Ha re ntse re hōla, ho boloka bophelo bo botle ba rona ka kakaretso ho ba bohlokoa le ho feta. Lipatlisiso tse amanang le tsona li bontša hore nicotinamide riboside, mofuta oa vithamine B3, e ka loantša botsofali ba lisele le ho khothalletsa botsofali bo botle. Nicotinamide Riboside Ntle le ho nchafatsa lisele tse tsofetseng, nicotinamide riboside e boetse e bonts'a ts'episo ea ho ntlafatsa bophelo bo botle ka kakaretso le bophelo bo bolelele. Lithuto tsa liphoofolo li bontša hore li-supplement tsa NR li ka lelefatsa nako ea bophelo le ho ntlafatsa bophelo bo botle maemong a fapaneng a amanang le lilemo, ho kenyelletsa botenya, lefu la pelo le mafu a neurodegenerative.
Botsofali ke mokhoa oa tlhaho oo lintho tsohle tse phelang li fetang ho oona. Joaloka batho, ’mele ea rōna le likelello tsa rōna li ba le liphetoho tse ngata ha re ntse re hōla.
Phetoho e totobetseng ka ho fetisisa ke ea letlalo, le nang le wrinkles, matheba a lilemo, joalo-joalo. Ho phaella moo, mesifa ea fokola, masapo a lahleheloa ke ho teteana, manonyeletso a thatafala, 'me motho a sitoa ho tsamaea.
Karolo e ’ngoe ea bohlokoa ea botsofali ke kotsi e eketsehileng ea ho tšoaroa ke mafu a sa foleng a kang lefu la pelo, lefu la tsoekere le mefuta e itseng ea mofetše. Ho phaella moo, ho fokotseha ha kelello ke bothata bo bong bo tloaelehileng. Ho lahleheloa ke mohopolo, bothata ba ho tsepamisa mohopolo, le ho fokotsa matla a kelello ho ka ama bophelo ba rona ba letsatsi le letsatsi.
Batho ba bangata ba hōlileng le bona ba jeoa ke bolutu, ba tepella maikutlong kapa ba tšoenyehile, haholo-holo haeba ba kula kapa ba shoetsoe ke moratuoa. Boemong bona, ke habohlokoa ho batla tšehetso ea maikutlo ho ba lelapa, metsoalle, esita le litsebi.
Le hoja re ke ke ra emisa ho tsofala, ho na le litsela tseo re ka li fokotsang le ho boloka ponahalo ea bocha nako e telele. Li-supplement tse thibelang botsofali ke khetho e le 'ngoe e ntle.
NAD+ ke coenzyme ea bohlokoa e fumanehang liseleng tsohle tse phelang. Mosebetsi oa eona o ka sehloohong ke ho khothaletsa metabolism ea cellular ka ho thusa phetiso ea elektrone lits'ebetsong tse ngata tsa tlhaho joalo ka tlhahiso ea matla. Leha ho le joalo, ha re ntse re tsofala, maemo a NAD+ 'meleng ea rona a theoha ka tlhaho. Liphuputso tse ling li fana ka maikutlo a hore ho fokotseha ha maemo a NAD+ e ka ba sesosa sa botsofali.
E 'ngoe ea likhatelopele tsa bohlokoa lipatlisisong tsa NAD+ ke ho sibolloa ha molek'hule ea pele ea NAD+ e bitsoang nicotinamide riboside (NR). NR ke mofuta oa vithamine B3 e fetoloang NAD + ka har'a lisele tsa rona. Lithuto tse ngata tsa liphoofolo li bonts'itse liphetho tse ts'episang, tse fanang ka maikutlo a hore tlatsetso ea NR e ka eketsa maemo a NAD + mme e ka fokotsa ho fokotseha ho amanang le lilemo.
Mafu a mangata a amanang le lilemo, joalo ka mafu a neurodegenerative le ho se sebetse hantle ha metabolism, a amahanngoa le ts'ebetso ea mitochondrial e sa sebetseng hantle. Mitochondria ke matla a matla a lisele tsa rona, tse ikarabellang bakeng sa ho hlahisa matla. NAD+ e bapala karolo ea bohlokoa ho boloka tšebetso e nepahetseng ea mitochondrial. Ka ho sireletsa bophelo bo botle ba mitochondrial, NAD+ e na le monyetla oa ho fokotsa kotsi ea mafu a amanang le lilemo le ho lelefatsa bophelo.
Ntle le moo, NAD+ e kenya letsoho ts'ebetsong ea li-sirtuin, lelapa la liprotheine tse amanang le bophelo bo bolelele. Li-Sirtuin li laola mekhoa e fapaneng ea likokoana-hloko, ho kenyelletsa le tokiso ea DNA, likarabo tsa khatello ea kelello le ho ruruha. NAD+ e bohlokoa bakeng sa ts'ebetso ea Sirtuin, e sebetsa joalo ka coenzyme e kenyang tšebetso ea eona ea enzymatic. Ka ho tlatselletsa NAD+ le ho ntlafatsa ts'ebetso ea Sirtuin, re ka khona ho liehisa botsofali le ho khothaletsa bophelo bo botle le bophelo bo bolelele.
Liphuputso tse ngata li bontšitse hore tlatsetso ea NAD + e na le litlamorao tse ntle mefuteng ea liphoofolo. Ka mohlala, phuputso e 'ngoe ho litoeba e bontšitse hore ho tlatsetsa ka NR ho ntlafatsa ts'ebetso ea mesifa le mamello. Liphuputso tse ling li bontšitse hore tlatsetso ea NR e ka ntlafatsa ts'ebetso ea metabolic ho litoeba tse tsofetseng, e etsa hore e tšoane le ea litoeba tse nyane. Liphuputso tsena li fana ka maikutlo a hore tlatsetso ea NAD + e kanna ea ba le litlamorao tse tšoanang ho batho, leha lipatlisiso tse ling li hlokahala.
Nicotinamide riboside(e tsejoang hape e le niagen) ke mofuta o mong oa niacin (eo hape e tsejoang e le vithamine B3) 'me e fumanoa ka tlhaho ka tekanyo e nyenyane lebeseng le lijong tse ling. E ka fetoleloa hoNAD+ ka har'a lisele. Joalo ka selelekela, NR e kenella habonolo ebe e isoa liseleng, moo e fetoloang NAD+ ka letoto la karabelo ea enzymatic.
Lithuto tsa tlatsetso ea NR lithutong tsa liphoofolo le tsa batho li bonts'itse litholoana tse ts'episang. Ho litoeba, tlatsetso ea NR e fumanoe e eketsa maemo a NAD + meleng e fapaneng le ho ntlafatsa ts'ebetso ea metabolic le mitochondrial.
NAD+ e kenya letsoho lits'ebetsong tse fapaneng tsa cellular tse fokotsehang ka lilemo, ho kenyelletsa tokiso ea DNA, tlhahiso ea matla, le taolo ea polelo ea liphatsa tsa lefutso. Ho nahanoa hore ho tlatsa maemo a NAD+ ka NR ho ka khutlisetsa tšebetso ea cellular, ka hona ho ntlafatsa bophelo bo botle le ho lelefatsa bophelo.
Ho feta moo, thutong ea banna ba batenya le ba batenya haholo, tlatsetso ea NR e ile ea eketsa maemo a NAD+, kahoo ea ntlafatsa kutloisiso ea insulin le ts'ebetso ea mitochondrial. Liphuputso tsena li fana ka maikutlo a hore tlatsetso ea NR e ka ba le ts'ebeliso e ka bang teng ho sebetsana le mafu a metabolic a kang mofuta oa 2 lefu la tsoekere le botenya.
1. Mehloli ea lijo tsa tlhaho tsa nicotinamide riboside
Mohloli o mong o ka bang teng oa NR ke lihlahisoa tsa lebese. Liphuputso tse ling li bontšitse hore lihlahisoa tsa lebese li na le palo e fokolang ea NR, haholo-holo lebese le matlafalitsoeng ka NR. Leha ho le joalo, litaba tsa NR lihlahisoa tsena li batla li le tlase 'me ho fumana chelete e lekaneng ka ho ja lijo feela ho ka ba thata.
Ntle le mehloli ea lijo, li-supplement tsa NR li fumaneha ka capsule kapa foromo ea phofo. Li-supplement tsena hangata li tsoa mehloling ea tlhaho joalo ka tomoso kapa ho belisoa ha baktheria. NR e entsoeng ka tomoso hangata e nkoa e le mohloli o ka tšeptjoang le o tsitsitseng hobane o ka hlahisoa ka bongata ntle le ho itšetleha ka mehloli ea liphoofolo. NR e hlahisoang ke baktheria ke khetho e 'ngoe, hangata e fumanoang mefuteng e itseng ea libaktheria tse hlahisang NR ka tlhaho.
2. Tlatselletsa nicotinamide riboside
Mohloli o atileng haholo le o tšepahalang oa nicotinamide riboside ke ka li-supplement tsa lijo. Li-supplement tsa NR li fana ka mokhoa o bonolo le o sebetsang oa ho etsa bonnete ba ho noa motsoako ona oa bohlokoa. Ha u khetha tlatsetso e ntle ka ho fetisisa ea NR, ho bohlokoa ho nahana ka lintlha tse latelang:
a) Tiisetso ea Boleng: Batla li-supplement tse entsoeng ke lik'hamphani tse tsebahalang 'me li khomarele litekanyetso tse thata tsa taolo ea boleng. Sena se tla etsa bonnete ba hore o fumana sehlahisoa sa boleng bo holimo se se nang litšila kapa litšila.
b) Bioavailability: Li-supplement tsa NR li sebelisa mekhoa e tsoetseng pele ea ho fana ka thepa e kang encapsulation kapa theknoloji ea liposome ho ntlafatsa bioavailability ea NR e le hore e ka kenngoa hantle le ho sebelisoa ke 'mele. Khetha mofuta ona oa tlatsetso ho eketsa melemo eo u e fumanang ho tsoa ho NR.
c) Bohloeki: Etsa bonnete ba hore tlatsetso ea NR eo u e khethang e hloekile ebile ha e na li-additives tse sa hlokahaleng, li-filler kapa li-preservatives. Ho bala lileibole le ho utloisisa metsoako ho ka u thusa ho etsa qeto e nepahetseng.
1. Ntlafatsa tlhahiso ea matla a cellular
NR e bapala karolo ea bohlokoa tlhahisong ea molek'hule ea bohlokoa nicotinamide adenine dinucleotide (NAD+). NAD+ e nka karolo lits'ebetsong tse fapaneng tsa cellular, ho kenyeletsoa metabolism ea matla. Ha re ntse re tsofala, maemo a NAD+ 'meleng ea rona a fokotseha, e leng se bakang ho fokotseha ha tlhahiso ea matla. Ka ho khothaletsa motsoako oa NAD +, NR e thusa ho nchafatsa lisele le ho thusa tlhahiso e nepahetseng ea matla. Matla ana a ntlafetseng a cellular a eketsa matla, a ntlafatsa tšebetso ea 'mele, 'me a fokotsa mokhathala.
2. Anti-botsofali le tokiso ea DNA
Ho fokotseha ha maemo a NAD + ho amahanngoa le botsofali le mafu a amanang le lilemo. NR e ka eketsa maemo a NAD + 'meleng, ea e etsa moemeli ea ka thibelang botsofali. NAD+ e kenya letsoho mekhoeng ea tokiso ea DNA, ho netefatsa bonnete ba liphatsa tsa lefutso tsa rona. Ka ho khothaletsa tokiso ea DNA, NR e ka thusa ho thibela tšenyo ea DNA e amanang le lilemo le ho tšehetsa botsofali bo botle. Ho feta moo, karolo ea NR ea ho kenya tšebetsong li-sirtuin, sehlopha sa liprotheine tse tsejoang ka ho laola bophelo bo botle ba lisele le nako ea bophelo, e ntlafatsa le ho feta matla a eona a ho thibela botsofali.
3. Bophelo bo botle ba pelo
Ho boloka tsamaiso ea pelo e phetseng hantle ke ea bohlokoa bakeng sa bophelo bo botle ka kakaretso. Nicotinamide riboside e bonts'itse litlamorao tse ts'episang ho bophelo bo botle ba pelo. E tšehetsa mosebetsi oa lisele tsa vascular endothelial, e khothalletsa phallo ea mali le ho fokotsa ho ruruha. NR e boetse e ntlafatsa ts'ebetso ea mitochondrial liseleng tsa pelo, ho thibela khatello ea oxidative le ho ntlafatsa tlhahiso ea matla. Litlamorao tsena li ka thusa ho fokotsa kotsi ea mafu a pelo le methapo a kang atherosclerosis le ho hloleha ha pelo.
4. Neuroprotection le ts'ebetso ea kelello
NR e bontšitsoe hore e na le lisebelisoa tsa neuroprotective, e leng se etsang hore e be motsoalle ea ka khonang ho boloka bophelo bo botle ba boko. E ka ba le phello e ntle mosebetsing oa neuronal le ho sireletsa khahlanong le ho fokotseha ha kelello ho amanang le lilemo. Ka ho eketsa maemo a NAD +, NR e ts'ehetsa ts'ebetso ea mitochondrial liseleng tsa boko, e ntlafatsa tlhahiso ea matla le ho khothaletsa tokiso ea lisele. Ho ntlafatsa ts'ebetso ea mitochondrial ho ka ntlafatsa bokhoni ba kelello joalo ka mohopolo, ho tsepamisa mohopolo le ho hlaka kelellong ka kakaretso.
5. Boima ba Boima le Bophelo bo Botle ba Metaboliki
Ho boloka boima ba 'mele bo phetseng hantle le ho leka-lekana ha metabolism ho bohlokoa ho bophelo bo botle ba rona ka kakaretso. NR e 'nile ea amahanngoa le liphello tse molemo ho metabolism, e leng se etsang hore e be thuso e ka bang teng ho laola boima ba' mele. NR e kenya tšebetsong protheine e bitsoang Sirtuin 1 (SIRT1), e laolang lits'ebetso tsa metabolic joalo ka metabolism ea tsoekere le polokelo ea mafura. Ka ho kenya tšebetsong SIRT1, NR e ka thusa ho theola boima ba 'mele le ho ntlafatsa bophelo bo botle ba metabolic, ka hona ho fokotsa kotsi ea mafu a kang botenya le lefu la tsoekere la mofuta oa 2.
P: Nicotinamide Riboside (NR) ke eng?
A: Nicotinamide Riboside (NR) ke selelekela sa Nicotinamide Adenine Dinucleotide (NAD+), coenzyme e bapalang karolo ea bohlokoa lits'ebetsong tse fapaneng tsa tlhaho, ho kenyeletsoa tlhahiso ea matla le taolo ea tšebetso ea metabolic le cellular.
P: Na Nicotinamide Riboside (NR) e ka thusa metabolism?
A: E, Nicotinamide Riboside (NR) e fumanoe e thusa metabolism. Ka ho eketsa maemo a NAD +, NR e ka kenya tšebetsong li-enzyme tse itseng tse amehang metabolism, joalo ka li-sirtuin. Ts'ebetso ena e ka ntlafatsa ts'ebetso ea metabolic, ea ntlafatsa kutlo ea insulin, le ho ts'ehetsa taolo e nepahetseng ea boima ba 'mele.
Boitlhotlhollo: Sengoloa sena ke sa tlhaiso-leseling e akaretsang feela 'me ha ea lokela ho nkuoa e le keletso efe kapa efe ea bongaka. Tse ling tsa litaba tsa poso ea blog li tsoa Marang-rang mme ha se setsebi. Sebaka sena sa marang-rang se na le boikarabello ba ho hlophisa, ho hlophisa le ho hlophisa lingoliloeng. Sepheo sa ho fetisa boitsebiso bo bongata ha se bolele hore u lumellana le maikutlo a eona kapa u tiisa bonnete ba litaba tsa eona. Kamehla buisana le setsebi sa tlhokomelo ea bophelo pele u sebelisa li-supplement leha e le life kapa u etsa liphetoho tsamaisong ea tlhokomelo ea bophelo.
Nako ea poso: Nov-13-2023
