Bo-rasaense ba fumane hore ha re ntse re tsofala, mitochondria ea rona e fokotseha butle-butle mme e hlahisa matla a fokolang. Sena se ka lebisa ho mafu a amanang le botsofali a kang mafu a neurodegenerative, lefu la pelo le tse ling.
Urolithin A
Urolithin A ke metabolite ea tlhaho e nang le litlamorao tsa antioxidant le antiproliferative. Litsebi tsa phepo e nepahetseng tse tsoang Univesithing ea Nova Southeastern United States li fumane hore ho sebelisa urolithin A e le ho kenella ha lijo ho ka liehisa mokhoa oa ho tsofala le ho thibela tsoelo-pele ea mafu a amanang le lilemo.
Urolithin A (UA) e hlahisoa ke libaktheria tsa rona tsa mala ka mor'a ho ja li-polyphenols tse fumanoang lijong tse kang likharenate, fragole le walnuts. Tlatsetso ea UA ho litoeba tsa lilemo tse mahareng e kenya tšebetsong li-sirtuin mme e eketsa NAD + le maemo a matla a cellular. Habohlokoa, UA e bontšitsoe ho hlakola mitochondria e senyehileng mesifa ea motho, ka tsela eo e ntlafatsa matla, ho hanyetsa mokhathala le ts'ebetso ea liatleletiki. Ka hona, tlatsetso ea UA e ka eketsa nako ea bophelo ka ho hanyetsa botsofali ba mesifa.
Urolithin A ha e tsoe ka ho toba ho tsoa lijong, empa metsoako e kang ellagic acid le ellagitannins e nang le linate, likharenate, morara le monokotsoai o mong o tla hlahisa urolithin A ka mor'a hore e sebelisoe ke likokoana-hloko tsa mala.
Spermidine
Spermidine ke mofuta oa tlhaho oa polyamine o fumaneng tlhokomelo lilemong tsa morao tjena bakeng sa bokhoni ba eona ba ho lelefatsa bophelo le ho eketsa bophelo bo botle. Joalo ka NAD+ le CoQ10, spermidine ke molek'hule ea tlhaho e fokotsehang ka lilemo. Ho tšoana le UA, spermidine e hlahisoa ke libaktheria tsa rona tsa mala 'me e baka mitophagy - ho tlosoa ha mitochondria e sa pheleng, e senyehileng. Liphuputso tsa litoeba li bontša hore tlatsetso ea spermidine e ka sireletsa khahlanong le lefu la pelo le botsofali ba basali. Ho feta moo, spermidine ea lijo (e fumanehang lijong tse fapaneng ho kenyelletsa soya le lijo-thollo) e ntlafalitse mohopolo ho litoeba. Ho hlokahala lipatlisiso tse eketsehileng ho fumana hore na liphuputso tsena li ka phetoa ho batho.
Mokhoa o tloaelehileng oa botsofali o fokotsa bongata ba mefuta ea tlhaho ea spermidine 'meleng, ho latela lipatlisiso tse hatisitsoeng ho Scientific Reports ke bafuputsi ba Kyoto Prefectural University of Medicine Japane. Leha ho le joalo, ketsahalo ena ha e e-s'o bonoe ho batho ba lilemo li lekholo;
"Spermidine" e ka khothalletsa lefu la 'mele.
Lijo tse nang le li-spermidine tse ngata li kenyelletsa: lijo tsa koro, kelp, li-mushroom tsa shiitake, linate, bracken, purslane, joalo-joalo.
curcumin
Curcumin ke motsoako o sebetsang oa turmeric o nang le thepa e khahlanong le ho ruruha le antioxidant.
Litsebi tsa baeloji tsa liteko tsa Polish Academy of Sciences li fumane hore curcumin e ka fokotsa matšoao a botsofali le ho liehisa tsoelo-pele ea mafu a amanang le lilemo tseo lisele tsa senescent li amehang ka ho toba, kahoo li lelefatsa nako ea bophelo.
Ho phaella ho turmeric, lijo tse nang le curcumin li kenyelletsa: ginger, garlic, eiee, pepere e ntšo, mosetareta le curry.
NAD + tlatsetso
Moo ho nang le mitochondria, ho na le NAD+ (nicotinamide adenine dinucleotide), molek'hule e hlokahalang bakeng sa ho eketsa tlhahiso ea matla. NAD+ ka tlhaho e fokotseha ka lilemo, e shebahalang e lumellana le ho fokotseha ho amanang le lilemo ts'ebetsong ea mitochondrial. Lena ke le leng la mabaka a entseng hore li-boost tsa NAD + tse kang NR (Nicotinamide Ribose) li ntlafatsoe ho khutlisetsa maemo a NAD +.
Lipatlisiso li bonts'a hore ka ho khothaletsa NAD+, NR e ka ntlafatsa tlhahiso ea matla a mitochondrial le ho thibela khatello ea maikutlo e amanang le lilemo. Lisebelisoa tsa NAD + precursor li ka ntlafatsa ts'ebetso ea mesifa, bophelo bo botle ba boko, le metabolism ha li ntse li ka loants'a mafu a neurodegenerative. Ho feta moo, ba fokotsa boima ba 'mele, ba ntlafatsa kutloisiso ea insulin,' me ba etsa hore maemo a lipid a tloaelehe, joalo ka ho theola LDL cholesterol.
Nako ea poso: Jul-24-2024
