telomerase activator-cycloastraganol e fumanoeng hajoale ke eng?

Ka 1985, Greider et al. telomerase ea pele e ileng ea sibolloa, ’me enzyme ena e sa tsoa sibolloa e ka eketsa phetisetso ea DNA lipheletsong tsa li-chromosome ho boloka bolelele ba telomere. Telomerase ke motsoako oa ribonucleoprotein oo mantlha oa ona o kenyelletsang TERT le TERC, eo TERT e leng senotlolo sa ho laola ts'ebetso ea telomerase. Bolelele ba telomere bo tsoela pele ho khutsufala ha lisele li arohana. Ha e fihla boleng ba bohlokoa, e baka matšoao a tšenyo ea DNA, e lebisang ho potoloho e khuts'oane ea lisele le letoto la mafu a ho hloleha ha lisele tse khetholloang ke li-telomere tse khutšoane.

Ka 2010, k'hamphani ea Amerika ea Geron e ile ea sebelisana le Univesithi ea Hong Kong ea Saense le Theknoloji morerong oa ho etsa lipatlisiso ho hlahloba li-activators tsa telomerase. Ho ile ha fumaneha horecycloastraganole ka kenya tšebetsong tšebetso ea telomerase 'me ea etsa hore telomere e atolosoe. Ho sibolloa hona ho khothalelitse ka mafolofolo nts'etsopele ea li-activator tsa telomerase. Tsoelo-pele ea lipatlisiso le nts'etsopele ea lihlahisoa tse amanang le joala ea astragalus. Cycloastragenol (CAG) hajoale ke eona feela activator ea telomerase e tlalehiloeng har'a lihlahisoa tsa tlhaho. E ka loantša ka katleho ho khutsufatsa ha telomere 'me e na le anti-botsofali, anti-apoptosis, anti-fibrosis, tsamaiso ea' mele ea ho itšireletsa mafung, ho khothalletsa ho ata ha lisele le ho folisa maqeba, joalo-joalo Liphello tsa meriana, kahoo li na le liphello tse ka 'nang tsa e-ba le phekolo ea mafu a amanang le ho se sebetse ha telomere.

Cycloastragenol le botsofali

li-telomere
Li-telomere ke libopeho tse khethehileng lipheletsong tsa li-chromosome tse sireletsang li-chromosome le ho khutsufatsa ka ho ikatisa ha chromosome le karohano ea lisele. Lisele le tsona lia tsofala ha li-telomere li khutsufala.

telomerase
Telomerase e ka etsa li-telomere ho tsitsisa bolelele le sebōpeho sa li-telomere, kahoo ea sireletsa li-chromosome le ho liehisa botsofali ba lisele.

Anti-botsofali: Sesebelisoa sa telomerase, se bapalang phello e thibelang botsofali ka ho eketsa telomerase 'me kahoo e liehe ho khutsufatsoa ha li-telomere.

Li-telomere ke li-caps tse lipheletsong tsa li-chromosome tsa lisele tse li sireletsang tšenyo nakong ea karohano ea lisele. Ha lisele li ntse li tsoela pele ho arohana, li-telomere li tsoela pele ho khutsufala, li fihla sebakeng se mahlonoko moo lisele li tla tsofala kapa li shoe. Telomerase e ka lelefatsa bolelele ba li-telomere, ’me nako ea bophelo ea lisele e tla eketseha ka tsela e loketseng.

Botsofali ke karolo e ke keng ea qojoa ea bophelo; leha ho le joalo, bafuputsi ba ntse ba ithuta mekhoa e fapaneng ea phekolo ho leka ho qoba liphello tse ling tsa botsofali, ho akarelletsa le ho ithuta senolytics. Senolytics ke metsoako e felisang lisele tsa senescent (botsofali) 'me li bontšitsoe ho fokotsa liphello tsa botsofali. Phuputso e ncha e fana ka maikutlo a hore cycloastraganol e na le litlamorao tse khahlanong le botsofali.

Boithuto bona, bo tsoang Chaena mme bo phatlalalitsoe ho International Journal of Molecular Sciences, bo ne bo tsepamisitse maikutlo ho lisele tsa motho le litoeba tse nang le senescence e bakoang ke mahlaseli. Cycloastragenol e fokotsa lisele tsa senescent ntle le ho ama lisele tse se nang senescent. Kalafo ea Cycloastragenol e boetse e fokotsa liprotheine liseleng tsa senescent tse hlokahalang bakeng sa kholo ea lisele le ho phela. Ho feta moo, e thibela ho sisinyeha ha lisele tse amanang le lisele tsa ho ruruha tse amanang le lilemo le lits'ebetso. Litoeba tse tsofetseng tse tšoaroang ka cycloastraganol li fumanoe li e-na le lisele tse fokolang tsa 'mele le ho se sebetse hantle ha' mele ho amanang le lilemo.

Cycloastragenol e fokotsa lisele tsa senescent

Senescence ke letšoao le tsebahalang la botsofali, empa bafuputsi ba fumane hore ho tlosa lisele tsa senescent le limolek'hule tsa tsona tse bontšang ho ruruha ho ka thusa ho thibela mafu a amanang le botsofali esita le ho a khutlisa maemong a mang. Mona, bafuputsi ba ile ba alafa lisele tsa motho ka cycloastraganol mme ba fumana hore e felisitse lisele tsa senescent ka nepo ntle le ho ama lisele tse se nang senescent. Ntle le moo, matšoao a cellular a lisele tsa senescent a fokotsehile haholo kamora kalafo ea cycloastraganol.

Lipatlisiso tse fetileng li bontšitse hore tsela ea PI3K/AKT/mTOR-e leng tsela ea pontšo e amehang khōlong ea lisele le ho phela-e ameha mekhoeng ea ho ruruha e qalisoang ke lisele tsa senescent, tse thusang ho khothalletsa senescence liseleng tse potolohileng. Bafuputsi ba fumane hore cycloastragenol e thusitse ho fokotsa liprotheine tseleng ena, e fana ka maikutlo a hore motsoako o ka sebetsa ka ho thibela tsela ea PI3K/AKT/mTOR ho thusa ho thibela botsofali. Ho feta moo, cycloastragenol e bontšitsoe ho fokotsa bokhoni ba lisele tsa senescent ho khothaletsa senescence ka ho lokolloa ha limolek'hule tse ruruhileng, lintlha tsa kholo, le li-immunomodulators, tse lumellanang le litlhahiso tse fokotsang pontšo ea PI3K, AKT, le mTOR e ka fokotsa liphello tse khothalletsang senescence har'a lisele tse potolohileng. .

Cycloastragenol ke ea triterpene saponins mme e fumaneha haholo ho tsoa ho hydrolysis ea astragaloside IV. E na le boima ba limolek'hule tse batlang li le nyane le lipophilicity e matla, e leng molemo ho ho kenella ha biofilm le ho monya ka mpeng ho fihlela bioavailability e ntle. Ho sebetsa hantle ha cycloastragalinol
1. Kalafo ea tšenyo ea boko
2. Ntlafatsa fibrosis ea sebete
3. Kalafo ea lefu la ho fokola ha masapo
4. Phello e khahlanong le botsofali
5. Liehisa botsofali ba lisele

Hobaneng ho hlokahala ho kopanya cycloastraganol?

① Cycloastraganol e na le litlamorao tse fapaneng tsa pharmacological joalo ka ho thibela boko apoptosis le neuroinflammation nakong ea cerebral ischemia le ho boloka tšitiso ea mali le boko.
② Cycloastragenol ke eona feela molek'hule e nyane ea terpenoid e nang le ts'ebetso ea telomerase e fumanoeng ho fihlela joale mme e ka phekola mafu a neurodegenerative.
③ E na le litlamorao tsa ho thibela myocardial fibrosis le ho matlafatsa sesole sa 'mele. Ke molek'hule e tsebahalang lipatlisisong le nts'etsopele ea lithethefatsi tse thibelang botsofali.

Mathata a teng

Likahare tsa cycloastraganol ho Astragalus membranaceus li tlase haholo mme ho thata ho li fumana ka kotloloho. Leano le teng la tlhahiso ea cycloastraganol le itšetlehile ka ho ntšoa ha meriana ea setso ea China, e fumanoang haholo ka ho fetola astragaloside IV ho Astragalus membranaceus. Ke hore, astragaloside IV e fumanoa ka ho lema astragalus le theknoloji ea setso sa lisele, ebe astragaloside IV e fetoloa cycloastragaloside e sebelisa acidolysis, Smith degradation, enzyme le microbial hydrolysis. Leha ho le joalo, mekhoa ena ea ho itokisa e theko e boima, e bonolo ho baka tšilafalo ea tikoloho, ho thata ho arola le ho e hloekisa, 'me ha e lumellane le kopo le ts'ebetsong. Ka hona, batho ba lebisitse tlhokomelo ea bona ho motsoako oa maiketsetso oa cycloastraganol.

Mokhoa oa ho sebelisa baeloji ea maiketsetso ho kopanya? ---Synthetic Biology

Synthetic Biology e bua ka moralo o reriloeng, phetoho, esita le pōpo ea "bophelo ba maiketsetso" bo nang le mesebetsi eo eseng ea tlhaho tlasa tataiso ea mehopolo ea boenjiniere, ke hore, boenjiniere ba baeloji. Ka kakaretso, e hlahisoa ho sebelisoa mekhoa ea baeloji.