U hloka ho tseba eng ka palmitoylethanolamide (PEA)?

Palmitoylethanolamide (PEA) ke amide ea tlhaho ea mafura a acid e seng e hohetse tlhokomelo bakeng sa melemo ea eona ea bophelo bo botle. Motsoako ona o fumaneha liseleng tse fapaneng ho pholletsa le 'mele, mme lipatlisiso li fana ka maikutlo a hore palmitamideethanol (PEA) e ka fokotsa ho ruruha, ea fokotsa bohloko, hape e ka khothaletsa bophelo bo botle ba mala le ho lieha ho tsofala. E ka ba le melemo e mengata ea bophelo bo botle. Litaba tse latelang li tla hlahloba melemo ea bophelo bo botle ea palmitoylethanolamide (PEA), hore na e sebetsa joang 'meleng oa motho, le mokhoa oa ho fumana palmitoylethanolamide ea boleng bo phahameng (PEA).

Palmitoylethanolamide (PEA) ke eng?

Palmitoylethanolamide (PEA) ke motsoako oa tlhaho oa endocannabinoid o tsejoang ka thepa ea ona e sa foleng ea analgesic le anti-inflammatory. Ntle le ho etsoa ke 'mele, PEA e fumanoa lijong tse fapaneng tse kenyelletsang: chisi, li-yolk tsa mahe, nama, lebese, makotomane, soy lecithin.

na u ne u tseba? Ha 'mele o tobana le khatello ea maikutlo, joalo ka ho tsoa kotsi kapa ho ruruha, maemo a PEA a fetoha ho boloka cellular homeostasis.

Palmitoylethanolamide e ama 'mele oa motho joang?

Bo-rasaense ha ba e-s'o utloisise ka botlalo mokhoa oa ts'ebetso ea palmitoylethanolamide. Leha ho le joalo, re fihlile hōle, ka lebaka la Moprofesa Rita Levi-Montalcini, eo ka 1992-1996 a ileng a hlakisa mokhoa o akaretsang oa liketso tsa palmitoylethanolamide . Ho tloha ka nako eo, o 'nile a tsoela pele ho ithuta liphello tsa palmitoylethanolamide ka bohloko ba neuropathic le ho kula.

Palmitoylethanolamide e ka tlisa melemo e mene ea bophelo bo botle ho batho:

● Fokotsa maikutlo a ho ruruha.

● Fokotsa ho sebetsa ha mast cell (allergy).

● Matlafatsa tšebetso ea endogenous hemp system.

● Kenya tšebetsong li-receptor tse itseng 'meleng.

PEA e na le litlamorao tsa eona tse khahlanong le ho ruruha le li-analgesic joang?

Melemo ea bophelo bo botle ea PEA e kenyelletsa litlamorao ho lisele tsa 'mele tse laolang ho ruruha, haholo bokong. PEA e ka thusa ho fokotsa tlhahiso ea lintho tse ruruhisang. Leha ho le joalo, PEA e sebetsa haholo ho li-receptor tse liseleng, tse laolang likarolo tse fapaneng tsa tšebetso ea lisele. Li-receptor tsena li bitsoa PPARs. PEA le metsoako e meng e thusang ho kenya PPAR e ka fokotsa bohloko hape e ka eketsa metabolism ka ho chesa mafura, ho fokotsa serum triglycerides, ho eketsa serum HDL cholesterol, ho ntlafatsa taolo ea tsoekere ea mali, le ho thusa ho theola boima ba 'mele.

Palmitoylethanolamide Melemo

Ka lebaka la litlamorao tsa eona tsa analgesic le anti-inflammatory, lipatlisiso li fana ka maikutlo a hore PEA e ka thusa ka maemo a fapaneng a amanang le bohloko, joalo ka fibromyalgia, sciatica le osteoarthritis.

1. Fokotsa bohloko le karabelo ea ho ruruha

Bohloko bo sa foleng ke bothata bo tebileng bo hlaselang bakuli lefatšeng ka bophara, 'me ha baahi ba ntse ba tsofala, bothata bona bo tla ba ba bohlokoa le ho feta. E 'ngoe ea mesebetsi ea palmitoylethanolamide ke hore e ka thusa ho imolla bohloko le ho ruruha. palmitoylethanolamide e sebelisana le li-receptor tsa CB1 le CB2, e leng likarolo tsa bohlokoa tsa tsamaiso ea endogenous hemp. Tsamaiso ena e na le boikarabelo ba ho boloka homeostasis kapa ho leka-lekana 'meleng.

Ha ho hlaha kotsi kapa karabelo ea ho ruruha, 'mele o ntša metsoako ea endogenous hemp ho thusa ho laola karabelo ea 'mele ea ho itšireletsa mafung. palmitoylethanolamide e ka thusa ho eketsa maemo a tlhaho a hemp 'meleng, ka hona ho imolla bohloko le ho ruruha.

Ho feta moo, palmitoylethanolamide e ka fokotsa ho lokolloa ha lik'hemik'hale tsa ho ruruha le ho fokotsa likarabo tsa ho ruruha ha methapo ka kakaretso. Liphello tsena li etsa hore palmitoylethanolamide e be sesebelisoa se ka thusang ho laola bohloko le likarabo tsa ho ruruha. Liphuputso li bontša hore palmitoylethanolamide e ka boela ea sebetsa bakeng sa bohloko ba sciatica le lefu la carpal tunnel syndrome.

2. Fibromyalgia

Liphuputso tse 'maloa li bontša hore PEA e ka thusa ho fokotsa matšoao a fibromyalgia, lefu le sa foleng la methapo e bakang bohloko bo atileng. Ha e sebelisoa e le tlatsetso ea phekolo ea setso, ho kenngoa ha PEA ho fokotsa bohloko bo matla le ho ntlafatsa boleng ba bophelo ha nako e ntse e ea. Ho ea ka phuputso e 'ngoe, ho nka PEA ka likhoeli tse tharo ho ile ha fokotsa bohloko ho batho ba nang le fibromyalgia.

3. Ho opeloa ke mokokotlo

Lipatlisiso tsa pele li bontša bokhoni bo ka bang teng ba PEA bakeng sa bohloko ba morao. Phuputso ea 2017 e bontšitse hore PEA e boetse e fokotsa bohloko bo boholo ho bakuli ba nang le lefu la ho buuoa ka morao.

Batho ba nang le bothata ba sciatica, bohloko bo tlohang ka tlaase ho ea tlaase ho ea maotong a le mong kapa ka bobeli, ba ka boela ba fumana phomolo ka mor'a ho nka PEA. Teko e sa reroang, e sa boneng habeli, e laoloang ke placebo e ithutile litlamorao tsa tekanyo e phahameng le e tlase ea PEA khahlano le placebo. Bohloko bo fokotsehile ho feta 50% sehlopheng sa litekanyetso tse phahameng. Le hoja tekanyo e tlaase ea PEA e sa ka ea finyella tekanyo e lekanang ea ho fokotsa bohloko joaloka tekanyo e phahameng, litekanyetso ka bobeli li ne li sebetsa haholo ho feta placebo.

4. Osteoarthritis

PEA e ka ’na ea e-ba molemo ho batho ba tšoeroeng ke lefu la masapo a manonyeletso, lefu le khetholloang ka ho senyeha ha lefufuru le manonyeletso. Barupeluoa thutong e 'ngoe ba amohetseng PEA ba bile le lintlafatso tse kholo ho Western Ontario le McMaster Universities Osteoarthritis Index (WOMAC) ha e bapisoa le sehlopha sa placebo. WOMAC ke lethathamo la lipotso tse etselitsoeng ho hlahloba boemo le matšoao (mohlala, bohloko, ho satalla, tšebetso ea 'mele) ho bakuli ba nang le lefu la masapo a manonyeletso la lengole le letheka.

Phuputso e 'ngoe e amang bakuli ba nang le bohloko ba temporomandibular arthritic (TMJ) e amanang le osteoarthritis e bontšitse hore tlatsetso ea PEA e ntlafalitse matla a bohloko ka mor'a matsatsi a 14 ha a bapisoa le ibuprofen. Sehlopha se fuoeng PEA bakeng sa matsatsi a 14 se bontšitse ntlafatso e kholo haholo ho buloa ha molomo ka bongata (tekanyo ea phomolo ea bohloko) ho feta sehlopha sa ibuprofen.

5. Bohloko ba neuropathic

Liphuputso tsa pele le tlhahlobo ea liphoofolo li bontša hore PEA e ka thusa ka bohloko ba methapo ea kutlo (e bakoang ke tšenyo ea methapo e tsamaisang melaetsa pakeng tsa boko le lesapo la mokokotlo), haholo-holo ho batho ba nang le lefu la carpal tunnel syndrome, lefu la tsoekere, chemotherapy bohloko ba pelvic, le bohloko bo amanang le stroke le multiple sclerosis. Ho hlokahala liteko tse ling tsa kliniki ho fumana hore na PEA e sebetsa hantle hakae ho rarolla bohloko ba neuropathic.

6. Botsofali bo Botle

Ho lieha ho tsofala ke pakane ea bohlokoa bo sebetsang e phehelloang ke bo-rasaense ba bangata lefatšeng ka bophara. Palmitoylethanolamide e nkoa e le tlatsetso e khahlanong le botsofali e ka thusang ho sireletsa lisele ho tsoa tšenyo ea oxidative, e leng eona sesosa se ka sehloohong sa botsofali.

Ha lisele li pepesehetse ts'ebetso e feteletseng ea li-radicals tsa mahala, karabelo ea oxidative e ka hlaha, e lebisang ho lefu la sele pele ho nako. Ho ja lijo tse sa pheleng hantle, ho tsuba, le lintho tse ling tse hlahisoang ke tikoloho tse kang tšilafalo ea moea le tsona li eketsa tšenyo ea oxidative.Palmitoylethanolamide e ka thibela tšenyo ena ka ho tlosa li-radicals tsa mahala le ho fokotsa karabelo ea ho ruruha ka kakaretso 'meleng.

Ho feta moo, palmitoylethanolamide ethanol e bontšitsoe hore e ka susumetsa tlhahiso ea collagen le liprotheine tse ling tsa bohlokoa tsa letlalo. Ka hona, e ka fokotsa ponahalo ea wrinkles le mela e metle, e sebetsang e le mosireletsi ho tsoa ka har'a lisele.

Suzhou Myland Pharm & Nutrition Inc. ke moetsi ea ngolisitsoeng ke FDA ea fanang ka phofo ea Palmitoylethanolamide (PEA) ea boleng bo phahameng le bo hloekileng.

Ho Suzhou Myland Pharm re ikemiselitse ho fana ka lihlahisoa tsa boleng bo holimo ka litheko tse ntle. Phofo ea rona ea Palmitoylethanolamide (PEA) e lekoa ka matla bakeng sa bohloeki le potency, ho netefatsa hore o fumana tlatsetso ea boleng bo holimo eo u ka e tšepang. Hore na o batla ho ts'ehetsa bophelo bo botle ba cellular, ho matlafatsa sesole sa hau sa 'mele, kapa ho ntlafatsa bophelo bo botle ka kakaretso, phofo ea rona ea Palmitoylethanolamide (PEA) ke khetho e phethahetseng.

Ka boiphihlelo ba lilemo tse 30 'me e susumetsoa ke thekenoloji e phahameng le maano a R&D a ntlafalitsoeng haholo, Suzhou Myland Pharm e hlahisitse lihlahisoa tse ngata tsa tlholisano mme e fetohile tlatsetso e ncha ea mahlale a bophelo, ho kopanya tloaelo le k'hamphani ea lits'ebeletso tsa tlhahiso.

Ntle le moo, Suzhou Myland Pharm le eona ke moetsi ea ngolisitsoeng ke FDA. Lisebelisoa tsa R&D tsa k'hamphani, lisebelisoa tsa tlhahiso, le lisebelisoa tsa tlhahlobo ke tsa sejoale-joale ebile li na le mesebetsi e mengata, 'me li ka hlahisa lik'hemik'hale ho tloha ho limiligrama ho isa ho lithane ka tekanyo,' me li latela litekanyetso tsa ISO 9001 le litlhaloso tsa tlhahiso ea GMP.