5-amino-1-methylquinolinium iodide CAS No.: 42464-96-0 98.0% bohloeki min. | moetsi oa lisebelisoa tsa tlatsetso
Lihlahisoa tsa lihlahisoa
| Lebitso la sehlahisoa | 5-amino-1-methylquinolinium iodide |
| Lebitso le leng | NNMTi5-Amino-1-mq iodide 5-amino-1-methylquinolinium iodide 5-AMINO-1-METHYLQUINOLIN-1-IUM IODIDE 5-Amino-1-methylquinolin-1-iumiodide 1-methylquinolin-1-ium-5-amine;iodide 5-Amino-1-methyl-1-quinolinium Iodide |
| Nomoro ea CAS. | 42464-96-0 |
| Mokhoa oa limolek'hule | C10H11IN2 |
| Boima ba molek'hule | 286.11 |
| Bohloeki | 98% |
| Ponahalo | E sootho ho isa bokgubetsong bo sootho bo tiileng |
| Ho paka | 1kg/ mokotla, 25kg/barrel |
| Kopo | Tlatsetso ea Lijo tse tala |
Kenyelletso ea sehlahisoa
NNMTi ke enzyme e hlahisoang haholo nakong ea botsofali ba mesifa ea masapo 'me e amahanngoa le ho lokisoa ha tšenyo ea tsela ea NAD+, ts'ebetso ea sirtuin1 e sa sebetseng, le ho eketseha ha mesifa ea stem cell senescence. NNMTi e khothalletsa phapang ea myoblast in vitro le ho ntlafatsa fusion le tsosoloso ea lisele tsa mesifa ea mesifa ho litoeba tse tsofetseng. NNMTi e boetse e le inhibitor e matla ea nicotinamide N-methyltransferase (NNMT) (IC50 = 1.2 μM), e khethang ho tlama masalla a sebaka se tlamang sa NNMT. NNMTi e khothalletsa phapang ea myoblast in vitro le ho ntlafatsa fusion le tsosoloso ea lisele tsa mesifa ea mesifa ho litoeba tse tsofetseng. Har'a tsona, enzyme ea cytosolic nicotinamide N-methyltransferase (NNMT) e sa tsoa sibolloa ho laola maemo a li-precursors tsa nicotinamide tse hlokehang bakeng sa NAD + biosynthesis, ka hona e bapala karolo ea bohlokoa ho laola tsela ea NAD + salvage le metabolism ea cellular.
Sebopeho
(1) Bohloeki bo phahameng: NNMTi e ka fumana lihlahisoa tse hloekileng ka mekhoa e hloekisitsoeng ea tlhahiso. Bohloeki bo phahameng bo bolela bioavailability e ntlafetseng.
(2) Sepheo: NNMTi e lebisa ka ho khetheha enzyme ea NNMT 'me e ka thibela mosebetsi oa eona ka katleho, kahoo e ama tsela ea metabolism ea nicotinamide.
(3) Botsitso: NNMTi e na le botsitso bo botle mme e ka boloka ts'ebetso ea eona le phello tlas'a maemo a fapaneng le maemo a polokelo.
(4) Litebello tsa nts'etsopele: Ka lebaka la litšobotsi tse sa tšoaneng tsa NNMT, tsoelo-pele ea eona e fumane tlhokomelo e pharaletseng 'me e na le lipatlisiso tse pharaletseng le litebello tsa tšebeliso.
Lisebelisoa
NNMTi ke nicotinamide N-methyltransferase (NNMT) inhibitor e khothalletsang phapang ea myoblast. NNMTi e ka boela ea sebelisoa e le tlatsetso ho thusa ho fokotsa boima ba 'mele le mafura le ho ntlafatsa mafura a sebete.
