Choline Alfoscerate ke Eng 'me E ka Thusa Boko Ba Hao Joang?

E le ntho ea tlhaho 'meleng oa motho, L-α-glycerophosphocholine e ka phunyeletsa mokoallong oa mali le boko 'me e na le bioavailability e phahameng haholo. Ke limatlafatsi tsa boleng bo holimo tse bohlokoa 'meleng oa motho. "Lepheko la mali-boko ke sebopeho se teteaneng, se kang "lebota" pakeng tsa li-capillary plexuses tsa boko. L-α-glycerophosphocholine e ka phunyeletsa habonolo mokoallo oa mali-boko 'me ea phetha karolo ea ho ntlafatsa mohopolo, ho ntlafatsa monahano, le ho E. e na le melemo e ka 'nang ea e-ba teng ho fokotsa ho tšoenyeha, ho tsitsisa maikutlo, le ho eketsa matla a mesifa le mamello "Liphello tsa phepo ea L-α-glycerophosphocholine li bonahala haholo-holo likarolong tsa 5.

E ’ngoe ke ho ntlafatsa tšebetso ea boko. Ha palo ea lisele tsa methapo bokong e ntse e eketseha, matla a tsona a matlafala, li fetisa melaetsa ea methapo ka potlako le matla a ho sebetsa a boko. L-α-glycerophosphocholine e ka ntlafatsa ka botlalo tšebetso ea boko ka ho matlafatsa matla a lisele tsa methapo le bokhoni ba phetisetso ea matšoao a methapo. Mabapi le ho ntlafatsa cholinergic neurotransmission, phetisetso ea matšoao lipakeng tsa lisele tsa methapo e itšetlehile ka phetiso ea li-neurotransmitters, 'me acetylcholine ke lenģosa la bohlokoa la lik'hemik'hale le li-neurotransmitter tse netefatsang monahano o mafolofolo le ho boloka ho sebelisana pakeng tsa boko le' mele oohle.

L-α-glycerophosphocholine e ka senyeha ka 3-glycerol phosphate le choline bokong 'me ke phepelo e sebetsang ka ho fetisisa ea acetylcholine. E ka ntlafatsa mohopolo le ho ntlafatsa monahano ka ho khothaletsa motsoako le ho lokolloa ha acetylcholine bokong. Mabapi le ho ntlafatsa botsitso le ho phalla ha lisele tsa lisele, L-α-glycerophosphocholine e ka khothalletsa motsoako oa phosphoinositide, kahoo e matlafatsa botsitso le metsi a lisele tsa lisele. Li-neurone tse nang le libopeho tse sa fetoheng li ka fetisa litaba hamolemo. Ntlafatsa matla a 'mele a ho nahana.

Ea bobeli ke phepo e nepahetseng le tšireletso ea methapo. Lintlha tsa neurotrophic, lintlha tsa kholo ea lisele tsa methapo, li ka laola phapang ea lisele tsa stem le ho khothalletsa ho thehoa ha likhokahano tse ncha tsa methapo. L-α-glycerophosphocholine e ka khothalletsa secretion ea mefuta e sa tšoaneng ea neurotrophic factor and activate signaling pathways related to cell survival, ka hona E na le phello ea neuroprotective le ho ntlafatsa boemo ba kelello ba 'mele. Ka nako e ts'oanang, L-α-glycerophosphocholine e ka boela ea khothalletsa secretion ea hormone ea ho hōla le ho boloka bophelo bo botle ba 'mele ka ho eketsa maemo a' mele oa ho hōla ha hormone.

Ea boraro ke antioxidant. Oxidation le ho ruruha ke lisosa tse ka sehloohong tsa botsofali le lefu la lisele tsa boko. L-α-glycerophosphocholine e ka senya li-radicals tse sa lefelloeng 'meleng, ea loantša khatello ea kelello ea oxidative, hape e ka fokotsa nyutlelie NF-κB, tumor necrosis factor TNF-α, le interleukins. Ho lokolloa ha mabaka a ho ruruha joalo ka IL-6 ho hanyetsa ho ruruha ha boko, ka hona ho khutlisa haholo ho fokotseha ha ts'ebetso ea kelello le ho thibela ho hlaha le nts'etsopele ea mafu a neurodegenerative.

Liphello tse amehang li 'nile tsa tšehetsoa ke liphello tsa kliniki. Thutong "Phello ea L-α-glycerophosphocholine ka ho senyeha ha mohopolo o amanang le lilemo", lihlooho tsa 4 li ile tsa fuoa placebo, 'me lihlooho tse ling tsa 5 li ile tsa fuoa Ka mor'a ho nka L-α-glycerophosphocholine (1200 mg / letsatsi) ka molomo bakeng sa likhoeli tsa 3. , Li-electrode tsa 16 li ne li sebelisetsoa ho rekota maqhubu a boko bakeng sa metsotso ea 5 ha bafo ba ntse ba falimehile ba bile ba phomotse. Liphetho li bonts'itse hore ha e bapisoa le placebo, L-alpha-glycerophosphocholine e ekelitse haholo karolo ea maqhubu a boko a potlakileng ha a ntse a e-na le tšekamelo ea ho fokotsa maqhubu a liehang. Ke hore, e ka matlafatsa matla a boko ba batho ba lilemong tse bohareng le ho liehisa ho tsofala ha 'mele.

Ea bone ke ho laola maikutlo. Dopamine e ka etsa hore batho ba ikutloe ba thabile, ’me serotonin le gamma-aminobutyric acid li ka laola maikutlo a ’mele. L-α-glycerophosphocholine e ka khothalletsa ho lokolloa ha dopamine, ho phahamisa-ho laola polelo ea lipalangoang tsa dopamine, ho ntlafatsa dopamine neurotransmission bokong, le ho eketsa maemo a serotonin ho striatum le prefrontal cortex; e ka boela ea khothalletsa haholo endogenous Ho lokolloa ha γ-aminobutyric acid ka cortical tissue ho imolla ho hlobaela, kahoo ho fana ka liphello tsa eona tse khahlanong le ho tepella maikutlong, ho tšoenyeha le ho tsitsisa maikutlo.

Ea bohlano ke ho ntlafatsa ts'ebetso ea lipapali. Nakong ea boikoetliso, L-alpha-glycerophosphocholine e boetse e ntlafatsa sebopeho sa 'mele ka ho eketsa boima ba mesifa le ho ntlafatsa ts'ebetso ea metabolic ka kakaretso ka ho eketsa tlhahiso ea lihormone tsa kholo le tlhahiso ea matla. Ho feta moo, L-α-glycerophosphocholine e ka boela ea potlakisa phetisetso ea li-neurotransmitter, ea ntlafatsa ts'ebetso ea li-neuromuscular connections, ea eketsa tumellano le mamello ea mesifa ea masapo, kahoo ea matlafatsa boikoetliso ba 'mele, ho thibela mokhathala le ho ba le tšusumetso e ntle ho hola ha mesifa. . tshusumetso.

Joale ke hokae moo batho ba ka fumanang limatlafatsi tsee tse nang le melemo e mengata hakaale? Ha e le hantle, L-α-glycerophosphocholine e fumaneha lijong tse ngata tse kang mahe, khoho, le trout ea mookoli, empa litaba ka kakaretso li nyenyane. Ho ea ka "Khatiso ea Bobeli ea US General Food Choline Content Database" e hatisitsoeng ke Lefapha la Temo la United States, litaba tsa L-α-glycerophosphocholine ka kakaretso ea lijo tse 630 likarolong tse 22 li bontšitse hore L-α-glycerophosphocholine ka 100. Ligrama tsa lijo Litaba tsa glycerophosphocholine li tloha ho 0 ho isa ho 190 mg. Ka hona, e le ho finyella litlhoko tsa kholo ea 'mele oa motho, nts'etsopele le metabolism, li-supplement tse eketsehileng li ka etsoa ka nepo.

Tšebeliso ea lik'hemik'hale ke e 'ngoe ea mekhoa e ka sehloohong ea tlhahiso ea L-α-glycerophosphocholine. Ho sebelisa polyphosphoric acid, choline chloride, R-3-chloro-1,2-propanediol, sodium hydroxide le metsi e le thepa e tala, ka mor'a condensation le esterification reaction, e decolorized, litšila tlosoa, concentrated, hloekisoa le omisitsoeng. L-α-glycerophosphocholine e entsoeng ke mekhoa e meng e ka kenyelletsoa ho lino tse tahang, lino tsa lipapali, kofi, li-gummies, li-oatmeal energy bar, joalo-joalo, 'me li ka fana ka liphello tsa eona tsa phepo e nepahetseng ka mokhoa o lebisitsoeng ho kopana le bophelo bo fapaneng ba phepo e nepahetseng ba bareki. tlhokeho.

United States, Japane, Canada le linaheng tse ling, L-α-glycerophosphocholine e 'nile ea sebelisoa haholo lijong. Lihlahisoa tse amanang li koahela li-supplement tsa lijo, lino, li-gummies le lihlopha tse ling, 'me sehlahisoa ka seng se na le Mesebetsi e hlakileng, litekanyetso tse khothalletsoang le lihlopha tse khothalletsoang.

Suzhou Myland Pharm & Nutrition Inc.ke moetsi ea ngolisitsoeng ke FDA ea fanang ka phofo ea boleng bo holimo le e hloekileng ea Alpha GPC.

Ho Suzhou Myland Pharm re ikemiselitse ho fana ka lihlahisoa tsa boleng bo holimo ka litheko tse ntle. Alpha GPC ea rona ea phofo e lekoa ka matla bakeng sa bohloeki le potency, ho netefatsa hore u fumana tlatsetso ea boleng bo phahameng eo u ka e tšepang. Hore na o batla ho ts'ehetsa bophelo bo botle ba cellular, ho matlafatsa sesole sa hau sa 'mele kapa ho ntlafatsa bophelo bo botle ka kakaretso, phofo ea rona ea Alpha GPC ke khetho e phethahetseng.

Ka boiphihlelo ba lilemo tse 30 'me e susumetsoa ke thekenoloji e phahameng le maano a R&D a ntlafalitsoeng haholo, Suzhou Myland Pharm e hlahisitse lihlahisoa tse ngata tsa tlholisano mme e fetohile tlatsetso e ncha ea mahlale a bophelo, ho kopanya tloaelo le k'hamphani ea lits'ebeletso tsa tlhahiso.

Ntle le moo, Suzhou Myland Pharm hape ke moetsi ea ngolisitsoeng ke FDA. Lisebelisoa tsa R&D tsa k'hamphani, lisebelisoa tsa tlhahiso, le lisebelisoa tsa tlhahlobo ke tsa sejoale-joale ebile li na le mesebetsi e mengata, 'me li ka hlahisa lik'hemik'hale ho tloha ho limiligrama ho isa ho lithane ka tekanyo,' me li lumellana le litekanyetso tsa ISO 9001 le litlhaloso tsa tlhahiso ea GMP.