Urolithin A ke metsoako ea tlhaho eo e leng metsoako ea metabolite e hlahisoang ke libaktheria tsa mala tse fetolang ellagitannins ho ntlafatsa bophelo bo botle boemong ba lisele. Urolithin B e fumane tlhokomelo ea bafuputsi ka bokhoni ba eona ba ho ntlafatsa bophelo bo botle ba mala le ho fokotsa ho ruruha. Urolithin A le urolithin B li na le thepa e amanang, empa li na le liphapang tse itseng. Ke liphapang life tse khethehileng tseo u li etsang, a re boneng!
Lilemong tsa morao tjena, bo-rasaense ba ntse ba ithuta melemo ea bophelo bo botle ea urolithin, motsoako oa tlhaho oo e leng motsoako oa metabolite o hlahisoang ke phetoho ea ellagitannins ke libaktheria tsa mala. Li-precursors tsa eona ke ellagic acid le ellagitannins, tse hlahang ka tlhaho mehloling e mengata ea lijo tse kang kharenate, guava, tee, pecans, linate le monokotsoai o kang fragole, li-raspberries tse ntšo le li-blackberries. Ho phaella moo, urolithin A, polyphenol ea tlhaho, e thahasella e le moemeli ea matla oa antioxidant le anti-inflammatory o nang le melemo ea bophelo bo botle.
Slithuto tse batlisisang the liphello tsa UA mesebetsing ea cellular le litsela tsa likokoana-hloko li bontšitse hore e na le mekhoa e mengata ea liketso. Liphuputso li boetse li fumane hore UA e etsa hore mitochondrial autophagy e sebetse, e leng mokhoa o tlosang mitochondria e senyehileng seleng le ho ntlafatsa tlhahiso ea matla. Ketso ena e bohlokoa haholo ho mafu a amanang le botsofali, kaha mitochondria e sa sebetseng e lebisa ho bokelleng ha khatello ea oxidative le ho ruruha. UA e boetse e laola polelo ea liphatsa tsa lefutso tse amehang karabelong ea khatello ea oxidative, tokiso ea DNA le apoptosis, tse bohlokoa bakeng sa ho boloka botšepehi ba lisele le ho thibela mofetše.
E 'ngoer tšobotsi e thahasellisang ea UA kebokhoni ba eona e le senescence scavenger, e leng se bolelang hore e ka khetha ho susumetsa apoptosis ka lisele tse senescent, e leng lisele tse senyehileng tse seng li sa arohane empa li ntša lintho tse kotsi tse lematsang lisele le lisele tsa boahelani. Lisele tsa senescent li amahanngoa le mafu a sa tšoaneng a amanang le botsofali, a kang ramatiki, atherosclerosis le neurodegeneration. Ka ho khetha ho felisa lisele tsena, UA e ka lieha kapa ea thibela ho qala ha mafu ana le ho ntlafatsa bophelo bo botle ka kakaretso.
Urolithins ke sehlopha sa metsoako e tsejoang e le ellagitannin metabolites, e hlahisoang haholo ke gut microbiota. Har'a tsona, limolek'hule tse peli, urolithin A le urolithin B, li fumane tlhokomelo e kholo bakeng sa melemo ea tsona ea bophelo bo botle. Metsoako ena e fumanoa litholoana tse fapa-fapaneng tse kang likharenate, fragole le li-raspberries. Ho blog ena, re tla shebisisa litšobotsi tse amanang le urolithin A le urolithin B.
Urolithin A ke molek'hule e ngata ka ho fetisisa ea lelapa la urolithin, 'me e se e batlisisitsoe hantle bakeng sa thepa ea eona ea antioxidant le e khahlanong le ho ruruha. Ho feta moo, liphuputso li bontšitse hore UA e ka ntlafatsa mosebetsi oa mitochondrial le ho thibela tšenyo ea mesifa. UA e boetse e tsejoa ka matla a eona a ho thibela mofetše. Patlisiso e bonts'itse hore UA e ka thibela ho ata ha lisele le ho baka lefu la lisele meleng e fapaneng ea mofetše, ho kenyeletsoa tšoelesa ea senya, matsoele le mofetše oa mala.
Ka lehlakoreng le leng, urolithin B e hapile tlhokomelo ea bafuputsi bakeng sa bokhoni ba eona ba ho ntlafatsa bophelo bo botle ba mala le ho fokotsa ho ruruha. Boithuto bo bonts'itse hore UB e ka ntlafatsa phapano ea likokoana-hloko tsa mala le ho fokotsa li-cytokine tsa pro-inflammatory, joalo ka interleukin-6 le tumor necrosis factor-alpha. Ho feta moo, UB e boetse e sibollotsoe e na le thepa e ka sireletsang methapo ea kutlo, kaha lithuto li bontšitse hore e ka thusa ho thibela mafu a neurodegenerative a kang Parkinson's le Alzheimer's.
Leha ho na le thepa e amanang le eona, UA le UB li na le liphapang tse ikhethang. Mohlala, UA e bonts'itsoe e le matla haholo joalo ka anti-inflammatory le antioxidant ho feta UB. Ka lehlakoreng le leng, UB e fumanoe e sebetsa haholo ho thibela mathata a amanang le botenya, joalo ka ho hanyetsa insulin le phapang ea adipocyte. Ho feta moo, ho fapana le UA, UB ha e so ithutoe haholo joalo ka moemeli oa anti-cancer.
Mokhoa oa ts'ebetso oa UA le UB le ona o fapane. UA e kenya tšebetsong tsela ea Peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1α) tsela, e bapalang karolo ho mitochondrial biogenesis, ha UB e ntlafatsa tsela ea AMP-activated protein kinase (AMPK), e amehang ho matla a homeostasis. Litsela tsena li kenya letsoho liphellong tse molemo tsa metsoako ena bophelong bo botle.
Leha ho na le melemo e khahlisang ea UA le UB, ho ntse ho na le meeli ts'ebelisong ea bona. Mohlala, bioavailability ea metsoako ena e ntse e le tlase, 'me pharmacokinetics ea bona ha e utloisisoe hantle. Ho feta moo, phello ea metsoako ena bathong e sa ntse e tla hlakisoa ka botlalo, kaha liphuputso tse ngata li entsoe ka in vitro kapa mehlala ea liphoofolo. Leha ho le joalo, lipatlisiso tse seng li ntse li le teng li fana ka maikutlo a hore UA le UB e ka ba batho ba tšepisang ho hlahisa lijo tse sebetsang kapa li-supplement ho tšehetsa bophelo bo botle ka kakaretso le ho thibela maloetse.
Urolithin A. Molek'hule ona o monyenyane o fumanoang ka tlhaho litholoanang le linate tse itseng o tumme ka lebaka la bokhoni ba oona ba ho ntlafatsa ntho e 'ngoe le e' ngoe ho tloha khōlong ea mesifa ho ea ho ts'ebetso ea boko. Urolithin A ke metabolite, e bolelang hore ke sehlahisoa sa metsoako e meng 'meleng. Ka ho khetheha, e hlahisoa ha libaktheria tsa mala li senya ellagitannins, tse fumanoang lijong tse itseng tse kang likharenate, fragole le walnuts. Empa mona ke karolo e thahasellisang: hase bohle ba nang le libaktheria tsa mala tse hlokahalang ho hlahisa urolithin A. Ha e le hantle, liphuputso li bontšitse hore ke batho ba ka bang 30-50% feela ba ka hlahisang molek'hule ena ka tlhaho. Mona ke moo li-supplement li tlang teng.
Kahoo, ke engmelemo ea urolithin A? Hantle, e 'ngoe ea lipolelo tse kholo ka ho fetisisa ke hore e ka thusa ho ntlafatsa bophelo bo botle ba mesifa. Phuputso e phatlalalitsoeng koranteng ea Nature Medicine e fumane hore ha likhoto li fuoa urolithin A, li ne li e-na le keketseho ea 42% ea mamello le keketseho ea 70% ea mesifa ea mesifa. Leha liphetho tsena ehlile li khahla, ho bohlokoa ho hlokomela hore ena e ne e le phuputso e nyane mme ho hlokahala lipatlisiso tse ngata ho netefatsa liphumano tsena bathong.
Empa ha se sona feela seo urolithin A ho thoeng e se etsa. E boetse e bontšitsoe ho ntlafatsa mosebetsi oa mitochondrial. Ha e le hantle, mitochondria ke limela tsa matla tsa lisele, tse ikarabellang bakeng sa ho hlahisa matla ao 'mele o ka o sebelisang. Ha re ntse re hōla, mosebetsi oa rona oa mitochondrial o qala ho fokotseha, e leng se ka lebisang mathateng a mangata a bophelo bo botle. Leha ho le joalo, lipatlisiso tsa pele li fana ka maikutlo a hore urolithin A e ka thusa ho liehisa ho theoha hona, ho ka ntlafatsa bophelo bo botle ka kakaretso le ho lelefatsa nako ea bophelo.
Joalokaha eka seo ha sea lekana, urolithin A e boetse e bontšitsoe hore e na le melemo ea kelello. Phuputso e phatlalalitsoeng koranteng ea Scientific Reports e fumane hore ha likhoto li fuoa urolithin A, mohopolo oa tsona le bokhoni ba ho ithuta bo ile ba ntlafala. Bafuputsi ba lumela hore sena se ka bakoa ke litlamorao tsa molek'hule tse thibelang ho ruruha, tse thusang ho sireletsa lisele tsa boko hore li se ke tsa senyeha.
Urolithin B, motsoako o fumanehang ka har'a monokotsoai le likharenate tse fapaneng, o tsejoa ka melemo ea ona e ka bang teng ho ntlafatseng bophelo ba metabolism le ho lelefatsa bophelo. Liphuputso tsa morao-rao li bontšitse hore urolithin B e na le thepa e khahlanong le ho ruruha le ea antioxidant e ka thusang ho thibela maloetse a sa foleng le ho ntlafatsa bophelo bo botle ka kakaretso.
1. Lintho tse khahlanong le ho ruruha
Ho ruruha ho sa foleng ke sesosa se ka sehloohong sa mafu a mangata, ho akarelletsa lefu la pelo, lefu la tsoekere le kankere. Urolithin B e na le thepa e khahlanong le ho ruruha e thusang ho fokotsa ho ruruha 'meleng, kahoo e fokotsa kotsi ea lefu le sa foleng. Phuputso e 'ngoe e fumane hore urolithin B e fokolitse ho ruruha ha litoeba tse nang le lefu la ho ruruha ha mala, ho fana ka maikutlo a bokhoni ba eona ba ho phekola batho ba nang le mafu a tšoanang.
2. Antioxidant thepa
Urolithin B ke antioxidant e matla, e bolelang hore e ka thusa ho sireletsa 'mele khatellong ea oxidative, ts'ebetso e senyang lisele le ho khothaletsa botsofali. Urolithin B e thusa ho thibela tšenyo ea oxidative ka ho fokotsa li-radicals tsa mahala, tse ka bakang tšenyo ea lisele le ho baka mafu a sa foleng. Phuputso e 'ngoe e fumane hore urolithin B e fokolitse khatello ea oxidative ho litoeba, e tsoela pele ho tšehetsa bokhoni ba eona e le tlatsetso e thibelang botsofali.
3. Khothaletsa bophelo bo botle ba mesifa
Urolithin B e bontšitsoe ho susumetsa mitochondrial autophagy, mokhoa oa cellular o thusang ho tlosa mitochondria e senyehileng liseleng. Ts'ebetso ena e thusa ho ntlafatsa bophelo bo botle ba mesifa le ts'ebetso, e etsa hore e be tlatsetso e ka bang teng ho ba batlang ho ntlafatsa ts'ebetso ea 'mele. Phuputso e 'ngoe e fumane hore urolithin B e ntlafatsa ts'ebetso ea mesifa le matla ho litoeba le batho.
4. E tšehetsa bophelo bo botle ba kelello
Urolithin B e bontšitsoe ho tšehetsa bophelo bo botle ba kelello ka ho khothalletsa neuroplasticity, mokhoa o thusang boko ho ikamahanya le boitsebiso bo bocha 'me o ka ntlafatsa ts'ebetso ea kelello. Phuputso e 'ngoe e fumane hore urolithin B e ntlafalitse ts'ebetso ea kelello le ho ntlafatsa mohopolo ho likhoto.
5. Melemo e ka bang teng ea ho phela nako e telele
Liphuputso tsa morao-rao li bontšitse hore urolithin B e na le monyetla oa ho khothalletsa bophelo bo bolelele ka ho ntlafatsa bophelo bo botle ba metabolism, ho fokotsa ho ruruha, le ho sireletsa khahlanong le khatello ea oxidative. Phuputso e 'ngoe e fumane hore urolithin B e ekelitse nako ea bophelo ho C. elegans, mofuta oa seboko sa nematode, e tšehetsang melemo e ka bang teng bakeng sa ho khothalletsa bophelo bo bolelele.
1. Kharenate
Kharenate ke e 'ngoe ea mehloli e molemo ka ho fetisisa ea urolithin. Bafuputsi ba fumane hore lero la kharenate le ka eketsa maemo a mali a urolithin A le B. Ho phaella moo, likharenate li na le melemo e meng ea bophelo bo botle, ho akarelletsa le thepa e khahlanong le ho ruruha le ea antioxidant.
2. monokotsoai
Monokotšoai o kang fragole, raspberries le blackberries le tsona ke mehloli e metle ea urolithin. Liphuputso li bontšitse hore ho noa monokotšoai ho ka eketsa maemo a mali a urolithin A le B.
3. Linate
Li-walnuts le li-pecans le linate tse ling le tsona ke mohloli o motle oa urolithin. Phuputso e fumane hore ho sebelisoa ha linate ho tla eketsa boemo ba urolithin A le B maling.
Urolithin A le B ke metsoako ea tlhaho e teng lijong tse itseng, e na le melemo e mengata ea bophelo bo botle. Metsoako ena e na le thepa e khahlanong le ho ruruha, e ntlafatsa bophelo ba mitochondrial le mesifa, 'me e khothalletsa bophelo bo botle ba kelello. Likharenate, monokotsoai, linate le li-supplement tsa ellagitannin ke tse ling tsa mehloli e molemo ka ho fetisisa ea lijo e ka fanang ka urolithin. Ho kenyelletsa lijo tsena lijong tsa hau ho ka u thusa ho notlolla melemo ea urolithin A le B le ho khothaletsa botsofali bo botle.
Nako ea poso: Jun-05-2023
