Metsoako ea tlhaho e ntse e eketseha tlhokahalong ea kajeno ea lipatlisiso tsa saense le indasteri ea meriana. 7,8-Dihydroxyflavone (7,8-Dihydroxyflavone), e le motsoako oa bohlokoa o nkiloeng ke semela, e hohetse tlhokomelo e atileng ka lebaka la ts'ebetso ea eona ea bohlokoa ea likokoana-hloko. Bakeng sa bafuputsi ba saense le likhoebo, ho bohlokoa ho fumana barekisi ba tšepahalang ba 7,8-Dihydroxyflavone Powder. Phofo ea 7,8-Dihydroxyflavone e fanoeng ke Suzhou Myland e na lenomoro ea CAS ea 38183-03-8 le bohloeki bo fihlang ho 98%, ho u fa khetho e tšepahalang.
7,8-Dihydroxyflavone(eo hape e tsejoang e le 7,8-DHF kapa proflavonoid) ke molek'hule ea tlhaho e leng ea sehlopha sa flavonoid sa metsoako. E fumaneha makhasi a Godmania aesculifolia, Tridax procumbens le primula.
7,8-DHF ke motsoako oa manyolo o nang le foromo ea molek'hule C15H10O4. E qhibiliha ka har'a metsoako ea tlhaho 'me e na le' mala, monko le tatso e amanang le metsoako ea flavonoid.
7,8-DHF e hlahile e le motsoako o tšepisang oa nootropic. E bonts'itse mefuta e mengata ea litlamorao tsa neuropharmacological lithutong tsa preclinical, ho kenyelletsa ho ntlafatsa mohopolo, ho khothaletsa neurogenesis le ho thibela ho senyeha ha methapo.
E le agonist e matla le e khethang e nyane ea molek'hule ea tropomyosin receptor kinase B (TrkB), proflavin e bonts'itse katleho mefuteng ea liphoofolo khahlano le mafu a fapaneng, ho kenyeletsoa lefu la Alzheimer's.
Li-Flavonoids ke sehlopha sa metsoako ea polyphenolic e fumanehang mefuteng e fapaneng ea litholoana, meroho le mehloli e meng ea limela. Lilemong tsa morao tjena, ba fumane tlhokomelo e kholo ka lebaka la thepa ea bona ea antioxidant, anti-inflammatory le neuroprotective.
Metsoako ena e bontšitsoe e na le litlamorao tse ntle bokong, ho kenyelletsa le ho matlafatsa ts'ebetso ea kelello le ho thibela mafu a neurodegenerative. 7,8-DHF ke e 'ngoe ea metsoako e tsebahalang haholo ea polyphenolic e amohelang tlhokomelo e ntseng e eketseha joalo ka nootropic. E 'nile ea ithutoa ka liphello tsa eona tse ka bang teng maikutlong, mohopolong, ho ithuta, ho tšoenyeha le mesebetsi e meng ea kelello.
Liphello tsa methapo ea 7,8-DHF ho nahanoa hore li kena lipakeng ka ho sebelisana ha eona le li-receptor tse itseng. E fumanoe e le TrkA, mokelikeli o amehang pontšong ea ho hōla ha methapo le ea bohlokoa bakeng sa ho phela ha neuronal le polasetiki.
7,8-DHF e sebetsa ka ho laola polelo ea li-receptor tse fapaneng, ho kenyelletsa le li-subunits tsa glutamate receptor le BDNF. E boetse e ama sebopeho sa synapse, metabolism ea matla, le ho lokolloa ha acetylcholine libakeng tse itseng tsa boko.
Lipatlisiso ka 7,8-dihydroxyflavone e atolohile liphellong tsa eona bophelong ba batho, haholo-holo ho sheba kamoo e etsisang mosebetsi oa boko bo entsoeng ke neurotrophic factor (BDNF), protheine ea bohlokoa bakeng sa ho phela le ho sebetsa ha neuronal. ea protheine.
Mabapi le ts'ebeliso ea eona, 7,8-DHF e 'nile ea hlahlojoa bakeng sa mekhoa e ka' nang ea e-ba teng ho phekola mafu a methapo ea kutlo ka lebaka la bokhoni ba eona ba ho phunyeletsa mokoallo oa mali-boko.
7,8-Dihydroxyflavone e hlaha ka tlhaho mehloling e fapaneng ea lijo tsa limela, ho kenyelletsa:
● Litholoana: liapole, monokotsoai, morara le litholoana tsa lamunu
●Meroho: eiee, khale, broccoli le spinach
● Litlama: Parsley, thyme le oregano
Ntle le mehloli ena ea tlhaho, 7,8-DHF e fumaneha hape ka foromo ea tlatsetso bakeng sa tšebeliso e bonolo le e reriloeng.
Ithute ka flavonoids
Li-Flavonoids ke metsoako ea polyphenolic e phethang karolo ea bohlokoa ho fetola 'mala oa limela, ho hloekisa mahlaseli a kotsi le ho thibela maloetse. Li arotsoe ka likaroloana tse 'maloa, ho kenyelletsa flavonols, flavone, isoflavones, flavanones le anthocyanins. Sehlopha se seng le se seng se na le likarolo tse fapaneng tsa lik'hemik'hale le mesebetsi ea tlhaho, e hlahisang melemo e fapaneng ea bophelo bo botle.
7,8-dihydroxyflavone ke eng?
7,8-Dihydroxyflavone ke mofuta o khethehileng oa flavonoid oo e leng oa sehlopha sa flavonoid. Sebopeho sa eona sa lik'hemik'hale se na le lihlopha tse peli tsa hydroxyl maemong a 7 le a 8 a mokokotlo oa flavonoid, o ikarabellang bakeng sa thepa ea eona e ikhethang. Motsoako ona o fumanoa haholo-holo limeleng tse kang dioscorea (yam) 'me o ithutoe bakeng sa liphello tsa eona tse ka 'nang tsa e-ba le methapo ea kutlo, thepa e thibelang ho ruruha, le ntlafatso ea kelello.
Phapang ea Sehloho Pakeng tsa 7,8-DHF le Li-Flavonoids Tse Ling
1. Sebopeho sa lik'hemik'hale
Phapang e totobetseng haholo lipakeng tsa 7,8-DHF le li-flavonoid tse ling ke sebopeho sa eona sa lik'hemik'hale. Leha li-flavonoid tse ngata li arolelana mokokotlo o tšoanang, boteng ba lihlopha tsa hydroxyl maemong a ikhethileng bo ka ama ts'ebetso ea bona ea tlhaho haholo. Ka mohlala, quercetin, flavonol e tsebahalang, e na le tokisetso e fapaneng ea lihlopha tsa hydroxyl, tse amang ho qhibiliha ha eona le ho sebelisana le lipakane tsa likokoana-hloko.
2. Mosebetsi oa likokoana-hloko
7,8-DHF e bontšitsoe hore e na le mesebetsi e ikhethang ea likokoana-hloko ha e bapisoa le li-flavonoids tse ling. Patlisiso e bonts'a hore e kenya tšebetsong tsela ea matšoao ea "brain-derived neurotrophic factor (BDNF), e leng bohlokoa bakeng sa ho phela ha neuron, kholo le phapang. Mokhoa ona o bohlokoa ka ho khetheha maemong a mafu a neurodegenerative le ho fokotseha ha kelello.
Ka lehlakoreng le leng, li-flavonoids tse ling tse kang li-catechin (tse fumanoang ka tee e tala) le li-anthocyanins (tse fumanoang ka monokotsoai) li sebetsa haholo-holo ka ts'ebetso ea antioxidant, ho senya li-radicals tsa mahala le ho fokotsa khatello ea oxidative. Le hoja lisebelisoa tsena li le molemo, li ka 'na tsa se ke tsa ama ka ho toba lintlha tsa neurotrophic ka tsela e tšoanang le ea 7,8-DHF.
3. Bioavailability
Bioavailability e bolela tekanyo le sekhahla seo motsoako o sebetsang kapa karolo e sebetsang e monngoang le ho ba teng sebakeng sa ts'ebetso. 7,8-DHF e bontšitse bioavailability e ntle lithutong tsa liphoofolo, e bontšang hore e ka tšela ka katleho mokoallo oa mali le boko, e leng ntho ea bohlokoa bakeng sa liphello tsa eona tsa neuroprotective.
Ka lehlakoreng le leng, bioavailability ea flavonoids tse ling e ka fapana haholo. Ka mohlala, le hoja quercetin e sebelisoa haholo, ho monya ha eona hangata ho lekanyelitsoe ka lebaka la metabolism ea eona e potlakileng. Phapang ena ea bioavailability e ama katleho ea metsoako ena ho fihlela liphello tse lakatsehang tsa bophelo bo botle.
7,8-DHF mokhoa oa ts'ebetso: taolo ea BDNF le ts'ebetso ea Trkb receptor
Mabapi le mokhoa oa ts'ebetso, 7,8-DHF e tsejoa ho khothalletsa tlhahiso ea BDNF (brain-derived neurotrophic factor) ka ho tlama le ho kenya ts'ebetsong ea eona ea ho amohela TrkB. Ntle le ho sebelisa tekheniki haholo, sena se lebisa ho phokotseho ea mesebetsi ea cellular e molemo ho boloka tšebetso e nepahetseng ea methapo ea kutlo le ho khothaletsa neurogenesis.
7,8-DHF Mokhoa oa mantlha oa ts'ebetso:
(1) Boko bo entsoeng ke neurotrophic factor (BDNF) le karolo ea eona ho neuroplasticity
Ka ho sibolloa hore polelo ea boko-derived neurotrophic factor (BDNF) e fokotsehile mafung a neurodegenerative, haholo-holo lefu la Alzheimer's (AD), bohlokoa ba eona ba ho boloka le ho ntlafatsa bophelo bo botle ba boko bo ntse bo bonahala haholoanyane .
BDNF e bohlokoa bakeng sa mesebetsi e sa tšoaneng ea neuronal kaha e khothalletsa phetiso ea synaptic, synaptogenesis, le synaptic plasticity ka ho fana ka lipontšo le li-receptor tsa TrkB. Sena se etsa hore BDNF-TrkB e be sepheo se ts'episang bakeng sa nts'etsopele ea mehato ea phekolo e reretsoeng ho loantša mafu a neurodegenerative.
(2) Tropomyosin receptor kinase B (Trkb) receptor signaling pathway
The tropomyosin receptor kinase B (TrkB) receptor e phetha karolo ea bohlokoa ho kopanyelletsa liphello tsa BDNF ho li-neurons. Joaloka receptor ea transmembrane tyrosine kinase, TrkB ke mokelikeli oa mantlha oa BDNF mme e qala letoto la liketsahalo tsa matšoao a intracellular holim'a tlamahano le lintlha tsa neurotrophic.
BDNF e kenya ts'ebetsong TrkB ho qala litsela tse 'maloa tsa bohlokoa tsa intracellular, ho akarelletsa phosphatidylinositol 3-kinase (PI3K) -Akt, mitogen-activated protein kinase (MAPK) -extracellular signal-regulated kinase (ERK), le phospholipase Cγ (PLCγ) -protein kinase C. PKC) tsela. E 'ngoe le e' ngoe ea litsela tsena e kenya letsoho karolong e fapaneng ea ts'ebetso ea neuronal le bophelo bo botle.
Tsela ea PI3K-Akt e bohlokoa bakeng sa ho khothaletsa ho phela ha neuronal le ho thibela apoptosis. Letšoao la BDNF-TrkB le kenya tšebetsong tsela ena ho eketsa pholoho ea lisele ka ho thibela lintlha tsa pro-apoptotic le ho susumetsa li-anti-apoptotic factor, ka hona ho netefatsa ho bolokoa ha li-neurone tse phetseng hantle.
Ka lehlakoreng le leng, tsela ea MAPK-ERK e phetha karolo ea bohlokoa ho khethollang le ho ata ha neuronal. Letšoao la BDNF-TrkB le khothalletsa ts'ebetso ea tsela ea MAPK-ERK, eo le eona e tšehetsang kholo ea methapo ea kutlo le phapang le ho kopanngoa ha tsona ho marang-rang a teng a neuronal.
Tsela ea PLCγ-PKC e bohlokoa bakeng sa ho laola polasetiki ea synaptic, mokhoa oa motheo oa ho ithuta le ho hopola. Letšoao la BDNF-TrkB le hlophisa mosebetsi oa tsela ena, e qetellang e lebisa liphetohong tsa matla a synaptic le khokahanyo.
Mokhoa ona oa ho feto-fetoha o khothalletsa ho ikamahanya le maemo le ho hlophisoa bocha ha li-circuits tsa neural ho arabela liphihlelo tse ncha le tšusumetso ea tikoloho.
Ka ho sebetsa e le TrkB agonist, 7,8-DHF e fana ka liphello tsa eona tsa nootropic haholo-holo ka ho laola litsela tse amanang le BDNF, ka tsela eo ho khothalletsa neurogenesis le ho ntlafatsa polasetiki ea synaptic.
Ka ho etsisa liphello tsa BDNF, 7,8-DHF e thusa ho sireletsa li-neurone ho senya, ho khothalletsa ho phela ha tsona, le ho khothalletsa kholo le tlhokomelo ea likhokahano tse ncha tsa neuronal. Bokhoni bona ba ho khothaletsa neuroplasticity, ho ntlafatsa ts'ebetso ea kelello, le ho imolla matšoao a mafu a methapo e etsa hore 7,8-DHF e be mokhethoa ea tšepisang bakeng sa nts'etsopele ea lithethefatsi le lipatlisiso tse tsoelang pele.
7,8-DHF Melemo ea Nootropic: Ntlafatso ea Kelello le Neuroprotection
Mabapi le melemo ea eona ea nootropic, 7,8-DHF e sebetsa ka mekhoa e 4 e meholo:
Ho kopanya mohopolo le ho khutlisa: mosebetsi o itšetlehileng ka hippocampus
7,8-DHF e fumanoe e matlafatsa khokahanyo ea mohopolo le ho khutlisa mesebetsing e fapaneng e itšetlehileng ka hippocampus ea ho ithuta le memori mefuteng ea litoeba. Liphuputso tsena li fana ka maikutlo a hore 7,8-DHF e ka ba nootropic e tšepisang, E ka sebelisoa ho ntlafatsa ts'ebetso ea memori ho batho ba phetseng hantle le ba nang le bothata ba ho hopola.
Synaptic plasticity: bokhoni ba nako e telele le khatello ea maikutlo
7,8-DHF e bonts'itsoe hore e laola polasetiki ea synaptic ka ho khothaletsa LTP le ho fokotsa LTD ka har'a hippocampus. Liphello tsena ho nahanoa hore li na le matla a ho kenya tšebetsong li-receptor tsa TrkB ebe ka mor'a moo li ntlafatsa tsela ea matšoao ea BDNF. Phetoho ena ea polasetiki ea synaptic e kenya letsoho ntlafatsong ea ts'ebetso ea kelello e hlokometsoeng kamora tsamaiso ea 7,8-DHF.
Antioxidant thepa: ROS scavenging le lipid peroxidation
7,8-DHF e na le thepa ea antioxidant joalokaha ho pakoa ke bokhoni ba eona ba ho senya mefuta ea oksijene e sebetsang (ROS) le ho fokotsa lipid peroxidation. Litlamorao tsena li kenya letsoho litlamorao tsa eona tsa "neuroprotective" ka ho fokotsa tšenyo ea neuronal e bakoang ke oxidative le ho se sebetse hantle.
Phello e khahlanong le ho ruruha: e laola ts'ebetso ea microglial le tlhahiso ea cytokine
Ntle le thepa ea eona ea antioxidant, 7,8-DHF e fumanoe e na le liphello tse khahlanong le ho ruruha ka ho fetola ts'ebetso ea microglial le ho fokotsa tlhahiso ea li-cytokine tse nang le pro-inflammatory tse kang TNF-α le IL-1β. Sena se tlatsetsa ka ho eketsehileng liphellong tsa eona tsa neuroprotective le nootropic ka ho thibela tšenyo e bakoang ke ho ruruha ha neuronal.
Ha u batla mofani oa thepa ea7,8-DihydroxyflavonePowder, o ka nahana ka lintlha tse latelang:
1. Setumo sa mofani oa thepa
Ho bohlokoa ho khetha morekisi ea nang le botumo bo botle. U ka utloisisa botumo ba morekisi ka ho sheba maikutlo a bareki, litlaleho tsa indasteri, le liforamu tsa litsebi. Suzhou Myland e natefeloa ke botumo bo botle indastering, e nang le maikutlo a nepahetseng a bareki le boleng ba sehlahisoa se tsebahalang haholo.
2. Boleng ba sehlahisoa
Netefatsa hore lihlahisoa tse fanoang ke barekisi li latela maemo a machaba le litlhokahalo tsa taolo ea boleng. Suzhou Myland 7,8-Dihydroxyflavone Powder e entse tlhahlobo e tiileng ea boleng 'me e na le bohloeki bo fihlang ho 98%, ho netefatsa katleho le polokeho ea sehlahisoa.
3. Setifikeiti le Tumellano
Ho khetha mofani oa thepa ea nang le GMP (Good Manufacturing Practice) le setifikeiti sa ISO ho netefatsa hore ts'ebetso ea eona ea tlhahiso e fihlella maemo a machaba. Suzhou Myland e latela ka tieo litekanyetso tsena ho netefatsa botsitso le botsitso ba sehlopha ka seng sa lihlahisoa.
4. Tšehetso ea tekheniki le litšebeletso
Mofani oa thepa ea ka tšeptjoang o lokela ho fana ka tšehetso ea botekgeniki ea litsebi le tšebeletso ea bareki. Suzhou Myland e na le sehlopha sa profeshenale se ka fang bareki litlhahiso tsa tšebeliso ea sehlahisoa le tataiso ea botekgeniki ho thusa bareki ho fumana litholoana tse ntle ho lipatlisiso le ts'ebeliso.
5. Theko le nako ea ho fana
Theko le nako ea ho fana le tsona ke lintlha tsa bohlokoa ha u khetha mofani oa thepa. U ka kopa mantsoe a qotsitsoeng ho tsoa ho barekisi ba bangata 'me u bapise litheko tsa bona le linako tsa ho tlisa thepa ho fumana khetho e nepahetseng ka ho fetisisa. Suzhou Myland
e fana ka litheko tsa tlholisano le linako tse feto-fetohang tsa thomello ha o ntse o netefatsa boleng ba sehlahisoa.
Mokhoa oa ho Fumana Phofo ea 7,8-Dihydroxyflavone
Haeba u batla Powder ea boleng bo holimo ea 7,8-Dihydroxyflavone, Suzhou Myland ke khetho ea hau e nepahetseng. O ka ikopanya le rona ka:
Webosaete ea semmuso: Etela howebosaete ea semmuso ea Suzhou Mylandho ithuta haholoanyane ka lintlha tsa sehlahisoa le tšehetso ea tekheniki.
Litherisano tsa Marang-rang: Buisana ka kotloloho le sehlopha sa rona sa litšebeletso tsa bareki ka ts'ebetso ea therisano ea Marang-rang e fanoeng ke sebaka sa Marang-rang ho fumana leseli la sehlahisoa le mantsoe a qotsitsoeng ao u a hlokang.
Khokahano ea mohala: Letsetsa nomoro ea rona ea puisano ho buisana le basebetsi ba porofeshenale ba thekiso le ho fumana lintlha tse qaqileng tsa sehlahisoa le litlhahiso tsa ho reka.
Tlhahlobo ea lengolo-tsoibila: U ka boela ua re kopa tlhahisoleseling ka lengolo-tsoibila, 'me re tla u araba kapele kamoo ho ka khonehang.
Ho fumana bafani ba Powder ba 7,8-Dihydroxyflavone ba tšepahalang ha ho bonolo, empa ka ho ela hloko botumo ba mofani oa thepa, boleng ba sehlahisoa, setifikeiti le ho lumellana, tšehetso ea theknoloji le tšebeletso, hammoho le theko le nako ea ho fana ka thepa, u ka etsa qeto e bohlale. khetha. Suzhou Myland ke molekane oa hau ea loketseng ea nang le Powder ea eona ea boleng bo holimo ea 7,8-Dihydroxyflavone le tšebeletso e ntle haholo ea bareki. Re labalabela ho sebetsa le uena ho hlahloba menyetla e mengata ea ts'ebeliso ea 7,8-Dihydroxyflavone.
P: Na proflavin e ka ntlafatsa bokhoni ba ho ithuta?
A: E, proflavin e bontšitsoe ho ntlafatsa bokhoni ba ho ithuta lithutong tsa liphoofolo ka ho khothaletsa neurogenesis le likhokahano tsa synaptic. E laola litsamaiso tsa li-neurotransmitter tse bohlokoa haholo ts'ebetsong ea ho ithuta, haholo-holo hippocampus, sebaka sa bohlokoa sa boko bakeng sa ho ithuta.
P: Na 7,8-DHF e thusa ho hlaphoheloa kelellong ka mor'a kotsi?
A: E, liphuputso tsa pele ho kliniki li fana ka maikutlo a hore 7,8-DHF e ka thusa ho hlaphoheloa kelellong ka mor'a kotsi ea boko ka ho khothalletsa ts'ireletso ea methapo le tsosoloso ea methapo. E fokotsa lefu la neuronal mme e ts'ehetsa kholo ea li-neurone tse ncha, e ka ntlafatsang ts'ebetso ea kelello e senyehileng ka lebaka la ts'oaetso kapa kotsi ea ischemic.
P: Ke karolo efe eo 7,8-dihydroxyflavone e e bapalang ho fokotseng kelello e amanang le botsofali?
A: Lipatlisiso tse ntseng li hlaha li fana ka maikutlo a hore 7,8-DHF e ka liehisa ho fokotseha ha kelello ho amanang le botsofali ka ho sireletsa khahlanong le khatello ea oxidative le ho ruruha, mabaka a tloaelehileng a mafu a amanang le lilemo.
Ka ho ntlafatsa maemo a BDNF le ts'ebetso ea TrkB receptor, e thusa ho boloka botsitso ba kelello, leha ho hlokahala lithuto tse ngata tsa batho ho hlahloba litlamorao tsena ka botlalo.
P: Na 7,8-DHF e ka ntlafatsa tlhokomelo le ts'ebetso ea tsamaiso?
A:Lithuto tsa pele tsa liphoofolo li fana ka maikutlo a hore 7,8-DHF e ka ntlafatsa tlhokomelo le ts'ebetso ea tsamaiso ka ho ntlafatsa taolo ea methapo ea kutlo le likhokahano tsa methapo libakeng tsa boko tse amehang lits'ebetsong tsena.
Boitlhotlhollo: Sengoloa sena ke sa tlhaiso-leseling e akaretsang feela 'me ha ea lokela ho nkuoa e le keletso efe kapa efe ea bongaka. Tse ling tsa litaba tsa poso ea blog li tsoa Marang-rang mme ha se setsebi. Sebaka sena sa marang-rang se na le boikarabello ba ho hlophisa, ho hlophisa le ho hlophisa lingoliloeng. Sepheo sa ho fetisa boitsebiso bo bongata ha se bolele hore u lumellana le maikutlo a eona kapa u tiisa bonnete ba litaba tsa eona. Kamehla buisana le setsebi sa tlhokomelo ea bophelo pele u sebelisa li-supplement leha e le life kapa u etsa liphetoho tsamaisong ea tlhokomelo ea bophelo.
Nako ea poso: Oct-16-2024
