Ho utulla Mekhoa ea morao-rao ea Litlhahiso tsa Alpha GPC tsa 2024

Choline Alfoscerate,e tsejoang hape e le Alpha-GPC, ke ntho e nkiloeng ho lecithin ea semela, empa ha se phospholipid, empa ke phospholipid e tsoang linthong tsa Lipophilic fatty acid. Alpha-GPC ke limatlafatsi tse sebetsang ka bongata tse fumanehang liseleng tsohle tsa mammalia. Hobane e na le hydrophilic haholo, e kenella ka potlako ka mor'a ho tsamaisoa ka molomo. GPC ke selelekela sa acetylcholine (ACh) mme e na le ts'episo e kholo ea ho se sebetse ha choline.

GPC e tšela habonolo mokoallo oa mali-boko 'me e fana ka mohloli oa choline bakeng sa biosynthesis ea ACh le phosphatidylcholine. Phospholipids le acetylcholine, ha li finyelloa ka maemo a nepahetseng, li khothalletsa bophelo bo botle ba kelello, kelello le cerebrovascular. Ho phaella moo, motsoako o leka-lekaneng oa Alpha-GPC le Ach o ka khothalletsa mekhoa ea 'mele le ho ntlafatsa ts'ebetso ea' mele. ACh e kenya letsoho ho honyela ha mesifa 'me ke neurotransmitter e ka sehloohong e laolang likarabo tsa 'mele ho ikoetlisa.

Kaha metsamao eohle ea mesifa e amana le ho fokotseha, 'me ho fokotseha ho amana le motsoako o fumanehang oa ACh oa lisele, ho eketsa maemo a ACh ho ntlafatsa ts'ebetso ea mesifa. Ha ho bapisoa le li-precursors tse ling tse tloaelehileng tsa choline, Alpha-GPC ka mokhoa o sireletsehileng le ka katleho e eketsa maemo a choline maling le bokong. Liphuputso tse ngata li tiisitse melemo e sa tšoaneng ea Alpha-GPC 'me li fana ka maikutlo a hore tlatsetso ea molomo e ka bapala karolo ea bohlokoa ho ntlafatsa ts'ebetso ea methapo, ts'ebetso ea' mele le ho ntlafatsa mohopolo.

Alpha-GPC e sebetsang hantle

Ntlafatsa matla a boko

Ha palo ea lisele tsa methapo bokong e ntse e eketseha, matla a tsona a matlafala, li fetisa melaetsa ea methapo ka potlako le matla a ho sebetsa a boko. Alpha-GPC e ka ntlafatsa ka botlalo ts'ebetso ea boko ka ho matlafatsa matla a lisele tsa methapo le bokhoni ba phetisetso ea matšoao a methapo. Mabapi le ho ntlafatsa cholinergic neurotransmission, phetisetso ea matšoao lipakeng tsa lisele tsa methapo e itšetlehile ka phetiso ea li-neurotransmitters, 'me acetylcholine ke lenģosa la bohlokoa la lik'hemik'hale le li-neurotransmitter tse netefatsang monahano o mafolofolo le ho boloka ho sebelisana pakeng tsa boko le' mele oohle. Alpha-GPC e ka senyeha ho ba 3-glycerol phosphate le choline bokong 'me ke phepelo e sebetsang ka ho fetisisa ea acetylcholine. E ka ntlafatsa mohopolo le ho ntlafatsa monahano ka ho khothaletsa motsoako le ho lokolloa ha acetylcholine bokong. Mabapi le ho ntlafatsa botsitso le metsi a lisele tsa lisele, Alpha-GPC e ka khothalletsa motsoako oa phosphoinositide, kahoo e matlafatsa botsitso le metsi a lisele tsa lisele. Li-neurone tse nang le sebopeho se felletseng li ka fetisa leseli hamolemo le ho ntlafatsa matla a 'mele a ho nahana. Sebelisa.

Sireletsa methapo

Mabaka a ho hōla ha lisele tsa methapo, e leng "neurotrophic factor", a ka laolang phapang ea lisele tsa stem le ho khothalletsa ho thehoa ha likhokahano tse ncha tsa methapo. Alpha-GPC e ka khothalletsa secretion ea mefuta e sa tšoaneng ea li-neurotrophic le ho kenya tšebetsong litsela tsa lipontšo tse amanang le ho phela ha lisele, ka hona ho fana ka phello ea neuroprotective. Ntlafatsa boemo ba 'mele ba kelello. Ka nako e ts'oanang, Alpha-GPC e ka boela ea khothalletsa secretion ea hormone ea ho hōla le ho boloka bophelo bo botle ba 'mele ka ho eketsa litekanyetso tsa hormone ea ho hōla.

Antioxidant

Oxidation le ho ruruha ke lisosa tse ka sehloohong tsa botsofali ba lisele tsa boko le lefu. Alpha-GPC e ka senya li-radicals tse sa lefelloeng 'meleng, ea loantša khatello ea oxidative, hape e ka fokotsa ho ruruha ho kang nuclear factor NF-κB, tumor necrosis factor TNF-α, le interleukin IL-6. Ho lokolloa ha lintlha ho hanyetsana le ho ruruha ha boko, ka hona ho fetola haholo ho fokotseha ha ts'ebetso ea kelello le ho thibela ho hlaha le nts'etsopele ea mafu a neurodegenerative. Liphello tse amehang li 'nile tsa tšehetsoa ke liphello tsa kliniki.

Thutong "Phello ea Alpha-GPC ka Ho Senyeha ha Memori e Amanang le Lilemo", lihlooho tsa 4 li ile tsa fuoa placebo, 'me lihlooho tse ling tsa 5 li ile tsa fuoa Alpha-GPC (1200 mg / letsatsi), ka mor'a tsamaiso ea molomo e tsoelang pele bakeng sa likhoeli tsa 3, 16. li-electrode li ne li sebelisetsoa ho rekota maqhubu a boko bakeng sa metsotso ea 5 ha bafo ba ntse ba falimehile ba bile ba phomotse. Liphetho li bonts'itse hore ha e bapisoa le placebo, Alpha-GPC e khonne ho eketsa haholo karolo ea maqhubu a boko a potlakileng, ha a ntse a e-na le tšekamelo ea ho fokotsa maqhubu a liehang. Ke hore, e ka matlafatsa matla a boko ba batho ba lilemong tse bohareng le ho liehisa ho tsofala ha 'mele.

Laola maikutlo

Dopamine e ka etsa hore batho ba ikutloe ba thabile, ’me serotonin le gamma-aminobutyric acid li ka laola maikutlo a ’mele. Alpha-GPC e ka khothalletsa ho lokolloa ha dopamine, ho phahamisa-ho laola polelo ea lipalangoang tsa dopamine, ho ntlafatsa dopamine neurotransmission bokong, le ho eketsa maemo a serotonin ho striatum le prefrontal cortex; e ka boela ea khothalletsa haholo γ- Ho lokolloa ha aminobutyric acid ho imolla ho hlobaela, ka hona ho sebelisa liphello tsa eona tse khahlanong le ho tepella maikutlo, ho imolla matšoenyeho le ho tsitsisa maikutlo.

Ho phaella moo, Alpha-GPC e boetse e bonahala e khona ho ntlafatsa ho kenngoa ha tšepe e se nang heme lijong, e tšoanang le phello ea vithamine C ka 2: 1 karo-karolelano ea tšepe, kahoo Alpha-GPC e nkoa e le, kapa bonyane kenya letsoho ho, ntlafatso ea lihlahisoa tsa nama. Phenomenon ea ho monya tšepe e sa tloaelehang. Ho feta moo, ho tlatsana le Alpha-GPC ho ka thusa le ts'ebetso ea ho chesa mafura le ho ts'ehetsa metabolism ea lipid. Sena se bakoa ke karolo ea choline joalo ka limatlafatsi tsa lipophilic. Maemo a phetseng hantle a limatlafatsi tsena a netefatsa hore li-acid tse mafura li fumaneha ho mitochondria ea sele, e ka fetolang mafura ana ho ATP kapa matla.

Lintlafatso tsa taolo

Alpha GPC esale e sebelisoa ka lilemo tse fetang 10. Hajoale, Alpha GPC ke lijo tse ncha tse tala Japane 'me hangata li sebelisoa ho nts'etsopele ea lijo tse sebetsang. Ntle le moo, United States, Canada, Switzerland le linaha tse ling li amohetse kapa li lumelletse Alpha GPC ho eketsoa lijong kamora Japane. Kwa United States, Alpha GPC e laolwa e le Sesebediswa ka Kakaretso se Tsejwang Hore se Sireletsehile (GRAS). Canada, Alpha GPC e amohetsoe e le sehlahisoa sa tlhaho sa bophelo bo botle.

Lisebelisoa tsa 'maraka le mekhoa ea lihlahisoa

Ka lebaka la boitsebiso bo sa lekaneng mabapi le polokeho ea Alpha GPC ho masea, bakhachane le basali ba anyesang, ho itšetlehile ka molao-motheo oa thibelo ea kotsi, lihlopha tse ka holimo ha lia lokela ho e ja, 'me letšoao le litaelo li lokela ho bontša sehlopha se sa lokelang. United States, Japane, Canada le linaheng tse ling, Alpha GPC e sebelisitsoe haholo lijong. Lihlahisoa tse amanang li koahela li-supplement tsa lijo, lino, li-gummies le lihlopha tse ling, 'me sehlahisoa ka seng se na le ts'ebetso e hlakileng le tšebeliso e khothalletsoang.

Bongata le lihlopha tse khothalelitsoeng. Ka mohlala, United States, ho na le li-supplement tse fetang 300 tsa lijo tsa Alpha GPC feela, tse nang le liphello tse boleloang tse kenyelletsang ho ntlafatsa mohopolo le ts'ebetso ea kelello, ho ntlafatsa mosebetsi oa motlakase, joalo-joalo Tekanyetso ea letsatsi le letsatsi ke 300-1200 mg.
Boemo ba hona joale ba theknoloji ea tlhahiso

Lipatlisiso li bontša hore motsoako oa lik'hemik'hale ke o mong oa mekhoa e ka sehloohong ea tlhahiso ea Alpha GPC. Ho sebelisa polyphosphoric acid, choline chloride, R-3-chloro-1,2-propanediol, sodium hydroxide le metsi e le thepa e tala, ka mor'a condensation le esterification reaction, e decolorized, litšila tlosoa, concentrated, hloekisoa le omisitsoeng. e ka fumanoa ka mekhoa e meng. Leha ho le joalo, motsoako oa lik'hemik'hale tse tloaelehileng, lik'hemik'hale tsa hydrolysis, lik'hemik'hale tsa joala le mekhoa e meng kaofela li tobana le mathata a kang tšilafalo ea tikoloho, litšenyehelo tse phahameng le mekhoa e rarahaneng ea ho lokisetsa.

Lilemong tsa morao tjena, ho lokisoa ha Alpha GPC ka mekhoa ea bioenzymatic ho fumane tlhokomelo e eketsehileng. Mekhoa ea enzymatic ea metsi, mekhoa ea enzymatic e seng ea metsi, joalo-joalo e hlahile ka mor'a e 'ngoe. Ha ho bapisoa le mekhoa ea lik'hemik'hale, ho lokisoa ha Alpha GPC ka mekhoa ea bioenzymatic ho na le maemo a bonolo a ho itšoara le mekhoa e bonolo. , ts'ebetso e phahameng ea catalytic mme e loketse tlhahiso e kholo ea khoebo.

Suzhou Myland Pharm & Nutrition Inc. ke moetsi ea ngolisitsoeng ke FDA ea fanang ka phofo ea Alpha GPC Supplement ea boleng bo holimo le bo hloekileng.

Ho Suzhou Myland Pharm re ikemiselitse ho fana ka lihlahisoa tsa boleng bo holimo ka litheko tse ntle. Alpha GPC Supplement ea rona ea phofo e lekoa ka matla bakeng sa bohloeki le potency, ho netefatsa hore u fumana tlatsetso ea boleng bo phahameng eo u ka e tšepang. Hore na o batla ho ts'ehetsa bophelo bo botle ba cellular, ho matlafatsa sesole sa hau sa 'mele kapa ho ntlafatsa bophelo bo botle ka kakaretso, phofo ea rona ea Alpha GPC Supplement ke khetho e phethahetseng.

Ka boiphihlelo ba lilemo tse 30 'me e susumetsoa ke thekenoloji e phahameng le maano a R&D a ntlafalitsoeng haholo, Suzhou Myland Pharm e hlahisitse lihlahisoa tse ngata tsa tlholisano mme e fetohile tlatsetso e ncha ea mahlale a bophelo, ho kopanya tloaelo le k'hamphani ea lits'ebeletso tsa tlhahiso.

Ntle le moo, Suzhou Myland Pharm le eona ke moetsi ea ngolisitsoeng ke FDA. Lisebelisoa tsa R&D tsa k'hamphani, lisebelisoa tsa tlhahiso, le lisebelisoa tsa tlhahlobo ke tsa sejoale-joale ebile li na le mesebetsi e mengata, 'me li ka hlahisa lik'hemik'hale ho tloha ho limiligrama ho isa ho lithane ka tekanyo,' me li lumellana le litekanyetso tsa ISO 9001 le litlhaloso tsa tlhahiso ea GMP.

Alpha GPC e tsejoa e le hygroscopic, ho bolelang hore e monya mongobo moeeng o potolohileng. Ka lebaka lena, li-supplement li lokela ho bolokoa ka har'a lijana tse sa keneleng moea 'me ha lia lokela ho pepesetsoa moea nako e telele.

Mehopolo ea ho qetela

Alpha GPC e sebelisoa ho isa choline bokong ho pholletsa le mokoallo oa mali le boko. Ke selelekela sa acetylcholine, neurotransmitter e khothalletsang bophelo bo botle ba kelello. Lisebelisoa tsa Alpha GPC li ka sebelisoa ho thusa bophelo bo botle ba kelello ka ho ntlafatsa mohopolo, ho ithuta le ho tsepamisa mohopolo. Lipatlisiso li boetse li bontša hore Alpha GPC e thusa ho eketsa matla a 'mele le matla a mesifa.