BAM15A CAS No.:210302-02-6 Haha mesifa mme o fokotse mafura.
Liparamente tsa Sehlahisoa
| Lebitso la sehlahisoa | BAM15A |
| Lebitso le leng | N5,N6-Bis(2-Chlorophenyl)-[1,2,5]oxadiazolo[3,4-b]pyrazine-5,6-diamine |
| Nomoro ea CAS | 210302-02-6 |
| Foromo ea limolek'hule | C16H10Cl2N6O |
| Boima ba limolek'hule | 373.2 |
| Bohloeki | 98% |
| Ponahalo | Phofo e sa soeufalang ho isa ho e mosehla o bobebe |
| Ho paka | 1kg/mokotla, 25kg/barele |
| Kopo | Lisebelisoa tse Tala tsa Tlatsetso ea Lijo |
Selelekela sa sehlahisoa
BAM15A ke modulator ea mitochondrial ea moloko o mocha. Jwalo ka mocoupler e ntle ea proton ea mitochondrial, e laola ka bonolo gradient ea proton ho pholletsa le lera la mitochondrial le ka hare, e eketsa katleho ea metabolism ea matla a 'mele le ho potlakisa ho senyeha ha oxidative ea tlhaho ea mafura, ntle le ho ama boima ba mesifa kapa takatso e tloaelehileng ea lijo.
Lithuto tsa pele ho tleliniki li netefalitse hore motsoako ona o thusa ho ntlafatsa ho ruruha ha 'mele, ho eketsa kutloisiso ea insulin, ho fokotsa ho bokellana ha mafura sebeteng le ho fokotsa likarabo tsa ho ruruha 'meleng. O na le bioavailability ea molomo ea ho fihla ho 67% 'me o na le thepa e bobebe e sireletsehileng haholo. Ho fapana le metsoako ea setso e tšoanang, ha e bake mocheso o sa tloaelehang oa' mele kapa tšenyo ea sele, e leng se etsang hore e be thepa e tala ea phepo e nepahetseng bakeng sa taolo ea boima ba 'mele le taolo ea metabolism.
Tšobotsi
(1) Bohloeki bo phahameng: BAM15Ae ka hlahisa dihlahiswa tse hlwekileng haholo ka tshebetso ya tlhahiso e hlwekileng. Bohloeki bo phahameng bo bolela ho fumaneha ha dihlahiswa hantle.
(2) Mokhoa o sebetsang hantle oa ho kopanya: Jwalo ka mojari oa proton ea mitochondrial, e sitisa ho phahama ha proton ea lera la ka hare la mitochondrial, e khothalletsa phetoho ea matla a oxidative ho tloha limatlafatsing ho ea matla a mocheso ho e-na le ATP, e leng se eketsang tšebeliso ea matla haholo.
(3) Tahlehelo e sireletsehileng ea mafura le ntlafatso ea metabolism: Litekong tsa liphoofolo, bioavailability ea molomo e fihlile ho 67%, e fokotsa mafura a 'mele ka ho feta 20% ntle le ho fokotsa boima ba mesifa, e amang takatso ea lijo kapa mocheso oa 'mele, ha ka nako e ts'oanang e ntlafatsa kutloisiso ea insulin, e fokotsa sebete se mafura le ho ruruha.
(4) Molemo o tlase oa chefo: Ha ho bapisoa le lintho tsa setso tse kopanyang, ha ho na kotsi ea feberu e phahameng kapa chefo ea cytotoxicity. Ha ho na tšenyo ea litho kapa litla-morao tsa methapo ea kutlo..
Likopo
1. Phokotso ea mafura le ntlafatso ea metabolism: Ka ho kopanya mitochondrial, e fokotsa mafura a 'mele haholo (mefuteng ea liphoofolo, mafura a 'mele a fokotseha ka ho feta 20%), ka nako e le 'ngoe e fokotsa tsoekere maling, ho hanyetsa insulin, le ho bokellana ha mafura sebeteng, ntle le ho ama takatso ea lijo kapa boima ba mesifa;
2. Thibelo ea botsofali: E ntlafatsa boima ba mesifa (ka 8%) le matla (ka 40%) liphoofolong tse hōlileng, e fokotsa mafura le ho thibela ho ruruha ho sa foleng, 'me e loantša botenya ba myogenic.
3. Thibelo ea ho ruruha: E fokotsa kotsi ea kotsi ea liphio e bakoang ke sepsis (AKI), 'me e fokotsa likarabo tsa ho ruruha ka har'a tsamaiso ka ho thibela tlhahiso ea ROS ea mitochondrial le ho lokolloa ha mtDNA.
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