Evodiamine ke motsoako oa tlhaho o fumanoang litholoana tsa semela sa Evodiamine, se tsoaletsoeng Chaena le linaheng tse ling tsa Asia. E 'nile ea sebelisoa meriana ea setso ea Chaena ka makholo a lilemo ka lebaka la melemo ea eona ea bophelo bo botle. Har'a tsona, evodiamine e na le bokhoni bo boholo ba ho laola ho ruruha le ho thusa ho theola boima ba' mele. Matla a eona a ho thibela ho ruruha a e etsa mokhethoa oa bohlokoa bakeng sa ho phekola mafu a fapaneng a ho ruruha, ha bokhoni ba eona ba ho eketsa thermogenesis le ho khothaletsa lipolysis bo ka thusa ho laola boima ba 'mele.
Na o kile wa kopana le lentswe "evodiamine" mme wa ipotsa hore na le bolela eng hantle? Evodiamine, e tswang semeleng Evodiamine, ke motswako wa tlhaho o tswang Chaena le dinaheng tse ding tsa Asia. Evodiamine ke ya sehlopha sa di-alkaloid tse tsejwang e le "quinazole alkaloids," e leng metswako e ntshwang ditholwaneng tse sa butswang tsa semela mme e tsejwa ka thepa ya yona ya bongaka. Ka makgolo a dilemo, meriana ya setso ya China e sebedisitse matla a evodiamine ho imolla malwetse a fapaneng.
Evodiamine e tsebahala ka thepa ea eona ea ho futhumatsa 'mele, e leng mokhoa oo 'mele o hlahisang mocheso ka oona, o ka ntlafatsang sekhahla sa metabolism le ho khothaletsa ho chesoa ha lik'hilojule. Ka ho eketsa thermogenesis, evodiamine e ka thusa ho chesa mafura le ho laola boima ba 'mele.
Ho ruruha ke karabelo ea tlhaho ea 'mele kotsing kapa tšoaetso. Leha ho le joalo, ho ruruha ho sa foleng ho ka lebisa mafung a fapaneng. Ka ho fokotsa ho ruruha, evodiamine e ka thusa ho ntlafatsa bophelo bo botle ka kakaretso le ho fokotsa kotsi ea mafu a itseng.
Evodiamine e tsebahala ka thepa ea eona ea ho hlahisa mocheso. Thermogenesis e bolela mokhoa oa ho hlahisa mocheso 'meleng. Joale evodiamine e hlahisa mocheso joang ka ho khetheha?
E 'ngoe ea litsela tseo evodiamine e sebelisang litlamorao tsa eona tsa thermogenic ka tsona ke ka ho kenya tšebetsong protheine e bitsoang transient receptor potential vanilloid subtype 1 (TRPV1). TRPV1 ke receptor e fumanoang haholo-holo tsamaisong ea methapo 'me e ameha taolong ea mocheso oa' mele le metabolism. Ha evodiamine e tlamahana le TRPV1, e baka letoto la likarabo tsa 'mele, ho kenyeletsoa le keketseho ea litšenyehelo tsa matla le thermogenesis.
Evodiamine e fumanoe e susumetsa litšoelesa tsa adrenal ho lokolla li-catecholamine tse kang epinephrine le norepinephrine. Li-catecholamine li bapala karolo ea bohlokoa ho eketseheng ha lipolysis, e leng ho qhaqha mafura a bolokiloeng hore e be li-fatty acid tse lokolohileng tse ka sebelisoang e le mohloli oa matla. Ts'ebetso ena e ntšetsa pele litlamorao tsa thermogenic tsa evodiamine.
Ho phaella moo, evodiamine e bontšitsoe e thibela mosebetsi oa li-enzyme tse itseng tse amehang ho thehoeng le ho bolokoeng ha lisele tsa mafura. Mohlala, e thibela tlhahiso ea peroxisome proliferator-activated receptor gamma (PPARγ), e leng transcription factor e khothalletsang ho bokellana ha mafura ka har'a li-adipocyte. Ka ho thibela mosebetsi oa PPARγ, evodiamine e ka thusa ho thibela ho thehoa ha lisele tse ncha tsa mafura le ho fokotsa polokelo ea mafura.
1. Taolo ea boima ba 'mele
E 'ngoe ea melemo e tsebahalang haholo ea evodiamine ke bokhoni ba eona ba ho thusa ka tlhaho ho laola boima ba 'mele. Lipatlisiso li bontša hore evodiamine e ka hlasimolla li-receptor tsa "mocheso" 'meleng ea rona, tse tsejoang e le li-receptor tsa transient receptor potential vanilloid 1 (TRPV1). Ka ho kenya tšebetsong li-receptor tsena, evodiamine e ka thusa ho eketsa thermogenesis le oxidation ea mafura, ka hona e matlafatsa metabolism le tahlehelo ea boima ba 'mele. Ho feta moo, e thibela kholo ea lisele tse ncha tsa mafura, e tšehetsa haholoanyane thepa ea eona ea taolo ea boima.
2. Litšobotsi tsa ho thibela ho ruruha
Ho ruruha ho sa feleng ho amahanngoa le mathata a fapaneng a bophelo bo botle, ho kenyeletsoa le lefu la pelo le methapo ea mali, lefu la tsoekere le tse ling. Evodiamine e nkoa e le moemeli ea ka thibelang ho ruruha ka lebaka la bokhoni ba eona ba ho thibela tlhahiso ea limolek'hule tse bakang ho ruruha. Lithuto tse 'maloa li bontšitse hore evodiamine e ka thibela ts'ebetso ea nuclear factor-κB (NF-κB), e leng ntlha ea bohlokoa ea ho ngola e laolang polelo ea liphatsa tsa lefutso tse bakang ho ruruha. Ka ho thibela NF-κB, evodiamine e fokotsa ho ruruha ka ho fokotsa tlhahiso ea li-cytokine tse bakang ho ruruha tse kang interleukin-1β (IL-1β) le tumor necrosis factor-α (TNF-α).
3. Matla a ho kokobetsa bohloko le a ho kokobetsa bohloko
Bohloko, boo hangata bo amanang le ho ruruha, ke letšoao le leng la bohlokoa le ka amang boleng ba bophelo haholo. Litšobotsi tsa evodiamine tse kokobetsang bohloko li ithutiloe ka botlalo, ka liphetho tse khothatsang. Lipatlisiso li bontša hore evodiamine e ka kenya tšebetsong kanale ea vanilloid 1 (TRPV1) ea transient receptor, e amehang phetisong ea matšoao a bohloko. Ka ho kenya tšebetsong likanale tsena, evodiamine e ka thibela maikutlo a bohloko 'me ea fana ka phomolo ho batho ba nang le mefuta eohle ea bohloko, ho kenyeletsoa bohloko ba methapo ea kutlo le ba ho ruruha.
4. Bophelo bo botle ba pelo le methapo ea mali
Ho boloka tsamaiso e phetseng hantle ea pelo le methapo ea mali ho bohlokoa bakeng sa bophelo bo botle ka kakaretso. Evodiamine e bontšitsoe e na le litlamorao tse ntle tsa pelo le methapo ea mali, joalo ka ho fokotsa khatello e phahameng ea mali le ho thibela ho kopana ha liplatelete. Ka ho phomotsa methapo ea mali le ho thibela ho thehoa ha makhopho a mali, evodiamine e ka thusa ho ntlafatsa phallo ea mali le ho fokotsa kotsi ea lefu la pelo le methapo ea mali, ho kenyeletsoa le tlhaselo ea pelo le stroke.
5. Bophelo bo Botle ba Mala
Evodiamine e ka ba le tšusumetso e ntle bophelong ba mala ka ho khothaletsa ts'ebetso ea tšilo ea lijo le ho fokotsa mathata a tšilo ea lijo. Lipatlisiso li bontša hore evodiamine e ka hlasimolla tlhahiso ea lienzyme tsa tšilo ea lijo le ho ntlafatsa motsamao oa mala, qetellong ea thusa tšilo ea lijo le ho imolla ho se phutholohe ha tšilo ea lijo. Ho feta moo, thepa ea evodiamine e ka bang ea ho loantša likokoana-hloko e ka thusa ho loantša libaktheria tse kotsi le ho khothaletsa microbiome e phetseng hantle ea mala.
Evodiamine e reheletsoe ka e 'ngoe ea mehloli ea eona e meholo ea limela, Evodia rutaecarpa, e tsejoang haholo e le litholoana tsa Evodia kapa Evodia rutaecarpa. Semela sena se tsoa Asia Bochabela 'me se' nile sa sebelisoa meriana ea setso ea Chaena ka makholo a lilemo. Litholoana tse sa butsoang tsa semela sa Evodia carota ke mohloli o moholo oa evodiamine. Mohlolo ona oa limela o na le li-alkaloid tse 'maloa, ho kenyeletsoa le evodiamine, tse bontšitseng liphello tse molemo bophelong.
Mehloli e meng ea limela
Ntle le Evodiamine, evodiamine e fumaneha mehloding e meng e mengata ya dimela. Tsena di kenyeletsa Alstonia macrophylla, Evodia lepta le Euodia lepta, hara tse ding. Dimela tsena di hlaha dikarolong tse fapaneng tsa Asia, ho kenyeletswa Chaena, Japane le Thailand.
Hoa thahasellisa hore mehloli ena ea limela ha e felle feela likarolong tse itseng tsa semela. Le hoja litholoana tse sa butsoang e le mohloli oa mantlha, evodiamine e ka boela ea ntšoa makhasing, likutung le metsong ea limela tsena. Mefuta ena e mengata ea mehloli e fa bafuputsi le bo-rasaense menyetla e mengata ea ho hlahloba melemo e fapaneng ea bophelo bo botle le ts'ebeliso ea evodiamine.
●Tekanyo e nepahetseng: Tekanyo e nepahetseng ea evodiamine e itšetlehile ka lintlha tse 'maloa tse kang lilemo tsa mosebelisi, bophelo bo botle le maemo a mang a' maloa. Hopola hore lihlahisoa tsa tlhaho ha li bolokehe kamehla, 'me tekanyo ea bohlokoa. Ho bohlokoa ho bala mabitso a lihlahisoa ka hloko le ho buisana le setsebi sa tlhokomelo ea bophelo ho fumana tekanyo e loketseng litlhoko tsa hau.
●Lintho Tse ka Amehang ka Bophelo ba Motho ka Mong: Ha o etsa qeto ea ho sebelisa tlatsetso efe kapa efe, ho kenyeletsoa le evodiamine, ho bohlokoa ho nahana ka bophelo bo botle ba motho ka kakaretso, nalane ea bongaka le mamello ea hae ea botho. Ho phaella moo, ela hloko likamano tse ka bang teng tsa lithethefatsi 'me u nahane ka lintlha tsa bophelo bo botle ba motho ka mong ho eketsa melemo ea evodiamine ha u ntse u fokotsa likotsi life kapa life tse amanang le eona.
P: Evodiamine e laola ho ruruha joang?
K: Evodiamine e fumanoe e na le thepa ea ho thibela ho ruruha. E thibela ts'ebetso ea limolek'hule tse itseng tsa ho ruruha, tse kang nuclear factor-kappa B (NF-kB) le cyclooxygenase-2 (COX-2), tse bapalang karolo ea bohlokoa ho ruruha. Ka ho fokotsa tlhahiso ea limolek'hule tsena, evodiamine e thusa ho fokotsa ho ruruha 'meleng.
P: Na evodiamine e ka sebediswa bakeng sa ho theola boima ba mmele?
K: Evodiamine e fuputsitswe ka ditlamorao tsa yona tse ka bang teng ho theoleng boima ba mmele. Ho dumelwa hore e kenya tshebetsong tshebetso e bitswang thermogenesis, e eketsang mocheso wa mantlha wa mmele le sekgahla sa metabolism. Sena, ka lehlakoreng le leng, se ka eketsa tshebediso ya dikhalori mme sa thusa ho theoleng boima ba mmele. Leha ho le jwalo, ho hlokahala dipatlisiso tse ding ho fumana katleho le polokeho ya evodiamine bakeng sa ho theola boima ba mmele.
Tlhokomeliso: Sengoloa sena ke sa tlhahisoleseding e akaretsang feela mme ha sea lokela ho nkuwa e le keletso efe kapa efe ya bongaka. Tse ding tsa tlhahisoleseding ya poso ya blog di tswa Inthaneteng mme ha se tsa botsebi. Webosaete ena e ikarabella feela bakeng sa ho hlophisa, ho hlophisa le ho hlophisa dihlooho. Morero wa ho fetisa tlhahisoleseding e eketsehileng ha o bolele hore o dumellana le maikutlo a yona kapa o tiisa bonnete ba dikahare tsa yona. Kamehla buisana le setsebi sa tlhokomelo ya bophelo pele o sebedisa ditlatsetso dife kapa dife kapa o etsa diphetoho tsamaisong ya hao ya tlhokomelo ya bophelo.
Nako ea poso: Loetse-26-2023
