Mitochondria ke ea bohlokoa haholo e le mohloli oa matla oa lisele tsa 'mele ea rona, e fana ka matla a maholo ho boloka lipelo tsa rona li otla, matšoafo a rona a hema le 'mele ea rona e sebetsa ka ho nchafatsa letsatsi le letsatsi. Leha ho le joalo, ha nako e ntse e ea, le ha botsofali bo ntse bo hōla, meaho ea rona e hlahisang matla, mitochondria, e ba kotsing ea ho senyeha 'me e lahleheloa ke bokhoni ba eona ba ho sebetsa hantle. Mitochondria e sebetsang ka botlalo e bohlokoa bophelong ba motho. Leha ho le joalo, mitochondria le eona e kotsing ea ho senyeha ho tsoa mehloling e fapaneng, ho kenyeletsoa khatello ea oxidative, ho ruruha le chefo ea tikoloho. Lintho tsena li ka baka tšenyo ho DNA ea mitochondrial, tsa sitisa bokhoni ba tsona ba ho hlahisa ATP le metsoako e meng ea bohlokoa.
Ka lehlohonolo, 'mele ea rona e tlosa mitochondria e senyehileng le e sa sebetseng hantle liseleng tsa rona ka ho sebelisa mitochondrial autophagy e le ho boloka bophelo bo botle le ho qoba litlamorao tse mpe tsa mitochondria ena e senyehileng, ho latela lithuto tse bontšang hore ts'ebetso ea mitochondrial autophagy e na le karolo ho thibeleng botsofali. A re utloisiseng kamano pakeng tsa mitochondria le ho thibela botsofali!
Mesebetsi ea mitochondria ke efe?
Mitochondria ke li-organelle tsa bohlokoa tse hlahisang matla liseleng tsa rona. Karolo ea tsona e ka sehloohong ke ho hlahisa adenosine triphosphate (ATP), e leng chelete ea matla ea lisele tsa rona. Ha re e-na le mitochondria e ngata, re ka hlahisa ATP e ngata, e leng se lebisang ho eketseheng ha matla le ho fokotseha ha mokhathala. Har'a mesebetsi e meholo eo e e bapalang ke:
(1)ho fana ka matla le metsoako e kopanyang metabolism 'meleng
(2)Autophagy ea Mitochondrial e lemoha mitochondria e senyehileng 'me e e tlosa ka khetho, 'me ho tlosoa ha mitochondria ena e senyehileng ho khothalletsa biosynthesis ea mitochondria e ncha.
(3)E ka bapala karolo ho thibeleng lefu la sele ka ho tlosa mitochondria
(4)E 'nile ea amahanngoa le nts'etsopele ea mathata a fapaneng a bophelo bo botle, ho kenyeletsoa lefu la pelo, mafu a methapo ea kutlo esita le mefuta e meng ea mofetše.
Khokahano ke efe pakeng tsa mitochondria le thibelo ea botsofali?
Lithuto li bontšitse hore ha re ntse re tsofala, ho tlosoa ha lisele tsa mitochondrial autophagy hoa senyeha, ho bolelang hore lisele tsa mitochondrial ha li khone ho hlakola mesebetsi ea tsona. Ntle le mekhoa e ntlafalitsoeng ea taolo ea boleng joalo ka mitochondrial autophagy, tšenyo ea lisele e ka potlakisoa.
Lithutong tsa liphoofolo, nako e telele ea bophelo e 'nile ea bonoa ha liphatsa tsa lefutso tse laolang autophagy ea mitochondrial li hlahisoa, e leng se bontšang hore autophagy ea mitochondrial le bophelo bo bolelele lia amana. Ho phaella moo, autophagy ea mitochondrial e senyehileng hangata e bonoa mafung a 'maloa a amanang le botsofali, ho kenyeletsoa lefu la Parkinson le la Alzheimer, lefu la pelo le kankere, e leng se bontšang hore mekhoa e shebaneng le autophagy ea mitochondrial e ka ba le karolo thibelong le kalafong ea mafu. Qetellong, senotlolo sa botsofali ka bokhabane se ho utloisisa le ho tšehetsa lits'ebetso tse rarahaneng haholo tse bolokang 'mele o sebetsa. Ka ho sebetsa ho khothaletsa autophagy e phetseng hantle ea mitochondrial le ho etsa likhetho tsa mokhoa oa bophelo tse behang boiketlo ba rona pele, re ka notlolla liphiri tsa bophelo bo bolelele le bo phetseng hantle!
Mokhoa oa ho eketsa autophagy ea mitochondrial
(1)Nahana ka ho itima lijo ka mekhahlelo le ho fokotsa lik'hilojule
Lithuto li bontšitse hore autophagy ea mitochondrial e ka hlohlelletsoa ke mekhoa e fapaneng ea mekhoa ea bophelo. Mohlala, boikoetliso bo bontšitsoe bo eketsa autophagy ea mitochondrial, ka hona bo ntlafatsa ts'ebetso ea mitochondrial. Ho phaella moo, mekhoa ea lijo e kang ho itima lijo nako le nako kapa ho fokotsa lik'hilojule le eona e ka hlohlelletsa autophagy ea mitochondrial, e leng se fellang ka keketseho ea mitochondria e phetseng hantle.
(2)Boikoetliso bo sa tloaelehang
Boikoetliso ke bona bo bonolo le bo bonolo ho bo latela. Bo ka ntlafatsa bophelo bo botle le ho phela nako e telele hammoho le ho ntlafatsa ts'ebetso ea mitochondrial hammoho le ho susumetsa autophagy ea mitochondrial, kahoo boikoetliso bo ka hlophisoa ka mokhoa o utloahalang ka koetliso ea matla, aerobic le mamello ho eketsa autophagy ea mitochondrial.
(3)Urolithin A ke molek'hule e bakang autophagy ea mitochondrial
Urolithin A ke motsoako o hlahisoang ke phetoho ea li-tannins tsa ellagic ke libaktheria tsa mala. Li-precursor tsa eona ke ellagic acid le ellagitannin, tse ka fumanoang limela tse ngata tse jeoang, joalo ka kharenate, fragole, raspberry, walnuts, jj., empa ha se hore e teng lijong, hobane ke libaktheria tse ling feela tse ka fetolang ellagitannin ho ba urolithin. 'Me urolithin A, motsoako oa tlhaho o entsoeng ka lintho tse ka pele ho lijo, ke ntho e bontšitsoeng e baka autophagy ea mitochondrial.
Bohlokoa ba autophagy ea mitochondrial
Mitochondrial autophagy ke ts'ebetso ea tlhaho le ea bohlokoa e thusang ho boloka mitochondria e phetseng hantle ka har'a lisele tsa rona. Ts'ebetso ena e kenyelletsa ho khetholla mitochondria e senyehileng kapa e sa sebetseng hantle le ho e tlosa ka khetho sele ho etsa sebaka sa mitochondria e ncha, e sebetsang ho e nkela sebaka. Ka nako e ts'oanang, ts'ebetso ea mitochondrial autophagy e thusa ho netefatsa hore maemo a matla a 'mele ea rona a lula a tsitsitse le hore lisele le lisele tsa rona li lula li phetse hantle ebile li sebetsa.
Qetellong, ho boloka mitochondria e phetseng hantle ho bohlokoa bakeng sa bophelo bo botle ba rona ka kakaretso le boiketlo ba rona, 'me lisele tsa rona li hlahisitse mokhoa o bitsoang mitochondrial autophagy ho netefatsa hore re na le phepelo e tsoelang pele ea mitochondria e phetseng hantle. Leha ho le joalo, mekhoa ea bophelo (joalo ka boikoetliso) le mekhoa ea lijo (joalo ka lijo tsa ketogenic) le tšebeliso ea li-supplement li ka tšehetsa ts'ebetso ea mitochondrial le ho thusa ho thibela mafu a amanang le botsofali. Ka ho hlokomela mitochondria ea rona, re ka netefatsa hore re na le matla le matla ao re a hlokang ho phela bophelo bo felletseng.
Ho phaella moo, re ka tseba ka ho hlaka kamano pakeng tsa mitochondria le ho thibela botsofali, ha re ntse re tsofala, ts'ebetso ea autophagy ea mitochondrial ea senyeha, ke hore, e lebisa ho bokellaneng ha mitochondria liseleng, tseo ho tsona ho itima lijo, ho fokotsa lik'hilojule, urolithin A, jj. li ka bakang autophagy ea mitochondrial 'me li ka ntlafatsa bophelo bo botle le ho thibela botsofali, moo NAD+ le urolithin A ka bobeli li kenyang letsoho tlhahisong ea mitochondria e ncha ka ts'ebetso e bitsoang biogenesis ts'ebetso e bitsoang biogenesis; leha ho le joalo, urolithin A e na le mosebetsi o mong oa bohlokoa. E ntlafatsa ts'ebetso e bitsoang mitochondrial autophagy, eo ho eona mitochondria e senyehileng e tlosoang le ho sebelisoa hape ho ba mitochondria e ncha, e sebetsang hantle haholoanyane. Batho ba bangata maphelong a rona ba kanna ba se khone ho ikoetlisa nako e telele, empa sehlahisoa se hlahelletseng seo re se fanang ka sona, Urolithin A, se ka fana ka bophelo bo botle bo botle.
P: Na ho na le dijo tse itseng bophelong ba hao tse ka thusang ho thibela botsofali pele ho nako?
K: E, lijo tse ling tse nang le li-antioxidants, livithamine le liminerale li ka thusa ho ntlafatsa letlalo le phetseng hantle le ho liehisa ts'ebetso ea botsofali. Mehlala e kenyelletsa litholoana, meroho, liprotheine tse se nang mafura le mafura a phetseng hantle.
Nako ea poso: Phuptjane-01-2023
