5-Amino-1-methylquinolinium chloride Nomoro ea CAS:42464-96-0 Bohloeki ba 98.0% bonyane | moetsi oa metsoako ea tlatsetso
Liparamente tsa Sehlahisoa
| Lebitso la sehlahisoa | 5-Amino-1-methylquinolinium chloride (5-amino-1MQ) |
| Lebitso le leng | 5-amino-1MQ5-Amino-1-mq chloride 5-Amino-1-methylquinolinium chloride 5-Amino-1-methylquinolin-1-ium chloride 5-AMINO-1-METHYLQUINOLIN-1-IUM CHLOEIDE 5-Amino-1-methyl-1-quinolinium chloride |
| Nomoro ea CAS | 42464-96-0 |
| Foromo ea limolek'hule | C₁₀H₁₁ClN₂ |
| Boima ba limolek'hule | 194.6 |
| Bohloeki | 98% |
| Ponahalo | Sootho ho isa ho bofubelu bo sootho bo tiileng |
| Ho paka | 1kg/mokotla, 25kg/barele |
| Kopo | Lisebelisoa tse Tala tsa Tlatsetso ea Lijo |
Selelekela sa sehlahisoa
5-Amino-1-methylquinolinium chloride ke enzyme e hlahisoang haholo nakong ea botsofali ba mesifa ea masapo 'me e amahanngoa le ho lokisoa ha tšenyo ea tsela ea NAD+, ts'ebetso e sa laoleheng ea sirtuin1, le keketseho ea botsofali ba lisele tsa mesifa. 5-Amino-1-methylquinolinium chloride e khothalletsa phapang ea myoblast ka har'a vitro mme e ntlafatsa ho kopana le ho tsosolosoa ha lisele tsa mesifa ho litoeba tse tsofetseng. 5-Amino-1-methylquinolinium chloride le eona ke thibelo e matla ea nicotinamide N-methyltransferase (NNMT), e tlamang ka mokhoa o ikhethileng ho masala a sebaka sa ho tlama substrate ea NNMT. 5-Amino-1-methylquinolinium chloride e khothalletsa phapang ea myoblast ka har'a vitro mme e ntlafatsa ho kopana le ho tsosolosoa ha lisele tsa mesifa ho litoeba tse tsofetseng. Har'a tsona, enzyme ea cytosolic nicotinamide N-methyltransferase (NNMT) e sa tsoa fumanoa ho laola maemo a li-precursors tsa nicotinamide tse hlokahalang bakeng sa biosynthesis ea NAD+, ka hona e bapala karolo ea bohlokoa ho laoleng tsela ea pholoho ea NAD+ le metabolism ea sele.
5-Amino-1-Methylquinolinium Chloride e sebetsa ka har'a microbiome ea hau ho fokotsa mafura le ho u thusa ho theola boima ba 'mele. Ha lisele tse ngata tsa mafura li bokellana, 'mele oa hau o hlahisa enzyme e tsejoang e le NNMT (nicotinamide N-methyltransferase). Ha NNMT e le ngata, 'mele oa hau o eketsa ho ruruha le ho boloka mafura. 5-Amino-1-Methylquinolinium Chloride e thibela NNMT, e lumellang 'mele oa hau ho theola boima bo feteletseng.
Tšobotsi
(1) Bohloeki bo phahameng: 5-Amino-1-methylquinolinium chloride e ka fumana dihlahiswa tse hlwekileng haholo ka mekgwa ya tlhahiso e hlwekileng. Bohloeki bo phahameng bo bolela ho fumaneha ha dihlahiswa hantle.
(2) Ho Lebisa: 5-Amino-1-methylquinolinium chloride e shebane ka ho khetheha le enzyme ea NNMT 'me e ka thibela ts'ebetso ea eona ka katleho, ka hona e ama tsela ea metabolism ea nicotinamide.
(3) Botsitso: 5-Amino-1-methylquinolinium chloride e na le botsitso bo botle mme e ka boloka ts'ebetso le phello ea eona tlas'a maemo a fapaneng a tikoloho le a polokelo.
(4) Litebello tsa ntshetsopele: Ka lebaka la litšobotsi tse fapaneng tsa 5-Amino-1-methylquinolinium chloride, ntshetsopele ya yona e fumane tlhokomelo e pharaletseng mme e na le ditebello tse pharaletseng tsa dipatlisiso le tshebediso.
Likopo
5-Amino-1-methylquinolinium chloride ke sethibela-mafu sa nicotinamide N-methyltransferase (NNMT) se khothalletsang phapang ea myoblast. 5-Amino-1-methylquinolinium chloride e ka boela ea sebelisoa e le tlatsetso ho thusa ho fokotsa boima ba 'mele le mafura le ho ntlafatsa mafura a sebete.
