Lilemong tsa morao tjena, ho bile le thahasello e ntseng e eketseha ea metsoako ea tlhaho e ka ntlafatsang bophelo bo botle le bophelo bo botle ka kakaretso. Urolithin A le urolithin B ke metsoako e 'meli ea tlhaho e tsoang ho ellagitannins e fumanoang litholoana le linate tse itseng. Lintho tsa bona tse khahlanong le ho ruruha, li-antioxidant, le ho haha mesifa li etsa hore e be metsoako e thahasellisang bakeng sa ho khothalletsa bophelo bo botle ka kakaretso. Leha urolithin A le urolithin B li na le thepa e amanang, li boetse li na le liphapang tse kholo.
Urolithin A le B ke li-metabolite tse hlahisoang ka tlhaho ka har'a 'mele oa motho ka lebaka la tšilo ea likarolo tse itseng tsa lijo, haholo-holo ellagitannins. Ellagitannins e teng litholoana le linate tse fapaneng, ho kenyelletsa likharenate, fragole, li-raspberries, li-blackberries le walnuts. Leha ho le joalo, ke karolo e nyane feela ea baahi e nang le baktheria ea mala e khonang ho fetola ellagitannins hore e be urolithin, e leng se etsang hore maemo a urolithin ho batho a fetohe haholo.
Bakeng sa ba nang le bothata ba ho fihlela litlhoko tsa bona tsa magnesium ka lijo feela, li-supplement tsa magnesium li ka thusa bophelo bo botle ka litsela tse 'maloa' me tsa tla ka mefuta e kang magnesium oxide, magnesium threonate, magnesium taurate, le magnesium glycinate. Leha ho le joalo, ho khothalletsoa ho buisana le setsebi sa tlhokomelo ea bophelo pele u qala mokhoa leha e le ofe oa tlatsetso ho qoba litšebelisano tse ka bang teng kapa mathata.
Urolithin A ke molek'hule e ngata ka ho fetisisa lelapeng la urolithin, 'me thepa ea eona ea antioxidant le anti-inflammatory e ithutile hantle. Liphuputso li bontšitse hore urolithin A e ka ntlafatsa mosebetsi oa mitochondrial le ho thibela tšenyo ea mesifa. Ho feta moo, liphuputso li bontšitse hore urolithin A e ka thibela ho ata ha lisele le ho baka lefu la lisele meleng e fapaneng ea lisele tsa mofetše.
Urolithin B e hohetse tlhokomelo ea bafuputsi ka bokhoni ba eona ba ho ntlafatsa bophelo bo botle ba mala le ho fokotsa ho ruruha. Patlisiso e bonts'a hore urolithin B e ka ntlafatsa phapano ea likokoana-hloko tsa mala le ho fokotsa li-cytokine tsa pro-inflammatory joalo ka interleukin-6 le tumor necrosis factor alpha. Ho feta moo, ho fumanoe hore urolithin B e na le lintho tse ka sireletsang methapo ea kutlo, 'me liphuputso li bontša hore e ka thusa ho thibela mafu a neurodegenerative a kang Parkinson's le Alzheimer's.
Leha urolithin A le urolithin B li na le thepa e amanang, li na le liphapano tse itseng tse kholo. Ka mohlala, urolithin A e bontšitsoe hore e sebetsa haholo e le e khahlanong le ho ruruha le antioxidant ho feta urolithin B. Urolithin B, ka lehlakoreng le leng, e fumanoe e sebetsa hantle ho thibela mathata a amanang le botenya, a kang ho hanyetsa insulin le adipocyte. karohano.
Mekhoa ea ts'ebetso ea urolithin A le urolithin B le eona e fapane. Urolithin A e kenya tšebetsong tsela ea peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1α) tsela, e bapalang karolo ho mitochondrial biogenesis, ha urolithin B e ntlafatsa tsela ea AMP-activated protein kinase (AMPK), e amehang ho matla a homeostasis. Litsela tsena li kenya letsoho liphellong tse molemo tsa bophelo bo botle ba metsoako ena.
●Anti-inflammatory Properties
Ho ruruha ho sa foleng ho tsejoa ho kenya letsoho mafung a 'maloa. Urolithin A e bontšitsoe hore e na le thepa e matla e thibelang ho ruruha, e fokotsang tlhahiso ea limolek'hule tsa ho ruruha. Ka ho hatella ho ruruha, e ka thusa ho laola maemo a fapaneng a sa foleng a kang ramatiki, lefu la pelo le mefuta e meng ea mofetše.
●Bophelo bo Botle ba Mesifa le Matla
Ha re ntse re hōla, tahlehelo ea mesifa ea masapo e fetoha ntho e amehang haholo. Urolithin A e fumanoe e susumetsa kholo ea lisele tsa mesifa le ho ntlafatsa ts'ebetso ea mesifa, ho khothalletsa bophelo bo botle ba mesifa le matla. Sena se na le ts'episo bakeng sa batho ba batlang ho boloka boima ba mesifa le ho loants'a ho fokotseha ho amanang le lilemo.
●Bophelo bo Botle ba Mitochondrial le Bophelo bo Bolelele
Urolithin A e bonts'a litlamorao tse matla ho mitochondria, eo hangata e bitsoang matlo a matla a lisele tsa rona. E baka ts'ebetso e bitsoang mitophagy, e kenyelletsang ho tlosoa ha mitochondria e senyehileng. Ka ho khothaletsa ts'ebetso ea mitochondrial e phetseng hantle, urolithin A e ka kenya letsoho ho phela nako e telele le ho sireletsa khahlanong le maemo a amanang le botsofali joalo ka mafu a neurodegenerative.
●Ts'ebetso ea Antioxidant
Urolithin B ke antioxidant e matla e thusang ho fokotsa li-radicals tsa mahala tse kotsi 'meleng. Li-radicals tsa mahala ke limolek'hule tse sebetsang haholo tse ka tlatsetsang ho senyeha ha lisele le khatello ea oxidative, e amehang maloetseng a sa tšoaneng. Tšebetso ea antioxidant ea Urolithin B e thusa ho sireletsa lisele tsa rona khahlanong le tšenyo e joalo 'me e ka fokotsa kotsi ea mafu a sa foleng.
●Gut Health le Microbiome Modulation
Mala a rona a phetha karolo ea bohlokoa bophelong ba rona ka kakaretso, 'me urolithin B e hlahile e le karolo ea bohlokoa ea ho boloka microbiome e phetseng hantle ea mala. E khothalletsa kholo ea molemolibaktheria tsa cial le ho thibela ho hōla ha libaktheria tse kotsi, kahoo ho khothalletsa tikoloho e leka-lekaneng ea likokoana-hloko. Microbiome e nepahetseng ea mala e amahanngoa le tšilo ea lijo e ntlafalitsoeng, ts'ebetso ea 'mele ea ho itšireletsa mafung, le bophelo bo botle ba kelello.
●Khothaletsa bophelo bo botle ba mesifa
Urolithin B e bontšitsoe ho susumetsa mitochondrial autophagy, mokhoa oa cellular o thusang ho tlosa mitochondria e senyehileng liseleng. Ts'ebetso ena e thusa ho ntlafatsa bophelo bo botle ba mesifa le ts'ebetso, e etsa hore e be tlatsetso e ka bang teng ho ba batlang ho ntlafatsa ts'ebetso ea 'mele. Phuputso e 'ngoe e fumane hore urolithin B e ntlafatsa ts'ebetso ea mesifa le matla ho litoeba le batho.
Urolithin e hlahisoa 'meleng ea rona ka mor'a ho ja lijo tse itseng tse nang le ellagitannins.Mehloli e meholo ea lijo ea ellagitannins e kenyelletsa:
a) Likharenate
Likharenate ke e 'ngoe ea mehloli ea lijo tse ruileng ka ho fetisisa ea ellagitannins, e fetoloang urolithin A le urolithin B ke libaktheria tsa mala. Ho ja tholoana ea kharenate, lero kapa li-extracts ho ka matlafatsa ho ja ha metsoako ena e matla, ho matlafatsa bophelo bo botle ba lisele le ho ba le liphello tse khahlanong le ho ruruha.
b) monokotsoai
Menokotšoai e fapa-fapaneng e kang fragole, li-raspberries le li-blackberries li na le li-ellagitannins tse ngata. Liphuputso li bontšitse hore ho ja litholoana tsena tse mahlahahlaha ho khothalletsa tlhahiso ea urolithin A le urolithin B ka maleng. Ho kenya monokotsoai lijong tsa hau ha ho ntlafatse tatso feela empa hape ho fana ka melemo e ka bang teng ea nako e telele ea bophelo bo botle.
c) Linate
Linate, haholo-holo walnuts le pecans, ke mehloli e ruileng ea ellagitannins. Ho feta moo, li na le mafura a phetseng hantle, fiber le limatlafatsi tse ling tsa bohlokoa. Ho kenyelletsa linate lijong tsa hau tsa letsatsi le letsatsi ha ho fane ka urolithin A le B feela empa hape ho fana ka melemo e mengata ea bophelo bo botle bakeng sa pelo, boko le bophelo bo botle ka kakaretso.
d) Liveine tsa khale tsa Oak
Leha ho ka makatsa, tšebeliso e itekanetseng ea veine e khubelu ea khale ea oak le eona e ka tlatsetsa tlhahisong ea urolithin. Metsoako e teng ka har'a libarele tsa oak tse sebelisoang ho tsofala veine e ka ntšoa nakong ea botsofali, e tšela veine ka ellagitannins. Leha ho le joalo, ke habohlokoa ho hopola hore ho noa joala ho tlōla ho na le liphello tse mpe tsa bophelo bo botle, kahoo ho lekanyetsa ke ntho ea bohlokoa.
e) Limela tse ruileng tsa Ellagitannin
Haufi le likharenate, limela tse ling tse kang makhapetla a oak, fragole le makhasi a oak ka tlhaho li ngata ka ellagitannins. Ho kenyelletsa limela tsena lijong tsa hau ho ka thusa ho eketsa maemo a urolithin A le urolithin B 'meleng oa hau, ho ts'ehetsa bophelo bo botle ba cellular le ho ntlafatsa bophelo bo botle ka kakaretso.
Ho kenyelletsaurolithin A le B bophelong ba hau, mokhoa o le mong o bonolo ke ho ja lijo tse nang le li-ellagitannins tse ngata. Likharenate, fragole, raspberries le walnuts ke mehloli e babatsehang.
Leha ho le joalo, ke habohlokoa ho hlokomela hore litaba tsa ellagitannin li fapana ka har'a tholoana e 'ngoe le e' ngoe, 'me hase bohle ba nang le gut microbiota e tšoanang e khonang ho fetola ellagitannins ho urolithins. Ka hona, batho ba bang ba ka 'na ba se ke ba hlahisa urolithin hantle ho tsoa mehloling ena ea lijo. li-supplement ke khetho e 'ngoe ea ho netefatsa ho noa ka ho lekaneng ha urolithin A le B.
P: Urolithin A le Urolithin B li khothalletsa bophelo bo botle ba mitochondrial joang?
A: Urolithin A le Urolithin B li kenya tšebetsong tsela ea cellular e bitsoang mitophagy, e ikarabellang bakeng sa ho tlosa mitochondria e senyehileng liseleng. Ka ho khothaletsa mitophagy, metsoako ena e thusa ho boloka bophelo bo botle ba mitochondrial, bo bohlokoa bakeng sa tlhahiso ea matla le ts'ebetso ea cellular ka kakaretso.
P: Na Urolithin A le Urolithin B li ka fumanoa ka li-supplement?
A: E, li-supplement tsa Urolithin A le Urolithin B lia fumaneha 'marakeng. Leha ho le joalo, ke habohlokoa ho hlokomela hore katleho le polokeho ea lisebelisoa tsena li ka fapana. Ho kgothaletswa ho buisana le setsebi sa tlhokomelo ya bophelo pele o qala disebediswa leha e le dife tse ncha tsa dijo.
Boitlhotlhollo: Sengoliloeng sena ke sa merero ea tlhahisoleseling feela mme ha sea lokela ho nkuoa e le keletso ea bongaka. Kamehla buisana le setsebi sa tlhokomelo ea bophelo pele u sebelisa li-supplement kapa ho fetola mokhoa oa hau oa tlhokomelo ea bophelo.
Nako ea poso: Sep-13-2023
