Ha re ntse re tsofala, 'mele ea rona ka tlhaho e feta liphetohong tse fapaneng tse ka amang bophelo bo botle ba rona le bophelo bo botle.E 'ngoe ea matšoao a botsofali a bonahalang ka ho fetisisa ke ho hlaha ha makhopho, mela e metle, le letlalo le thellang.Le hoja ho se na mokhoa oa ho thibela botsofali, bafuputsi ba ’nile ba sebetsa ka thata ho fumana metsoako e ka ’nang ea liehisa kapa ea fetola e meng ea liphello tsa botsofali.Urolithin A ke e 'ngoe ea metsoako e bontšang tšepiso e kholo tabeng ena.Lipatlisiso tsa morao-rao li bontša hore urolithin A e ka ntlafatsa ts'ebetso ea mesifa le mamello, ea ntlafatsa mosebetsi oa mitochondrial, esita le ho khothalletsa ho tlosoa ha likarolo tsa cellular tse senyehileng ka mokhoa o bitsoang autophagy.Liphello tsena li etsa hore urolithin A e be mokhethoa ea tšepisang bakeng sa nts'etsopele ea litlhare tse thibelang botsofali.Ntle le litlamorao tsa eona tse thibelang botsofali, urolithin A e ithutoe bakeng sa karolo e ka bang teng ea ho khothaletsa bophelo bo bolelele.
Pele re kenella ka har'a litlamorao tse ka thibelang botsofali tsa urolithin A, a re qaleng ka ho utloisisa hore na botsofali ke eng.Botsofali ke mokhoa o rarahaneng o kenyelletsang ho fokotseha butle-butle ha ts'ebetso ea lisele le ho bokella tšenyo ea lisele ka nako.Ts'ebetso ena e susumetsoa ke lintlha tse fapaneng tse kenyeletsang liphatsa tsa lefutso, mokhoa oa bophelo le ho pepeseha ha tikoloho.Ho fumana litsela tsa ho liehisa kapa ho khutlisa ts'ebetso ena e bile sepheo sa nako e telele lipatlisisong tsa botsofali.
Urolithin A e bontšitsoe hore e kenya tšebetsong tsela ea cellular e bitsoang mitophagy, e ikarabellang bakeng sa ho hloekisa le ho tsosolosa mitochondria e senyehileng (motlakase oa sele).Mitochondria e bapala karolo ea bohlokoa tlhahisong ea matla 'me ke mohloli o moholo oa mefuta ea oksijene e sebetsang (ROS), e ka senyang likarolo tsa cellular le ho potlakisa botsofali.Ka ho khothalletsa mitophagy, urolithin A e thusa ho boloka ts'ebetso ea mitochondrial e phetseng hantle le ho fokotsa khatello ea oxidative, eo ho nahanoang hore e tlatsetsa botsofaling.
Lithuto tse 'maloa li fane ka liphetho tse ts'episang mabapi le litlamorao tsa urolithin A botsofaling.Phuputso e 'ngoe ea li-nematode e fumane hore urolithin A e atolositse nako ea bophelo ea li-nematode ho fihla ho 45%.Liphetho tse ts'oanang li ile tsa bonoa liphuputsong tsa litoeba, moo tlatsetso ka urolithin A e atolositseng bophelo ba bona bo tloaelehileng le ho ntlafatsa bophelo ba bona ka kakaretso.Liphuputso tsena li fana ka maikutlo a hore urolithin A e na le monyetla oa ho fokotsa botsofali le ho lelefatsa bophelo.
Ntle le liphello tsa eona bophelong ba nako ea bophelo, urolithin A e boetse e na le liphello tse tsotehang bophelong ba mesifa.Hangata botsofali bo amahanngoa le ho lahleheloa ke mesifa le ho fokotseha ha matla, boemo bo tsejoang e le sarcopenia.Bafuputsi ba fumane hore urolithin A e ka khothalletsa kholo ea mesifa le ho eketsa matla a mesifa.Tekong ea tleliniki e amang batho ba baholo ba baholo, tlatsetso ea urolithin A e ile ea eketsa boima ba mesifa le ho ntlafatsa ts'ebetso ea 'mele.Liphuputso tsena li fana ka maikutlo a hore urolithin A ha e na liphello tse khahlanong le botsofali feela empa hape e na le melemo e ka bang teng bakeng sa bophelo bo botle ba mesifa, haholo-holo ho batho ba hōlileng.
Ho feta moo, ho bohlokoa ho bolela hore urolithin A e tsoa ho likharenate, empa palo ea urolithin A lihlahisoa tsa kharenate e ka fapana haholo.Ka hona, metsoako ea maiketsetso e fetoha khetho e ntle, 'me e hloekile ebile e bonolo ho e fumana.
Urolithin A e tsoa ho ellagitannins, eo hangata e fumanoang litholoana le linate tse itseng.Li-ellagitannins tsena li sebelisoa ke libaktheria tsa mala ho hlahisa urolithin A le metabolite tse ling.Hang ha e kenngoa, urolithin A e ama 'mele boemong ba lisele.
E 'ngoe ea melemo e hlokomelehang ea urolithin A ke bokhoni ba eona ba ho susumetsa mitophagy, ts'ebetso ea bohlokoa bophelong ba lisele.Hangata mitochondria e bitsoa matla a matla a sele mme e bapala karolo ea bohlokoa tlhahisong ea matla.Leha ho le joalo, ha re ntse re tsofala, katleho ea mitochondrial ea fokotseha, e lebisang ho se sebetse ha lisele le ho ka ba le nts'etsopele ea mafu a sa tšoaneng a amanang le lilemo.
Mitophagy ke mokhoa oa bohlokoa oa ho tlosa mitochondria e senyehileng le e sa sebetseng, e lumellang mitochondria e ncha, e phetseng hantle ho e nkela sebaka.Urolithin A e bontšitsoe ho tsamaisa ts'ebetso ena, ho khothaletsa phetoho ea mitochondrial le ho ntlafatsa bophelo bo botle ba lisele.Ka ho felisa mitochondria e sa sebetseng, urolithin A e liehisa mokhoa oa ho tsofala le ho fokotsa kotsi ea mafu a amanang le lilemo.
Ntle le litlamorao tsa eona ho mitophagy, urolithin A e boetse e na le thepa e khahlanong le ho ruruha.Ho ruruha ho sa foleng ke sesosa se seholo sa maemo a 'maloa a bophelo bo botle, ho kenyelletsa lefu la pelo, botenya le mafu a neurodegenerative.Lipatlisiso li fumane hore urolithin A e hatella matšoao a ho ruruha le ho thibela tlhahiso ea metsoako e thibelang ho ruruha, kahoo e fokotsa kotsi ea ho ruruha ho sa foleng le mafu a amanang le eona.
Ho feta moo, urolithin A e bontšitse bokhoni ba eona e le antioxidant e matla.Khatello ea oxidative e bakoa ke ho se leka-lekane pakeng tsa tlhahiso ea li-radicals tsa mahala le bokhoni ba 'mele ba ho li fokotsa,' me li phetha karolo ea bohlokoa ho tsofalang le nts'etsopele ea mafu a sa tšoaneng.Urolithin A e ka senya li-radicals tsa mahala tse kotsi, ea ntlafatsa bokhoni ba 'mele ba ho itšireletsa khahlanong le antioxidant, ea sireletsa lisele ho tsoa tšenyo ea oxidative,' me e ka liehisa ts'ebetso ea ho tsofala.
Lipatlisiso li boetse li totobatsa melemo e ka bang teng ea urolithin A bakeng sa bophelo bo botle ba mesifa le ts'ebetso ea liatleletiki.Hangata botsofali bo tsamaisana le ho fokotseha ha mesifa le matla, e leng se lebisang kotsing e eketsehileng ea ho oa, ho robeha le ho lahleheloa ke boipuso.Urolithin A e bontšitsoe ho eketsa motsoako oa mesifa ea mesifa le ho ntlafatsa ts'ebetso ea mesifa, e ka fokotsang tahlehelo ea mesifa e amanang le lilemo.
Ho feta moo, urolithin A e fumanoe e matlafatsa ts'ebetso ea boikoetliso ka ho susumetsa tlhahiso ea liprotheine tse amehang kholong ea mesifa le ho lokisoa.Ka ho ts'ehetsa bophelo bo botle ba mesifa le ts'ebetso ea liatleletiki, urolithin A e ka thusa ho boloka bophelo bo mafolofolo le bo ikemetseng ha re ntse re tsofala.
● Etsa hore mala a phele hantle
Bakeng sa ho ntlafatsa tlhahiso ea Urolithin A 'meleng ea rona, ho ntlafatsa bophelo bo botle ba mala ke ntho ea bohlokoa.Mefuta e fapa-fapaneng le e atlehang ea gut microbiome e thusa phetoho e sebetsang hantle ea ellagitannins hore e be urolithin A. Ho ja lijo tse nang le fiber tse ngata tse akarelletsang litholoana, meroho, lijo-thollo le limela tsa linaoa ho matlafatsa libaktheria tse molemo tsa mala 'me ho theha tikoloho e loketseng tlhahiso ea urolithin A.
● Urolithin A lijong
Kharenate ke e 'ngoe ea mehloli e ruileng ka ho fetisisa ea tlhaho ea urolithin A. Litholoana ka boeona li na le li-precursor ellagitannins, tse fetoloang ho urolithin A ka libaktheria tsa mala nakong ea tšilo ea lijo.Lero la kharenate ka ho khetheha le fumanoe le na le likhahla tse phahameng tsa urolithin A mme e nkuoa e le khetho e ntle ea ho fumana motsoako ona ka tlhaho.Ho noa khalase ea lero la kharenate letsatsi le leng le le leng kapa ho eketsa likharenate tse ncha lijong tsa hau ho ka thusa ho eketsa tlhahiso ea hau ea urolithin A.
Litholoana tse ling tse nang le urolithin A ke fragole, tse nang le ellagic acid e ngata.Ho tšoana le likharenate, fragole e na le ellagitannins, e fetoloang urolithin A ke libaktheria tsa mala.Ho eketsa fragole lijong tsa hau, ho li sebeletsa e le seneke, kapa ho li kenya ho smoothies ea hau kaofela ke litsela tse monate tsa ho eketsa maemo a hau a urolithin A.
Ntle le litholoana, linate tse ling li boetse li na le ellagitannins, e ka 'nang ea e-ba mohloli oa tlhaho oa urolithin A. Li-walnuts, haholo-holo, li fumanoe li na le li-ellagitannins tse ngata, tse ka fetoloang ho urolithin A ka maleng.Ho kenyelletsa li-walnuts tse seng kae lijong tsa hau tsa letsatsi le letsatsi ha ho molemo bakeng sa bophelo bo botle ka kakaretso feela, empa hape le ho fumana urolithin A ka tlhaho.
● Lisebelisoa tsa phepo e nepahetseng le sekhechana sa urolithin A
Bakeng sa ba batlang tekanyo e tsepamisitsoeng haholoanyane, e ka tšeptjoang ea urolithin A, li-supplement tsa phepo e nepahetseng le li-extracts e ka ba khetho.Tsoelo-pele ea lipatlisiso e lebisitse ho nts'etsopele ea lisebelisoa tsa boleng bo phahameng tse nkiloeng ho qotsulo ea kharenate e entsoeng ka ho khetheha ho fana ka tekanyo e nepahetseng ea urolithin A. Leha ho le joalo, ho bohlokoa ho khetha mofuta o tsebahalang le o tsebahalang ho netefatsa boleng ba sehlahisoa le polokeho.
● Nako le mabaka a botho
Ela hloko, phetoho ea ellagitannins ho urolithin A e fapana ho ea ka batho ka bomong, ho latela sebopeho sa bona sa mala a microbiota le liphatsa tsa lefutso.Ka hona, nako e hlokahalang ho bona molemo o moholo oa tšebeliso ea urolithin A e ka fapana.Mamello le botsitso li bohlokoa ha o kenyelletsa lijo tse nang le urolithin A-rich kapa li-supplement kemisong ea hau ea letsatsi le letsatsi.Ho fa 'mele oa hau nako ea ho ikamahanya le maemo le ho fumana botsitso ho tla u thusa ho kotula litholoana tsa motsoako ona o makatsang.
Myland ke tlatsetso e ncha ea mahlale a bophelo, k'hamphani e kopanyang tloaelo le lits'ebeletso tsa tlhahiso e hlahisang le ho fana ka mefuta e mengata ea litlatsetso tsa phepo e nepahetseng ka boleng bo tsitsitseng le kholo e tsitsitseng ea bophelo bo botle ba batho.Lisebelisoa tsa Urolithin A tse hlahisoang ke myland:
(1) Bohloeki bo phahameng: Urolithin A e ka ba sehlahisoa sa bohloeki bo phahameng ka ho ntša tlhaho le ho hloekisa mekhoa ea tlhahiso.Bohloeki bo phahameng bo bolela bioavailability e betere le ho fokotseha ho hoholo ha maikutlo.
(2) Tšireletseho: Urolithin A ke sehlahisoa sa tlhaho se bontšitsoeng se sireletsehile bakeng sa 'mele oa motho.Ka har'a mefuta ea litekanyetso, ha ho na litla-morao tse chefo.
(3) Botsitso: Urolithin A e na le botsitso bo botle 'me e ka boloka ts'ebetso ea eona le phello tlas'a maemo a fapaneng le maemo a polokelo.
(4) Ho bonolo ho monya: Urolithin A e ka monngoa kapele ke ’mele oa motho, ea kena phallong ea mali ka maleng, ’me e abeloa lisele le litho tse fapaneng.
1. Ntlafatsa bophelo bo botle ba mesifa
Urolithin A e na le bokhoni bo boholo tšimong ea bophelo bo botle ba mesifa.Lipatlisiso li bontša hore ke activator e matla ea mitophagy, ts'ebetso ea tlhaho e hloekisang mitochondria e sa sebetseng liseleng.Ka ho susumetsa mitophagy, urolithin A e thusa ho nchafatsa le ho tsosolosoa ha mesifa ea mesifa, ka tsela eo ho ntlafatsa ts'ebetso ea mesifa le ho fokotsa ho fokola ha mesifa e amanang le lilemo.Bokhoni bona bo tsotehang ba urolithin A bo bula tsela bakeng sa mehato ea phekolo ho fokotsa lefu la mesifa le ho ntlafatsa matla a 'mele ka kakaretso.
2. Lintho tse khahlanong le ho ruruha
Ho ruruha ho phetha karolo ea bohlokoa ho nts'etsopele ea mafu a sa foleng a fapaneng, joalo ka lefu la pelo, mafu a neurodegenerative, esita le mefuta e itseng ea mofetše.Urolithin A e fumanoe e e-na le thepa e matla e thibelang ho ruruha e thusang ho loantša ho ruruha boemong ba lisele.Ka ho fokotsa maemo a limolek'hule tsa pro-inflammatory, urolithin A e thusa ho boloka karabelo e leka-lekaneng ea ho ruruha, e leng bohlokoa bakeng sa ho thibela le ho laola lefu le sa foleng.
3. Mosebetsi o matla oa antioxidant
Khatello ea oxidative, e bakoang ke ho se leka-lekane pakeng tsa li-radicals tsa mahala le li-antioxidants 'meleng ea rona, e ka baka tšenyo ea lisele le ho kenya letsoho ho nts'etsopele ea mafu a sa tšoaneng, ho kenyelletsa le a amanang le botsofali.Urolithin A ke antioxidant e matla ea tlhaho e thibelang li-radicals tse kotsi le ho sireletsa lisele tsa rona ho tsoa tšenyo ea oxidative.Ka ho kenyelletsa urolithin A lijong tsa rona kapa mofuta oa tlatsetso, re ka khona ho matlafatsa tsamaiso ea 'mele ea rona ea ho itšireletsa khahlanong le antioxidant le ho khothaletsa botsofali bo botle.
4. Gut Health Booster
Lilemong tsa morao tjena, gut microbiome e fumane tlhokomelo e kholo bakeng sa phello ea eona ho bophelo bo botle le boiketlo ba rona ka kakaretso.Urolithin A e bapala karolo e ikhethang bophelong bo botle ba mala ka ho khetha mefuta e itseng ea baktheria ka maleng.E fetoloa hore e be sebopeho se sebetsang ke libaktheria tsena, ka tsela eo e khothalletsa ho tšepahala ho thibela mala le bophelo bo botle ba mala.Ho feta moo, lipatlisiso tsa morao-rao li bonts'a hore urolithin A e ka ntlafatsa tlhahiso ea li-acid tse khutšoane tsa mafura, tse fanang ka matla a bohlokoa liseleng tse lutseng koloneng le ho ts'ehetsa tikoloho e phetseng hantle ea mala.
5. Litlamorao tse thibelang botsofali tsa urolithin A
(1) Ntlafatsa bophelo bo botle ba mitochondrial: Mitochondria ke mohloli oa matla a lisele tsa rona 'me li na le boikarabelo ba ho hlahisa matla.Ha re ntse re tsofala, katleho ea mitochondrial ea fokotseha.Urolithin A e bonts'itsoe ho kenya tšebetsong tsela e itseng ea mitochondrial e bitsoang mitophagy, e tlosang mitochondria e senyehileng le ho khothaletsa ho theoa ha mitochondria e ncha, e phetseng hantle.Ho tsosolosoa ha bophelo bo botle ba mitochondrial ho ka ntlafatsa tlhahiso ea matla le matla ka kakaretso.
(2) Ntlafatsa autophagy: Autophagy ke mokhoa oa ho itlhoekisa oa lisele moo likarolo tse senyehileng kapa tse sa sebetseng li sebelisoang hape le ho felisoa.Liseleng tse tsofalang, ts'ebetso ena e ba butle, e lebisang ho bokelleng litšila tse kotsi tsa cellular.Lipatlisiso li fumane hore urolithin A e ka ntlafatsa bophelo ba 'mele, kahoo e hloekisa lisele ka katleho le ho khothalletsa bophelo bo bolelele ba lisele.
P: Na lisebelisoa tse thibelang botsofali li bolokehile?
A: Ka kakaretso, li-supplement tse thibelang botsofali li nkuoa li bolokehile ha li nkuoa ka har'a litataiso tsa litekanyetso tse khothaletsoang.Leha ho le joalo, ke habohlokoa hore u buisane le setsebi sa tlhokomelo ea bophelo pele u kenya li-supplement leha e le life tse ncha kemisong ea hau, haholo-holo haeba u e-na le mathata leha e le afe a bophelo bo botle kapa u noa meriana ea ngaka.
P: Ho nka nako e kae hore li-supplement tse thibelang botsofali ho bontša liphetho?
A: Nako ea nako ea liphetho tse hlokomelehang e ka fapana ho latela motho le tlatsetso e itseng e sebelisoang.Le hoja batho ba bang ba ka 'na ba qala ho hlokomela ntlafatso ka mor'a libeke tse' maloa, ba bang ba ka 'na ba hloka nako e telele ea tšebeliso e tsitsitseng pele ba e-ba le liphetoho tse kholo bophelong ba bona le ponahalo ea bona.
Boitlhotlhollo: Sengoloa sena ke sa tlhaiso-leseling e akaretsang feela 'me ha ea lokela ho nkuoa e le keletso efe kapa efe ea bongaka.Tse ling tsa litaba tsa poso ea blog li tsoa Marang-rang mme ha se setsebi.Sebaka sena sa marang-rang se na le boikarabello ba ho hlophisa, ho hlophisa le ho hlophisa lingoliloeng.Sepheo sa ho fetisa boitsebiso bo bongata ha se bolele hore u lumellana le maikutlo a eona kapa u tiisa bonnete ba litaba tsa eona.Kamehla buisana le setsebi sa tlhokomelo ea bophelo pele u sebelisa li-supplement leha e le life kapa u etsa liphetoho tsamaisong ea tlhokomelo ea bophelo.
Nako ea poso: Dec-04-2023
