NAD+ ke Eng 'me Ke Hobane'ng ha U E Hloka Bakeng sa Bophelo bo Botle ba Hao?

Lefats'eng le ntseng le hola la bophelo bo botle le bophelo bo botle, NAD+ e se e le puo e monate, e hohelang bo-ramahlale le ba chesehelang bophelo bo botle ka ho tšoanang. Empa NAD+ ke eng hantle? Ke hobane'ng ha e le ea bohlokoa hakaale bophelong ba hau? Ha re ithute haholoanyane ka lintlha tse nepahetseng tse ka tlase!

NAD+ ke eng?

Lebitso la saense la NAD ke nicotinamide adenine dinucleotide. NAD+ e teng seleng e 'ngoe le e 'ngoe ea 'mele ea rona. Ke metabolite ea bohlokoa le coenzyme mekhoeng e fapaneng ea metabolic. E kenella le ho kenya letsoho lits'ebetsong tse fapaneng tsa baeloji. Li-enzyme tse fetang 300 li itšetlehile ka NAD+ Ho sebetsa.

NAD+ke khutsufatso ea Senyesemane ea Nicotinamide adenine dinucleotide. Lebitso la eona le felletseng ka Sechaena ke nicotinamide adenine dinucleotide, kapa Coenzyme I ka bokhutšoanyane. Joaloka coenzyme e fetisang li-ion tsa hydrogen, NAD + e bapala karolo likarolong tse ngata tsa metabolism ea motho, ho akarelletsa le glycolysis, Gluconeogenesis, tricarboxylic acid cycle, joalo-joalo Liphuputso tse ling li bontšitse hore ho fokotseha ha NAD + ho amana le lilemo, 'me mekhoa ea physiological e buisana. ka NAD + li amana le botsofali, mafu a metabolic, methapo ea kutlo le mofets'e, ho kenyelletsa le ho laola cell homeostasis, li-sirtuin tse tsejoang e le "liphatsa tsa lefutso tsa nako e telele", ho lokisa DNA, PARPs liprotheine tsa lelapa tse amanang le necroptosis le CD38 tse thusang ho bontša khalsiamo.

NAD+ e sebetsa joalo ka bese ea shuttle, e tsamaisang lielektrone ho tloha molek'hule ea sele ho ea ho e 'ngoe. Hammoho le molek'hule oa eona NADH, e kenya letsoho liketsong tse fapaneng tsa metabolism ka phapanyetsano ea elektronike e hlahisang adenosine triphosphate (ATP), molek'hule ea "matla" a 'mele.

Ka mantsoe a bonolo, NAD + e bohlokoa ho boloka bophelo bo botle ba 'mele le ho leka-lekana. Metabolism, redox, tlhokomelo le tokiso ea DNA, botsitso ba liphatsa tsa lefutso, taolo ea epigenetic, joalo-joalo kaofela li hloka ho kenya letsoho ha NAD +.

Ka hona, 'mele ea rona e na le tlhoko e phahameng ea NAD +. NAD+ e ntse e etsoa ka mokhoa o tsoelang pele, ea robeha, 'me e sebelisoa hape ka liseleng ho boloka maemo a tsitsitseng a cellular a NAD+.

NAD+ ke karolo ea bohlokoa ea ts'ebetso ea cellular mme e ameha phepelong ea matla le tokiso ea DNA, tseo ka bobeli li amanang haholo le botsofali bo botle.

1) E ajoa ka bongata liseleng tsohle tsa 'mele oa motho mme e nka karolo ho likete tsa karabelo ea biocatalytic. E ka khothaletsa metabolism ea tsoekere, mafura le li-amino acid, 'me ea kenya letsoho ho qaleng ha matla. Ke coenzyme ea bohlokoa e hlokahalang bakeng sa 'mele oa motho.

2) NAD + ke eona feela substrate bakeng sa li-enzyme tse jang coI (e leng eona feela substrate bakeng sa enzyme ea tokiso ea DNA PARP, eona feela substrate bakeng sa protheine ea nako e telele ea Sirtuins, le eona feela substrate bakeng sa cyclic ADP ribose synthase CD38/157).

Leha ho le joalo, ha lilemo li ntse li eketseha, boemo ba NAD + 'meleng bo fokotseha ka potlako. E tla fokotseha ka 50% lilemo tse ling le tse ling tse 20. Hoo e ka bang lilemo tse 40, litaba tsa NAD + 'meleng oa motho ke 25% feela ea seo e neng e le sona baneng.

Haeba lisele tsa motho li haelloa ke NAD +, ho se sebetse ha mitochondrial ho fokotsehile, bokhoni ba ho lokisa tšenyo ea DNA bo fokotsehile, 'me bophelo bo bolelele ba liphatsa tsa lefutso tsa lelapa la Sirtuin le tsona li sa sebetse, joalo-joalo Lintho tsena tse mpe li ka lebisa ho apoptosis, lefu la batho, botsofali esita le lefu.

Karolo ea NAD+ ho Bophelo bo Botle ba Hao ka Kakaretso

Khahlanong le botsofali

NAD+ e boloka puisano ea lik'hemik'hale pakeng tsa nucleus le mitochondria, 'me puisano e fokolang ke sesosa sa bohlokoa sa botsofali ba lisele.

NAD+ e ka tlosa palo e ntseng e eketseha ea likhoutu tse fosahetseng tsa DNA nakong ea metabolism ea lisele, ea boloka polelo e tloaelehileng ea liphatsa tsa lefutso, ea boloka ts'ebetso e tloaelehileng ea lisele, le ho fokotsa botsofali ba lisele tsa motho.

Lokisa tšenyo ea DNA

NAD+ ke karolo ea bohlokoa bakeng sa enzyme ea tokiso ea DNA PARP, e nang le tšusumetso e kholo ho lokisoeng ha DNA, polelo ea liphatsa tsa lefutso, nts'etsopele ea lisele, ho phela ha lisele, kaho ea chromosome, le botsitso ba liphatsa tsa lefutso.

Kenya protheine ea bophelo bo bolelele

Li-Sirtuin hangata li bitsoa lelapa la protheine ea nako e telele 'me li bapala karolo ea bohlokoa ea taolo mesebetsing ea lisele, joalo ka ho ruruha, kholo ea lisele, morethetho oa circadian, metabolism ea matla, tšebetso ea neuronal, le ho hanyetsa khatello ea maikutlo, mme NAD + ke enzyme ea bohlokoa bakeng sa ho qaptjoa ha liprotheine tsa nako e telele. .

E kenya tšebetsong liprotheine tsohle tse 7 tsa bophelo bo bolelele 'meleng oa motho, e bapala karolo ea bohlokoa ho hanyetsa khatello ea kelello ea cellular, metabolism ea matla, ho thibela phetoho ea lisele, apoptosis le botsofali.

Fana ka matla

E etsa hore ho be le tlhahiso ea matla a fetang 95% a hlokahalang bakeng sa mesebetsi ea bophelo. Mitochondria liseleng tsa motho ke limela tsa matla tsa lisele. NAD+ ke coenzyme ea bohlokoa ho mitochondria ho hlahisa molek'hule ea matla ATP, e fetolang limatlafatsi ho ba matla a hlokoang ke 'mele oa motho.

Khothalletsa ho nchafatsoa ha methapo ea mali le ho boloka methapo ea mali e le elasticity

Methapo ea mali ke lisele tse hlokahalang bakeng sa mesebetsi ea bophelo. Ha re ntse re hōla, butle-butle methapo ea mali e lahleheloa ke ho feto-fetoha ha eona 'me e ba thata, e teteaneng le e fokolang, e bakang "arteriosclerosis."

NAD + e ka eketsa ts'ebetso ea elastin methapong ea mali, ka hona, ea boloka botsitso ba methapo ea mali le ho boloka bophelo bo botle ba methapo ea mali.

Khothalletsa metabolism

Metabolism ke kakaretso ea liphetoho tse fapaneng tsa lik'hemik'hale 'meleng. 'Mele o tla tsoela pele ho fapanyetsana taba le matla. Ha phapanyetsano ena e emisa, bophelo ba 'mele le bona bo tla fela.

Moprofesa Anthony le sehlopha sa hae sa lipatlisiso Univesithing ea California, USA, ba fumane hore NAD+ e ka ntlafatsa ka katleho ho fokotseha ha metabolism ea lisele ho amanang le botsofali, kahoo ea ntlafatsa bophelo bo botle ba batho le ho lelefatsa bophelo.

Sireletsa bophelo bo botle ba pelo

Pelo ke setho sa bohlokoahali sa batho, 'me boemo ba NAD+' meleng bo bapala karolo ea bohlokoa ho boloka tšebetso e tloaelehileng ea pelo.

Phokotso ea NAD + e kanna ea amana le pathogenesis ea mafu a mangata a pelo, mme palo e kholo ea lithuto tsa mantlha le eona e netefalitse phello ea tlatsetso ea NAD + ho mafu a pelo.

Thibela mafu a pelo le cerebrovascular

Liphuputso li bontšitse hore hoo e ka bang li-subtypes tse supileng tsa li-sirtuin (SIRT1-SIRT7) li amana le ketsahalo ea lefu la pelo. Li-Sirtuin li nkoa e le liphofu tsa agonistic bakeng sa phekolo ea mafu a pelo, haholo-holo SIRT1.

NAD+ ke eona feela substrate ea Sirtuins. Tlatsetso e nakong ea NAD + 'meleng oa motho e ka kenya tšebetsong tšebetso ea mofuta o mong le o mong oa Sirtuins, ka hona e sireletsa bophelo bo botle ba pelo le ho thibela mafu a pelo.

Khothalletsa ho hola ha moriri

Sesosa se seholo sa ho lahleheloa ke moriri ke tahlehelo ea matla a sele ea 'm'a moriri, mme tahlehelo ea matla a sele ea moriri ke hobane boemo ba NAD + 'meleng oa motho boa fokotseha. Lisele tsa 'm'a tsa moriri ha li na ATP e lekaneng ho etsa protheine ea moriri, ka hona li lahleheloa ke matla le ho lebisa tahlehelong ea moriri.

Ka hona, ho tlatsetsa NAD + ho ka matlafatsa potoloho ea acid le ho hlahisa ATP, e le hore lisele tsa 'mè oa moriri li be le bokhoni bo lekaneng ba ho hlahisa protheine ea moriri, kahoo e ntlafatsa ho lahleheloa ke moriri.

Moo u ka Rekang Tlatsetso ea Beta-NAD+ ka Sireletsehile Marang-rang

Suzhou Myland Pharm & Nutrition Inc. ke moetsi ea ngolisitsoeng ke FDA ea fanang ka phofo ea boleng bo holimo le bohloeki bo phahameng ba NAD + Supplement.

Ho Suzhou Myland Pharm re ikemiselitse ho fana ka lihlahisoa tsa boleng bo holimo ka litheko tse ntle. Phofo ea rona ea NAD + Supplement e lekoa ka thata bakeng sa bohloeki le potency, ho netefatsa hore o fumana tlatsetso ea boleng bo holimo eo u ka e tšepang. Hore na o batla ho ts'ehetsa bophelo bo botle ba cellular, ho matlafatsa sesole sa hau sa 'mele kapa ho ntlafatsa bophelo bo botle ka kakaretso, phofo ea rona ea NAD + Supplement ke khetho e phethahetseng.

Ka boiphihlelo ba lilemo tse 30 'me e susumetsoa ke thekenoloji e phahameng le maano a R&D a ntlafalitsoeng haholo, Suzhou Myland Pharm e hlahisitse lihlahisoa tse ngata tsa tlholisano mme e fetohile tlatsetso e ncha ea mahlale a bophelo, ho kopanya tloaelo le k'hamphani ea lits'ebeletso tsa tlhahiso.

Ntle le moo, Suzhou Myland Pharm le eona ke moetsi ea ngolisitsoeng ke FDA. Lisebelisoa tsa R&D tsa k'hamphani, lisebelisoa tsa tlhahiso, le lisebelisoa tsa tlhahlobo ke tsa sejoale-joale ebile li na le mesebetsi e mengata, 'me li ka hlahisa lik'hemik'hale ho tloha ho limiligrama ho isa ho lithane ka tekanyo,' me li lumellana le litekanyetso tsa ISO 9001 le litlhaloso tsa tlhahiso ea GMP.