Spermidine trihydrochloride le spermidine ke metsoako e 'meli e fumaneng tlhokomelo e kholo tšimong ea biomedicine. Metsoako ena e ameha mekhoeng e fapaneng ea 'mele' me e bontšitse litholoana tse ts'episang ho khothaletsa botsofali bo botle le bophelo bo bolelele. Sehloohong sena, re tla hlahloba saense ka mor'a spermidine trihydrochloride le spermidine le ho fana ka papiso e pharaletseng pakeng tsa tse peli.
Spermidine trihydrochloride ke motsoako o qhibilihang ka metsi o fumaneng tlhokomelo e ngata tšimong ea bophelo bo botle le bophelo bo botle. Ke ea lelapa la polyamines, limolek'hule tsa tlhaho tse hlahang ka tlhaho linthong tsohle tse phelang. Li-polyamine li phetha karolo ea bohlokoa mekhoeng e fapaneng ea lisele, ho kenyelletsa kholo ea lisele, phapang le lefu la lisele. Ho feta moo, spermidine trihydrochloride e fumanoe e na le melemo e mengata ea bophelo bo botle, ho kenyelletsa le bokhoni ba ho susumetsa autophagy, ho sireletsa boko le ho khothaletsa bophelo bo botle ba pelo. Ha lipatlisiso li ntse li tsoela pele, bokhoni bo felletseng ba spermidine trihydrochloride bo ka hlaka haholoanyane. Leha spermidine trihydrochloride e le teng mehloling e meng ea lijo, joalo ka kokoana-hloko ea koro, soya le chisi e tsofetseng, ho ja lijo tsa tlhaho ho kanna ha se lekane ho fihlela maemo a nepahetseng. Tabeng ena, tlatsetso e fetoha khetho e sebetsang.
E 'ngoe ea melemo e hlokomelehang ea spermidine trihydrochloride ke karolo ea eona ho autophagy, mokhoa oa cellular o ikarabellang bakeng sa ho tlosa likarolo tse senyehileng le ho khothalletsa ho tsosolosoa ha lisele. Autophagy e bapala karolo ea bohlokoa ho boloka bophelo bo botle le ts'ebetso ea lisele. Ka ho ntlafatsa autophagy, spermidine trihydrochloride e thusa ho felisa lintho tse chefo le liprotheine tse senyehileng, ka hona ho fokotsa kotsi ea mafu a neurodegenerative a kang Alzheimer's le Parkinson.
Liphuputso tse 'maloa li bontšitse hore spermidine trihydrochloride e na le phello e ntle ho bophelo bo botle ba pelo. E bontšitsoe ho ntlafatsa mosebetsi oa pelo, ho fokotsa khatello ea mali le ho thibela mafu a amanang le pelo. Spermidine trihydrochloride e khothalletsa vasodilation, e ntlafatsa phallo ea mali, 'me e fokotsa kotsi ea atherosclerosis. Ka ho boloka tsamaiso ea pelo e phetseng hantle, e ka tlatsetsa haholo bophelong bo bolelele, bo botle.
Ho feta moo, spermidine trihydrochloride e boetse e na le thepa e matla ea antioxidant. Khatello ea oxidative e bakoang ke ho se leka-lekane pakeng tsa li-radicals tsa mahala le li-antioxidants 'meleng ke sesosa se seholo sa botsofali le mafu a sa foleng a fapaneng. Ka ho fokotsa li-radicals tsa mahala tse kotsi, spermidine trisalt e thusa ho loants'a khatello ea oxidative, ka hona e fokotsa kotsi ea mathata a bophelo a amanang le botsofali joalo ka mofets'e, lefu la tsoekere le ho ruruha.
Lilemong tsa morao tjena, bafuputsi le bona ba sibollotse kamano lipakeng tsa spermidine trihydrochloride le litlamorao tsa eona tse ka holisang bophelo bo bolelele. Lithuto tsa lintho tse phelang tse fapa-fapaneng, ho akarelletsa le liboko, lintsintsi le litoeba, li bontšitse hore tlatsetso ka spermidine trihydrochloride e eketsa nako ea bophelo le ho ntlafatsa bophelo bo botle ka kakaretso. Le hoja lipatlisiso tse ling li hlokahala ho utloisisa ka botlalo phello ea eona bophelong bo bolelele ba motho, liphuputso tsena li na le tšepiso e kholo bakeng sa spermidine trihydrochloride e le motsoako o thibelang ho tsofala.
Ke habohlokoa ho hlokomela hore tlatsetso ka spermidine trihydrochloride e lokela ho etsoa ka hloko le tlas'a tataiso ea setsebi sa tlhokomelo ea bophelo. Joalo ka tlatsetso efe kapa efe, litekanyetso le litšebelisano tse ka bang teng le meriana li lokela ho nahanoa ka hloko.
Ka bobeli spermidine trihydrochloride le spermidine ke litho tsa lelapa la polyamine mme li bapala karolo ea bohlokoa lits'ebetsong tse fapaneng tsa 'mele' meleng. Le hoja ba arolelana lintho tse tšoanang liphellong tsa bona tsa bophelo bo botle, ho boetse ho na le phapang e khōlō pakeng tsa spermidine trihydrochloride le spermidine.
●E 'ngoe ea lintho tse ka sehloohong tse tšoanang pakeng tsa spermidine trihydrochloride le spermidine ke bokhoni ba bona ba ho khothalletsa autophagy, mokhoa oa cellular o ikarabellang bakeng sa ho tlosoa ha likarolo tse senyehileng kapa tse sa sebetseng. Autophagy e bapala karolo ea bohlokoa ho bolokeng bophelo bo botle ba liselefouno 'me e kentse letsoho maloetseng a fapaneng a amanang le lilemo, ho kenyelletsa mafu a neurodegenerative le pelo. Ka bobeli spermidine trihydrochloride le spermidine li bonts'itsoe hore li susumetsa autophagy, tse ka fokotsang kotsi ea mafu ana a amanang le lilemo.
●Molemo o mong oa bophelo bo botle o arolelanoang ke spermidine trihydrochloride le spermidine ke bokhoni ba bona ba ho ntlafatsa bophelo bo botle ba pelo. Liphuputso li bontšitse hore metsoako ena e ka ntlafatsa tšebetso ea pelo, ea theola khatello ea mali, ’me ea thibela ho thehoa ha plaque methapong ea mali. Liphello tsena ho nahanoa hore li fetisetsoa ka bokhoni ba ho khothalletsa ho iketsetsa boithaopo le ho susumetsa tlhahiso ea nitric oxide, molek'hule ea bohlokoa ho boloka mali a tloaelehileng le ho thibela tsoelo-pele ea lefu la pelo.
●Leha spermidine trihydrochloride le spermidine li arolelana melemo e tšoanang ea bophelo bo botle, li boetse li na le liphapang tsa bohlokoa. Phapang e totobetseng ka ho fetisisa ke mokhoa oa bona oa tsamaiso. Spermidine trihydrochloride ke mofuta oa maiketsetso oa spermidine oo hangata o sebelisoang e le tlatsetso ea lijo. Ka lehlakoreng le leng, spermidine ke motsoako oa tlhaho o fumanoang mehloling e sa tšoaneng ea lijo, e kang linaoa tsa soya, li-mushroom le chisi e tsofetseng. Phapang ena e ka ama bioavailability le litla-morao tse ka bang teng tsa metsoako ena.
●Ho feta moo, matla a kakaretso a spermidine trihydrochloride le spermidine a ka fapana. Kaha spermidine trihydrochloride ke mofuta o matla oa spermidine, e ka fana ka litlamorao tse matla ka tekanyo e tlase ho feta mehloli ea tlhaho ea spermidine. Leha ho le joalo, lipatlisiso tse ling lia hlokahala ho fumana hore na liphapang tsena tsa katleho li fetolela liphapang tse kholo melemo ea bona ea bophelo bo botle.
●Ho feta moo, spermidine trihydrochloride le spermidine li ka fapana ka botsitso le bophelo ba sethala. Joaloka motsoako oa maiketsetso, spermidine trihydrochloride ka kakaretso e tsitsitse haholoanyane 'me e na le nako e telele ea bophelo ho feta spermidine, e ka' nang ea senyeha ka potlako. Phapang ena e ka 'na ea ama polokelo le tlhahiso ea lihlahisoa tse nang le metsoako ena.
Spermidine trihydrochloride ke motsoako oa maiketsetso o tsoang ho spermidine. Autophagy ke ts'ebetso ea bohlokoa ea cellular e nyenyefatsang le ho nchafatsa likarolo tsa cellular tse sa hlokahaleng kapa tse sa sebetseng. E bapala karolo ea bohlokoa ho boloka homeostasis ea cellular le ho thibela ho bokellana ha limolek'hule tse senyehileng. Ka lehlakoreng le leng, senescence ea cellular ke boemo bo ke keng ba qojoa ba ho tšoaroa ha khōlo e hlahang ka lebaka la likhatello tse sa tšoaneng 'me e amahanngoa le botsofali le mafu a amanang le lilemo.
Liphuputso tsa morao-rao li bontšitse hore spermidine le trihydrochloride e tsoang ho eona e na le bokhoni ba ho laola autophagy le senescence ea cellular. Spermidine ke polyamine e hlahang ka tlhaho liseleng tsohle tse phelang moo e amehang mefuteng e sa tšoaneng ea likokoana-hloko tse kenyelletsang ho hōla ha lisele, matla le tsosoloso ea lisele. Ka ho khothalletsa autophagy, spermidine e bontšitsoe hore e na le liphello tse ka 'nang tsa e-ba khahlanong le botsofali.
E 'ngoe ea mekhoa e ka sehloohong eo spermidine le spermidine trihydrochloride li sebetsang ka eona ke ka ho kenya tšebetsong autophagy. Autophagy e bakoa ke ho thehoa ha likarolo tse peli tsa "autophagosomes" tse bitsoang "autophagosome" tse reretsoeng ho senyeha. Ts'ebetso ena e laoloa ke letoto la liphatsa tsa lefutso tse amanang le autophagy (ATGs) le litsela tse sa tšoaneng tsa lipontšo.
Boithuto bo bonts'itse hore spermidine le spermidine trihydrochloride li eketsa sebopeho sa autophagosome le ho ntlafatsa phallo ea autophagic. Sena se fella ka ho tlosoa ha liprotheine le li-organelle tse senyehileng, ho khothalletsa bophelo bo botle ba lisele le ho thibela ho qala botsofali. Ho phaella moo, spermidine e bontšitsoe ho kenya tšebetsong molaoli oa bohlokoa oa autophagy, tsela ea mTOR, kahoo e ntlafatsa mosebetsi oa boipheliso.
Lilemong tsa morao tjena, spermidine trihydrochloride e hohetse tlhokomelo e ngata bakeng sa melemo ea eona ea bophelo bo botle le thepa ea ho thibela botsofali. Le hoja spermidine trihydrochloride e ka fumanoa ka mehloli ea lijo, ho na le litsela tsa ho eketsa maemo a eona 'meleng ka tlhaho.
E 'ngoe ea litsela tse sebetsang tsa ho eketsa maemo a hau a spermidine trihydrochloride ke ka ho ja lijo tse leka-lekaneng. Lijo tse kang kokoana-hloko ea koro, linaoa tsa soya, li-mushroom le mefuta e itseng ea chisi li na le tekanyo e ngata ea motsoako ona. Ho kenyelletsa lijo tsena lijong tsa hau tsa letsatsi le letsatsi ho ka thusa ho netefatsa hore o fumana spermidine trihydrochloride e lekaneng. Ke habohlokoa ho hlokomela hore ho pheha le ho sebetsa ho ka fokotsa maemo a spermidine trihydrochloride lijong tsena, kahoo ho molemo ho khetha lijo tse ncha le tse sa sebelisoang hanyane.
Ho itima lijo ka nakoana, mokhoa oa ho ja o kenyelletsang ho palama libaesekele lipakeng tsa ho itima lijo le ho ja, ho boetse ho fumanoe ho eketsa maemo a spermidine trihydrochloride 'meleng. Lipatlisiso li bontša hore ho itima lijo bonyane lihora tse 16 ho susumetsa tlhahiso ea spermidine trihydrochloride, e khothalletsang autophagy le ho ntlafatsa bophelo bo botle ba lisele. Leha ho le joalo, ho bohlokoa ho buisana le setsebi sa tlhokomelo ea bophelo pele u kenyelletsa mokhoa leha e le ofe oa ho itima lijo kemisong ea hau, haholo-holo haeba u na le maemo a tlase a bongaka.
Li-supplement ke khetho e 'ngoe ea ho eketsa maemo a spermidine trihydrochloride ka tlhaho. Li-supplement tsa Spermidine li tla ka mefuta e mengata, joalo ka li-capsules kapa phofo, 'me li ka fumanoa mabenkeleng a bophelo bo botle kapa inthaneteng. Ha u khetha tlatsetso, ho bohlokoa ho khetha mofuta o tsebahalang o fanang ka sehlahisoa sa boleng. Ho buisana le setsebi sa tlhokomelo ea bophelo ho ka boela ha thusa ho fetola litekanyetso ho latela litlhoko tsa motho ka mong.
Ntle le liphetoho tsa lijo, mokhoa oa bophelo o phetseng hantle o ka ts'ehetsa keketseho ea tlhaho ea spermidine trihydrochloride. Ho ikoetlisa khafetsa, mekhoa ea ho laola khatello ea maikutlo joalo ka ho thuisa kapa yoga, le ho robala ka ho lekaneng kaofela li hokahane le ntlafatso ea bophelo bo botle le ts'ebetso ea cellular. Mekhoa ena e ka eketsa ka tsela e sa tobang maemo a spermidine trihydrochloride 'meleng.
Nako ea poso: Jun-27-2023
