Urolithin A ke metsoako ea tlhaho e leng metsoako ea metabolite e hlahisoang ke libaktheria tsa mala tse fetolang li-ellagitannins ho ntlafatsa bophelo bo botle boemong ba sele. Urolithin B e hapile tlhokomelo ea bafuputsi ka bokhoni ba eona ba ho ntlafatsa bophelo bo botle ba mala le ho fokotsa ho ruruha. Urolithin A le urolithin B li na le thepa e amanang, empa li na le liphapang tse itseng tse fapaneng. Ha re fumaneng liphapang tse tobileng ke life!
Lilemong tsa morao tjena, bo-rasaense ba ntse ba ithuta melemo ea bophelo bo botle ea urolithin, motsoako oa tlhaho oo e leng motsoako oa metabolite o hlahisoang ke phetoho ea ellagitannins ke libaktheria tsa mala. Lintho tse tlang pele ho eona ke ellagic acid le ellagitannins, tse hlahang ka tlhaho mehloling e 'maloa ea lijo joalo ka kharenate, guava, tee, pecans, linate le monokotšoai joalo ka fragole, raspberry tse ntšo le monokotšoai o motšo. Ho phaella moo, urolithin A, polyphenol ea tlhaho, e ea thahasellisa e le antioxidant e matla le moemeli oa ho thibela ho ruruha o nang le melemo e metle ea bophelo bo botle.
Slithuto tse batlisisang thLitlamorao tsa UA mesebetsing ea sele le litseleng tsa baeloji li bontšitse hore e na le mekhoa e mengata ea ts'ebetso. Lithuto li boetse li fumane hore UA e kenya tšebetsong autophagy ea mitochondrial, e leng ts'ebetso e tlosang mitochondria e senyehileng sele le ho ntlafatsa tlhahiso ea matla. Ketso ena e amana haholo le mafu a amanang le botsofali, kaha mitochondria e sa sebetseng hantle e lebisa ho bokellaneng ha khatello ea oxidative le ho ruruha. UA e boetse e laola polelo ea liphatsa tsa lefutso tse amehang karabelong ea khatello ea oxidative, tokiso ea DNA le apoptosis, e leng tsa bohlokoa bakeng sa ho boloka botšepehi ba sele le ho thibela mofetše.
E 'ngoeKarolo e khahlisang ea UA kebokgoni ba yona e le sebolaya-botsofali, ho bolelang hore e ka baka apoptosis ka boikgethelo diseleng tse seng di hodile, e leng disele tse senyehileng tse seng di sa arohane empa di ntsha dintho tse kotsi tse lematsang disele le dinama tse haufi. Disele tse seng di hodile di amana le mafu a fapaneng a amanang le botsofali, a kang ramatiki, atherosclerosis le neKa ho felisa lisele tsena ka mokhoa o ikhethileng, UA e ka liehisa kapa ea thibela ho qala ha mafu ana le ho ntlafatsa bophelo bo botle ka kakaretso.
Li-Urolithin ke sehlopha sa metsoako e tsejoang e le ellagitannin metabolites, e hlahisoang haholo ke gut microbiota. Har'a tsona, limolek'hule tse peli, urolithin A le urolithin B, li fumane tlhokomelo e kholo ka lebaka la melemo ea tsona ea bophelo bo botle. Metsoako ena e fumanoa litholoana tse fapaneng tse kang likharenate, fragole le raspberry. Ho blog ena, re tla shebisisa haufi-ufi thepa e amanang le urolithin A le urolithin B.
Urolithin A ke molek'hule e ngata ka ho fetisisa lelapeng la urolithin, 'me e entsoe lipatlisiso tse ntle ka lebaka la thepa ea eona ea antioxidant le anti-inflammatory. Ho feta moo, lithuto li bontšitse hore UA e ka ntlafatsa ts'ebetso ea mitochondrial le ho thibela tšenyo ea mesifa. UA e boetse e tsejoa ka thepa ea eona e ka bang teng ea ho loantša kankere. Lipatlisiso li bontšitse hore UA e ka thibela ho ata ha lisele le ho baka lefu la lisele mefuteng e fapaneng ea lisele tsa kankere, ho kenyeletsoa lisele tsa kankere ea prostate, ea matsoele le ea mala.
Ka lehlakoreng le leng, urolithin B e hapile tlhokomelo ea bafuputsi ka bokhoni ba eona ba ho ntlafatsa bophelo bo botle ba mala le ho fokotsa ho ruruha. Lithuto li bontšitse hore UB e ka ntlafatsa mefuta-futa ea likokoana-hloko tsa mala le ho fokotsa li-cytokine tse bakang ho ruruha, tse kang interleukin-6 le tumor necrosis factor-alpha. Ho feta moo, UB e boetse e fumanoe e na le litšobotsi tse ka sireletsang methapo ea kutlo, kaha lithuto li bontšitse hore e ka thusa ho thibela mafu a ho senyeha ha methapo a kang Parkinson's le Alzheimer's.
Ho sa tsotellehe litšobotsi tsa tsona tse amanang, UA le UB li na le liphapang tse itseng tse hlokomelehang. Mohlala, UA e bontšitsoe e le matla haholo e le moemeli oa ho thibela ho ruruha le oa antioxidant ho feta UB. Ka lehlakoreng le leng, UB e fumanoe e sebetsa hantle ho thibeleng mathata a amanang le botenya, joalo ka ho hanyetsa insulin le ho fapana ha mafura. Ho feta moo, ho fapana le UA, UB ha e so ithutiloe ka botlalo e le moemeli oa ho thibela kankere.
Mokhoa oa tšebetso bakeng sa UA le UB le oona o fapane. UA e kenya tšebetsong tsela ea Peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1α), e bapalang karolo ho mitochondrial biogenesis, ha UB e ntlafatsa tsela ea AMP-activated protein kinase (AMPK), e amehang ho homeostasis ea matla. Litsela tsena li kenya letsoho liphellong tse molemo tsa metsoako ena bophelong bo botle.
Ho sa tsotellehe melemo e thabisang ea UA le UB, ho ntse ho e-na le meeli tšebelisong ea tsona. Mohlala, ho fumaneha ha metsoako ena ho ntse ho le tlase haholo, 'me pharmacokinetics ea eona ha e so utloisisoe hantle. Ho feta moo, phello ea metsoako ena ho batho ha e so hlakisoe ka botlalo, kaha lithuto tse ngata li entsoe ka har'a vitro kapa mehlaleng ea liphoofolo. Leha ho le joalo, lipatlisiso tse teng li bontša hore UA le UB e ka ba bakhethoa ba tšepisang ba ho nts'etsapele lijo tse sebetsang kapa li-supplement ho tšehetsa bophelo bo botle ka kakaretso le ho thibela mafu.
Urolithin A. Molek'hule ena e nyane e fumanoang ka tlhaho litholoana le linate tse itseng e tumme ka bokhoni ba eona ba ho ntlafatsa ntho e 'ngoe le e 'ngoe ho tloha kholong ea mesifa ho ea ts'ebetsong ea boko. Urolithin A ke metabolite, e bolelang hore ke sehlahisoa sa metsoako e meng 'meleng. Haholo-holo, e hlahisoa ha libaktheria tsa mala li qhaqha li-ellagitannins, tse fumanoang lijong tse itseng tse kang likharenate, fragole le linate. Empa karolo e khahlisang ke ena: ha se motho e mong le e mong ea nang le libaktheria tsa mala tse hlokahalang ho hlahisa urolithin A. Ha e le hantle, lithuto li bontšitse hore ke batho ba ka bang 30-50% feela ba ka hlahisang molek'hule ena ka tlhaho. Mona ke moo li-supplement li thusang.
Joale, ke engMelemo ea urolithin A ke efe? E 'ngoe ea lipolelo tse kholo ka ho fetisisa ke hore e ka thusa ho ntlafatsa bophelo bo botle ba mesifa. Phuputso e phatlalalitsoeng koranteng ea Nature Medicine e fumane hore ha litoeba li fuoa urolithin A, li bile le keketseho ea 42% ea mamello le keketseho ea 70% ea boima ba mesifa. Le hoja liphetho tsena li hlile li khahla, hoa bohlokoa ho hlokomela hore ena e ne e le phuputso e nyane 'me ho hlokahala lipatlisiso tse ling ho netefatsa liphuputso tsena ho batho.
Empa ha se sona feela seo ho thoeng urolithin A e se etsang. E boetse e bontšitsoe e ntlafatsa ts'ebetso ea mitochondrial. Mitochondria ha e le hantle ke litsi tsa matla tsa lisele, tse ikarabellang bakeng sa ho hlahisa matla ao 'mele o ka a sebelisang. Ha re ntse re tsofala, ts'ebetso ea rona ea mitochondrial e qala ho fokotseha, e leng se ka lebisang mathateng a mangata a bophelo bo botle. Leha ho le joalo, lipatlisiso tsa pele li bontša hore urolithin A e ka thusa ho liehisa ho fokotseha hona, e leng se ka ntlafatsang bophelo bo botle ka kakaretso le ho lelefatsa nako ea bophelo.
Joalokaha eka seo ha sea lekana, urolithin A le eona e bontšitsoe e na le melemo ea kelello. Phuputso e phatlalalitsoeng koranteng ea Scientific Reports e fumane hore ha litoeba li fuoa urolithin A, bokhoni ba tsona ba ho hopola le ho ithuta bo ile ba ntlafala. Bafuputsi ba lumela hore sena se ka 'na sa bakoa ke liphello tsa molek'hule khahlanong le ho ruruha, tse thusang ho sireletsa lisele tsa boko tšenyong.
Urolithin B, motsoako o fumanoang monokotšoai le likharenate tse fapaneng, o tsebahala ka melemo ea oona e ka bang teng ho ntlafatseng bophelo bo botle ba 'mele le ho lelefatsa nako ea bophelo. Lithuto tsa morao tjena li bontšitse hore urolithin B e na le thepa ea ho thibela ho ruruha le ea antioxidant e ka thusang ho thibela mafu a sa foleng le ho ntlafatsa bophelo bo botle ka kakaretso.
1. Litšobotsi tsa ho thibela ho ruruha
Ho ruruha ho sa foleng ke sesosa se seholo sa mafu a mangata, ho kenyeletsoa lefu la pelo, lefu la tsoekere le kankere. Urolithin B e na le thepa ea ho thibela ho ruruha e thusang ho fokotsa ho ruruha 'meleng, ka hona e fokotsa kotsi ea lefu le sa foleng. Phuputso e 'ngoe e fumane hore urolithin B e fokotsa ho ruruha haholo ho litoeba tse nang le lefu la ho ruruha ha mala, e leng se bontšang hore e ka ba le katleho e kholo ho phekoleng batho ba nang le mafu a tšoanang.
2. Thepa ea Antioxidant
Urolithin B ke antioxidant e matla, e bolelang hore e ka thusa ho sireletsa 'mele khatellong ea oxidative, e leng ts'ebetso e senyang lisele le ho khothalletsa ts'ebetso ea botsofali. Urolithin B e thusa ho thibela tšenyo ea oxidative ka ho felisa li-free radicals, tse ka bakang tšenyo ea sele le ho lebisa mafung a sa foleng. Phuputso e 'ngoe e fumane hore urolithin B e fokotsa khatello ea oxidative ho litoeba, e tšehetsa bokhoni ba eona e le tlatsetso ea ho thibela botsofali.
3. Ntlafatsa bophelo bo botle ba mesifa
Ho bontšitsoe hore Urolithin B e khothalletsa autophagy ea mitochondrial, e leng ts'ebetso ea sele e thusang ho felisa mitochondria e senyehileng liseleng. Ts'ebetso ena e thusa ho ntlafatsa bophelo bo botle ba mesifa le ts'ebetso ea eona ka kakaretso, e leng se etsang hore e be tlatsetso e ka bang teng bakeng sa ba batlang ho ntlafatsa ts'ebetso ea 'mele. Phuputso e 'ngoe e fumane hore urolithin B e ntlafalitse ts'ebetso ea mesifa le matla ho litoeba le batho.
4. E tšehetsa bophelo bo botle ba kelello
Urolithin B e bontšitsoe e tšehetsa bophelo bo botle ba kelello ka ho khothalletsa neuroplasticity, e leng mokhoa o thusang boko ho ikamahanya le tlhahisoleseling e ncha 'me o ka ntlafatsa ts'ebetso ea kelello. Phuputso e 'ngoe e fumane hore urolithin B e ntlafalitse ts'ebetso ea kelello le ho ntlafatsa mohopolo ho likhoto.
5. Melemo e ka bang teng bakeng sa nako e telele
Lithuto tsa morao tjena li bontšitse hore urolithin B e na le bokhoni ba ho ntlafatsa bophelo bo bolelele ka ho ntlafatsa bophelo bo botle ba metabolism, ho fokotsa ho ruruha, le ho sireletsa khahlanong le khatello ea oxidative. Phuputso e 'ngoe e fumane hore urolithin B e ekelitse bophelo bo bolelele ho C. elegans, mofuta oa seboko sa nematode, e tšehetsang melemo ea eona e ka bang teng bakeng sa ho ntlafatsa bophelo bo bolelele.
1. Kharenate
Kharenate ke e 'ngoe ea mehloli e metle ka ho fetisisa ea urolithin. Bafuputsi ba fumane hore lero la kharenate le ka eketsa maemo a mali a urolithin A le B. Ho phaella moo, likharenate li na le melemo e meng ea bophelo bo botle, ho kenyeletsoa le thepa ea ho thibela ho ruruha le ea antioxidant.
2. Litholoana
Menokotšoai e kang fragole, raspberry le monokotšoai o motsho le yona ke mehlodi e metle ya urolithin. Diphuputso di bontshitse hore ho ja monokotšoai ho ka eketsa maemo a urolithin A le B mading.
3. Linate
Li-walnut le li-pecan le linate tse ling le tsona ke mohloli o motle oa urolithin. Phuputso e fumane hore ho ja linate ho tla eketsa boemo ba urolithin A le B maling.
Urolithin A le B ke metsoako ea tlhaho e fumanehang lijong tse itseng, li na le melemo e mengata ea bophelo bo botle. Metsoako ena e na le thepa ea ho thibela ho ruruha, e ntlafatsa bophelo bo botle ba mitochondrial le mesifa, 'me e khothalletsa bophelo bo botle ba kelello. Likharenate, monokotšoai, linate le li-supplement tsa ellagitannin ke tse ling tsa mehloli e metle ea lijo e ka fanang ka li-urolithin. Ho kenyelletsa lijo tsena lijong tsa hau ho ka u thusa ho notlolla melemo ea li-urolithin A le B le ho khothaletsa botsofali bo phetseng hantle.
Nako ea poso: Phuptjane-05-2023
