7,8-Dihydroxyflavone (7,8-DHF) moetsi oa phofo CAS No.: 38183-03-8 98.0% bohloeki min.bakeng sa lisebelisoa tsa tlatsetso
Lihlahisoa tsa lihlahisoa
| Lebitso la sehlahisoa | 7,8-Dihydroxyflavone |
| Lebitso le leng | 7,8-DIHYDROXYFLAVONE; 7,8-dihydroxy-2-phenyl-4-benzopyrone; DIHYDROXYFLAVONE, 7,8-(RG); 7,8-Dihydroxyflavone hydrate; 7,8-dihydroxy-2-phenyl-1-benzopyran-4-one |
| Nomoro ea CAS. | 38183-03-8 |
| Mokhoa oa limolek'hule | C15H10O4 |
| Boima ba molek'hule | 254.24 |
| Bohloeki | 98.0% |
| Ponahalo | Phofo e mosehla |
| Kopo | Tlatsetso ea Lijo tse tala |
Kenyelletso ea sehlahisoa
7,8-Dihydroxyflavone, eo hape e tsejoang e le 7,8-DHF, ke flavonoid ea tlhaho e fumanehang limela tse fapaneng, ho kenyeletsoa Tridacna tridacna.E tsebahala ka thepa ea eona ea antioxidant le neurotrophic, e 'ngoe ea lintlha tse khahlang haholo tsa 7,8-dihydroxyflavone ke bokhoni ba eona ba ho ts'ehetsa bophelo bo botle ba boko le ho matlafatsa ts'ebetso ea kelello.Lipatlisiso li bontša hore motsoako ona o sebetsa e le neurotrophin e matla, e susumetsang khōlo le ho phela ha li-neurone bokong.Liphuputso tse entsoeng liphoofolong tsa laboratori li bontšitse hore 7,8-DHF e ntlafatsa mohopolo le bokhoni ba ho ithuta haholo.Ka ho khothalletsa ho thehoa ha likhokahano tse ncha tsa synaptic le ho matlafatsa puisano pakeng tsa lisele tsa boko, motsoako ona o tšepisa ho bula bokhoni ba rona ba ho tseba.Ho feta moo, 7,8-dihydroxyflavone e sebelisana le li-receptor tsa boko tsa serotonin, tse amehang taolong ea maikutlo.Ka ho fetola li-receptor tsena, e ka khona ho fokotsa matšoao a ho tšoenyeha le khatello ea maikutlo.
Sebopeho
(1) Bohloeki bo phahameng: 7,8-Dihydroxyflavone e ka fumana lihlahisoa tse phahameng tsa bohloeki ka ho ntša tlhaho le mokhoa o motle oa tlhahiso.Bohloeki bo phahameng bo bolela bioavailability e betere le ho fokotseha ho hoholo ha maikutlo.
(2) Tšireletseho: 7,8-Dihydroxyflavone ke sehlahisoa sa tlhaho se bontšitsoeng hore se sireletsehile ho batho.Ka har'a mefuta ea litekanyetso, ha e na chefo kapa litla-morao.
(3) Botsitso: 7,8-Dihydroxyflavone e na le botsitso bo botle 'me e ka boloka mosebetsi oa eona le phello tlas'a maemo a fapaneng a tikoloho le polokelo.
(4) Ho bonolo ho monya: 7,8-Dihydroxyflavone e ka kenngoa ka potlako ke 'mele oa motho, ea kena ho potoloha ha mali ka pampitšana ea mala,' me ea abela lisele le litho tse fapaneng.
Lisebelisoa
7, 8-DHF, e le activator e nyenyane e sebetsang ea molek'hule ea TrkB receptor, e ka bapala karolo ea tšireletso ea neuron, ho tsosolosoa ha neuron, tsamaiso ea synaptic plasticity, joalo-joalo ka ho etsisa BDNF e tlamang ka ho khetheha ho TrkB le ho kenya tšebetsong litsela tsa matšoao a tlaase, e le hore ho be le haholo. ntlafatsa matšoao a ho ithuta maikutlong le ho fokotseha ha mohopolo oa sebaka, ho fokotseha ha bokhoni ba kelello, ho fokotseha ha mosebetsi oa motlakase le matšoao a mang a lefu la tsamaiso ea methapo e kang lefu la Alzheimer kapa mefuta ea liphoofolo tse tsofalang, Le ho fokotsa liphenotypes tse amanang le lefu la kelello le liphoofolo tse nonneng.Ho sa le joalo, ho fihlela joale, ha ho litla-morao tse bohlokoa tse chefo tsa 7,8-DHF tse fumanoeng liphoofolong tsa liteko.7,8-DHF e na le bokhoni le bohlokoa bo boholo thibelong le kalafong ea litaba tse amanang le BDNF/TrkB.
