsa ho ngolisa kapa mananeo a botšepehi. Leha ho le joalo, ela hloko lihlahisoa tsa theko e tlase kaha li ka senya boleng le polokeho.
5. Tšehetso le Khotsofalo ea Bareki: Mofani ea ka tšeptjoang oa Aniracetam o tla etelletsa pele khotsofalo ea bareki le ho fana ka tšehetso ea bareki ba arabelang ho rarolla lipotso leha e le life kapa mathata. Haeba u na le lipotso, nahana ka ho ikopanya le morekisi le ho lekola boemo ba bona ba boiphihlelo le tsebo. Ho feta moo, batla barekisi ba fanang ka tiisetso ea khotsofalo kapa pholisi ea ho khutlisa e u lumellang ho leka sehlahisoa ntle le kotsi.
Matsatsi a fetile o ne o sa tsebe moo o ka rekang li-supplement tsa hau. Ho phethesela ka nako eo e ne e le ntho ea sebele. U tlameha ho tloha lebenkeleng ho ea ho lebenkele, ho ea mabenkeleng a maholo, mabenkeleng, 'me u botse ka li-supplement tseo u li ratang. Ntho e mpe ka ho fetisisa e ka etsahalang ke ho tsamaea letsatsi lohle 'me u se ke ua qetella u fumane seo u se batlang. Ho hobe le ho feta, haeba u fumana sehlahisoa sena, u tla ikutloa u le tlas'a khatello ea ho reka sehlahisoa seo.
Kajeno, ho na le libaka tse ngata ho reka phofo ea Aniracetam. Ka lebaka la Marang-rang, u ka reka ntho leha e le efe ntle le ho tloha lapeng. Ho ba inthaneteng ha ho nolofatse mosebetsi oa hau feela, ho boetse ho etsa hore boiphihlelo ba hau ba ho reka bo be bonolo haholoanyane. U boetse u na le monyetla oa ho bala haholoanyane ka tlatsetso ena e makatsang pele u etsa qeto ea ho e reka.
Ho na le barekisi ba bangata ba marang-rang kajeno mme ho ka ba thata ho uena ho khetha e ntle ka ho fetisisa. Seo u hlokang ho se tseba ke hore leha kaofela ha bona ba tla ts'episa khauta, ha se kaofela ba tla lopolla.
Haeba u batla ho reka phofo ea Aniracetam ka bongata, u ka lula u itšetlehile ka rona. Re fana ka li-supplement tse ntle ka ho fetisisa tse tla fana ka liphetho. Odara ho tsoa Suzhou Myland kajeno 'me u qale leeto la hau la bophelo bo botle haholo.
Suzhou Myland Pharm & Nutrition Inc. esale e sebetsa khoebong ea tlatsetso ea phepo e nepahetseng ho tloha ka 1992. Ke k'hamphani ea pele naheng ea China ho nts'etsapele le ho rekisa sekhechana sa peo ea morara.
Ka boiphihlelo ba lilemo tse 30 'me e khannoa ke theknoloji e phahameng le leano le ntlafalitsoeng la R&D, k'hamphani e thehile lihlahisoa tse ngata tsa tlholisano mme ea fetoha tlatsetso e ncha ea mahlale a bophelo, ho kopanya tloaelo le khamphani ea lits'ebeletso tsa tlhahiso.
Ho feta moo, Suzhou Myland Pharm & Nutrition Inc. hape ke moetsi ea ngolisitsoeng ke FDA. Lisebelisoa tsa R&D tsa k'hamphani, lisebelisoa tsa tlhahiso, le lisebelisoa tsa tlhahlobo ke tsa sejoale-joale ebile li sebetsa ka bongata mme li ka hlahisa lik'hemik'hale ho tloha ho limiligrama ho isa ho lithane ka sekala, 'me li latela litekanyetso tsa ISO 9001 le litlhaloso tsa tlhahiso ea GMP.
P: Aniracetam e sebelisetsoa eng?
A: Aniracetam ke motsoako oa nootropic o sebelisetsoang ho ntlafatsa ts'ebetso ea kelello le ho ntlafatsa mohopolo, ho tsepamisa maikutlo le ho ithuta.
P: Melemo ea aniracetam ke efe?
A: Aniracetam e tsejoa ka bokhoni ba eona ba ho ntlafatsa ts'ebetso ea kelello, ho kenyelletsa le ho ntlafatsa mohopolo, ho tsepamisa mohopolo le tlhokomelo, le ho khothaletsa ho hlaka kelellong. Hape ho lumeloa hore e na le thepa ea anxiolytic, e thusang ho fokotsa khatello ea maikutlo le khatello ea maikutlo.
P: Aniracetam e sebetsa joang?
A: Ho nahanoa hore Aniracetam e sebetsa ka ho fetola li-neurotransmitters tse itseng bokong, tse kang acetylcholine le glutamate, tse phethang karolo ea bohlokoa mosebetsing oa kelello. Ka ho susumetsa li-neurotransmitters tsena, Aniracetam e ka thusa ho ntlafatsa puisano lipakeng tsa lisele tsa boko le ho ntlafatsa ts'ebetso ea boko ka kakaretso.
P: Na aniracetam e bolokehile ho sebelisoa?
A: Aniracetam hangata e nkoa e sireletsehile ha e sebelisoa ho litekanyetso tse khothalletsoang. Leha ho le joalo, joalo ka tlatsetso efe kapa efe, ke habohlokoa ho buisana le setsebi sa tlhokomelo ea bophelo pele u qala mokhoa o mocha, haholo-holo ho batho ba nang le maemo a bophelo a seng a ntse a le teng kapa ba noang meriana e meng.
P: Aniracetam e lokela ho nkoa joang?
A: Aniracetam e atisa ho nkoa ka capsule kapa foromo ea phofo, 'me tekanyo e khothalletsoang e ka fapana ho itšetlehile ka litlhoko tsa motho ka mong le mamello. Hangata e nkoa ka lijo ho ntlafatsa ho monya, 'me basebelisi ba bang ba ka rua molemo ka ho palama libaesekele ho thibela ho eketseha ha mamello. Joalo ka mehla, ho molemo ho latela tataiso ea mofani oa tlhokomelo ea bophelo ha ho khethoa litekanyetso tse nepahetseng le kemiso ea tšebeliso ea aniracetam.
Boitlhotlhollo: Sengoloa sena ke sa tlhaiso-leseling e akaretsang feela 'me ha ea lokela ho nkuoa e le keletso efe kapa efe ea bongaka. Tse ling tsa litaba tsa poso ea blog li tsoa Marang-rang mme ha se setsebi. Sebaka sena sa marang-rang se na le boikarabello ba ho hlophisa, ho hlophisa le ho hlophisa lingoliloeng. Sepheo sa ho fetisa boitsebiso bo bongata ha se bolele hore u lumellana le maikutlo a eona kapa u tiisa bonnete ba litaba tsa eona. Kamehla buisana le setsebi sa tlhokomelo ea bophelo pele u sebelisa li-supplement leha e le life kapa u etsa liphetoho tsamaisong ea tlhokomelo ea bophelo.
Nako ea poso: Aug-07-2024
