N-Methyl-DL-Aspartic Acid ke motsoako oa sehlopha sa amino acid. E tsejoa haholo-holo ka karolo ea eona ho neurobiology, motsoako ona ke analoge ea maiketsetso ea aspartate e kenyang li-receptor tsa N-Methyl-DL-Aspartic Acid bokong. Li-receptor tsa NMDA li bapala karolo ea bohlokoa lits'ebetsong tse fapaneng tsa tsamaiso ea methapo, ho kenyelletsa ho ithuta, mohopolo, le polasetiki ea synaptic.
Haeba u batla ho tseba hore na N-Methyl-DL-Aspartic Acid ke eng, a re utloisise pele hore na amino acid ke eng? Amino acid ke karolo ea mantlha ea protheine, 'me protheine ke karolo ea mantlha ea lintho tse fapaneng tse sebetsang ka har'a lisele tsa motho, joalo ka li-enzyme, li-antibodies, mesifa le lisele. Ho ja li-amino acid tse lekaneng ho ka boloka protheine e phetseng hantle le ho lokisoa, le ho khothaletsa kholo le tokiso ea lisele tsa 'mele.
Li-amino acid li bohlokoa bakeng sa ts'ebetso e nepahetseng ea litsamaiso le mesebetsi e mengata 'meleng. Ho ja ka mokhoa o utloahalang le o lekaneng oa li-amino acid tse fapaneng ke e 'ngoe ea lintlha tsa bohlokoa bakeng sa ho boloka bophelo bo botle.
N-Methyl-DL-Aspartic Acid ke methylated derivative of aspartic acid (Astentic Acid) e nang le sehlopha sa methyl.
Ke isomer ea asiti ea aspartic e nang le sehlopha sa methyl se kopantsoeng le athomo ea naetrojene. ke motsoako oa amino acid o sebetsang e le agonist e khethehileng ho li-receptor tsa NMDA, tse etsisang ketso ea glutamate, neurotransmitter eo ka tloaelo e sebetsang ho receptor ena.
N-Methyl-DL-Aspartic Acid e teng mefuteng e fapaneng ea lintho tse phelang, ho kenyeletsoa limela le liphoofolo.
E na le ts'ebetso e itseng ea tlhaho 'meleng o phelang' me e nka karolo lits'ebetsong tse fapaneng tsa 'mele, joalo ka ho kopanya le ho lokolloa ha li-neurotransmitters, protheine synthesis, joalo-joalo.
Ho phaella moo, hape ke neuromodulator, N-Methyl-DL-Aspartic Acid e na le phello ea taolo tsamaisong ea methapo, 'me e kenya letsoho phetisong ea matšoao a methapo le ts'ireletso ea methapo.
N-Methyl-DL-Aspartic Acid, motsoako o hlahang ka tlhaho bokong ba motho, o phetha karolo ea bohlokoa ho polasetiki ea synaptic, mokhoa oa bohlokoa oa ho ithuta le ho theha mohopolo. Synaptic plasticity e bolela bokhoni ba li-synapse tsa boko ho matlafatsa kapa ho fokolisa ha nako e ntse e ea, ho itšetlehile ka matla le makhetlo a ts'ebetso ea methapo. NMDAA e ama ka ho khetheha li-receptor tsaN-Methyl-DL-Aspartic (NMDA), tse amehang ho matla a nako e telele (LTP) - ho matlafatsa likamano tsa synaptic.
E 'ngoe ea litsela tse ka sehloohong tseo N-Methyl-DL-Aspartic Acid e ka ntlafatsang mohopolo ka tsona ke ka ho nolofatsa puisano pakeng tsa lisele tsa boko. NMDA e sebetsa joalo ka neurotransmitter e tlamellang li-receptor tse itseng bokong, haholo-holo ka har'a hippocampus, e ikarabellang bakeng sa ho theha mehopolo e mecha. Ka ho tlama li-receptor tsena, NMDA e thusa ho matlafatsa likhokahano lipakeng tsa li-neurone, ho etsa hore ho be bonolo hore tlhahisoleseling e sebetsoe le ho bolokoa ka nepo.
Ho feta moo, liphuputso li bontšitse hore N-Methyl-DL-Aspartic Acid e khothalletsa ho lokolloa ha boko-derived neurotrophic factor (BDNF), protheine ea bohlokoa bakeng sa ho hōla le ho phela ha methapo e mecha bokong. BDNF e bapala karolo ea bohlokoa ho neuroplasticity, bokhoni ba boko ba ho bopa bocha le ho hlophisa likhokahano tsa methapo ho arabela thutong le liphihlelong. Ka ho eketsa boteng ba BDNF, NMDA e ts'ehetsa ho theoa ha litsela tse ncha tsa methapo, ho matlafatsa bokhoni ba ho hopola le ho ithuta.
Ha e le hantle, melemo ea N-Methyl-DL-Aspartic Acid ha e felle feela mohopolong le bokhoni ba ho ithuta. Liphuputso tse ling li bontša hore e ka boela ea ntlafatsa ts'ebetso ea kelello ka kakaretso. Li-NMDAA li bontšitsoe hore li ama mekhoa e meng ea li-neurotransmitter, tse kang litsela tsa dopaminergic le serotonergic, tse amehang ho laola maikutlo, tlhokomelo le tšusumetso. Ka ho fetola litsamaiso tsena, N-Methyl-DL-Aspartic Acid e ka thusa ho ntlafatsa ho tsepamisa maikutlo, ho falimeha le ho hlaka ha mohopolo, ho ntlafatsa ts'ebetso ea kelello le ho feta.
Ka kakaretso, N-Methyl-DL-Aspartic Acid e bonts'a monyetla o moholo oa ho ntlafatsa mohopolo le ho ithuta. E ntlafatsa mesebetsi ea kelello e hlokahalang bakeng sa katleho ea thuto le ea botsebi ka ho ama polasetiki ea synaptic le mekhoa ea methapo ea methapo. Ho feta moo, litlamorao tsa eona lits'ebetsong tse ling tsa neurotransmitter li ka thusa ho ntlafatsa ts'ebetso ea kelello ka kakaretso. Leha lipatlisiso tse ling li ntse li hlokahala, tlatsetso ea NMDAA e fana ka mokhoa o khahlisang bakeng sa ba batlang ho ntlafatsa bokhoni ba bona ba kelello le ho boloka likelello tsa bona li falimehile bophelo bohle ba bona.
N-Methyl-DL-Aspartic Acid ke amino acid ea tlhaho e bapalang karolo ea bohlokoa lits'ebetsong tse fapaneng tsa 'mele. E fumaneha haholo lijong tse nang le protheine e ngata joalo ka nama, tlhapi, mahe le lihlahisoa tsa lebese. Leha ho le joalo, e fumaneha hape ka li-supplement. Ka mor'a moo, a re hlahlobeng ho tšoana le ho se tšoane pakeng tsa ho fumana N-Methyl-DL-Aspartic Acid ho tsoa mehloling ea lijo le ho e nka e le tlatsetso!
Ntlha ea pele, bakeng sa ho fumana N-Methyl-DL-Aspartic Acid ka ho toba lijong, lijo tse nang le protheine li na le mefuta e sa tšoaneng ea amino acid. Batho ka tlhaho ba ka fihlela litlhoko tsa bona tsa NMDAA ka ho ja lijo tse leka-lekaneng tse kenyelletsang mehloli ea liprotheine. Hape, ho fumana N-Methyl-DL-Aspartic Acid ho tsoa lijong tse felletseng ho na le molemo o eketsehileng oa ho ba le limatlafatsi tse ling tsa bohlokoa tseo u li hlokang bakeng sa bophelo bo botle ka kakaretso.
Ka lehlakoreng le leng, lijo feela li ka 'na tsa se ke tsa lekana kamehla ho finyella litlhoko tse khethehileng tsa N-Methyl-DL-Aspartic Acid tsa batho ba bang. Baatlelete, baetsi ba 'mele, kapa ba ntseng ba koetlisoa ka matla a' mele ba ka 'na ba hloka litekanyetso tse phahameng tsa li-NMDAA ho tšehetsa ho hlaphoheloa ha mesifa le ho hōla. Tabeng ena, tlatsetso ea N-Methyl-DL-Aspartic Acid e ka nahanoa.
Li-supplement tsa N-Methyl-DL-Aspartic Acid li tla ka mefuta e mengata, ho kenyelletsa le phofo le li-capsules, 'me li fumaneha habonolo. Hangata li na le NMDAA e hloekisitsoeng kapa ea maiketsetso, e leng ho nolofalletsang ho laola le ho lekanya ho noa. Ho feta moo, li-supplement li fana ka mokhoa o bonolo oa ho netefatsa phepelo e lekaneng ea N-Methyl-DL-Aspartic Acid, haholo-holo ho ba nang le lithibelo tsa lijo, ho kula kapa bothata ba ho ja lijo tse lekaneng tse nang le protheine.
Leha ho le joalo, ho bohlokoa ho hlokomela hore li-supplement tsa N-Methyl-DL-Aspartic Acid li lokela ho sebelisoa ka hloko. Pele o kenyelletsa tlatsetso efe kapa efe e ncha tšebetsong ea hau, ho khothaletsoa ho buisana le setsebi sa tlhokomelo ea bophelo kapa setsebi sa lijo se ngolisitsoeng. Ba ka lekola litlhoko tsa hau tse ikhethileng mme ba fumana tekanyo e nepahetseng ea N-Methyl-DL-Aspartic Acid bakeng sa boemo ba hau bo ikhethileng.
Le hoja li-supplement li ka fana ka litlatsetso tse lebisitsoeng le tse loketseng, ha lia lokela ho nkela sebaka sa lijo tse nang le phepo e nepahetseng. Lijo tse felletseng ha li fane feela ka N-Methyl-DL-Aspartic Acid, empa hape le mefuta e fapaneng ea melemo ea phepo e nepahetseng le bophelo bo botle. Ho boloka lijo tse leka-lekaneng le tse fapaneng ho bohlokoa ho netefatsa bophelo bo botle le bophelo bo botle.
Ho akaretsa, re ka fumana N-Methyl-DL-Aspartic Acid ho tsoa mehloling ea lijo kapa ka li-supplement. Le hoja lijo tse leka-lekaneng e lokela ho ba mohloli o ka sehloohong oa NMDAA, li-supplement li ka fana ka tharollo e loketseng bakeng sa batho ba nang le litlhoko tse itseng kapa lithibelo tsa lijo. Leha ho le joalo, ho bohlokoa ho batla likeletso tsa litsebi pele o kenyelletsa tlatsetso efe kapa efe e ncha kemisong ea hau. Qetellong, motsoako oa phepo e nepahetseng le tlatsetso e lebisitsoeng (haeba ho hlokahala) e ka thusa ho netefatsa maemo a nepahetseng a N-Methyl-DL-Aspartic Acid bakeng sa bophelo bo botle.
Pele re sebelisa NMA, re tlameha ho utloisisa tšireletseho le litla-morao tsa NMA, e le hore re ka sebelisa matla a mangata a NMA ntle le ho ntša 'mele kotsi.
Mabapi le polokeho pele, ho bohlokoa ho hlokomela hore NMA hangata e nkuoa e bolokehile ha e nooa ka litekanyetso tse nepahetseng. Leha ho le joalo, joalo ka motsoako ofe kapa ofe, ho noa ho feteletseng ha NMDA ho ka baka litlamorao tse mpe. Ho bohlokoa ho latela litataiso tse khothaletsoang le ho buisana le setsebi sa tlhokomelo ea bophelo pele u qala tlatsetso efe kapa efe.
E 'ngoe ea litla-morao tse ka bang teng tsa li-NMA ke excitotoxicity. Excitotoxicity e etsahala ha li-receptor tsa NMA li sebetsa ho feta tekano, e leng se lebisang ho ion ea calcium e ngata le tšenyo e latelang ea methapo ea kutlo. Boemo bona bo 'nile ba amahanngoa le mafu a mangata a neurodegenerative, a kang Alzheimer's le Parkinson's. Leha ho le joalo, ke habohlokoa ho hlokomela hore excitotoxicity e amahanngoa haholo le litekanyetso tse phahameng tsa NMA, tseo hangata li sa fumaneheng mehloling ea lijo kapa li-supplement tse tloaelehileng.
Phello e 'ngoe ea lehlakore la NMA ke phello ea eona e ka bang teng ho leka-lekaneng la lihormone. Lipatlisiso tse ling li fana ka maikutlo a hore ho noa ho feteletseng ha NMA ho ka kena-kenana le tlhahiso le taolo ea lihomone tse itseng, tse kang testosterone. Ho se leka-lekane hona ha li-hormone ho ka ba le liphello tse mpe ho bophelo bo botle ba ho ba le bana le bophelo bo botle ka kakaretso. Leha ho le joalo, ho hlokahala lipatlisiso tse eketsehileng ho utloisisa mokhoa o nepahetseng le liphello tsa nako e telele tsa NMA maemong a li-hormone.
Ho feta moo, batho ba nang le maemo a bongaka a neng a le teng pele ba lokela ho ba hlokolosi ha ba nahana ka tlatsetso ea NMA. Ka mohlala, batho ba nang le lefu la sethoathoa kapa histori ea lefu la sethoathoa ba lokela ho qoba tlatsetso ea NMA, kaha e ka 'na ea baka ho tsieleha ka lebaka la liphello tsa eona ho li-receptor tsa NMA.
Bakeng sa Tšebeliso e Nahannoang Le hoja ka kakaretso e nkoa e sireletsehile ha e nooa ka litekanyetso tse nepahetseng, ho ja haholo ho ka baka liphello tse bohloko tse kang excitotoxicity le ho se leka-lekane ha li-hormone. Batho ba nang le maemo a bophelo a neng a le teng pele (haholo-holo lefu la sethoathoa le histori ea sethoathoa) ba lokela ho ba hlokolosi ha ba nahana ka tlatsetso ea NMA. Joalo ka tlatsetso efe kapa efe, ho bohlokoa ho buisana le setsebi sa tlhokomelo ea bophelo pele o kenyelletsa li-NMA ho mofuta oa kalafo oa motho ka mong.
P: Ho nka nako e kaeN-Methyl-DL-Asparticho sebetsa?
A: Liphello tsa N-Methyl-DL-Aspartic acid li ka fapana ho itšetlehile ka motho ka mong, litekanyetso le mokhoa oa tsamaiso. Leha ho le joalo, ka tloaelo, ho lumeloa hore N-Methyl-DL-Aspartic acid e ka nka kae kapa kae ho tloha metsotso e seng mekae ho ea ho lihora tse 'maloa ho qala ho sebetsa. Ho khothalletsoa ho buisana le setsebi sa tlhokomelo ea bophelo kapa ho latela litaelo tse fanoeng ke moetsi bakeng sa tlhahisoleseding e tobileng ea hore na ho nka nako e kae hore motsoako ona o sebetse.
Boitlhotlhollo: Sengoliloeng sena ke sa merero ea tlhahisoleseling feela mme ha sea lokela ho nkuoa e le keletso ea bongaka. Kamehla buisana le setsebi sa tlhokomelo ea bophelo pele u sebelisa li-supplement kapa ho fetola mokhoa oa hau oa tlhokomelo ea bophelo.
Nako ea poso: Jul-07-2023
