Urolithin A ke molek'hule e khahlisang lefapheng la lipatlisiso tse thibelang botsofali. Bokhoni ba eona ba ho tsosolosa tšebetso ea lisele le ho ntlafatsa bophelo bo botle bo 'nile ba tšepisa lithutong tsa liphoofolo. Leha ho le joalo, ho hlokahala lipatlisiso tse eketsehileng ho fumana katleho ea eona ho batho.Le hoja e ka 'na eaba ha re e-s'o fumane seliba sa bocha, Urolithin A e re atametsa haufi le ho utloisisa liphiri tsa botsofali le monyetla oa ho bula senotlolo sa bophelo bo bolelele, bo botle.
Urolithin A ke motsoako oa tlhaho o fumaneng tlhokomelo e ngata lilemong tsa morao tjena ka lebaka la melemo ea eona ea bophelo bo botle. Lipatlisiso tse ntseng li hlaha li fana ka maikutlo a hore e ka 'na ea e-ba le li-anti-inflammatory, anti-cancer le thepa ea ho tsofala.
●Urolithin A ke metabolite e hlahisoang ke ho senyeha ha ellagitannins, motsoako oa polyphenolic o fumanoang litholoana le linate tse itseng. Phetoho ea ellagitannins ho urolithin A e etsahala haholo ka maleng ka lebaka la ketso ea libaktheria tse ling tsa mala.
●Kharenate ke e 'ngoe ea mehloli e ruileng ka ho fetisisa ea ellagitannins' me kahoo urolithin A. Li-arils tse khubelu tse khanyang, kapa lipeo, tsa likharenate li na le likhahla tse ngata tsa ellagitannins, tse fetoloang ho urolithin A nakong ea tšilo ea lijo. Lero la kharenate le li-extracts le tsona ke mehloli e metle ea urolithin A.
●Litholoana tse ling tse nang le urolithin A ke li-raspberries. Joaloka likharenate, li-raspberries li na le li-ellagitannins tse ngata, haholo-holo peo ea tsona. Tšebeliso ea kamehla ea li-raspberries tse foreshe kapa tse leqhoa li ka eketsa maemo a urolithin A 'meleng.
●Linate tse ling, tse kang walnuts le pistachios, le tsona li na le trace amount of urolithin A. Le hoja urolithin A e fumanoa ka chelete e fokolang ha e bapisoa le litholoana tse kang likharenate, ho kenyelletsa le linate tsena lijong tsa hau li ka thusa ho eketsa tlhahiso ea hau ea urolithin A ka kakaretso.
Le ha litholoana tse ncha le linate e le mehloli e metle ea lijo tsa urolithin A, ho bohlokoa ho bolela hore li-supplement tsa urolithin A li teng. Li-supplement tsena li ka fana ka mokhoa o bonolo oa ho eketsa ho noa ha urolithin A.
Urolithin A ke motsoako o tsoang ho ntho ea tlhaho e bitsoang ellagitannin, e fumanoang litholoana tse itseng tse kang likharenate le monokotsoai. Ha re ja litholoana tsena, libaktheria tsa rona tsa mala li senya ellagitannins ho urolithin A, e leng se lumellang 'mele ea rona ho rua molemo motsoako ona o tsotehang.
E 'ngoe ea lintho tse thabisang ka ho fetisisa tse sibollotsoeng ka urolithin A ke bokhoni ba eona ba ho nchafatsa mitochondria, matla a matla a lisele tsa rona. Ha re ntse re tsofala, mitochondria ea rona ha e sebetse hantle, e lebisang ho fokotseha ha tlhahiso ea matla a cellular. Lipatlisiso li bontšitse hore urolithin A e ka kenya tšebetsong tšebetso e bitsoang mitophagy, e hlakisang mitochondria e sa sebetseng le ho hlohlelletsa tlhahiso ea tse ncha tse phetseng hantle. Ts'ebetso ena e lebisa ntlafatsong ea tlhahiso ea matla le ts'ebetso ea cellular ka kakaretso.
Ho feta moo, urolithin A e fumanoe e ntlafatsa bophelo bo botle ba mesifa le matla. Ha re ntse re hōla, re atisa ho lahleheloa ke mesifa ea mesifa, e lebisang bofokoling le ho fokotsa ho tsamaea. Leha ho le joalo, lithuto tsa liphoofolo tse hōlileng li bontšitse hore tlatsetso ka urolithin A e khothalletsa ho hōla ha mesifa le ho thibela ho senyeha ha mesifa.
Molemo o mong o makatsang oa Urolithin A ke ts'ireletso ea eona khahlano le mafu a neurodegenerative joalo ka Alzheimer's le Parkinson's. Mafu ana a khetholloa ke ho bokellana ha liprotheine tse chefo bokong, e leng se lebisang ho fokotseha ha kelello le mathata a ho sisinyeha. Liphuputso tsa morao-rao li bontšitse hore urolithin A e ka thusa ho tlosa liprotheine tsena tse kotsi, ho fokotsa kotsi le tsoelo-pele ea mafu ana a neurodegenerative.
1. Ja lijo tse nang le li-ellagitannins tse ngata: Ho eketsa maemo a urolithin ka tlhaho, ho ja lijo tse nang le ellagitannins ke senotlolo. Likharenate, fragole, li-raspberries le li-blackberries ke mehloli e babatsehang ea ellagitannins. Ho kenyelletsa litholoana tsena lijong tsa hau ho ka matlafatsa tlhahiso ea urolithin ka maleng a hau.
2. Ho Ntlafatsa Bophelo bo Botle ba Gut: Ho ba le microbiota e phetseng hantle ea mala ho bohlokoa bakeng sa tlhahiso ea urolithin. Ho ts'ehetsa microbiome e fapaneng le e leka-lekaneng ea mala, kenyelletsa lijo tse lomositsoeng joalo ka yoghurt, kefir, sauerkraut le kimchi lijong tsa hau. Lijo tsena li hlahisa libaktheria tse ntle maleng a hau, tse matlafatsang tlhahiso ea urolithin.
3. Nka li-supplement tsa urolithin: Ntle le mehloli ea lijo, li-supplement tsa urolithin li fumaneha hape 'marakeng. Li-supplement tsena li fana ka litekanyetso tse tsepamisitsoeng tsa urolithin, tse ka bang molemo ho ba nang le bothata ba ho ja lijo tse lekaneng tse nang le ellagitannin khafetsa kapa ba nang le mathata a bophelo bo botle ba mala.
4. Kopanya ellagitannins le mehloli ea mafura: Ellagitannins e kenngoa habonolo ke 'mele ha e jeoa ka mehloli ea mafura a phetseng hantle. Nahana ka ho eketsa linate, lipeo, kapa oli e nyenyane ea mohloaare ho litholoana ho matlafatsa ho monya ha ellagitannins le ho eketsa tlhahiso ea urolithin.
Nako eo urolithin A e e nkang ho sebetsa e fapana ho latela lintlha tse 'maloa. Ntho ea bohlokoa ka ho fetisisa ke metabolism ea motho. 'Mele oa motho e mong le e mong o sebetsana le lintho ka tsela e fapaneng, e leng hape e amang hore na' mele o monya kapele hakae le ho sebelisa urolithin A. Ho phaella moo, tekanyo le foromo eo urolithin A e sebelisoang ka eona e ka boela ea ama nako ea ho qala ha eona.
Liphuputso li bontšitse hore ho ja mefuta ea tlhaho ea urolithin A, e kang lero la kharenate kapa monokotšoai o itseng, ho ka hlahisa maemo a bonahalang a motsoako maling ka mor’a lihora tse seng kae. Leha ho le joalo, liphello tsa urolithin A li ka 'na tsa se ke tsa bonahala hang-hang, kaha liketso tsa motsoako li lebisitsoe haholo melemo ea nako e telele ea bophelo bo botle.
Ho bohlokoa ho hlokomela hore urolithin A ha se tharollo e potlakileng bakeng sa boemo bo itseng ba bophelo bo botle. Ho e-na le hoo, ho nahanoa hore e na le liphello tsa eona ka ho kenya tšebetsong mokhoa oa ho tsosolosa lisele tsa 'mele o bitsoang autophagy. Ts'ebetso ena e kenyelletsa ho senya le ho tlosa lisele le liprotheine tse senyehileng, tse ka bang le liphello tsa nako e telele ho bophelo bo botle le bophelo bo botle. Lipatlisiso li ntse li tsoela pele mabapi le hore na ho tla nka nako e kae ho fumana melemo e ka bang teng ea urolithin A.
Lipatlisiso mabapi le litla-morao tsa urolithin A li ntse li fokola, kaha ke karolo e ncha ea lipatlisiso. Lithuto tse ngata tse entsoeng ho fihlela joale li tsepamisitse maikutlo litlamorao tsa eona tse ntle ho fapana le litlamorao life kapa life tse mpe. Leha ho le joalo, ho bohlokoa ho tsoela pele ka hloko le ho utloisisa likotsi tse ka bang teng.
Bothata bo ka bang teng ka tšebeliso ea urolithin A ke hore e ka sebelisana le meriana e itseng. E le tlatsetso ea lijo, e ka 'na ea sebelisana le lithethefatsi tse entsoeng ka metabolized ke li-enzyme tse tšoanang tsa sebete. Sena se ka fetola hore na meriana ena e sebetsa kapa e bolokehile hakae. Ka hona, ke habohlokoa ho buisana le setsebi sa tlhokomelo ea bophelo pele u noa urolithin A haeba u noa meriana leha e le efe e meng.
Ntho e 'ngoe e lokelang ho nahanoa ke tekanyo ea urolithin A. Hona joale, ha ho na mokhoa o khothalletsoang oa letsatsi le letsatsi kapa litataiso tse khethehileng tsa litekanyetso bakeng sa motsoako ona. Ka hona, ho thata ho fumana hore na ho na le tekanyo e nepahetseng, kapa haeba ho na le litla-morao tse amanang le litekanyetso tse phahameng. Ho kgothaletswa hore o latele ditaelo tse hodima leibole ya sehlahiswa kapa o buisane le mofani wa tlhokomelo ya bophelo ho fumana tekanyo e nepahetseng.
Nako ea poso: Jun-21-2023
