Mitochondria e bohlokoa haholo e le mohloli oa matla oa lisele tsa 'mele ea rona, e fana ka matla a maholo ho boloka pelo ea rona e otla, matšoafo a rona a phefumoloha le' mele ea rona e sebetsa ka nchafatso ea letsatsi le letsatsi. Leha ho le joalo, ha nako e ntse e ea, le ka lilemo, mehaho ea rona e hlahisang matla, mitochondria, e ba kotsing ea ho senyeha le ho lahleheloa ke bokhoni ba eona ba ho sebetsa ka katleho. Mitochondria e sebetsang ka botlalo e bohlokoa bophelong ba motho. Leha ho le joalo, mitochondria le eona e kotsing e kholo ea ho senyeha ho tsoa mehloling e fapaneng, ho kenyelletsa khatello ea oxidative, ho ruruha le chefo ea tikoloho. Lintlha tsena li ka baka tšenyo ho DNA ea mitochondrial, ea senya bokhoni ba bona ba ho hlahisa ATP le metsoako e meng ea bohlokoa.
Ka lehlohonolo, 'mele ea rona e khetha ho tlosa mitochondria e senyehileng le e sa sebetseng liseleng tsa rona ka mitochondrial autophagy e le ho boloka bophelo bo botle le ho qoba litlamorao tse ling tse mpe tsa mitochondria ena e senyehileng, ho latela liphuputso tse bonts'ang hore ts'ebetso ea mitochondrial autophagy e na le karolo ea anti- botsofali. Ha re utloisise kamano pakeng tsa mitochondria le anti-botsofali!
Mesebetsi ea mitochondria ke efe?
Mitochondria ke li-organelle tsa bohlokoa tse hlahisang matla liseleng tsa rona. Karolo ea bona e ka sehloohong ke ho hlahisa adenosine triphosphate (ATP), e leng chelete ea matla ea lisele tsa rona. Ha re e-na le mitochondria e ngata, re ka hlahisa ATP e eketsehileng, e leng se lebisang ho matla a eketsehileng le ho fokotsa mokhathala. Har'a likarolo tse kholo tseo e li bapalang ke:
(1)ho fana ka matla le metsoako ea metabolism 'meleng
(2)Mitochondrial autophagy e lemoha mitochondria e senyehileng ebe e e tlosa ka mokhoa o ikhethileng, 'me ho tlosoa ha mitochondria ena e senyehileng ho khothalletsa biosynthesis ea mitochondria e ncha.
(3)E ka bapala karolo ea ho thibela lefu la lisele ka ho tlosa mitochondria
(4)E 'nile ea amahanngoa le nts'etsopele ea mathata a mangata a bophelo bo botle, ho akarelletsa le lefu la pelo, mafu a neurodegenerative esita le mefuta e meng ea kankere.
Ke kamano efe pakeng tsa mitochondria le anti-botsofali?
Liphuputso li bontšitse hore ha re ntse re tsofala, ho hlaka ka mitochondrial autophagy ho senyeha, ho bolelang hore lisele tsa mitochondrial ha li khone ho hlakola mesebetsi ea tsona. Ntle le mekhoa e ntlafalitsoeng ea taolo ea boleng joalo ka mitochondrial autophagy, tšenyo ea cellular e ka potlakisa.
Lithutong tsa liphoofolo, nako e telele ea bophelo e 'nile ea bonoa ha liphatsa tsa lefutso tse laolang mitochondrial autophagy li hlahisoa, ho fana ka maikutlo a hore mitochondrial autophagy le bophelo bo bolelele li amana. Ho phaella moo, bofokoli ba mitochondrial autophagy bo atisa ho bonoa maloetseng a 'maloa a amanang le lilemo, ho akarelletsa lefu la Parkinson le Alzheimer's, lefu la pelo le kankere, ho fana ka maikutlo a hore mehato e lebisang ho autophagy ea mitochondrial e ka ba le karolo ea ho thibela le ho phekola mafu. Qetellong, senotlolo sa botsofali ka bokhabane ke ho utloisisa le ho tšehetsa mekhoa e rarahaneng haholo e bolokang 'mele o sebetsa. Ka ho sebeletsa ho nts'etsapele bophelo bo botle ba mitochondrial autophagy le ho etsa khetho ea mekhoa ea bophelo e etelletsang boiketlo ba rona pele, re ka notlolla liphiri tsa bophelo bo bolelele le bo botle!
Mokhoa oa ho eketsa autophagy ea mitochondrial
(1)Nahana ka ho itima lijo ka mekhahlelo le thibelo ea khalori
Liphuputso li bontšitse hore mitochondrial autophagy e ka susumetsoa ke mekhoa e fapaneng ea mekhoa ea bophelo. Ka mohlala, boikoetliso bo 'nile ba bontšoa ho eketsa boits'oaro ba mitochondrial, kahoo ho ntlafatsa mosebetsi oa mitochondrial. Ntle le moo, mehato ea lijo tse kang ho itima lijo ka nakoana kapa lithibelo tsa khalori le tsona li ka tsosa autophagy ea mitochondrial, e leng se fellang ka ho eketseha ha mitochondria e phetseng hantle.
(2)Boikoetliso bo sa tloaelehang
Boikoetliso ke bona bo bonolo le bo bonolo ho latela. E ka khothalletsa bophelo bo botle le ho phela nako e telele hammoho le ho ntlafatsa ts'ebetso ea mitochondrial hammoho le ho etsa hore motho a itšoare ka mitochondrial, kahoo boikoetliso bo ka hlophisoa ka mokhoa o utloahalang ka matla a itseng, koetliso ea aerobic le mamello ho eketsa autophagy ea mitochondrial.
(3)Urolithin A ke molek'hule e hlahisang lefu la mitochondrial autophagy
Urolithin A ke motsoako oa metabolite o hlahisoang ke phetoho ea ellagic tannins ke libaktheria tsa mala. Li-precursors tsa eona ke ellagic acid le ellagitannin, e ka fumanoang limela tse ngata tse jeoang, tse kang kharenate, fragole, tse tala, walnuts, joalo-joalo, empa eseng hore e teng lijong, hobane ke libaktheria tse ling feela tse ka fetolang ellagitannin ho urolithin. 'Me urolithin A, motsoako oa organic o entsoeng ho tsoa ho li-precursors tsa lijo, ke ntho e bonts'itsoeng hore e baka lefu la mitochondrial autophagy.
Bohlokoa ba mitochondrial autophagy
Mitochondrial autophagy ke ts'ebetso ea tlhaho le ea bohlokoa e thusang ho boloka mitochondria e phetseng hantle ka har'a lisele tsa rona. Ts'ebetso ena e kenyelletsa ho hloaea mitochondria e senyehileng kapa e sa sebetseng hantle le ho e tlosa ka mokhoa o ikhethileng seleng ho fana ka tsela ea hore mitochondria e ncha e ka nkeloa sebaka. Ka nako e ts'oanang, ts'ebetso ea mitochondrial autophagy e thusa ho netefatsa hore matla a 'mele ea rona a lula a tsitsitse le hore lisele le lisele tsa rona li lula li phetse hantle li bile li sebetsa.
Qetellong, ho boloka mitochondria e phetseng hantle ho bohlokoa bakeng sa bophelo bo botle le boiketlo ba rona ka kakaretso, 'me lisele tsa rona li fetohile mokhoa o bitsoang mitochondrial autophagy ho netefatsa hore re na le phepelo e tsoelang pele ea mitochondria e phetseng hantle. Leha ho le joalo, mekhoa ea mekhoa ea bophelo (e kang ho ikoetlisa) le mekhoa ea lijo (e kang lijo tsa ketogenic) le tšebeliso ea li-supplement li ka tšehetsa mosebetsi oa mitochondrial le ho thusa ho thibela maloetse a amanang le lilemo. Ka ho hlokomela mitochondria ea rona, re ka etsa bonnete ba hore re na le matla le mahlahahlaha ao re a hlokang ho phela bophelo bo feletseng.
Ntle le moo, re ka tseba ka ho hlaka kamano pakeng tsa mitochondria le anti-botsofali, ha re ntse re tsofala, ts'ebetso ea mitochondrial autophagy e senyeha, ke hore, e lebisa ho bokelleng ha mitochondria ka liseleng, tseo ho itima lijo, thibelo ea khalori, urolithin A. , joalo-joalo e ka etsa hore ho be le mitochondrial autophagy 'me e ka ntlafatsa bophelo bo botle le ho thibela botsofali, moo NAD + le urolithin A li kenyang letsoho ho hlahiseng mitochondria e ncha ka mokhoa o bitsoang biogenesis process e bitsoang biogenesis; leha ho le joalo, urolithin A e na le mosebetsi o mong oa bohlokoa. E ntlafatsa ts'ebetso e bitsoang mitochondrial autophagy, moo mitochondria e senyehileng e tlosoang ebe e sebelisoa hape ho mitochondria e ncha, e sebetsang hantle haholoanyane. Batho ba bangata bophelong ba rona ba kanna ba se khone ho ikoetlisa ka nako e telele, empa sehlahisoa se hlahisitsoeng seo re fanang ka sona, Urolithin A, se ka fana ka bophelo bo botle.
P: Na ho na le lijo tse itseng bophelong ba hao tse ka u thusang ho thibela botsofali pele ho nako?
A: E, lijo tse ling tse nang le li-antioxidants, livithamine le liminerale li ka thusa ho khothalletsa letlalo le phetseng hantle le ho liehisa mokhoa oa ho tsofala. Mehlala e kenyelletsa litholoana, meroho, liprotheine tse se nang mafura le mafura a phetseng hantle.
Nako ea poso: Jun-01-2023
