Tlatsetso ea lijo-Sesebelisoa se secha sa bophelo bo bolelele le se khahlanong le botsofali: Calcium Alpha-ketoglutarate

Calcium Alpha ketoglutarate (AKG) ke metabolite ea mahareng ea potoloho ea asiti ea tricarboxylic mme e nka karolo ho kopantseng li-amino acid, livithamini, le li-organic acid le metabolism ea matla. E ka sebelisoa e le tlatsetso ea lijo 'me e na le menyetla e pharaletseng ea ts'ebeliso. Ntle le mesebetsi ea eona ea tlhaho 'meleng oa motho, calcium alpha-ketoglutarate e boetse e sebelisoa haholo lefapheng la meriana' me e fetohile karolo ea bohlokoa ea lihlahisoa tse ngata tsa bophelo bo botle le tharollo ea bongaka.

Kamoo calcium alpha-ketoglutarate e sebetsang kateng

Pele,calcium alpha-ketoglutaratee bapala karolo ea bohlokoa ho metabolism ea matla. E le sehlahisoa sa lipakeng tsa potoloho ea tricarboxylic acid (TCA cycle), calcium α-ketoglutarate e kenya letsoho ts'ebetsong ea tlhahiso ea matla a intracellular. Ka potoloho ea TCA, limatlafatsi tse kang lik'habohaedreite, mafura le liprotheine li na le oxidized 'me li senyeha ho hlahisa ATP (adenosine triphosphate) ho fana ka matla bakeng sa lisele. E le setsi sa bohlokoa sa potoloho ea TCA, calcium α-ketoglutarate e ka khothalletsa metabolism ea matla a lisele, ea eketsa matla a 'mele, ea thusa ho matlafatsa matla a' mele le mamello, le ho ntlafatsa mokhathala oa 'mele.

Taba ea bobeli, calcium α-ketoglutarate e bapala karolo ea bohlokoa ho metabolism ea amino acid. Li-amino acid ke likarolo tsa motheo tsa protheine, 'me calcium α-ketoglutarate e ameha phetohong le metabolism ea amino acid. Nakong ea ho fetola li-amino acid ho li-metabolite tse ling, calcium α-ketoglutarate e fetela ka li-amino acid ho hlahisa li-amino acid tse ncha kapa α-keto acid, kahoo e laola ho leka-lekana le tšebeliso ea li-amino acid. Ho feta moo, khalsiamo α-ketoglutarate e ka boela ea sebetsa e le karolo ea oxidation bakeng sa li-amino acid, ea kenya letsoho ho metabolism ea oxidative ea amino acid, 'me ea hlahisa matla le carbon dioxide. Ka hona, calcium α-ketoglutarate e bohlokoa haholo ho boloka homeostasis ea amino acid le protheine metabolism 'meleng.

Ho feta moo, calcium alpha-ketoglutarate e sebetsa joalo ka antioxidant e senyang li-radicals tsa mahala le ho sireletsa lisele ho tsoa tšenyo ea oxidative. Ka nako e ts'oanang, calcium α-ketoglutarate e ka boela ea laola mosebetsi oa tsamaiso ea 'mele ea ho itšireletsa mafung, ea khothalletsa ts'ebetso le ho ata ha lisele tsa' mele tsa ho itšireletsa mafung, le ho matlafatsa ho hanyetsa 'mele ho mafu le tšoaetso. Ka hona, calcium α-ketoglutarate e bohlokoa haholo ho boloka botsitso ba 'mele le ho hanela mafu.

Lipatlisiso ka liphello tsa botsofali

Botsofali bo re ama kaofela 'me ke sesosa sa kotsi bakeng sa maloetse a mangata,' me ho ea ka palo ea batho ba indasteri ea Medicare, monyetla oa ho tšoaroa ke lefu o eketseha ka lilemo. E le ho fokotsa botsofali le ho fokotsa ka katleho kotsi ea mafu, lipatlisiso li sibolotse ntho e sireletsehileng le e sebetsang e ka amang botsofali - calcium alpha-ketoglutarate.

Calcium alpha-ketoglutarate ke metabolite ea bohlokoa 'meleng ea rona, e tsejoang ka karolo ea sele ho potoloho ea Krebs, potoloho ea bohlokoa bakeng sa oxidation ea mafura a acids le amino acid, e lumellang mitochondria ho hlahisa ATP (ATP ke mohloli oa matla oa lisele).

Sena se kenyelletsa ho kenya ts'ebetso ea calcium alpha-ketoglutarate, kahoo calcium alpha-ketoglutarate le eona e ka fetoloa glutamate ebe glutamine, e ka thusang ho susumetsa tlhahiso ea protheine le collagen (collagen ke protheine e nang le fiber e etsang 1/3 ea liprotheine tsohle 'meleng' me li thusa ho ts'ehetsa bophelo bo botle ba masapo, letlalo le mesifa).

Ponce De Leon Health, Inc., k'hamphani ea lipatlisiso tsa nako e telele e shebaneng le ho khutlisa botsofali ba liphatsa tsa lefutso, e ile ea etsa phuputso ea lilemo tse ngata e laoloang ea calcium alpha-ketoglutarate ho litoeba tse lilemong tse bohareng 'me ea fumana hore nako ea bophelo ea litoeba sehlopheng sa liteko e eketsehile ka 12%. Habohlokoa le ho feta, bofokoli bo fokotsehile ka 46% mme bophelo bo botle bo eketsehile ka 41%. Bopaki bo bonts'a hore tlatsetso ea alpha-ketoglutarate e kanna ea se ke ea lelefatsa bophelo feela empa hape ea eketsa nako ea bophelo bo botle ka bophara.

Calcium α-ketoglutarate, e le tlatsetso ea phepo e nepahetseng, e na le menyetla e pharaletseng ea ts'ebeliso lihlahisoa tsa tlhokomelo ea bophelo. Mesebetsi ea eona e fapaneng ea likokoana-hloko e kang antioxidant, anti-botsofali, taolo ea 'mele ea ho itšireletsa mafung le metabolism ea amino acid e etsa hore e be sesebelisoa se matla sa ho ntlafatsa bophelo bo botle ba batho. Ka tlhokomeliso e ntseng e eketseha ea tlhokomelo ea bophelo bo botle le ho teba ha lipatlisiso tsa saense, ho lumeloa hore tšebeliso ea α-ketoglutarate calcium tšimong ea lihlahisoa tsa tlhokomelo ea bophelo e tla fumana tlhokomelo le tsoelo-pele e eketsehileng.