Hobaneng ha Alpha Ketoglutarate Magnesium e le Bohlokoa Bakeng sa Bophelo bo Botle ba Hao

Calcium Alpha ketoglutarate (AKG) ke metabolite e mahareng ea potoloho ea asiti ea tricarboxylic mme e nka karolo ho kopantseng li-amino acid, livithamini le li-organic acid le metabolism ea matla. E ka sebelisoa e le tlatsetso ea lijo 'me e na le menyetla e pharaletseng ea ts'ebeliso. Ntle le mesebetsi ea eona ea tlhaho 'meleng oa motho, calcium alpha-ketoglutarate e boetse e sebelisoa haholo lefapheng la meriana' me e fetohile karolo ea bohlokoa ea lihlahisoa tse ngata tsa bophelo bo botle le tharollo ea bongaka.

Alpha-ketoglutarate ke eng?

AKG ke metabolite ea tlhaho ea tlhaho ea tlhaho eo e leng karolo ea potoloho ea Krebs, ho bolelang hore 'mele ea rona ea e hlahisa. Indasteri ea tlatsetso e boetse e hlahisa mofuta oa maiketsetso o ts'oanang ka lik'hemik'hale le AKG e hlahisoang ka tlhaho.

AKG e etsa eng?

AKG ke molek'hule e amehang litseleng tse ngata tsa metabolic le lisele. E sebetsa e le mofani oa matla, selelekela sa tlhahiso ea amino acid le molek'hule ea pontšo ea lisele, 'me ke modulator ea mekhoa ea epigenetic. Ke molek'hule ea bohlokoa potolohong ea Krebs, e laolang lebelo le akaretsang la potoloho ea asiti ea citric ea 'mele. E sebetsa ka litsela tse fapaneng 'meleng ho thusa ho haha ​​mesifa le ho thusa ho folisa maqeba, e leng le leng la mabaka a etsang hore e tumme lefatšeng la ho haha ​​​​'mele.

AKG e boetse e sebetsa joalo ka sehlaseli sa naetrojene, e thibela ho tlala ha naetrojene le ho thibela ho ata ha ammonia. Hape ke mohloli o moholo oa glutamate le glutamine, e leng se susumetsang protheine synthesis ka mesifa le ho thibela ho senyeha ha protheine.

Ntle le moo, e laola enzyme ea 10-11 translocation (TET) e amehang ho DNA demethylation le Jumonji C domain-containing lysine demethylase, e leng eona histone demethylase e kholo. Ka tsela ena, ke sebapali sa bohlokoa taolong ea lefutso le polelo.

Na AKG e ka lieha ho tsofala?

Ho na le bopaki ba hore AKG e ka susumetsa botsofali, 'me liphuputso tse ngata li bontša hore ho joalo. Phuputso ea 2014 e bontšitse hore AKG e atolositse nako ea bophelo ea batho ba baholo ba C. elegans ka hoo e ka bang 50% ka ho thibela ATP synthase le sepheo sa rapamycin (TOR).

Phuputsong ena, re fumane hore AKG ha e lelefatse nako ea bophelo feela empa e boetse e liehisa li-phenotype tse itseng tse amanang le lilemo, tse kang ho lahleheloa ke ho tsamaisana ha 'mele ka potlako ho tloaelehileng ho C. elegans ea khale. Ho utloisisa hore na AKG e ama botsofali joang, re tla hlalosa mekhoa eo AKG e thibelang ATP synthase le TOR ho lelefatsa nako ea bophelo ho C. elegans mohlomong le mefuta e meng.

Kamoo calcium alpha-ketoglutarate e sebetsang kateng

Taba ea pele, calcium alpha-ketoglutarate e bapala karolo ea bohlokoa ho metabolism ea matla. E le sehlahisoa sa lipakeng tsa potoloho ea tricarboxylic acid (TCA cycle), calcium α-ketoglutarate e kenya letsoho ts'ebetsong ea tlhahiso ea matla a intracellular. Ka potoloho ea TCA, limatlafatsi tse kang lik'habohaedreite, mafura le liprotheine li na le oxidized 'me li senyeha ho hlahisa ATP (adenosine triphosphate) ho fana ka matla bakeng sa lisele. E le setsi sa bohlokoa sa potoloho ea TCA, calcium α-ketoglutarate e ka khothalletsa metabolism ea matla a lisele, ea eketsa matla a 'mele, ea thusa ho matlafatsa matla a' mele le mamello, le ho ntlafatsa mokhathala oa 'mele.

Taba ea bobeli, calcium α-ketoglutarate e bapala karolo ea bohlokoa ho metabolism ea amino acid. Li-amino acid ke likarolo tsa motheo tsa protheine, 'me calcium α-ketoglutarate e ameha phetohong le metabolism ea amino acid. Nakong ea ho fetola li-amino acid ho li-metabolite tse ling, calcium α-ketoglutarate e fetela ka li-amino acid ho hlahisa li-amino acid tse ncha kapa α-keto acid, kahoo e laola ho leka-lekana le tšebeliso ea li-amino acid. Ho feta moo, khalsiamo α-ketoglutarate e ka boela ea sebetsa e le karolo ea oxidation bakeng sa li-amino acid, ea kenya letsoho ho metabolism ea oxidative ea amino acid, 'me ea hlahisa matla le carbon dioxide. Ka hona, calcium α-ketoglutarate e bohlokoa haholo ho boloka homeostasis ea amino acid le protheine metabolism 'meleng.

Ho feta moo, calcium alpha-ketoglutarate e sebetsa joalo ka antioxidant e senyang li-radicals tsa mahala le ho sireletsa lisele ho tsoa tšenyo ea oxidative. Ka nako e ts'oanang, calcium α-ketoglutarate e ka boela ea laola mosebetsi oa tsamaiso ea 'mele ea ho itšireletsa mafung, ea khothalletsa ts'ebetso le ho ata ha lisele tsa' mele tsa ho itšireletsa mafung, le ho matlafatsa ho hanyetsa 'mele ho mafu le tšoaetso. Ka hona, calcium α-ketoglutarate e bohlokoa haholo ho boloka botsitso ba 'mele le ho hanela mafu.

Lipatlisiso mabapi le litlamorao tsa calcium α-ketoglutarate botsofaling

Botsofali bo re ama kaofela 'me ke sesosa sa kotsi bakeng sa maloetse a mangata,' me ho ea ka palo ea batho ba indasteri ea Medicare, monyetla oa ho kula o eketseha ka lilemo.

Calcium alpha-ketoglutarate ke metabolite ea bohlokoa 'meleng ea rona, e tsejoang ka karolo ea sele ho potoloho ea Krebs, potoloho ea bohlokoa bakeng sa oxidation ea mafura a acids le amino acid, e lumellang mitochondria ho hlahisa ATP (ATP ke mohloli oa matla oa lisele).

Ho kenyelletsa ho kenya tšebetsong calcium alpha-ketoglutarate, kahoo calcium alpha-ketoglutarate le eona e ka fetoloa glutamate ebe glutamine, e ka thusang ho susumetsa tlhahiso ea protheine le collagen (collagen ke protheine e nang le fiber e etsang 1/3). ea liprotheine tsohle 'meleng le ho thusa ho ts'ehetsa bophelo bo botle ba masapo, letlalo le mesifa).

Calcium α-ketoglutarate, e le tlatsetso ea phepo e nepahetseng, e na le menyetla e pharaletseng ea ts'ebeliso lihlahisoa tsa tlhokomelo ea bophelo. Mesebetsi ea eona e fapaneng ea likokoana-hloko e kang antioxidant, anti-botsofali, taolo ea 'mele ea ho itšireletsa mafung le metabolism ea amino acid e etsa hore e be sesebelisoa se matla sa ho ntlafatsa bophelo bo botle ba batho. Ka tlhokomeliso e ntseng e eketseha ea tlhokomelo ea bophelo bo botle le ho teba ha lipatlisiso tsa saense, ho lumeloa hore tšebeliso ea α-ketoglutarate calcium tšimong ea lihlahisoa tsa tlhokomelo ea bophelo e tla fumana tlhokomelo le tsoelo-pele e eketsehileng.