Takatsong ea rona ea bophelo bo botle le bophelo bo botle ka kakaretso, hangata re kopana le metsoako le limolek'hule tse fapaneng tse bapalang karolo ea bohlokoa ho holiseng bokhoni ba 'mele ea rona.Adenosine, nucleoside ea tlhaho, ke e 'ngoe ea limolek'hule tse ntseng li fumana tlhokomelo e ntseng e eketseha bakeng sa melemo ea eona ea bohlokoa ea bophelo bo botle.Ho tloha ho nts'etsopele ea bophelo bo botle ba pelo ho fana ka matla le ho ts'ehetsa metabolism, adenosine e na le monyetla o moholo oa ho matlafatsa 'mele ea rona ho tsoa kahare.
Adenosine ke motsoako oa tlhaho o fumanehang hoo e batlang e le sele e 'ngoe le e' ngoe 'meleng ea rona.Ke molek'hule ea bohlokoa e amehang lits'ebetsong tse fapaneng tsa 'mele, ho kenyelletsa phetiso ea matla le taolo ea phallo ea mali.
Adenosine, nucleoside, e entsoe ka molek’hule ea tsoekere (ribose) le adenine, e leng e ’ngoe ea metheo e mene e fumanoang ho DNA le RNA.E phetha karolo ea bohlokoa tlhahisong ea adenosine triphosphate (ATP), chelete e ka sehloohong ea matla a lisele tsa rōna.Ha 'mele ea rona e hloka matla, ATP e aroloa hore e be adenosine diphosphate (ADP) le lihlopha tsa phosphate tse sa lefelloeng, tse lokollang matla ho matlafatsa mesebetsi e fapaneng ea metabolism.
Ntle le karolo ea eona ho metabolism ea matla, adenosine e boetse e ameha mekhoeng ea lipontšo 'meleng ea rona.E sebetsa joalo ka neurotransmitter, lenģosa la lik'hemik'hale le tsamaisang melaetsa pakeng tsa lisele tsa methapo.Adenosine e na le bokhoni ba ho tlama li-receptor tse itseng bokong, e bakang liphello tse sa tšoaneng mosebetsing oa methapo le ho ama mekhoa ea ho robala, ho tsosoa le ho tsosoa.
Lefapheng la bongaka, adenosine e atisa ho sebelisoa e le meriana nakong ea tlhahlobo ea khatello ea kelello ea pelo.E kenngoa ka har'a mothapo ho eketsa phallo ea mali ka nakoana ho ea pelong le ho baka khatello, ho lumella litsebi tsa bophelo bo botle ho lekola tšebetso ea pelo.Adenosine e na le halofo ea bophelo bo khutšoanyane 'me liphello tsa eona li fetoha ka potlako, e leng se etsang hore e be sesebelisoa se sireletsehileng le se sebetsang mekhoeng e joalo ea ho hlahloba.
Ho tloha lits'ebetsong tsa phetisetso ea matla tse kentsoeng ke limolek'hule tse joalo ka AMP, ADP le ATP, ho ea karolong ea taolo e bapaloang ke cAMP ho bonts'a lisele, adenosine e ntse e le karolo e rarahaneng le ea bohlokoa ea mochini o rarahaneng oa bophelo.
●Adenosine monophosphate (AMP): AMP ke metabolite ea bohlokoa e amehang phetisong ea matla a intracellular.Ka ho ts'oara matla a lokollotsoeng nakong ea lits'ebetso tsa cellular, li-AMP li phetha karolo ea bohlokoa ho nucleotide biosynthesis, protheine phosphorylation, le transduction ea matšoao.Ho feta moo, ke molek'hule oa pele bakeng sa motsoako oa adenosine triphosphate (ATP), chelete e ka sehloohong ea matla a lintho tse phelang.
●Adenosine diphosphate (ADP): Joaloka setho se latelang sa lelapa la adenosine, adenosine diphosphate (ADP) e bapala karolo ea bohlokoa ho metabolism ea matla a cellular.ATP e entsoe ka hydrolyzed ho theha ADP, e lokolla lihlopha tsa phosphate le matla a hlokahalang bakeng sa lits'ebetso tse fapaneng tsa 'mele.ADP e sebetsa e le selelekela sa AMP synthesis mme e ka tlatsa maemo a ATP a intracellular.Potoloho ena ea ATP hydrolysis ho ADP le nchafatso e latelang e netefatsa phepelo e tsoelang pele ea matla a hlokahalang bakeng sa ts'ebetso ea cellular.
●Adenosine triphosphate (ATP): Ntle ho pelaelo, adenosine triphosphate (ATP) ke mofuta o tsebahalang ka ho fetisisa le oa bohlokoa ka ho fetisisa oa adenosine.ATP e sebetsa e le chelete ea matla a bokahohleng linthong tsohle tse phelang, e sebetsa e le polokelo ea matla e fehlang mekhoa e mengata ea tlhaho.Ebang ke ho honyela ha mesifa, ho fetisoa ha methapo ea kutlo, kapa lipalangoang tse sebetsang ho pholletsa le lera la lisele, ATP e fana ka matla ka potlako kae kapa kae moo e hlokahalang.Ka ho fetisetsa ka potlako sehlopha sa eona sa "terminal phosphate" ho sepheo se itseng, ATP e fana ka matla a hlokahalang bakeng sa mesebetsi ea cellular ha qetellong e fetoloa ADP.
●Adenosine deaminase (ADA) - ADA e ameha ho metabolism ea purine, e hlokahalang bakeng sa phetoho ea nucleic acid liseleng, 'me e tšehetsa nts'etsopele le tlhokomelo ea sesole sa' mele ka ho fetola chefo deoxyadenosine lymphocyte.
●Cyclic adenosine monophosphate (cAMP): Ho phaella ho metabolism ea matla, re boetse re kopana le cyclic adenosine monophosphate (cAMP).Molek'hule ona o monyenyane empa o le matla ke lenģosa litseleng tsa lipontšo, tse sebetsang e le lenģosa la bobeli bakeng sa mefuta e sa tšoaneng ea lihomone le li-neurotransmitters.cAMP e fana ka litlamorao tsa eona ka ho kenya protheine kinases, e laolang lits'ebetso tse ngata tsa cellular joalo ka liphatsa tsa lefutso, ho ata ha lisele, le polasetiki ea synaptic.Ka ho laola mesebetsi ena ea mantlha, cAMP e thusa ho boloka homeostasis ea cellular le ho hokahanya likarabelo tse fapaneng tsa 'mele.
1. Ntlafatsa bophelo bo botle ba pelo
Adenosine e fumanoe e na le melemo e mengata bakeng sa tsamaiso ea rona ea pelo.Taba ea pele, adenosine e khatholla mesifa e boreleli ea methapo ka ho fokotsa ho monya calcium le ho kenya adenylate cyclase liseleng tsa mesifa e boreleli.Ke vasodilator e matla, e bolelang hore e atolosa methapo ea mali, kahoo e eketsa maro a 'mele.phallo ya madi.Ka ho netefatsa phepelo ea mali e lekaneng pelong le lithong tse ling, adenosine e fokotsa kotsi ea mafu a pelo le methapo a kang lefu la pelo le stroke.
Ho phaella moo, adenosine e na le liphello tsa cardioprotective, e thibelang tšenyo ea lisele tsa pelo nakong ea ho fokotseha ha mali.E fana ka tšireletso ea bohlokoa nakong ea tlhaselo ea pelo, e fokotsa tšenyo ea mesifa ea pelo, 'me e ka ba ea thusa ho hlaphoheloa ka mor'a lefu la pelo.
2. Fana ka matla le ts'ehetso ea metabolism
Adenosine ke molek'hule e bapalang karolo ea bohlokoa ho metabolism.Ke nucleoside e entsoeng ka adenine le ribose 'me e ameha lits'ebetsong tse fapaneng tsa metabolism' meleng.
ATP ke molek'hule e ka sehloohong e ikarabellang bakeng sa ho boloka matla le ho tsamaisa liseleng.Adenosine e kenya letsoho tlhahisong ea adenosine triphosphate (ATP) mme ke karolo ea bohlokoa ea ATP.Ka letoto la karabelo ea biochemical, e ka fetoloa ATP ho fana ka matla bakeng sa lits'ebetso tsa cellular.
Ho feta moo, adenosine e boetse e ameha taolong ea metabolism ka ho sebelisana le li-receptor ka liseleng.Li-receptor tsa Adenosine li fumaneha liseleng le lithong tse fapaneng, 'me ha adenosine e tlama ho li-receptor tsena, e laola lits'ebetso tsa metabolic' meleng.
Ho bontšitsoe hore Adenosine e thibela ho senyeha ha glycogen, mofuta oa polokelo ea tsoekere 'meleng.Ka ho thibela ho senyeha ha glycogen, adenosine e thusa ho boloka glucose homeostasis le ho netefatsa phepelo e tsitsitseng ea matla 'meleng.
3. Ntlafatsa boroko
Adenosine e bapala karolo ea bohlokoa ho fetisetsoang ha methapo bokong ba rona, haholoholo taolong ea potoloho ea boroko.E sebetsa joaloka sedative ea tlhaho ka har'a tsamaiso ea methapo e bohareng, e khothalletsang boroko le ho thusa ho laola mekhoa ea rona ea ho robala.Maemo a adenosine bokong a eketseha butle-butle letsatsi lohle, a khothalletsa maikutlo a mokhathala le ho robala.Ka ho tlama li-receptor tse itseng bokong, adenosine e thusa ho hohela le ho boloka boroko bo tebileng.Ka hona, maemo a lekaneng a adenosine a bohlokoa bakeng sa boleng bo botle ba ho robala le ho phomola ka kakaretso.
Ho feta moo, adenosine e ameha ho thehoeng ha memori le ho hopola.E bonts'itsoe hore e matlafatsa ho ithuta le ho kopanya mohopolo, ho etsa hore e be sepheo sa phekolo bakeng sa batho ba nang le maemo a kang lefu la Alzheimer kapa mathata a mang a kelello.
4. Ntlafatsa ts'ebetso ea boikoetliso le ho hlaphoheloa ha mesifa
Ho fumanoe hore Adenosine e na le litlamorao tse fapaneng ts'ebetsong ea liatleletiki, e ka bang molemo haholo ho baatlelete kapa batho ba batlang ho eketsa bokhoni ba bona ba 'mele.Ka ho eketsa phallo ea mali, adenosine e tiisa hore mesifa e fumana oksijene le limatlafatsi tse lekaneng nakong ea boikoetliso, kahoo e eketsa mamello le ho lieha ho khathala.
Ho phaella moo, adenosine e susumelletsa ho lokolloa ha nitric oxide, vasodilator e ntlafatsang ho phalla ha mali le ho fana ka oksijene mesifa.Oksijene ena e eketsehileng e tlatsetsa ho hlaphoheloa ha mesifa ka potlako le ho fokotsa kotsi ea kotsi e bakoang ke boikoetliso.
Le hoja adenosine e hlaha ka tlhaho 'meleng ea rona, re ka eketsa maemo a eona ka ho ja lijo tse nang le limatlafatsi tse itseng kapa li-precursors.A re hlahlobeng mehloli e meng ea lijo tse molemo ka ho fetisisa ho kenyelletsa lijong tsa rona ho matlafatsa maemo a adenosine ka tlhaho.
●Nama le likhoho: nama ea khomo e se nang mafura, khoho le turkey.Lijo tsena li boetse li fana ka li-amino acid tsa bohlokoa, 'me ho eketsa nama le likhoho lijong tsa hau ho ka thusa ho tšehetsa tlhahiso ea adenosine.
●Li-legumes le lentile: Li-legumes tse kang lentile, lierekisi le linaoa tsa liphio le tsona li khothalletsa tlhahiso ea ATP 'me ke mohloli o babatsehang oa protheine ea limela.Ho kenyelletsa limela tsa linaoa khafetsa lijong ho ka fana ka litlatsetso tsa phepo ha ka tlhaho ho eketsa maemo a adenosine.
●Lijo tsa Leoatleng: Mefuta ea litlhapi tse kang saalmon, sardine, trout, mackerel le cod ke mehloli e metle e amang maemo a adenosine.Ho phaella moo, lijo tsa leoatleng li fana ka omega-3 fatty acids, tse nang le melemo e mengata ea bophelo bo botle, e leng se etsang hore e be tlatsetso ea bohlokoa ho menu ea hau.
●Lijo-thollo: Ho kenyelletsa lijo-thollo tse kang oats, raese e sootho le quinoa lijong tsa hau ha li fane feela ka fiber le limatlafatsi tsa bohlokoa, empa hape li thusa tlhahisong ea adenosine.Lithollo tsena li na le adenosine monophosphate (AMP), selelekela sa adenosine e fetoloang 'meleng ea rona ho netefatsa phepelo e tsitsitseng ea nucleotide ena ea bohlokoa.
●Tee e tala: Tee e tala ke mohloli o ruileng oa analoge ea adenosine e bitsoang catechin.Le hoja e ka 'na ea se ke ea fana ka adenosine ka ho toba, li-catechin li na le mohaho o tšoanang o li lumellang ho tlama le ho kenya li-receptor tsa adenosine' meleng ea rona, ho khothalletsa boikhathollo le bophelo bo botle ka kakaretso.
Lijo tse leka-lekaneng ke tsa bohlokoa ho boloka matla a phahameng a matla hobane macronutrient ka 'ngoe e na le phello e fapaneng ho ATP.
ATPmaemo a ka fanoa ka lijo tse leka-lekaneng hobane 'mele o sebelisa limolek'hule lijong ho etsa ATP le matla, empa ho batho ba bang ba jang lijo tse nang le monotonous, ATP supplements ke khetho e ntle.
Ho ananela ka botlalo melemo ea adenosine le li-supplement tsa ATP, ho bohlokoa ho utloisisa karolo ea tsona tlhahisong ea matla ea 'mele ea rona.Adenosine triphosphate (ATP) hangata e bitsoa "chelete ea matla" ea sele.E na le boikarabelo ba ho fana ka matla ho sele e 'ngoe le e' ngoe ea 'mele ea rona le ho etsa mesebetsi ea motheo e kang ho fokotseha ha mesifa, ts'ebetso ea methapo le metabolism.Adenosine, ka lehlakoreng le leng, ke neurotransmitter ea bohlokoa e laolang boroko le ho falimeha.
Adenosine 5'-triphosphate disodium letsoai ke nucleotide e sebelisoang e le mohloli oa matla a cellular.E entsoe ka adenosine le lihlopha tse tharo tsa phosphate, ke molek'hule ea bohlokoa ka ho fetisisa metabolism.Motsoako ona o phetha karolo ea bohlokoa ho tsosolosoa ha matla a cellular 'me o ameha mefuteng e sa tšoaneng ea lik'hemik'hale le mekhoa ea physiological, e kang ho fokotseha ha mesifa le ho fetisoa ha methapo ea kutlo.E le tlatsetso ea ATP, e ka fana ka metabolism ea matla bakeng sa 'mele oa motho le ho sebetsa e le coenzyme ka har'a lisele.
Ha u nahana ka tlatsetso ea adenosine le ATP, ke habohlokoa ho khetha lihlahisoa tsa boleng ho tsoa mehloling e hlomphehang.Batla li-supplement tse hlahisoang tlas'a mehato e tiileng ea taolo ea boleng le ho lekoa ka botlalo bakeng sa bohloeki le katleho.Nahana ka ho buisana le setsebi sa tlhokomelo ea bophelo kapa setsebi sa phepo e nepahetseng ho fumana tekanyo e nepahetseng ea tlatsetso le nako ho latela litlhoko tsa hau.
P: Adenosine e ama bophelo bo botle ba pelo joang?
A: Adenosine e bapala karolo ea bohlokoa ho laola bophelo bo botle ba pelo.E sebetsa e le vasodilator ea tlhaho, ho bolelang hore e thusa ho atolosa methapo ea mali, ho ntlafatsa phallo ea mali le ho fokotsa khatello ea mali.Ka ho atolosa methapo ea mali, adenosine e lumella oksijene e eketsehileng le limatlafatsi ho finyella pelo le litho tse ling.Sena se thusa ho boloka bophelo bo botle ba pelo ka kakaretso.
P: Mehloli ea adenosine 'meleng ke efe?
A: Adenosine e etsahala ka tlhaho 'meleng' me e ka fumanoa mehloling e fapaneng.E tsoa ho adenosine triphosphate (ATP), molek'hule e ikarabellang bakeng sa ho boloka le ho fetisa matla ka har'a lisele.ATP e arotsoe ka adenosine diphosphate (ADP) ebe e tsoela pele ho aroloa ho adenosine monophosphate (AMP).Qetellong, AMP e fetoloa adenosine.Ntle le sena, adenosine e ka boela ea fumanoa mehloling ea lijo tse kang lijo le lino tse itseng.
Boitlhotlhollo: Sengoloa sena ke sa tlhaiso-leseling e akaretsang feela 'me ha ea lokela ho nkuoa e le keletso efe kapa efe ea bongaka.Tse ling tsa litaba tsa poso ea blog li tsoa Marang-rang mme ha se setsebi.Sebaka sena sa marang-rang se na le boikarabello ba ho hlophisa, ho hlophisa le ho hlophisa lingoliloeng.Sepheo sa ho fetisa boitsebiso bo bongata ha se bolele hore u lumellana le maikutlo a eona kapa u tiisa bonnete ba litaba tsa eona.Kamehla buisana le setsebi sa tlhokomelo ea bophelo pele u sebelisa li-supplement leha e le life kapa u etsa liphetoho tsamaisong ea tlhokomelo ea bophelo.
Nako ea poso: Oct-20-2023
