Evodiamine ke motsoako oa tlhaho o fumanoang limela tse itseng tse ratoang ka lebaka la melemo ea bophelo bo botle.Ho sa tsotellehe hore na u lefapheng la meriana, lijo tse tlatsetsang, kapa indasteri ea litlolo, ho fumana fektheri ea evodiamine eo u ka e tšepang ho bohlokoa katlehong ea khoebo ea hau.Leha ho fumana semela se tšepahalang sa evodiamine bakeng sa khoebo ea hau ho ka nka nako le boiteko, ho bohlokoa ho aha phepelo e atlehileng le e tšoarellang.Ka ho etsa lipatlisiso tse felletseng, ho netefatsa mehato ea taolo ea boleng, le ho lekola bokhoni ba tlhahiso, u ka fumana setsi se fihlelang litlhoko le maemo a khoebo ea hau.
Evodiamine ke motsoako oa tlhaho oa alkaloid o fumanoang litholoana tsa semela sa Evodia rutaecarpa, se tsoaletsoeng Chaena le libakeng tse ling tsa Asia.Ts'ebetso ea ho hula e kenyelletsa ho kotula litholoana ka hloko le ho arola motsoako oa evodiamine ka mekhoa e fapaneng ea ho ntša.Ka mor'a ho ntšoa, motsoako o etsoa phofo e ntle, e leng ho nolofalletsang ho kenngoa lijong tsa lijo le lihlahisoa tse ling tsa bophelo bo botle.
E na le histori e telele meriana ea setso ea Sechaena e le thuso ea ho theola boima ba 'mele, hape e' nile ea sebelisoa ho phekola mathata a sa tšoaneng a tšilo ea lijo, ho akarelletsa le ho nyekeloa ke pelo, ho hlatsa, letšollo, liso tsa ka mpeng le ho lahleheloa ke takatso ea lijo.
Hona joale, ho na le lik'hemik'hale tsa maiketsetso le metsoako e meng e nkiloeng 'marakeng.Le hoja liforomo li sa tšoane, liphello tsa tsona lia tšoana, 'me haholo-holo li itšetlehile ka khetho ea motho.
Evodiaminee tsoa ho tholoana ea semela sa Evodia rutaecarpa, se tsejoang hape e le Evodia kapa Evodia.Sefate sena se hlabang se tsoa Chaena 'me esale se sebelisoa meriana ea setso ea Machaena ka lilemo tse makholo.Litholoana tse omisitsoeng, tse sa butsoang tsa semela sa Evodia rutaecarpa li na le tekanyo e phahameng ea evodiamine, e leng se etsang hore e be mohloli o moholo oa motsoako ona oa bioactive.
Mokhoa oa ho ntša evodiamine o kenyelletsa ho kotula ka hloko litholoana tse sa butsoang le ho li beha tlas'a letoto la mekhoa ea ho ntša le ho hloekisa.Mekhoa ena hangata e kenyelletsa ho ntšoa ha solvent, filtration, le chromatography ho arola le ho tsepamisa mohopolo metsoako ea evodiamine.Sephetho se hlahisoang se ntse se sebetsoa ka ho eketsehileng ho hlahisa li-supplement tsa evodiamine kapa ho sebelisoa litokisetsong tsa setso tsa litlama.
Meriana ea setso ea Sechaena, semela sa Evodia rutaecarpa se nkoa e le sa bohlokoa ka lebaka la thepa ea eona e mengata ea bongaka, eo har'a eona evodiamine e bapalang karolo ea bohlokoa molemong oa eona oa phekolo.Ho lumeloa hore motsoako ona o na le thepa ea ho futhumatsa 'me hangata o sebelisoa ho tšehetsa bophelo bo botle ba ho sila lijo, ho imolla bohloko, le ho khothalletsa bophelo bo botle ka kakaretso.Ho phaella moo, evodiamine e tsejoa ka bokhoni ba eona ba ho tšehetsa metabolism e phetseng hantle le ho laola boima ba 'mele, e leng se etsang hore e be motsoako o tummeng oa lijo tse matlafatsang tse etselitsoeng ho khothalletsa tahlehelo ea mafura le tšebeliso ea matla.
Ntle le ts'ebeliso ea eona ea setso, evodiamine e hohetse thahasello ea morao-rao ea lipatlisiso tsa mahlale.Lipatlisiso li hlahloba liphello tsa eona tse ka 'nang tsa e-ba teng ho metabolism, thermogenesis le oxidation ea mafura, e senola mokhoa oa eona oa ts'ebetso le mekhoa e ka sebelisoang ho tšehetsa taolo ea boima ba' mele le bophelo bo botle ba metabolism.Ka lebaka leo, evodiamine e fetohile sehlooho se chesang lefapheng la lipatlisiso tsa lihlahisoa tsa tlhaho 'me e hohetse tlhokomelo ea batho ba batlang mekhoa e meng ea tlhaho ho tšehetsa lipakane tsa bona tsa bophelo bo botle le bophelo bo botle.
Le hoja semela sa Evodifolia e ntse e le mohloli o ka sehloohong oa evodiamine, tsoelo-pele ea theknoloji ea ho ntša le ho kopanya le eona e entse hore ho khonehe ho hlahisa evodiamine ho tsoa mehloling e meng ea tlhaho.Baetsi ba bang ba thehile mekhoa ea ho hlahisa evodiamine ho tsoa mefuteng e meng ea limela, ho atolosa ho fumaneha ha motsoako ona lijong tsa lijo le lihlahisoa tsa litlama.
Ke habohlokoa ho hlokomela hore boleng le katleho ea lisebelisoa tsa evodiamine li ka fapana ho itšetlehile ka mohloli le mokhoa oa ho ntša o sebelisitsoeng.Ha u khetha tlatsetso ea evodiamine, ho kgothaletswa ho khetha lihlahisoa ho tsoa ho bahlahisi ba nang le botumo bo botle ba khomarelang litekanyetso tse thata tsa taolo ea boleng le ho sebelisa mekhoa e tloaelehileng ea ho ntša metsi ho netefatsa bohloeki le matla a motsoako.
Liphuputso li bontšitse seoevodiaminee fana ka ts'ebetso ea eona e khahlanong le ho ruruha ka ho fetola litsela tse fapaneng tsa lipontšo tse amehang likarabong tsa ho ruruha.E bontšitsoe ho thibela tlhahiso ea li-cytokine tse nang le pro-inflammatory tse kang tumor necrosis factor-alpha (TNF-alpha) le interleukin-6 (IL-6), kahoo e fokotsa ho ruruha ha cascade.Ho phaella moo, evodiamine e ile ea fumanoa e thibela ts'ebetso ea nuclear factor-κB (NF-κB), e leng ntho e ngotsoeng e phethang karolo ea bohlokoa ho laola polelo ea liphatsa tsa lefutso tsa ho ruruha.Ka ho lebisa tlhokomelo ho bakena-lipakeng bana ba bohlokoa ba ho ruruha, evodiamine e bontša bokhoni bo boholo e le moemeli oa tlhaho o khahlanong le ho ruruha.
Boemong ba botenya, evodiamine e hohetse tlhokomelo bakeng sa bokhoni ba eona ba ho fetola mekhoa ea metabolic e amanang le metabolism ea lipid le tšebeliso ea matla.Lipatlisiso li bonts'a hore evodiamine e kenya likanale tsa "transient receptor" tse ka bang teng tsa vanilloid 1 (TRPV1), tse nang le karolo ho laola thermogenesis le ho leka-lekana ha matla.Ka ho kenya ts'ebetsong TRPV1, evodiamine e ka 'na ea khothalletsa ho soothoa ha lisele tse tšoeu tsa adipose, tse lebisang ho eketseha ha tšebeliso ea matla le mafura a mafura.Ho phaella moo, evodiamine e bontšitsoe ho thibela adipogenesis (mokhoa oa ho hlahisa lisele tsa mafura) ka ho laola polelo ea liphatsa tsa lefutso tsa bohlokoa tsa adipogenesis.Liphuputso tsena li senola bokhoni ba evodiamine e le motsoako oa tlhaho ho loantša botenya le mathata a metabolism.
Boithuto bo bontšitse hore evodiamine e bonts'a litlamorao tsa anti-proliferative le pro-apoptotic mefuteng e fapaneng ea lisele tsa mofetše.Mochine oo evodiamine e sebetsang ka oona khahlanong le kankere o na le likarolo tse ngata 'me o kenyelletsa taolo ea litsela tse amanang le ho hōla ha lisele, ho phela le metastasis.Haholo-holo, evodiamine e bontšitsoe ho thibela ts'ebetso ea transducer ea matšoao le activator ea transcription 3 (STAT3), e leng ntho e ngotsoeng e atisang ho senyeha mofetšeng 'me e tlatsetsa tsoelo-pele ea hlahala.Ho feta moo, ho tlalehiloe hore evodiamine e ka etsa hore ho ts'oaroe ha lisele tsa lisele le apoptosis liseleng tsa mofetše ka ho laola li-cell cycle regulators le liprotheine tsa apoptotic.
1. Ho laola boima ba 'mele
E 'ngoe ea liphello tse tsebahalang haholo tsa evodiamine ke karolo ea eona e ka bang teng ho laola boima ba' mele.Lipatlisiso li bonts'a hore evodiamine e ka thusa ho theola boima ba 'mele ka ho eketsa sekhahla sa metabolism ea' mele le ho khothaletsa oxidation ea mafura.Ho phaella moo, ho tlalehoa hore e na le thepa ea thermogenic, e bolelang hore e ka thusa ho eketsa mocheso oa 'mele oa mantlha le litšenyehelo tsa matla, tse lebisang ho melemo e ka' nang ea e-ba boima ba 'mele.
2. Lintho tse khahlanong le ho ruruha
Liphello tse ka 'nang tsa e-ba khahlanong le ho ruruha tsa evodiamine le tsona li ithutile.Ho ruruha ke karabelo ea tlhaho ea 'mele ho tsoa kotsi kapa tšoaetso, empa ho ruruha ho sa foleng ho amana le maemo a fapaneng a bophelo bo botle.Lipatlisiso li fana ka maikutlo a hore evodiamine e ka 'na ea e-ba le lintho tse thibelang ho ruruha, tse ka etsang hore e be motho ea ka khonang ho phekola ho ruruha.
3. Mosebetsi oa Antioxidant
Phello e 'ngoe e hlokomelehang ea evodiamine ke ts'ebetso ea eona ea antioxidant.Antioxidants ke metsoako e thusang ho sireletsa 'mele khatellong ea oxidative le tšenyo e bakoang ke li-radicals tsa mahala.Evodiamine e bontšitsoe hore e na le thepa ea antioxidant, e ka tlatsetsang melemo ea eona ea bophelo bo botle, ho kenyelletsa le ho sireletsa lisele ho senya le ho tšehetsa bophelo bo botle ka kakaretso.
4. Bophelo bo botle ba pelo
Liphuputso tse ling li bontša hore evodiamine e ka ba le melemo e ka bang teng bakeng sa bophelo bo botle ba pelo.Ho tlalehoa hore e na le liphello tsa vasodilatory, ho bolelang hore e ka thusa ho phomola le ho fokotsa methapo ea mali, e ka ntlafatsang phallo ea mali le ho potoloha ha mali.Ho feta moo, evodiamine e 'nile ea ithutoa ka karolo ea eona e ka bang teng ho tšehetsa maemo a bophelo bo botle ba k'holeseterole, e leng ea bohlokoa bakeng sa bophelo bo botle ba pelo.
5. Phello ea neuroprotective
Lipatlisiso li boetse li hlahlobile litlamorao tse ka bang teng tsa neuroprotective tsa evodiamine.Neuroprotection e bolela ho sireletsa sebopeho le ts'ebetso ea methapo ea kutlo bokong, e leng bohlokoa bakeng sa bophelo bo botle ba kelello.Liphuputso tse ling li fana ka maikutlo a hore evodiamine e ka ba le lisebelisoa tsa neuroprotective, tse ka bang le litlamorao ho ts'ehetsa bophelo bo botle ba boko le ts'ebetso ea kelello.
1. Tiisetso ea Boleng le Tlhahlobo
Ha u batla phofo ea evodiamine fekthering, ho bohlokoa ho etelletsa pele tiisetso ea boleng le tlhahlobo.Batla lifeme tse nang le mehato e tiileng ea taolo ea boleng ho netefatsa bohloeki le matla a lihlahisoa tsa bona.Botsa ka mekhoa ea bona ea tlhahlobo, ho kenyeletsoa tlhahlobo ea laboratoring ea motho oa boraro bakeng sa litšila le peresente ea metsoako e sebetsang ka har'a phofo.Feme e tsebahalang e tla ba pepeneneng mabapi le lits'ebetso tsa bona tsa netefatso ea boleng mme e u fe litokomane tse hlokahalang ho tšehetsa tleleime ea bona.
2. Maemo a Tlhahiso le Litifikeiti
Ntlha e ’ngoe ea bohlokoa e lokelang ho nahanoa ke litekanyetso tsa tlhahiso ea feme le litifikeiti.Batla lifeme tse lumellanang le Mekhoa e Metle ea Tlhahiso (GMP) le litekanyetso tse ling tse amehang tsa indasteri.Ho feta moo, litifikeiti tse kang ISO, HACCP, le setifikeiti sa manyolo li tiisa boitlamo ba feme ho hlahisa phofo ea boleng bo holimo ea evodiamine.Ka ho khetha fektheri e nang le litifikeiti tse nepahetseng, u ka kholiseha ka polokeho le katleho ea lihlahisoa tseo u li rekang.
3. Ponaletso ea ketane ea phepelo
Ponaletso ea ketane ea phepelo ke ea bohlokoa ha u batla phofo ea evodiamine lifekthering.Botsa mabapi le ho fumana thepa e tala, ts'ebetso ea tlhahiso, le bakena-lipakeng ba amehang khoebong ea phepelo.Lifeme tse khonang ho fana ka tlhahisoleseding e hlakileng le e hlakileng mabapi le liketane tsa bona tsa phepelo li bontša boitlamo ba mekhoa ea boitšoaro le e tsitsitseng.Ponaletso ena e boetse e o thusa ho lekola botshepehi le botsitso ba dihlahiswa tseo o di rekang.
4. Bokhoni ba ho iketsetsa le ho bopa
Ho itšetlehile ka litlhoko tsa hau tse khethehileng le kopo, ho ka 'na ha hlokahala hore u iketsetse mokhoa oa hau oa phofo ea evodiamine kapa motsoako.Ha u khetha fektheri, nahana ka bokhoni ba bona ba ho iketsetsa le ho bopa.Fumana moetsi ea ka fihlelang litlhoko tsa hau tse ikhethileng, ebang ke ho lokisa bongata ba evodiamine kapa ho theha motsoako o ikhethang le lisebelisoa tse ling.Ho khetha setsi se nang le bokhoni bo feto-fetohang ba sebopeho ho netefatsa hore u fumana sehlahisoa se ipapisitseng le lintlha tsa hau hantle.
5. Tumellano ea Taolo le Litokomane
Qetellong, ha u batla phofo ea evodiamine fekthering, ho tlameha ho nahanoa ka tumellano ea taolo le litokomane.Netefatsa hore ts'ebetso ea setsi e latela melao le litataiso tse amehang bakeng sa tlhahiso le kabo ea li-supplement tsa lijo kapa lihlahisoa tse ling tse nang le evodiamine.Ho feta moo, litokomane tsohle tse hlokahalang lia hlokahala, ho kenyelletsa le litifikeiti tsa tlhahlobo, litlhaloso tsa sehlahisoa, le tumello ea taolo.Ka ho netefatsa ho latela melao le litokomane tse fanoeng ke feme ea hau, u ka fokotsa likotsi tse ka bang teng le ho netefatsa hore lihlahisoa tsa hau li molaong.
Suzhou Myland Pharm & Nutrition Inc. esale e sebetsa khoebong ea tlatsetso ea phepo e nepahetseng ho tloha ka 1992. Ke k'hamphani ea pele naheng ea China ho nts'etsapele le ho rekisa sekhechana sa peo ea morara.
Ka boiphihlelo ba lilemo tse 30 'me e khannoa ke theknoloji e phahameng le leano le ntlafalitsoeng la R&D, k'hamphani e thehile lihlahisoa tse ngata tsa tlholisano mme ea fetoha tlatsetso e ncha ea mahlale a bophelo, ho kopanya tloaelo le khamphani ea lits'ebeletso tsa tlhahiso.
Ntle le moo, khamphani hape ke moetsi ea ngolisitsoeng ke FDA, e netefatsang bophelo bo botle ba batho ka boleng bo tsitsitseng le kholo e tsitsitseng.Lisebelisoa tsa k'hamphani tsa R&D le lisebelisoa tsa tlhahiso le lisebelisoa tsa tlhahlobo ke tsa sejoale-joale ebile li sebetsa ka mefuta-futa, 'me li khona ho hlahisa lik'hemik'hale ka tekanyo ea milligram ho ea ho tone, ho latela litekanyetso tsa ISO 9001 le mekhoa ea tlhahiso ea GMP.
P: Ke lintlha life tsa bohlokoa ha u batla fektheri e tšepahalang ea Evodiamine bakeng sa khoebo ea hau?
K: Lintlha tsa bohlokoa li kenyelletsa botumo ba feme, matla a tlhahiso, mehato ea taolo ea boleng, litheko, ho latela melao le litšebeletso tsa bareki.
P: Ke bokhoni bofe ba tlhahiso boo u lokelang ho bo sheba fekthering ea Evodiamine?
K: Ho lekola matla a tlhahiso ea feme ho netefatsa hore e ka fihlela tlhoko ea khoebo ea hau ea Evodiamine, e fana ka phepelo e tsitsitseng le e tsitsitseng.
P: Ke lintlha life tsa tsamaiso tse lokelang ho nahanoa ha u batla Evodiamine fekthering?
K: Ho ikamahanya le maemo a taolo, joalo ka tumello ea FDA, ho latela litekanyetso tsa machaba tsa pharmacopeial, le litifikeiti tse amehang, ho bohlokoa ho netefatsa hore Evodiamine e molaong le e sireletsehileng.
P: Ke lintlha life tsa likepe le tsa thepa ha u batla Evodiamine fekthering?
K: Ho lekola bokhoni ba feme ea ho tsamaisa thepa, linako tse etellang pele, le bokhoni ba ho sebetsana le thepa ea machaba ke ntho ea bohlokoa ho netefatsa phano ea Evodiamine ka nako e nepahetseng.
Boitlhotlhollo: Sengoloa sena ke sa tlhaiso-leseling e akaretsang feela 'me ha ea lokela ho nkuoa e le keletso efe kapa efe ea bongaka.Tse ling tsa litaba tsa poso ea blog li tsoa Marang-rang mme ha se setsebi.Sebaka sena sa marang-rang se na le boikarabello ba ho hlophisa, ho hlophisa le ho hlophisa lingoliloeng.Sepheo sa ho fetisa boitsebiso bo bongata ha se bolele hore u lumellana le maikutlo a eona kapa u tiisa bonnete ba litaba tsa eona.Kamehla buisana le setsebi sa tlhokomelo ea bophelo pele u sebelisa li-supplement leha e le life kapa u etsa liphetoho tsamaisong ea tlhokomelo ea bophelo.
Nako ea poso: Mar-25-2024
