Saense e ka morao ho Urolithin A: Seo U Lokelang ho se Tseba

Urolithin A (UA)ke motsoako o hlahisoang ke metabolism ea limela tsa mala lijong tse nang le ellagitannins (tse kang likharenate, raspberries, joalo-joalo). E nkoa e le anti-inflammatory, anti-aging, antioxidant, induction of mitophagy, joalo-joalo, 'me e ka tšela mokoallo oa mali-boko. Liphuputso tse ngata li tiisitse hore urolithin A e ka liehisa botsofali, 'me lithuto tsa bongaka le tsona li bontšitse liphello tse ntle.

Urolithin A ke eng?

Urolithin A (Uro-A) ke mofuta oa ellagitannin (ET) - mofuta oa flora metabolite ea mala. E ile ea sibolloa ka molao 'me ea rehoa lebitso ka 2005. Mokhoa oa eona oa molek'hule ke C13H8O4, 'me boima ba eona ba molek'hule ke 228.2. Joalo ka selelekela sa metabolic sa Uro-A, mehloli ea mantlha ea lijo tsa ET ke likharenate, fragole, raspberries, walnuts le veine e khubelu. UA ke sehlahisoa sa ETs se entsoeng ke likokoana-hloko tsa mala. UA e na le menyetla e pharaletseng ea ts'ebeliso ea ho thibela le ho phekola mafu a mangata. Ka nako e ts'oanang, UA e na le mefuta e mengata ea mehloli ea lijo.

Patlisiso mabapi le litlamorao tsa antioxidant tsa urolithin e entsoe. Urolithin-A ha e eo sebakeng sa tlhaho, empa e hlahisoa ke letoto la liphetoho tsa ET ka limela tsa mala. UA ke sehlahisoa sa ETs se entsoeng ke likokoana-hloko tsa mala. Lijo tse ruileng ka ET li feta ka mpeng le mala a manyane 'meleng oa motho,' me qetellong li kenngoa ka har'a Uro-A ka koloneng. Uro-A e nyane e ka boela ea bonoa ka har'a mala a manyane.

Joaloka metsoako ea tlhaho ea polyphenolic, li-ET li hohetse tlhokomelo e ngata ka lebaka la mesebetsi ea bona ea likokoana-hloko tse kang antioxidant, anti-inflammatory, anti-allergic le anti-viral. Ntle le ho tsoa lijong tse kang likharenate, fragole, walnuts, li-raspberries le lialmonde, li-ET li boetse li fumanoa ka makotomane, likhalase tsa kharenate, myrobalan, Dimininus, geranium, betel nut, makhasi a sea buckthorn, Phyllanthus, Uncaria, Sanguisorba, In Chinese. meriana e kang Phyllanthus emblica le Agrimony.

Sehlopha sa hydroxyl sebopeho sa limolek'hule tsa ETs se batla se le polar, se sa khoneng ho kenngoa ka lerako la mala, 'me bioavailability ea eona e tlaase haholo. Liphuputso tse ngata li fumane hore ka mor'a hore li-ET li kenngoe ke 'mele oa motho, li sebelisoa ke limela tsa mala ka har'a kolone ebe li fetoloa urolithin pele li kenngoa. Li-ET li kenngoa ka hydrolyzed ho ellagic acid (EA) karolong e ka holimo ea mala, 'me EA e fetisoa ka maleng. Limela tsa baktheria li tsoela pele ho sebetsa 'me li lahleheloa ke selikalikoe sa lactone ebe li tsoela pele ho etsa dehydroxylation ho hlahisa urolithin. Ho na le litlaleho tsa hore urolithin e ka 'na ea e-ba motheo oa lintho tse bonahalang bakeng sa liphello tsa likokoana-hloko tsa ET' meleng.

Bioavailability ea urolithin e amana le eng?

Ha u bona sena, haeba u le bohlale, mohlomong u se u ntse u tseba hore na bioavailability ea UA e amana le eng.

Ntho ea bohlokoa ka ho fetisisa ke ho hlophisoa ha microbiome, hobane hase mefuta eohle ea likokoana-hloko e ka hlahisang. Lintho tse tala tsa UA ke li-ellagitannins tse fumanoang lijong. Selelekela sena se fumaneha habonolo ebile se batla se fumaneha hohle ka tlhaho.

Ellagitannins e entsoe ka hydrolyzed ka maleng ho lokolla ellagic acid, e tsoelang pele ho sebetsoa ke limela tsa mala ho urolithin A.

Ho ea ka phuputso ho koranta ea Cell, ke 40% feela ea batho ba ka fetolang urolithin A ho tloha selelekela sa eona ho urolithin A e ka sebelisoang.

Mesebetsi ea urolithin A ke efe?

Khahlanong le botsofali

Khopolo-taba ea mahala ea botsofali e lumela hore mefuta ea oksijene e sebetsang e hlahisoang ke metabolism ea mitochondrial e baka khatello ea oxidative 'meleng' me e lebisa botsofaling, 'me mitophagy e phetha karolo ea bohlokoa ho boloka bophelo bo botle le botšepehi ba mitochondrial. Ho tlalehiloe hore UA e ka laola mitophagy mme kahoo e bontša monyetla oa ho lieha ho tsofala. Ryu le al. e fumane hore UA e fokolitse ho se sebetse ha mitochondrial le nako e telele ea bophelo ho Caenorhabditis elegans ka ho etsa hore mitophagy; ho litoeba, UA e ka fetola ho fokotseha ha mesifa e amanang le lilemo, e bontšang hore UA e ntlafatsa mosebetsi oa mitochondrial ka ho matlafatsa boima ba mesifa le ho lelefatsa bophelo ba 'mele. Liu et al. e sebelisitse UA ho kenella botsofaling ba letlalo la fibroblasts. Liphello li bontšitse hore UA e ekelitse haholo polelo ea mofuta oa I collagen le ho fokotsa polelo ea matrix metalloproteinase-1 (MMP-1). E boetse e kentse nyutlelie ea Factor E2-related factor 2 (nuclear factor erythroid 2-related factor 2, Nrf2) -mediated antioxidant response e fokotsa ROS ea intracellular, kahoo e bontša matla a matla a ho thibela botsofali.

Phello ea Antioxidant

Hajoale, ho entsoe lithuto tse ngata mabapi le phello ea antioxidant ea urolithin. Har'a metabolites eohle ea urolithin, Uro-A e na le ts'ebetso e matla ka ho fetisisa ea antioxidant, ea bobeli feela ho proanthocyanidin oligomers, catechins, epicatechin le 3,4-dihydroxyphenylacetic acid. Teko ea oksijene e monya matla a ho monya matla (ORAC) ea plasma ea baithaopi ba phetseng hantle e fumane hore matla a antioxidant a eketsehile ka 32% ka mor'a lihora tse 0.5 tsa ho kenngoa ha lero la kharenate, empa boemo ba mefuta ea oksijene e sebetsang ha ea ka ea fetoha haholo, nakong ea Neuro- In. liteko tsa vitro ho lisele tsa 2a li fumane hore Uro-A e ka fokotsa boemo ba mefuta ea oksijene e sebetsang liseleng. Liphetho tsena li bonts'a hore Uro-A e na le litlamorao tse matla tsa antioxidant.

03. Urolithin A le mafu a pelo le cerebrovascular

Palo ea lefats'e ea lefu la pelo (CVD) e ntse e eketseha selemo le selemo, 'me sekhahla sa batho ba shoang se ntse se le holimo. Ha e eke feela moroalo oa sechaba le oa moruo, empa hape e ama ka botebo boleng ba bophelo ba batho. CVD ke lefu le bakoang ke mefuta e mengata. Ho ruruha ho ka eketsa kotsi ea CVD. Khatello ea oxidative e amana le pathogenesis ea CVD. Ho na le litlaleho tsa hore metabolite e tsoang ho likokoana-hloko tsa mala li amahanngoa le kotsi ea CVD.

Ho tlalehiloe hore UA e na le litlamorao tse matla tse khahlanong le ho ruruha le li-antioxidant, 'me liphuputso tse nepahetseng li tiisitse hore UA e ka bapala karolo e molemo ho CVD. Savi et al. o sebelisitse mohlala oa rat ea lefu la tsoekere ho etsa lithuto tsa vivo mabapi le lefu la tsoekere la pelo mme a fumana hore UA e ka fokotsa karabelo ea pele ea ho ruruha ea lisele tsa myocardial ho hyperglycemia, ea ntlafatsa microenvironment ea myocardial, le ho khothaletsa ho hlaphoheloa ha cardiomyocyte contractility le calcium dynamics, e bonts'a hore UA e ka khona. e ka sebelisoa e le sethethefatsi se thusang ho laola lefu la pelo le lefu la tsoekere le ho thibela mathata a lona.

UA e ka ntlafatsa ts'ebetso ea mitochondrial le ts'ebetso ea mesifa ka ho susumetsa mitophagy. Mitochondria ea pelo ke litho tsa bohlokoa tse ikarabellang bakeng sa ho hlahisa ATP e nang le matla. Ho se sebetse hantle ha mitochondrial ke sesosa sa ho hloleha ha pelo. Ho se sebetse ha mitochondrial hajoale ho nkuoa e le sepheo sa kalafo se ka bang teng. Ka hona, UA e boetse e fetohile moriana o mocha oa phekolo ea CVD.

Urolithin A le mafu a methapo ea kutlo

Neuroinflammation ke ts'ebetso ea bohlokoa ketsahalong le nts'etsopele ea lefu la neurodegenerative (ND). Apoptosis e bakoang ke khatello ea oxidative le ho kopana ho sa tloaelehang ha protheine hangata ho baka neuroinfigueation, 'me li-cytokine tsa pro-inflammatory tse lokollotsoeng ke neuroinflammation ebe li ama neurodegeneration.

Liphuputso li fumane hore UA e sebelisana le ts'ebetso e khahlanong le ho ruruha ka ho kenya letsoho le ho kenya tšebetsong mochine o khutsitseng oa taolo ea 1 (SIRT-1), ho thibela neuroinflammation le neurotoxicity, le ho thibela neurodegeneration, ho fana ka maikutlo a hore UA ke Neuroprotective agent e sebetsang hantle. Ka nako e ts'oanang, liphuputso tse ling li fumane hore UA e ka hlahisa litlamorao tsa neuroprotective ka ho hlakola ka kotloloho li-radicals tsa mahala le ho thibela li-oxidase.

Liphuputso li bontšitse hore lero la kharenate le phetha karolo ea neuroprotective ka ho eketsa ts'ebetso ea mitochondrial aldehyde dehydrogenase, ho boloka boemo ba protheine ea anti-apoptotic Bcl-xL, ho fokotsa α-synuclein aggregation le tšenyo ea oxidative, le ho ama tšebetso ea neuronal le botsitso. Metsoako ea Urolithin ke metabolites le likarolo tsa phello ea ellagitannins 'meleng' me e na le mesebetsi ea tlhaho e kang anti-inflammation, anti-oxidative stress, le anti-apoptosis. Urolithin e ka fana ka ts'ebetso ea "neuroprotective" ka mokoallo oa mali le boko 'me ke molek'hule e nyane e sebetsang bakeng sa ho kenella ho mafu a neurodegenerative.

Urolithin A le mafu a kopantsoeng le a mokokotlo oa mokokotlo

Mafu a senyang a bakoa ke lintho tse ngata tse kang botsofali, khatello ea maikutlo le ho sithabela maikutlo. Mafu a tloaelehileng ka ho fetisisa a ho senyeha ha manonyeletso ke lefu la masapo a manonyeletso (OA) le lefu la mokokotlo la mokokotlo oa intervertebral disc degeneration (IDD). Ketsahalo e ka baka bohloko le ts'ebetso e fokolang, e bakang tahlehelo ea mosebetsi le ho beha bophelo bo botle ba sechaba kotsing. Mokhoa oa UA oa ho phekola IDD ea lefu la mokokotlo o ka 'na oa amana le ho lieha ha nucleus pulposus (NP) cell apoptosis. NP ke karolo ea bohlokoa ea "intervertebral disc". E boloka ts'ebetso ea likokoana-hloko ea intervertebral disc ka ho aba khatello le ho boloka matrix homeostasis. Liphuputso li fumane hore UA e etsa hore mitophagy e be teng ka ho kenya tšebetsong tsela ea pontšo ea AMPK, kahoo e thibela tert-butyl hydroperoxide (t-BHP) -e bakoang ke apoptosis ea lisele tsa NP tsa lisele tsa osteosarcoma tsa motho le ho fokotsa ho senyeha ha disc intervertebral.

Urolithin A le mafu a metabolic

Ketsahalo ea mafu a metabolic a kang botenya le lefu la tsoekere e ntse e eketseha selemo le selemo, 'me liphello tse molemo tsa polyphenols tsa lijo ho bophelo bo botle ba batho li tiisitsoe ke lihlopha tse ngata' me li bontšitse bokhoni ba ho thibela le ho phekola mafu a metabolic. Pomegranate polyphenols le intestinal metabolite UA e ka ntlafatsa matšoao a kliniki a amanang le mafu a metabolism, a kang lipase, α-glucosidase (α-glucosidase) le dipeptidyl peptidase-4 (dipeptidyl peptidase-4) e amehang ho metabolism ea tsoekere le mafura a acid. 4), hammoho le liphatsa tsa lefutso tse amanang le tsona tse kang adiponectin, PPARγ, GLUT4 le FABP4 tse amang phapang ea adipocyte le ho bokella triglyceride (TG).

Ho feta moo, liphuputso tse ling li fumane hape hore UA e na le monyetla oa ho fokotsa matšoao a botenya. UA ke sehlahisoa sa metabolism ea mala ea polyphenols. Li-metabolite tsena li na le bokhoni ba ho fokotsa ho bokella TG liseleng tsa sebete le adipocyte. Abdulrasheed et al. ho fepa likhoto tsa Wistar bakeng sa ho nona haholo. Kalafo ea UA ha ea ka ea eketsa feela ho ntšoa ha mafura mantleng, empa hape e fokolitse boima ba lithane tsa visceral adipose le boima ba 'mele ka ho laola liphatsa tsa lefutso tse amanang le lipogenesis le mafura a acid oxidation. E fokotsa ho bokellana ha mafura a sebete le khatello ea eona ea oxidative. Ka nako e ts'oanang, UA e ka eketsa tšebeliso ea matla ka ho ntlafatsa thermogenesis ea lisele tse sootho tsa adipose le ho etsa hore mafura a masoeu a be sootho. Mochine ke ho eketsa maemo a triiodothyronine (T3) ka mafura a sootho le li-depot tsa mafura a inguinal. E eketsa tlhahiso ea mocheso 'me kahoo e hanela botenya.

Ntle le moo, UA e boetse e na le phello ea ho thibela tlhahiso ea melanin. Boithuto bo fumane hore UA e ka fokolisa haholo tlhahiso ea melanin liseleng tsa B16 tsa melanoma. Mokhoa o ka sehloohong ke hore UA e ama ts'ebetso ea catalytic ea tyrosinase ka ho thibela tlholisano ea cell tyrosinase, ka hona e fokotsa pigmentation. Ka hona, UA e na le bokhoni le katleho ea ho soeufatsa le ho khantša matheba. 'Me lipatlisiso li bontša hore urolithin A e na le phello ea ho khutlisa botsofali ba sesole sa' mele. Liphuputso tsa morao-rao li fumane hore ha urolithin A e eketsoa e le tlatsetso ea lijo, ha e sebetse feela matla a sebaka sa lymphatic ea tsamaiso ea 'mele ea ho itšireletsa mafung, empa hape e ntlafatsa mosebetsi oa lisele tsa stem tsa hematopoietic. Ts'ebetso e akaretsang e bonts'a bokhoni ba urolithin A ho loants'a ho fokotseha ha sesole sa 'mele ho amanang le lilemo.

Ho akaretsa, UA, e le metabolite ea mala ea tlhaho ea phytochemicals ETs, e hohetse tlhokomelo e ngata lilemong tsa morao tjena. Ka lipatlisiso mabapi le liphello tsa pharmacological le mekhoa ea UA e ntse e eketseha le ho teba, UA ha e sebetse feela ka kankere le CVD (mafu a pelo). E na le phello e ntle ea thibelo le kalafo ho mafu a mangata a kliniki a kang ND (mafu a neurodegenerative) le mafu a metabolism. E boetse e bonts'a bokhoni bo boholo ba ts'ebeliso maemong a botle le tlhokomelo ea bophelo bo botle joalo ka ho lieha ho tsofala ha letlalo, ho fokotsa boima ba 'mele le ho thibela tlhahiso ea melanin.

Suzhou Myland Pharm & Nutrition Inc. ke moetsi ea ngolisitsoeng ke FDA ea fanang ka phofo ea Urolithin A ea boleng bo holimo le bo hloekileng.

Ho Suzhou Myland Pharm re ikemiselitse ho fana ka lihlahisoa tsa boleng bo holimo ka litheko tse ntle. Urolithin ea rona ea phofo e lekoa ka matla bakeng sa bohloeki le potency, ho netefatsa hore u fumana tlatsetso ea boleng bo phahameng eo u ka e tšepang. Hore na o batla ho ts'ehetsa bophelo bo botle ba cellular, ho matlafatsa sesole sa hau sa 'mele kapa ho ntlafatsa bophelo bo botle ka kakaretso, phofo ea rona ea Urolithin A ke khetho e phethahetseng.

Ka boiphihlelo ba lilemo tse 30 'me e susumetsoa ke thekenoloji e phahameng le maano a R&D a ntlafalitsoeng haholo, Suzhou Myland Pharm e hlahisitse lihlahisoa tse ngata tsa tlholisano mme e fetohile tlatsetso e ncha ea mahlale a bophelo, ho kopanya tloaelo le k'hamphani ea lits'ebeletso tsa tlhahiso.

Ntle le moo, Suzhou Myland Pharm le eona ke moetsi ea ngolisitsoeng ke FDA. Lisebelisoa tsa R&D tsa k'hamphani, lisebelisoa tsa tlhahiso, le lisebelisoa tsa tlhahlobo ke tsa sejoale-joale ebile li na le mesebetsi e mengata, 'me li ka hlahisa lik'hemik'hale ho tloha ho limiligrama ho isa ho lithane ka tekanyo,' me li lumellana le litekanyetso tsa ISO 9001 le litlhaloso tsa tlhahiso ea GMP.