Li-Supplement tse 5 tse ka Holimo-limo tse khahlanong le botsofali: Ke Efe e Betere ho Ntlafatsa Bophelo bo Botle ba Mitochondrial?

Hangata mitochondria e bitsoa "liteishene tsa matla" tsa sele, lentsoe le totobatsang karolo ea bona ea bohlokoa tlhahisong ea matla. Li-organelle tsena tse nyane li bohlokoa lits'ebetsong tse ngata tsa cellular, 'me bohlokoa ba tsona bo fetela hole ho feta tlhahiso ea matla. Ho na le li-supplement tse ngata tse fumanehang tse ka ntlafatsang bophelo bo botle ba mitochondrial. Ha re shebeng!

Sebopeho sa mitochondria

Li-mitochondria li ikhethile har'a li-organelle tsa cellular ka lebaka la sebopeho sa tsona se habeli. Lera la ka ntle le boreleli 'me le sebetsa e le mokoallo pakeng tsa cytoplasm le tikoloho e ka hare ea mitochondria. Leha ho le joalo, intima e kobehile haholo, e etsa mameno a bitsoang cristae. Li-cristae tsena li eketsa sebaka se ka holimo se fumanehang bakeng sa liphetoho tsa lik'hemik'hale, tse bohlokoa bakeng sa mosebetsi oa organelle.

Ka har'a lera le ka hare ho na le matrix ea mitochondrial, ntho e kang gel e nang le li-enzyme, DNA ea mitochondrial (mtDNA) le ribosomes. Ho fapana le li-organelle tse ling tse ngata, mitochondria e na le liphatsa tsa lefutso tsa tsona, tse futsitsoeng ho tloha moleng oa bo-'mè. Tšobotsi ena e ikhethang e etsa hore bo-rasaense ba lumele hore mitochondria e simolohile ho libaktheria tsa khale tsa symbiotic.

Mosebetsi oa Mitochondrial

1. Tlhahiso ea matla

Mosebetsi oa mantlha oa mitochondria ke ho hlahisa adenosine triphosphate (ATP), chelete ea mantlha ea matla ea sele. Ts'ebetso ena, e bitsoang phosphorylation ea oxidative, e hlaha ka har'a lera le ka hare 'me e kenyelletsa letoto le rarahaneng la liphetoho tsa biochemical. Ketane ea lipalangoang tsa elektronike (ETC) le ATP synthase ke libapali tsa bohlokoa ts'ebetsong ena.

(1) Ketane ea lipalangoang tsa elektronike (ETC): ETC ke letoto la liprotheine tse rarahaneng le limolek'hule tse ling tse kentsoeng ka har'a lera le ka hare. Li-electrone li fetisoa ka li-complexes tsena, ho lokolla matla a sebelisoang ho pompa li-proton (H +) ho tloha matrix ho ea sebakeng sa intermembrane. Sena se theha sekhahla sa electrochemical, se tsejoang hape e le matla a sepheo sa proton.

(2) ATP synthase: ATP synthase ke enzyme e sebelisang matla a bolokiloeng ka matla a matla a proton ho kopanya ATP ho tloha adenosine diphosphate (ADP) le inorganic phosphate (Pi). Ha li-proton li ntse li phalla ho khutlela matrix ka ATP synthase, enzyme e etsa hore ho be le sebopeho sa ATP.

2. Litsela tsa metabolism

Ntle le tlhahiso ea ATP, mitochondria e ameha litseleng tse fapaneng tsa metabolism, ho kenyelletsa le potoloho ea citric acid (Krebs cycle) le fatty acid oxidation. Litsela tsena li hlahisa limolek'hule tse mahareng tse bohlokoa bakeng sa lits'ebetso tse ling tsa cellular, joalo ka motsoako oa li-amino acid, li-nucleotide le lipids.

3. Apoptosis

Mitochondria e boetse e bapala karolo ea bohlokoa ho lefu la lisele tse hlophisitsoeng, kapa apoptosis. Nakong ea apoptosis, mitochondria e lokolla cytochrome c le lintlha tse ling tsa pro-apoptotic ho cytoplasm, e leng se bakang letoto la liketsahalo tse lebisang lefung la sele. Ts'ebetso ena e bohlokoa bakeng sa ho boloka homeostasis ea cellular le ho felisa lisele tse senyehileng kapa tse kulang.

4. Mitochondria le bophelo bo botle

Ho fanoe ka karolo e ka sehloohong ea mitochondria tlhahiso ea matla le metabolism ea lisele, ha ho makatse hore ebe ho se sebetse ha mitochondrial ho amahanngoa le mathata a mangata a bophelo bo botle. Mona ke tse ling tsa libaka tsa bohlokoa moo mitochondria e amang bophelo ba rona:

5.Ho tsofala

Ho nahanoa hore mitochondria e phetha karolo ea bohlokoa ts'ebetsong ea botsofali. Ha nako e ntse e ea, DNA ea mitochondrial e bokella liphetoho tse fetohang 'me ketane ea lipalangoang tsa elektronike ha e sebetse hantle. Sena se lebisa tlhahisong e eketsehileng ea mefuta ea oksijene e sebetsang (ROS), e senyang likarolo tsa cellular le ho kenya letsoho ho tsofalang. Mekhoa ea ho ntlafatsa ts'ebetso ea mitochondrial le ho fokotsa khatello ea oxidative e ntse e hlahlojoa e le mekhoa e ka thibelang botsofali.

6. Mathata a metabolism

Ho se sebetse hantle ha mitochondrial ho boetse ho amahanngoa le mathata a fapaneng a metabolism, ho kenyelletsa botenya, lefu la tsoekere le lefu la pelo. Ts'ebetso ea mitochondrial e senyehileng e fella ka ho fokotseha ha tlhahiso ea matla, ho eketsa polokelo ea mafura, le ho hanyetsa insulin. Ho ntlafatsa ts'ebetso ea mitochondrial ka mekhoa ea bophelo e kang boikoetliso le lijo tse phetseng hantle li ka thusa ho fokotsa maemo ana.

NADH, resveratrol, astaxanthin, coenzyme Q10, urolithin A, le spermidine kaofela ke li-supplement tse fumanang tlhokomelo e ngata ha ho tluoa tabeng ea ho ntlafatsa bophelo bo botle ba mitochondrial le anti-botsofali. Leha ho le joalo, tlatsetso ka 'ngoe e na le mekhoa le melemo ea eona e ikhethang.

1. NADH

Mosebetsi oa mantlha: NADH e ka hlahisa NAD + hantle 'meleng, mme NAD + ke molek'hule ea bohlokoa ts'ebetsong ea metabolism ea lisebelisoa tsa cellular le tlhahiso ea matla ea mitochondrial.

Mochine o thibelang botsofali: Ka ho eketsa maemo a NAD+, NADH e ka kenya protheine ea nako e telele ea SIRT1, ea lokisa oache ea tlhaho, ea kenya tšebetsong li-neurotransmitters, le ho laola mokhoa oa ho robala. Ho feta moo, NADH e ka lokisa DNA e senyehileng, ea hanela oxidation, 'me ea ntlafatsa metabolism ea motho, kahoo ea finyella phello e pharaletseng ea ho lieha ho tsofala.

Melemo: NASA e hlokomela le ho khothaletsa NADH bakeng sa bo-ramahlale hore ba laole lioache tsa bona tsa bophelo, ho bonts'a katleho ea eona lits'ebetsong tse sebetsang.

2. Astaxanthin

Mesebetsi ea mantlha: Astaxanthin ke carotenoid e khubelu ea β-ionone e nang le ts'ebetso e phahameng haholo ea antioxidant.

Mochine o thibelang botsofali: Astaxanthin e ka tima oksijene e le 'ngoe, ea senya li-radicals tsa mahala, le ho boloka ts'ebetso ea mitochondrial ka ho sireletsa tekanyo ea redox ea mitochondrial. Ho feta moo, e eketsa ts'ebetso ea superoxide dismutase le glutathione peroxidase.

Melemo: Matla a antioxidant a astaxanthin a feta vithamine C ka makhetlo a 6 000 le vithamine E ka makhetlo a 550, ho bontša matla a eona a matla a antioxidant.

3. Coenzyme Q10 (CoQ10)

Mosebetsi oa mantlha: Coenzyme Q10 ke sesebelisoa sa phetolo ea matla bakeng sa cell mitochondria hape ke limatlafatsi tse thibelang botsofali tse amoheloang ka kakaretso ke sechaba sa mahlale.

Mochine o thibelang botsofali: Coenzyme Q10 e na le matla a matla a antioxidant, a ka senyang li-radicals tsa mahala le ho thusa ho tsosolosa tšebetso ea antioxidant ea vithamine C le vithamine E e entsoeng ka oxidized. Ho phaella moo, e ka fana ka oksijene le matla a lekaneng ho lisele tsa mesifa ea pelo le lisele tsa boko.

Melemo: Coenzyme Q10 ke ea bohlokoa ka ho khetheha bophelong bo botle ba pelo 'me e na le phello e kholo ho ntlafatsa matšoao a ho hloleha ha pelo le ho fokotsa ho shoa le litekanyetso tsa ho kena sepetlele ho bakuli ba pelo.

4. Urolithin A (UA)

Karolo e ka sehloohong: Urolithin A ke metabolite ea bobeli e hlahisoang ke libaktheria tsa mala a metabolizing polyphenols.

Mochine o thibelang botsofali: Urolithin A e ka kenya li-sirtuin, ea eketsa NAD + le maemo a matla a cellular, le ho tlosa mitochondria e senyehileng mesifa ea motho. Ho phaella moo, e boetse e na le liphello tse khahlanong le ho ruruha le li-anti-proliferative.

Melemo: Urolithin A e ka tšela mokoallo oa mali le boko 'me e na le monyetla oa ho ntlafatsa mafu a metabolism le ho thibela botsofali.

5. Spermidine

Melemo ea bohlokoa: Spermidine ke molek'hule ea tlhaho e hlahisoang ke libaktheria tsa mala.

Mokhoa o thibelang botsofali: Spermidine e ka baka mitophagy le ho tlosa mitochondria e sa pheleng le e senyehileng. Ho feta moo, e na le monyetla oa ho thibela lefu la pelo le botsofali ba basali.

Melemo: Dietary spermidine e fumaneha lijong tse sa tšoaneng, tse kang soya le lijo-thollo, ’me e fumaneha habonolo.

Suzhou Myland Pharm & Nutrition Inc. ke moetsi ea ngolisitsoeng ke FDA ea fanang ka phofo ea tlatsetso ea boleng bo holimo le bohloeki bo holimo e thibelang botsofali.

Ho Suzhou Myland Pharm re ikemiselitse ho fana ka lihlahisoa tsa boleng bo holimo ka litheko tse ntle. Li-powders tsa rona tse khahlanong le botsofali li lekoa ka matla bakeng sa bohloeki le potency, li ba etsa khetho e phethahetseng hore na u batla ho tšehetsa bophelo bo botle ba lisele, ho matlafatsa sesole sa hau sa 'mele kapa ho ntlafatsa bophelo bo botle ka kakaretso.

Ka boiphihlelo ba lilemo tse 30 'me e susumetsoa ke thekenoloji e phahameng le maano a R&D a ntlafalitsoeng haholo, Suzhou Myland Pharm e hlahisitse lihlahisoa tse ngata tsa tlholisano mme e fetohile tlatsetso e ncha ea mahlale a bophelo, ho kopanya tloaelo le k'hamphani ea lits'ebeletso tsa tlhahiso.

Ntle le moo, Suzhou Myland Pharm le eona ke moetsi ea ngolisitsoeng ke FDA. Lisebelisoa tsa R&D tsa k'hamphani, lisebelisoa tsa tlhahiso, le lisebelisoa tsa tlhahlobo ke tsa sejoale-joale ebile li na le mesebetsi e mengata, 'me li ka hlahisa lik'hemik'hale ho tloha ho limiligrama ho isa ho lithane ka tekanyo,' me li latela litekanyetso tsa ISO 9001 le litlhaloso tsa tlhahiso ea GMP.