Botsofali ke mokhoa oo ntho e 'ngoe le e 'ngoe e phelang ho eona. Batho ka bomong ba ke ke ba thibela botsofali, empa ba ka nka mehato e itseng ho fokotsa botsofali le ho hlaha ha mafu a amanang le botsofali. Motsoako o mong o fumane tlhokomelo e ngata haholo - nicotinamide riboside, e tsejoang hape e le NR. Joalo ka selelekela sa NAD +, ho nahanoa hore nicotinamide riboside e na le phello e makatsang ea ho thibela botsofali.
Nicotinamide riboside (NR) ke mofuta oa vithamine B3, e tsejoang hape e le nicotinic acid kapa nicotinic acid. Ke motsoako oa tlhaho o fumanehang ka bongata lijong tse itseng, joalo ka lebese, tomoso le meroho e meng.
NR ke selelekela sa nicotinamide adenine dinucleotide (NAD+), coenzyme e teng liseleng tsohle tse phelang. NAD+ e bapala karolo ea bohlokoa lits'ebetsong tse fapaneng tsa tlhaho, ho kenyelletsa tlhahiso ea matla, tokiso ea DNA, le taolo ea metabolism ea cellular. Ha re ntse re tsofala, maemo a rona a NAD+ a atisa ho fokotseha, e leng se ka amang mesebetsi ena ea bohlokoa. Li-supplement tsa NR li hlahisitsoe e le mokhoa oa ho eketsa maemo a NAD+ le mohlomong ho fokotsa ts'ebetso ea botsofali.
O mong oa melemo e meholo ea tlatsetso ea NR ke bokhoni ba eona ba ho ntlafatsa ts'ebetso ea mitochondrial. Mitochondria ke matla a matla a sele, a ikarabellang bakeng sa ho hlahisa boholo ba matla a sele ka mokhoa oa adenosine triphosphate (ATP). NR e bonts'itsoe ho khothaletsa tlhahiso ea ATP ka ho eketsa maemo a NAD +, kahoo e khothaletsa tlhahiso e sebetsang ea matla le metabolism ea cellular. Keketseho ena ea tlhahiso ea matla e ka thusa lisele le litho tse fapaneng, ho kenyelletsa boko, pelo le mesifa.
●Ntlafatsa matla a cellular
Nicotinamide riboside e bapala karolo ea bohlokoa ho faneng ka matla ho matla a sele, mitochondria. Motsoako ona ke selelekela sa nicotinamide adenine dinucleotide (NAD+), coenzyme ea bohlokoa e amehang lits'ebetsong tse ngata tsa cellular, haholo metabolism ea matla. Lipatlisiso li bonts'a hore ho tlatselletsa ka NR ho ka eketsa maemo a NAD + le ho khothaletsa phefumoloho e sebetsang ea lisele le tlhahiso ea matla.
Maemo a NAD+ a atisa ho theoha ha re ntse re tsofala, e leng se lebisang ho fokotseng ts'ebetso ea mitochondrial le ho theola matla ka kakaretso. Leha ho le joalo, ka ho tlatselletsa ka nicotinamide riboside, hoa khonahala ho khutlisa ho theoha hona le ho khutlisa maemo a matla a bocha. NR e boetse e fumanoe e matlafatsa mamello ea 'mele le ho ntlafatsa ts'ebetso ea liatleletiki, e etsa hore e be motsoako o khahlehang bakeng sa baatlelete le batho ka bomong ba batlang bophelo bo botle.
●Ntlafatsa tokiso ea lisele le ho thibela botsofali
Ntho e 'ngoe e khahlang ea nicotinamide riboside ke bokhoni ba eona ba ho khothaletsa tokiso ea DNA le ho loants'a tšenyo e amanang le botsofali. NAD+ ke karolo ea bohlokoa ts'ebetsong ea tokiso ea DNA. Ka ho tlatselletsa NR ho eketsa maemo a NAD+, re ka ntlafatsa bokhoni ba sele ba ho lokisa DNA, ka ho etsa joalo e itšireletsa khahlanong le botsofali ka katleho.
Ntle le moo, NR e kentse letsoho taolong ea litsela tsa bohlokoa tsa bophelo bo bolelele, joalo ka li-sirtuin, tse bapalang karolo ea bohlokoa ho boloka tšebetso ea cellular e phetseng hantle. Liphatsa tsa lefutso tsena tsa nako e telele li thusa ho ntlafatsa mekhoa ea ts'ireletso ea cellular khahlano le khatello ea maikutlo le ho khothaletsa bophelo bo bolelele ka kakaretso. Ka ho kenya li-sirtuin, nicotinamide riboside e ka thusa ho liehisa mafu a amanang le botsofali mme e ka eketsa nako ea rona ea bophelo bo botle.
●Thibela mafu a neurodegenerative
Mafu a amanang le neurodegenerative a kang Alzheimer's le Parkinson a ntse a ata haholo sechabeng sa rona. Lipatlisiso li fana ka maikutlo a hore nicotinamide riboside e kanna ea ba le ts'episo ea ho thibela mafu ana a fokolisang. Liphuputso li fumane hore tsamaiso ea NR e ntlafatsa ts'ebetso ea mitochondrial, e fokotsa khatello ea oxidative, 'me e ntlafatsa neuroplasticity, tseo kaofela li tlatsetsang bokong bo botle.
Ho feta moo, tlatsetso ea NR e hokahane le ts'ebetso e ntlafalitsoeng ea kelello, ho boloka mohopolo, le ho tsepamisa maikutlo ho ntlafalitsoeng le nako ea tlhokomelo. Leha lipatlisiso tse ling li ntse li hlokahala, liphuputso tsena tsa pele li fana ka maikutlo a hore nicotinamide riboside e ka ipaka e le mokhoa oa ho thibela kapa oa ts'ehetso bakeng sa batho ba kotsing ea ho senyeha ha methapo ea kutlo.
●E eketsa kutloisiso ea insulin
Liphuputso tse ngata li bontšitse hore NR e na le monyetla oa ho ntlafatsa bophelo bo botle ba metabolism. Ho bontšitsoe ho matlafatsa kutloisiso ea insulin, e leng ntlha ea bohlokoa ho boloka maemo a tsoekere a mali a phetseng hantle le ho thibela nts'etsopele ea lefu la tsoekere la mofuta oa 2. Liphuputso li boetse li fumane hore tlatsetso ea NR e ka ntlafatsa metabolism ea lipid, kahoo e fokotsa ho potoloha ha cholesterol le maemo a triglyceride. Liphello tsena li bohlokoa haholo ho batho ba nang le mathata a metabolism kapa ba batenya kapa ba batenya.
●E na le matla a antioxidant
Ho feta moo, NR e bontšitsoe ho ntlafatsa ts'ireletso ea lisele khahlanong le khatello ea oxidative. Khatello ea oxidative e etsahala ha ho na le ho se leka-lekane pakeng tsa tlhahiso ea mefuta ea oksijene e sebetsang (ROS) le bokhoni ba 'mele ba ho e fokotsa ka li-antioxidants. Maemo a phahameng a khatello ea oxidative a ka senya lisele mme a kenya letsoho tsoelo-peleng ea mafu a fapaneng, ho kenyelletsa mofetše, lefu la pelo le mafu a neurodegenerative. Liphuputso li fumane hore ho tlatsetsa NR ho ka ntlafatsa matla a antioxidant a lisele le ho fokotsa tšusumetso ea khatello ea oxidative 'meleng.
Lipatlisiso li bontša hore nicotinamide riboside e na le monyetla oa ho fokotsa botsofali ka ho eketsa maemo a molek'hule ea nicotinamide adenine dinucleotide (NAD+). NAD+ ke molek'hule ea bohlokoa e bapalang karolo ea bohlokoa ho metabolism ea cellular.
Maemo a NAD+ ka tlhaho a fokotseha ha re ntse re tsofala. Ho fokotseha hona ho nkoa e le sesosa se ka sehloohong sa botsofali. Ka ho eketsa maemo a NAD+, nicotinamide riboside e ka thusa ho fokotsa ho theoha hona le ho liehisa litlamorao tsa botsofali.
NAD+ e kenya letsoho lits'ebetsong tse ngata tsa bohlokoa tsa cellular, ho kenyelletsa tlhahiso ea matla, tokiso ea DNA, le polelo ea liphatsa tsa lefutso. Ka ho eketsa maemo a NAD+, nicotinamide riboside e ka ntlafatsa lits'ebetso tsena le ho ntlafatsa ts'ebetso ea cellular ka kakaretso.
Liphuputso tse 'maloa li bontšitse liphello tse tšepisang liseleng tsa liphoofolo le tsa batho. Phuputsong e 'ngoe, bafuputsi ba fumane hore tlatsetso ea nicotinamide riboside e ekelitse maemo a NAD+ meleng ea mesifa, kahoo e ntlafatsa ts'ebetso ea mitochondrial le boikoetliso ba litoeba.
Phuputso e 'ngoe e fumane hore tlatsetso ea nicotinamide riboside e ntlafalitse kutloisiso ea insulin le mamello ea tsoekere ho litoeba tse nonneng, tse nang le lefu la tsoekere. Sena se fana ka maikutlo a hore nicotinamide riboside le eona e kanna ea ba le melemo ea bophelo bo botle ba metabolic.
Thutong e le 'ngoe e nyane ea batho ba baholo ba lilemo tse mahareng le ba baholo, tlatsetso ea nicotinamide riboside e ekelitse maemo a NAD+ le ho ntlafatsa khatello ea mali le ho satalla ha arterial, matšoao a mabeli a bohlokoa a bophelo bo botle ba pelo.
Phuputsong e 'ngoe, bafuputsi ba fumane hore nicotinamide riboside supplementation e ntlafalitse ts'ebetso ea mesifa le ho thibela tahlehelo ea mesifa ho batho ba baholo. Sena se fana ka maikutlo a hore nicotinamide riboside e kanna ea ba le melemo e ka bang teng khahlano le ho theoha ha mesifa e amanang le lilemo.
Ke habohlokoa ho hlokomela hore botsofali ke mokhoa o rarahaneng o susumetsoang ke lintlha tse ngata, ho akarelletsa le liphatsa tsa lefutso, mokhoa oa bophelo le tikoloho. Nicotinamide riboside e lokela ho talingoa e le tlatsetso e ka thusang ho lieha ho tsofala le ho ts'ehetsa botsofali bo phetseng hantle ho fapana le kulo ea boloi.
Tse ngatanyanaNAD+ li-precursors li khethiloe, ho kenyelletsa nicotinamide riboside (NR), nicotinamide mononucleotide (NMN), le nicotinic acid (NA). Li-precursor tsena li fetoloa NAD+ hang ka har'a sele.
Har'a li-precursor tsena, nicotinamide riboside e fumane tlhokomelo e pharalletseng ka lebaka la botsitso ba eona, bioavailability, le bokhoni ba ho eketsa maemo a NAD+ ka nepo. NR ke mofuta oa tlhaho oa vithamine B3 mme e fumaneha ka bongata lebeseng le lijong tse ling. E bonts'itsoe ho ntlafatsa motsoako oa NAD + le ho susumetsa ts'ebetso ea li-sirtuin, sehlopha sa liprotheine tse amanang le bophelo bo bolelele.
O mong oa melemo ea nicotinamide riboside ke bokhoni ba eona ba ho feta mehato e mahareng e hlokahalang bakeng sa motsoako oa NAD+. E ka fetoloa ka kotloloho ho NAD + ntle le tlhoko ea li-enzyme tse eketsehileng. Ka lehlakoreng le leng, li-precursor tse ling tse kang nicotinamide mononucleotide li hloka mehato e eketsehileng ea enzymatic e kenyelletsang nicotinamide phosphoribosyltransferase (NAMPT) hore e fetoleloe ho NAD +.
Lithuto tse ngata li bapisitse katleho ea nicotinamide riboside le li-precursor tse ling tsa NAD+, 'me NR e lula e tsoa holimo. Phuputsong ea pele ho litoeba tse tsofetseng, tlatsetso ea nicotinamide riboside e fumanoe e eketsa maemo a NAD+, e ntlafatsa ts'ebetso ea mitochondrial, le ho ntlafatsa ts'ebetso ea mesifa.
Boithuto bo sa reroang, bo sa boneng habeli, bo laoloang ke placebo ho batho ba baholo ba phetseng hantle le bona bo bontšitse litholoana tse tšepisang. Maemo a NAD+ a eketsehile haholo ho barupeluoa ba nkang nicotinamide riboside ha ba bapisoa le sehlopha sa placebo. Ho feta moo, ba tlalehile ts'ebetso e ntlafetseng ea kelello le ho fokotsa mokhathala oa maikutlo.
Leha li-precursors tse ling tsa NAD+, joalo ka nicotinamide mononucleotide le niacin, li bonts'itse litlamorao tse ntle maemong a NAD+ lithutong tse ling, ha li so bonts'e boemo bo ts'oanang ba ts'ebetso joalo ka nicotinamide riboside.
Ho bohlokoa ho hlokomela hore leha nicotinamide riboside e bonahala e sebetsa haholoanyane maemong a ntseng a eketseha a NAD+, likarabo tsa motho ka mong li ka fapana. Batho ba bang ba ka fumana hore li-precursor tse ling, joalo ka nicotinamide mononucleotide kapa niacin, li loketse litlhoko tsa bona tse khethehileng.
Lisebelisoa tsa Nicotinamide riboside li fumaneha ka mefuta ea letlapa, capsule le phofo. Ho fumana tekanyo e nepahetseng ea NR ho itšetlehile haholo ka lintlha tse fapa-fapaneng, ho kenyeletsa lilemo, bophelo bo botle le liphello tse lakatsehang. Ka hona, kamehla ke bohlale ho buisana le setsebi sa tlhokomelo ea bophelo pele u qala mokhoa leha e le ofe o mocha oa tlatsetso, kaha ba ka fana ka keletso ea botho ho latela litlhoko tsa hau tse khethehileng.
Hape, ka botumo ba NR bo ntseng bo eketseha le mefuta e mengata ea marang-rang e kenang 'marakeng, ho bohlokoa ho khetha mohloli o tšepahalang le o tsebahalang. Mona ke lintlha tsa bohlokoa tseo u ka li nahanang ha u khetha tlatsetso ea NR:
1. Bohloeki le Boleng: Batla lihlahisoa tse lekiloeng le tse netefalitsoeng ho netefatsa hore li finyella litekanyetso tse tiileng tsa boleng. Batla li-supplement tse se nang li-fillers, li-additives tse kotsi, le litšila tse ka bang teng.
2. Mekhoa ea Tlhahiso: Khetha li-supplement tse entsoeng litsing tse ngolisitsoeng ke FDA 'me u latele tataiso ea Good Manufacturing Practice (GMP). Sena se tiisa hore sehlahisoa se tsitsitse, polokeho le katleho.
4. Setumo le Maikutlo a Bareki: Sheba maikutlo a bareki le litekanyetso ho fumana temohisiso ea katleho ea tlatsetso le khotsofalo ea bareki ka kakaretso.
P: Nicotinamide Riboside (NR) e sebetsa joang?
A: Nicotinamide Riboside (NR) e sebetsa ka ho eketsa maemo a NAD+ 'meleng. NAD+ e kenya letsoho tlhahisong ea matla a cellular, tokiso ea DNA, le ho boloka bophelo bo botle le ts'ebetso ea mitochondria.
P: Ke liphello life tse ka 'nang tsa e-ba khahlanong le botsofali tsa Nicotinamide Riboside (NR)?
A: Nicotinamide Riboside (NR) e bonts'itse litlamorao tse ts'episang khahlanong le botsofali ka karolo ea eona ea ho holisa maemo a NAD+. Ho eketseha ha maemo a NAD + ho ka ntlafatsa ts'ebetso ea mitochondrial, ho ntlafatsa tlhahiso ea matla a cellular, le ho khothaletsa tokiso ea DNA, tseo kaofela li ka kenyang letsoho ho loants'eng ho theoha ho amanang le lilemo le ho ntlafatsa bophelo bo botle ka kakaretso.
Boitlhotlhollo: Sengoloa sena ke sa tlhaiso-leseling e akaretsang feela 'me ha ea lokela ho nkuoa e le keletso efe kapa efe ea bongaka. Tse ling tsa litaba tsa poso ea blog li tsoa Marang-rang mme ha se setsebi. Sebaka sena sa marang-rang se na le boikarabello ba ho hlophisa, ho hlophisa le ho hlophisa lingoliloeng. Sepheo sa ho fetisa boitsebiso bo bongata ha se bolele hore u lumellana le maikutlo a eona kapa u tiisa bonnete ba litaba tsa eona. Kamehla buisana le setsebi sa tlhokomelo ea bophelo pele u sebelisa li-supplement leha e le life kapa u etsa liphetoho tsamaisong ea tlhokomelo ea bophelo.
Nako ea poso: Nov-10-2023
