Ha lebelo la bophelo la batho le ntse le eketseha ka potlako le ka potlako, litlhoko tsa batho ka bomong li ntse li eketseha butle-butle, haholo-holo bakeng sa mosebetsi o hlokang hore batho ka bomong ba be le tlhokomelo e molemo le ho hopola.Empa ho boloka mohopolo le mohopolo e ka ba mosebetsi o boima.Haholo-holo hona joale ka lebaka la tšubuhlellano e sa khaotseng ea boitsebiso le litšitiso, batho ba bangata ba na le bothata ba ho tsepamisa mohopolo le ho hopola lintlha tsa sehlooho.Ka lehlakoreng le leng, saense e hatetse pele hantle ho utloisisa le ho rarolla mathata ana 'me butle-butle e fumane tharollo e tšepisang-galantamine hydrobromide.
Galantamine hydrobromide ke semela sa tlhaho sa alkaloid se nkiloeng ho semela sa Caucasian Snowdrop, se nkiloeng ho mofuta oa Galanthus, o tsejoang ka hore ke Snowdrop, e ka ntšoang ho limela tsa Narcissus le Snowdrop, ka lebaka la matla a eona a ho hopola, ke khale e le teng. e sebelisoang meriana ea setso, haholo-holo lefapheng la boko.
Ho phaella moo, galantamine hydrobromide ke cholinesterase inhibitor, e bolelang hore e sebetsa ka ho thibela ho senyeha ha neurotransmitter e bitsoang acetylcholine bokong.Acetylcholine e ameha mekhoeng e fapaneng ea kelello, ho kenyelletsa ho theha mohopolo, ho ela hloko le ho ithuta.
Lefu la Alzheimer's, khaello ea acetylcholine e bakoa ke ho senyeha ha methapo ea mali bokong.Galantamine HBr e thusa ho sebetsana le khaello ena ka ho thibela acetylcholinesterase, e senyang acetylcholine, kahoo e eketsa tšebeliso ea eona.Phello ena e thusa ho ntlafatsa ts'ebetso ea kelello le mohopolo ho batho ba anngoeng ke mathata a itseng a methapo.
Ka ho thibela acetylcholinesterase, galantamine hydrobromide e tiisa hore acetylcholine e lula nako e telele ka har'a li-synapse, kahoo e khothalletsa ho ntlafala ha neurotransmission.Ts'ebetso ena e ntlafatsa puisano lipakeng tsa methapo ea kutlo, haholo-holo libakeng tsa boko tse amanang le mohopolo le temoho.Galantamine hydrobromide e boetse e susumetsa li-receptor tsa nicotinic, ho ntlafatsa phetiso ea cholinergic, ka hona ho ntlafatsa ts'ebetso ea kelello.
1. E matlafatsa sebopeho sa mohopolo le ho khutlisa
Liphuputso tse 'maloa li bontšitse hore e sebetsa ka ho thibela ho senyeha ha acetylcholine, neurotransmitter e ikarabellang bakeng sa ho theha mohopolo le ho boloka.Ka ho eketsa maemo a acetylcholine bokong, Galantamine e thusa ho matlafatsa lipotoloho tsa mohopolo bakeng sa ho hopola hantle le ho boloka tlhahisoleseling.
2. Tsepamiso le Tsepamiso
Phuputsong ea batho ba baholo ba phetseng hantle, barupeluoa ba nkileng galantamine hydrobromide ba tlalehile hore galantamine e ntlafatsa mohopolo, e lumellang batho ho tsepamisa maikutlo hamolemo le ho thibela litšitiso.Ho nahanoa hore phello ena e bakoa ke phello ea moriana ho li-receptor tsa boko tsa nicotinic acetylcholine, tse phethang karolo ea bohlokoa tabeng ea ho ela hloko le ho falimeha.Ka ho lebisa tlhokomelo le ho susumetsa li-receptor tsena, Galantamine HBr e ka thusa batho ka bomong ho boloka tlhokomelo e tsitsitseng le ho ntlafatsa ts'ebetso ea bona ea kelello.
3. Kalafo ea bokooa ba kelello
Bokhoni ba kalafo ba galantamine hydrobromide bo feta ho ntlafatsa mohopolo le tlhokomelo.E sebelisoa haholo ho phekola mafu a kelello joalo ka Alzheimer's le dementia.Ho bontšitsoe ho fokotsa matšoao a amanang le mathata ana, ho kopanyelletsa le ho lahleheloa ke mohopolo, pherekano le ho ferekana kelellong.Galantamine e finyella liphello tsena ka ho eketsa palo ea acetylcholine bokong le ho ntlafatsa puisano ea neuronal.
Ithute ka lintlafatso tsa kelello:
Lintho tse matlafatsang tsebo, tse tsejoang hape e le nootropics kapa lithethefatsi tse bohlale, ke lintho tse nang le monyetla oa ho ntlafatsa likarolo tse fapaneng tsa ts'ebetso ea boko.Lintho tsena li tsoa ho metsoako ea tlhaho e kang caffeine le omega-3 fatty acids ho lithethefatsi tsa maiketsetso tse kang galantamine hydrobromide le modafinil.Li sebetsa ka ho ama li-neurotransmitters, phallo ea mali, kapa maemo a oksijene bokong, ka hona, li ntlafatsa bokhoni ba kelello joalo ka mohopolo, mohopolo le boqapi.
Ha ho bapisoa galantamine hydrobromide le lisebelisoa tse ling tsa kelello, ho bohlokoa ho nahana ka phello ea eona e khethehileng le mokhoa oa ts'ebetso.Tse ling tse tsebahalang tse matlafatsang tsebo li kenyelletsa racemate, modafinil, caffeine, le omega-3 fatty acids.Papiso ea Galantamine Hydrobromide le Lisebelisoa tse ling tsa Kelello:
●Li-piracetam (tse kang Piracetam) ke sehlopha sa metsoako ea maiketsetso eo liphello tsa eona tsa ho ntlafatsa tsebo li ithutoang haholo.Lisebelisoa tsena tsa kelello li sebetsa ka ho fetola li-neurotransmitters tse fapaneng bokong, ho kenyelletsa le acetylcholine.Leha ho le joalo, galantamine hydrobromide e bonahala e na le phello e hlakileng haholoanyane ho khothaletseng ho fumaneha ha acetylcholine, e leng se etsang hore e be matla haholoanyane ho ntlafatsa mohopolo le thuto.
●Modafinil: Modafinil ke lithethefatsi tsa ngaka tse sebelisoang haholo-holo ho phekola mathata a ho robala a kang ho robala.E na le melemo e khathollang le ea ho falimeha hape e sebelisoa kantle ho label joalo ka sehlahisoa sa kelello.Modafinil haholo-holo e ama ho falimeha, ha galantamine HBr e lebisa tlhokomelo mohopolong le tlhokomelo.Khetho pakeng tsa tse peli e itšetlehile haholo ka molemo o lakatsehang oa kelello.
●Caffeine: Caffeine ke ntho e atisang ho ananeloa ka mokhoa o sa ananeloang oa ho sebelisa kelello e fanang ka melemo ea nako e khutšoanyane ea kelello, haholo-holo ka ho thibela li-receptor tsa adenosine, ho khothalletsa ho falimeha, le ho ntlafatsa nakoana.Ka lehlakoreng le leng, galantamine hydrobromide e bile le phello e kholo ho boloka mohopolo le ho hopola.Ho kopanya caffeine le galantamine hydrobromide ho ka fana ka mokhoa o akaretsang oa ntlafatso ea kelello.
●Omega-3 fatty acids: Omega-3 fatty acids, e atisang ho fumanoa tlhapi e mafura, walnuts, le flaxseed, e 'nile ea amahanngoa le ts'ebetso e ntlafetseng ea kelello le bophelo bo botle ba boko.Leha ho le joalo, liphello tsa bona li poteletseng ho feta tsa galantamine hydrobromide.Omega-3 fatty acids haholo-holo e tšehetsa bophelo bo botle ba boko, ha Galantamine HBr e na le phello e khethehileng ho ntlafatsa mohopolo.
Qetellong, galantamine hydrobromide e na le ts'episo ea ho ntlafatsa kutloisiso, haholo-holo ka lebaka la bokhoni ba eona ba ho eketsa ho fumaneha ha acetylcholine bokong.Le hoja tse ling tse matlafatsang tsebo tse kang racemate, modafinil, le omega-3 fatty acids li ka 'na tsa e-ba le melemo ea tsona, galantamine HBr e bonahala e na le phello e tobileng haholoanyane mohopolong le mekhoa ea ho ithuta.Leha ho le joalo, lipatlisiso tse ling lia hlokahala ho hlokomela bokhoni ba eona bo felletseng le ho ntlafatsa ts'ebeliso ea eona.
Lethal dose:
Tekanyo e nepahetseng ea galantamine hydrobromide e ka fapana ho latela ts'ebeliso e reriloeng le lintlha tsa motho ka mong.Ho bohlokoa ho latela litataiso tse khothalelitsoeng le ho buisana le setsebi sa tlhokomelo ea bophelo pele u qala mofuta ofe kapa ofe o mocha oa tlatsetso.
Lintlha tsa bohlokoa:
1.Boikutlo ba Motho: Motho e mong le e mong a ka arabela galantamine ka tsela e fapaneng.Qala ka tekanyo e tlaase ka ho fetisisa e ka khonehang 'me u shebe karabo ea hau ka hloko pele u fetola lethal dose ea hau.
2.Nako ea ho nka: Nako ea ho nka Galantamine ke ea bohlokoa.Bakeng sa ntlafatso ea kelello le phekolo ea bokooa ba kelello, hangata e nkoa hoseng kapa ka lijo tsa hoseng.Bakeng sa toro e hlakileng, e lokela ho nkoa har'a mpa ea bosiu, ka mor'a lihora tse ka bang 'nè tsa boroko.
3.Litla-morao: Le hoja galantamine ka kakaretso e mamelloa hantle, e ka baka litla-morao tse fokolang ho isa ho tse itekanetseng tse kang ho nyekeloa ke pelo, ho tsekela, ho lora, kapa ho hlobaela.Batho ba nang le nalane ea liso tsa ka mpeng kapa asthma ba lokela ho ba hlokolosi ha ba sebelisa galantamine.
Ha re phethela:
Ho fumana tekanyo e nepahetseng ea litekanyetso tsa galantamine hydrobromide ho bohlokoa ho fihlela litlamorao tse lakatsehang tsa ntlafatso ea kelello.Ebang u ikemiselitse ho ntlafatsa mohopolo, ho loantša bothata ba kelello, kapa ho teba ka ho teba tabeng ea ho lora ka mokhoa o hlakileng, ho bohlokoa ho buisana le setsebi sa bophelo bo botle le ho latela litataiso tse khothalelitsoeng.Ka ho utloisisa metheo ea galantamine, tšebeliso ea eona e tsebahalang, litekanyetso tse khothalelitsoeng, le lintlha tsa bohlokoa, batho ba ka sebelisa melemo ea motsoako ona ka mokhoa o sireletsehileng le ka katleho bakeng sa ts'ebetso e ntlafalitsoeng ea kelello le bophelo bo botle ka kakaretso.
P: Na Galantamine Hydrobromide e bolokehile bakeng sa tšebeliso ea nako e telele?
A: Galantamine Hydrobromide e nkoa e sireletsehile bakeng sa tšebeliso ea nako e khutšoanyane le ea nako e telele ha e nooa ka litekanyetso tse nepahetseng.Leha ho le joalo, ke habohlokoa ho hlokomela hore tšebeliso ea nako e telele e ka lebisa ho nts'etsopele ea mamello, e ka 'nang ea fokotsa katleho ea eona ka nako.Ho eletsoa ho nka khefu ea kamehla kapa lipotoloho tsa tšebeliso ea Galantamine ho fokotsa liphello tsa mamello.
P: Na Galantamine Hydrobromide e ka rekoa ntle le lengolo la ngaka?
A: E, Galantamine Hydrobromide e fumaneha e le tlatsetso e rekisoang linaheng tse ngata.Leha ho le joalo, kamehla ho khothalletsoa ho buisana le setsebi sa tlhokomelo ea bophelo pele u qala mokhoa leha e le ofe o mocha oa tlatsetso, haholo-holo haeba u e-na le maemo leha e le afe a bophelo bo botle kapa u noa meriana e meng.
Boitlhotlhollo: Sengoliloeng sena ke sa merero ea tlhahisoleseling feela mme ha sea lokela ho nkuoa e le keletso ea bongaka.Kamehla buisana le setsebi sa tlhokomelo ea bophelo pele u sebelisa li-supplement kapa ho fetola mokhoa oa hau oa tlhokomelo ea bophelo.
Nako ea poso: Jul-31-2023
