Saense Ka morao Palmitoylethanolamide (PEA) Phofo: Seo U Lokelang ho se Tseba

Palmitoylethanolamide  ke endogenous mafura acid amide eo e leng ea sehlopha sa nuclear factor agonists. Ke e 'ngoe ea metsoako ea bohlokoa ka ho fetisisa ea endogenous analgesic le anti-inflammatory e bontšitsoeng hore ha e sebetse feela ka bohloko bo bohloko empa hape le bohloko bo sa foleng. E le ho kokobetsa bohloko ba tlhaho, ke mokhoa o mong o motle ho meriana ea setso e ka bakang litla-morao.

PEA e bontšitsoe hore e na le li-anti-inflammatory, antinociceptive, neuroprotective le anticonvulsant properties. PEA esale e ntse e hlahloba batho ba nang le maemo a fapaneng a bohloko, ho ruruha le matšoao a bohloko litekong tse fapaneng tsa bongaka. Likopo: Palmitoylethanolamide ke organic synthesis e bohareng le ea meriana, e ka sebelisoang lipatlisisong tsa laboratori le mekhoa ea nts'etsopele le lipatlisiso tsa lik'hemik'hale le tsa meriana le nts'etsopele.

Liphuputsong tsa kajeno tsa saense le indasteri ea indasteri, Palmitoylethanolamide, e le lisebelisoa tsa bohlokoa tsa lik'hemik'hale, e fumane tlhokomelo e pharaletseng bakeng sa lisebelisoa tsa eona tse ikhethang tsa lik'hemik'hale le tebello e pharaletseng ea kopo.

1. Tokisetso ea Palmitoylethanolamide

Ho lokisoa ha Palmitoylethanolamide hangata ho kenyelletsa karabelo ea esterification. Nakong ea ts'ebetso ea boitokiso, palmitadecanoic acid le ethanol li ba le karabelo ea esterification tlasa ts'ebetso ea sesebelisoa ho hlahisa palmitadecanamide ethanol. Nakong ea ts'ebetso ea ho itokisa, lintlha tse kang mocheso oa karabelo, mofuta oa catalyst le litekanyetso, le nako ea ho itšoara li na le tšusumetso ea bohlokoa boleng le chai ea sehlahisoa. Ka hona, ho ntlafatsa mokhoa oa ho lokisa ke senotlolo sa ho ntlafatsa boleng ba sehlahisoa le ho fokotsa litšenyehelo.

2. Thepa ea Palmitoylethanolamide

Palmitoylethanolamide ke 'mala o mosoeu ho isa ho o mosehla hanyane o nang le monyetla o motle le botsitso. E tiile mocheso oa kamore, empa e qhibiliha ka mefuta e sa tšoaneng ea li-solvents ka mocheso o itseng, joalo ka ethanol, acetone, joalo-joalo Ho phaella moo, Palmitoylethanolamide e boetse e na le botsitso bo botle ba mocheso le lik'hemik'hale, e leng se lumellang ho boloka sebopeho le thepa ea eona tlas'a mocheso o phahameng le tikoloho e rarahaneng.

3. Tšebeliso ea Palmitoylethanolamide

1. Patlisiso le nts'etsopele ea meriana le laboratori:

●PEA ke setsi sa bohlokoa sa meriana, se sebelisoang lipatlisisong tsa laboratori le mekhoa ea ntlafatso le lipatlisiso tsa meriana ea lik'hemik'hale le mekhoa ea ntlafatso.

● E bontšitsoe hore e na le lintho tse thibelang ho ruruha, tse thibelang bohloko, methapo ea methapo le li-anticonvulsant 'me li loketse ho phekola bohloko bo sa foleng, lefu la sethoathoa, cerebral ischemia le stroke.

2. Indasteri ea litlolo:

●PEA e na le mesebetsi ea ho surfactant le foam accelerator 'me e sebelisoa ha ho etsoa litlolo tse kang moisturizer le li-shampoo.

● E ka ntlafatsa ho tsitsisa le botsitso ba sehlahisoa, ha e ntse e ntlafatsa phello ea moisturizing le moisturizing ea sehlahisoa.

3. Indasteri ea masela:

●PEA e sebelisoa e le sesebelisoa se bonolo, antistatic agent le lubricant ho ntlafatsa bonolo le ho phatsima ha masela le ho fokotsa coefficient ea likhohlano le liphello tsa electrostatic.

4. Indasteri ea polasetiki:

● Joalo ka polasetiki, mafura le dispersant, PEA e ntlafatsa bonolo le ho tiea ha polasetiki le ho fokotsa mocheso oa ho sebetsa le tšebeliso ea matla.

5. Anti-inflammatory le analgesic:

●PEA e fokotsa matšoao a ho ruruha ka ho fetola liphatsa tsa lefutso, e na le liphello tse khahlanong le ho ruruha le tsa analgesic, 'me e loketse ho phekola maemo a sa tšoaneng a bohloko le mafu a ho ruruha.

6. Lisebelisoa tse ling tse ka bang teng:

● Sebakeng sa matla a macha, PEA e ka sebelisoa ho etsa lisebelisoa tse ncha tsa matla tse kang lisele tsa letsatsi le libeteri tsa lithium-ion.

● Lefapheng la ts'ireletso ea tikoloho, e ka sebelisoa ho etsa lipolasetiki tse senyehang habonolo, liphahlo tse silafatsang tikoloho le lihlahisoa tse ling tse baballang tikoloho.

● Lefapheng la meriana, e ka sebelisoa ho etsa lisebelisoa tsa meriana tse kang lik'hemik'hale tse tsamaisang lithethefatsi le li-agent tse sa khaotseng.

Ts'ebeliso ena e bonts'a ts'ebeliso e pharaletseng le boleng bo ka bang teng ba palmitamide ethanol liindastering tse ngata.

4. Mekhoa ea ntlafatso ea nako e tlang ea Palmitoylethanolamide

Ka tsoelo-pele e tsoelang pele ea saense le thekenoloji le tsoelo-pele e potlakileng ea indasteri, masimo a kopo ea Palmitoylethanolamide a tla tsoela pele ho atolosa. Nakong e tlang, tšebeliso ea Palmitoylethanolamide ka matla a macha, tšireletso ea tikoloho, meriana le masimo a mang a tla eketseha butle-butle. Ka mohlala, tšimong ea matla a macha, Palmitoylethanolamide e ka sebelisoa ho etsa lisebelisoa tse ncha tsa matla tse kang lisele tsa letsatsi le libeteri tsa lithium-ion; tšimong ea ts'ireletso ea tikoloho, e ka sebelisoa ho etsa lihlahisoa tse sa sireletsehang tikolohong tse kang lipolasetiki tse senyehang le ho koahela tikoloho; lefapheng la meriana, e ka sebelisoa Ho etsa lihlahisoa tsa meriana tse kang bajari ba lithethefatsi le li-agent tse tsoelang pele.

Ho feta moo, ha tlhokomeliso ea batho ea bophelo bo botle le ts'ireletso ea tikoloho e ntse e eketseha, litlhoko tsa boleng le ts'ebetso ea Palmitoylethanolamide le tsona li tla phahama le ho feta. Ka hona, lipatlisiso tsa nakong e tlang le nts'etsopele le tlhahiso ea Palmitoylethanolamide e tla lebisa tlhokomelo e eketsehileng ho ts'ireletso ea tikoloho, polokeho le ts'ireletso. Ka nako e ts'oanang, e le ho finyella litlhoko tsa masimo a fapaneng, lipatlisiso le nts'etsopele ea lihlahisoa tse ncha tsa Palmitoylethanolamide le tsona li tla fetoha tataiso ea bohlokoa nakong e tlang.

PEA ke endogenous fatty acid amide eo e leng ea sehlopha sa nuclear factor agonists. PEA e 'nile ea bontšoa hore e tlama li-receptor ka nucleus (nuclear receptors)' me e sebelisa mefuta e mengata e mengata ea likokoana-hloko e amanang le bohloko bo sa foleng le ho ruruha. Sepheo se seholo ho nahanoa hore ke peroxisome proliferator-activated receptor alpha (PPAR-alpha).　

Suzhou Myland Pharm & Nutrition Inc. ke moetsi ea ngolisitsoeng ke FDA ea fanang ka phofo ea Oleoylethanolamide (OEA) ea boleng bo phahameng le bo hloekileng.

Ho Suzhou Myland Pharm re ikemiselitse ho fana ka lihlahisoa tsa boleng bo holimo ka litheko tse ntle. Phofo ea rona ea Oleoylethanolamide (OEA) e lekoa ka matla bakeng sa bohloeki le potency, ho netefatsa hore o fumana tlatsetso ea boleng bo holimo eo u ka e tšepang. Hore na o batla ho ts'ehetsa bophelo bo botle ba cellular, ho matlafatsa sesole sa hau sa 'mele kapa ho ntlafatsa bophelo bo botle ka kakaretso, phofo ea rona ea Oleoylethanolamide (OEA) ke khetho e phethahetseng.

Ka boiphihlelo ba lilemo tse 30 'me e susumetsoa ke thekenoloji e phahameng le maano a R&D a ntlafalitsoeng haholo, Suzhou Myland Pharm e hlahisitse lihlahisoa tse ngata tsa tlholisano mme e fetohile tlatsetso e ncha ea mahlale a bophelo, ho kopanya tloaelo le k'hamphani ea lits'ebeletso tsa tlhahiso.

Ntle le moo, Suzhou Myland Pharm le eona ke moetsi ea ngolisitsoeng ke FDA. Lisebelisoa tsa R&D tsa k'hamphani, lisebelisoa tsa tlhahiso, le lisebelisoa tsa tlhahlobo ke tsa sejoale-joale ebile li na le mesebetsi e mengata, 'me li ka hlahisa lik'hemik'hale ho tloha ho limiligrama ho isa ho lithane ka tekanyo,' me li lumellana le litekanyetso tsa ISO 9001 le litlhaloso tsa tlhahiso ea GMP.