Ho notlolla Liphiri tsa Botsofali bo Botle: Karolo ea Urolithin A le Lihlahisoa tse Khahlanong le Botsofali.

Ha palo ea baahi ba lefats'e e ntse e tsoela pele, tabatabelo ea botsofali bo botle e se e le setsi sa mantlha ho bafuputsi, litsebi tsa bophelo bo botle le bareki ka ho tšoanang. Takatso ea ho boloka mahlahahlaha, bophelo bo botle ba 'mele, le ts'ebetso ea kelello ho fihlela lilemong tsa morao tjena e lebisitse' marakeng o ntseng o hola oa lihlahisoa tse thibelang botsofali. Har'a litšibollo tse ts'episang ka ho fetisisa lefapheng lena ke Urolithin A, motsoako o hapileng tlhokomelo bakeng sa melemo e ka bang teng molemong oa ho khothaletsa bophelo bo bolelele le bophelo bo botle ka kakaretso. Sengoliloeng sena se hlahloba mateano a botsofali bo phetseng hantle, lihlahisoa tse thibelang botsofali, le melemo e makatsang ea Urolithin A.

Ho Utloisisa Botsofali bo Botle

Botsofali bo botle hase feela ho ba sieo ha boloetse; e akaretsa mokhoa o akaretsang oa ho boloka bophelo bo botle ba ’mele, kelellong, le maikutlong ha motho a ntse a hōla. Mokhatlo oa Lefatše oa Bophelo (WHO) o hlalosa botsofali bo botle e le mokhoa oa ho ntlafatsa le ho boloka bokhoni ba ho sebetsa bo nolofalletsang ho phela hantle botsofaling. Sena se kenyeletsa bokhoni ba ho finyella litlhoko tsa mantlha, ho ithuta, ho hōla, le ho etsa liqeto, hammoho le bokhoni ba ho haha ​​​​le ho boloka likamano le ho kenya letsoho sechabeng.

Joale ke hobane’ng ha batho ba bang ba lula ba e-na le likelello tse hlabang, ha ba bang ba sekamela ho ba ba lebalang le ba nang le meeli ea lilemo? Karabo ea potso ena e ho khopolo ea cognitive reserve (CR). Cognitive reserve e hlalosa liphapang tsa motho ka mong tse bonoang botsofaling bo botle le ba pathological. Ka bokhutšoanyane, ke khopolo e batlang ho araba potso e latelang: Ke hobane'ng ha batho ba bang ba boloka ts'ebetso ea kelello, ho hlaka kelellong, le bokhoni ba ho beha mabaka, ha ba bang ba e-na le mathata 'me ka linako tse ling ba hloka tlhokomelo ea nako e tletseng?

Likarolo tsa bohlokoa tsa botsofali bo botle li kenyelletsa:

1. Boikoetliso ba 'Mele: Ho ikoetlisa kamehla ke habohlokoa bakeng sa ho boloka boima ba mesifa, ho teteana ha masapo le bophelo bo botle ba pelo. E boetse e phetha karolo ea bohlokoa bophelong ba kelello, ho fokotsa kotsi ea ho tepella maikutlong le ho tšoenyeha.

2. Phepo: Lijo tse leka-lekaneng tse ruileng litholoana, meroho, lijo-thollo, liprotheine tse se nang mafura le mafura a phetseng hantle li bohlokoa bakeng sa ho fana ka limatlafatsi tse hlokahalang bakeng sa bophelo bo botle. Li-antioxidants, livithamini le liminerale li bapala karolo ea bohlokoa ho loants'eng khatello ea oxidative le ho ruruha, tse amanang le botsofali.

3. Kelello ea Kelello: Ho lula u le mafolofolo kelellong ka ho ithuta, likamano tsa sechaba, le mathata a kelello ho ka thusa ho boloka ts'ebetso ea kelello le ho fokotsa kotsi ea 'dementia'.

4. Likamano tsa Sechaba: Ho boloka likamano tse matla tsa sechaba ho amahanngoa le bophelo bo botle ba kelello le bophelo bo bolelele. Ho sebelisana le ba lelapa, metsoalle le sechaba ho ka fana ka tšehetso ea maikutlo le boikutlo ba ho ba oa bohlokoa.

5. Ho Laola Khatello ea Maikutlo: Khatello ea kelello e sa feleng e ka ba le liphello tse kotsi bophelong bo botle, e leng se lebisang litabeng tse ngata ho tloha ho lefu la pelo ho ea ho fokotseha ha kelello. Ho ba le kelello, ho thuisa le mekhoa ea ho phomola ho ka thusa ho laola maemo a khatello ea maikutlo.

'Maraka oa Anti-botsofali

'Maraka o thibelang botsofali o phatlohile lilemong tsa morao tjena, ha bareki ba ntse ba batla lihlahisoa tse tšepisang ho fokotsa botsofali le ho ntlafatsa boleng ba bophelo. Mmaraka ona o kenyelletsa lihlahisoa tse ngata tse fapaneng, ho kenyeletsoa litlolo tsa skincare, li-supplement tsa lijo, le mekhoa ea bophelo.

1. Skincare Products: Lihlahisoa tse thibelang botsofali hangata li na le metsoako e kang retinoids, hyaluronic acid, peptides, le antioxidants. Metsoako ena e ikemiselitse ho fokotsa ponahalo ea makhopho, ho ntlafatsa sebopeho sa letlalo le ho etsa hore ho be le khanya ea bocha.

2. Tlatsetso ea Lijo: Lisebelisoa tse lebisang botsofaling hangata li kenyelletsa livithamini, liminerale le lihlahisoa tsa litlama. Metsoako e meng e tsebahalang haholo e kenyelletsa collagen, resveratrol le curcumin, e 'ngoe le e' ngoe e ipapisitse le bokhoni ba eona ba ho ts'ehetsa bophelo bo botle ba letlalo, ts'ebetso ea manonyeletso le matla ka kakaretso.

3. Mekhoa ea Boipheliso ea Bophelo: Ka ntle ho lihlahisoa, liphetoho tsa mokhoa oa bophelo tse kang ho ja lijo tsa Mediterranean, ho ikoetlisa kamehla, le ho beha boroko pele li nkoa e le mekhoa e sebetsang ea ho khothalletsa botsofali bo botle.

Saense ka Mora Urolithin A

Urolithin Ake metabolite e hlahisoang ke libaktheria tsa mala ha li pshatla ellagitannins, metsoako e fumanoang litholoana le linate tse fapaneng, haholo-holo likharenate, walnuts le monokotsoai. Lipatlisiso li bontšitse hore Urolithin A e ka bapala karolo ea bohlokoa ho khothalletsa botsofali bo botle ka liphello tsa eona ho bophelo bo botle ba lisele le mosebetsi oa mitochondrial.

Bophelo bo Botle ba Mitochondrial

Mitochondria, eo hangata e bitsoang li-powerhouses tsa sele, e ikarabella bakeng sa ho hlahisa matla. Ha re ntse re tsofala, ts'ebetso ea mitochondrial e atisa ho fokotseha, e lebisang ho fokotseng tlhahiso ea matla le ho eketseha ha khatello ea oxidative. Urolithin A e bontšitsoe ho susumetsa ts'ebetso e bitsoang mitophagy, e leng ho senyeha ho khethehileng ha mitochondria e senyehileng. Ka ho khothalletsa ho tlosoa ha mitochondria e sa sebetseng, Urolithin A e thusa ho boloka palo e phetseng hantle ea mitochondria, ka tsela eo e tšehetsa tlhahiso ea matla a cellular le bophelo bo botle ka kakaretso.

Thepa e Khahlanong le ho Ruta

Ho ruruha ho sa foleng ke letšoao la botsofali 'me ho amahanngoa le mafu a sa tšoaneng a amanang le lilemo, ho akarelletsa le lefu la pelo, lefu la tsoekere le lefu la neurodegenerative. Urolithin A e na le thepa e khahlanong le ho ruruha, e ka thusang ho fokotsa liphello tsa ho ruruha ho sa foleng le ho khothalletsa botsofali bo botle.

Bophelo bo Botle ba Mesifa

Sarcopenia, tahlehelo e amanang le lilemo ea boima ba mesifa le matla, ke ntho e amehang haholo ho batho ba baholo. Lipatlisiso li bontšitse hore Urolithin A e ka ntlafatsa ts'ebetso ea mesifa le ho khothalletsa ho tsosolosoa ha mesifa. Phuputsong e phatlalalitsoeng koranteng ea * Nature Metabolism *, bafuputsi ba fumane hore Urolithin A e ntlafalitse matla a mesifa le mamello ho batho ba baholo ba hōlileng, e fana ka maikutlo a bokhoni ba eona e le moemeli oa phekolo bakeng sa ho loantša sarcopenia.

Ho kenyelletsa Urolithin A Kemisong ea Hao

Ka lebaka la melemo e ts'episang ea Urolithin A, batho ba bangata ba batla litsela tsa ho kenyelletsa motsoako ona lits'ebetsong tsa bona tsa letsatsi le letsatsi. Le hoja Urolithin A e hlahisoa ka tlhaho 'meleng ka ho sebelisoa ha lijo tse itseng, katleho ea phetoho ena e ka fapana haholo har'a batho ka bomong ka lebaka la phapang ea gut microbiota.

1.Mehloli ea Lijo: Ho matlafatsa tlhahiso ea Urolithin A, nahana ka ho kenyelletsa lijo tse ruileng ka ellagitannins lijong tsa hau. Likharenate, li-raspberries, fragole, walnuts le veine ea khale ea oak ke mehloli e babatsehang.

2. Tlatsetso: Bakeng sa ba ka 'nang ba se ke ba hlahisa Urolithin A e lekaneng ka lijo feela, li-supplement li teng. Hangata lihlahisoa tsena li na le Urolithin A ka mokhoa o fumanehang, e leng ho nolofalletsang 'mele ho monya le ho o sebelisa.

3. Therisano le Litsebi tsa Bophelo bo Botle: Pele u qala mokhoa leha e le ofe o mocha oa tlatsetso, ho eletsoa ho buisana le setsebi sa tlhokomelo ea bophelo, haholo-holo ho batho ba nang le maemo a bophelo bo botle kapa ba noang meriana.

Bokamoso ba Botsofali bo Botle ba Bophelo bo Botle

Ha lipatlisiso li ntse li tsoela pele ho senola mekhoa ea botsofali le melemo e ka bang teng ea metsoako e kang Urolithin A, bokamoso ba botsofali bo botle bo shebahala bo tšepisa. Ho kopanngoa ha tsoelo-pele ea saense bophelong ba letsatsi le letsatsi, ka khetho ea lijo le lihlahisoa tse ncha, ho fana ka tšepo ho batho ba batlang ho ntlafatsa bophelo ba bona ha ba ntse ba tsofala.

Qetellong, ho lelekisa botsofali bo botle ke boiteko bo bongata bo kenyelletsang khetho ea mokhoa oa bophelo, mekhoa ea ho ja, le tšebeliso ea lihlahisoa tse lebisitsoeng. Urolithin A e hlahella e le motsoako o tsotehang o nang le bokhoni ba ho tšehetsa bophelo bo botle ba mitochondrial, ho fokotsa ho ruruha, le ho khothalletsa ho sebetsa ha mesifa. Ha re ntse re tsoela pele ho batlisisa saense ea botsofali, ho hlakile hore mokhoa o tsitsitseng oa bophelo bo botle o ka lebisa bophelong bo matla le bo khotsofatsang lilemong tsa rona tsa morao-rao. Ho amohela botsofali bo botle kajeno ho ka bula tsela ea hosane e khanyang.