Jwalo ka ntho e sa feleng mmeleng wa motho, L-α-glycerophosphocholine e ka phunyeletsa mokoallo oa mali le boko 'me e na le bioavailability e phahameng haholo. Ke phepo ea boleng bo holimo e leng ea bohlokoa 'meleng oa motho. "Mokoallo oa mali le boko ke sebopeho se teteaneng, se kang 'lebota' pakeng tsa li-capillary plexuses tsa boko. L-α-glycerophosphocholine e ka phunyeletsa habonolo mokoallo oa mali le boko 'me ea phetha karolo ea ho ntlafatsa mohopolo, ho ntlafatsa monahano, 'me E na le melemo e ka bang teng ho imolleng matšoenyeho, ho tsitsisa maikutlo, le ho eketsa matla a mesifa le mamello. "Litlamorao tsa phepo ea L-α-glycerophosphocholine li bonahala haholo-holo likarolong tse 5.
E 'ngoe ke ho ntlafatsa ts'ebetso ea boko. Ha palo ea lisele tsa methapo e le kholoanyane bokong, matla a tsona a matlafala, li fetisa matšoao a methapo kapele, 'me matla a ts'ebetso ea boko a matlafala. L-α-glycerophosphocholine e ka ntlafatsa ts'ebetso ea boko ka botlalo ka ho ntlafatsa matla a lisele tsa methapo le bokhoni ba phetisetso ea matšoao a methapo. Mabapi le ho ntlafatsa phetisetso ea cholinergic neurotransmission, phetisetso ea matšoao lipakeng tsa lisele tsa methapo e itšetlehile ka phetisetso ea li-neurotransmitters, 'me acetylcholine ke sesebelisoa sa bohlokoa sa lik'hemik'hale le neurotransmitter se netefatsang monahano o mafolofolo le ho boloka tšebelisano pakeng tsa boko le 'mele oohle.
L-α-glycerophosphocholine e ka aroloa ho ba 3-glycerol phosphate le choline bokong mme ke phepelo e sebetsang hantle ka ho fetisisa ea acetylcholine. E ka ntlafatsa mohopolo le ho ntlafatsa monahano ka ho khothaletsa tlhahiso le ho lokolloa ha acetylcholine bokong. Mabapi le ho ntlafatsa botsitso le ho phalla ha lera la sele, L-α-glycerophosphocholine e ka khothaletsa tlhahiso ea phosphoinositide, ka hona e ntlafatsa botsitso le ho phalla ha lera la sele. Li-neurone tse nang le meaho e sa senyehang li ka fetisa tlhahisoleseling hamolemo. Ntlafatsa bokgoni ba ho nahana ba 'mele.
Ea bobeli ke phepo e nepahetseng le tšireletso ea methapo. Lintho tse bakang kholo ea methapo, e leng lintho tse bakang kholo ea lisele tsa methapo, li ka laola phapang ea lisele tsa stem le ho khothalletsa ho thehoa ha likhokahano tse ncha tsa methapo. L-α-glycerophosphocholine e ka khothaletsa ho ntšoa ha lintho tse fapaneng tse bakang kholo ea methapo le ho kenya tšebetsong litsela tsa lipontšo tse amanang le ho phela ha sele, ka hona e fana ka phello ea tšireletso ea methapo le ho ntlafatsa boemo ba kelello ba 'mele. Ka nako e ts'oanang, L-α-glycerophosphocholine e ka boela ea khothaletsa ho ntšoa ha hormone ea kholo le ho boloka bophelo bo botle ba 'mele ka ho eketsa maemo a hormone ea kholo ea 'mele.
Ea boraro ke antioxidant. Oxidation le ho ruruha ke lisosa tse ka sehloohong tsa botsofali le lefu la lisele tsa boko. L-α-glycerophosphocholine e ka senya li-free radicals 'meleng, ea loantša khatello ea oxidative, 'me e ka boela ea fokotsa nuclear factor NF-κB, tumor necrosis factor TNF-α, le interleukins. Ho lokolloa ha lintho tse bakang ho ruruha tse kang IL-6 ho loantša ho ruruha ha boko, ka hona ho khutlisetsa morao haholo ho fokotseha ha ts'ebetso ea kelello le ho thibela ho hlaha le ho hola ha mafu a methapo.
Litlamorao tse amehang li tšehelitsoe ke litlamorao tsa bongaka. Thutong ea "Phello ea L-α-glycerophosphocholine ho holofala ha mohopolo ho amanang le botsofali", batho ba 4 ba ile ba fuoa placebo, 'me batho ba bang ba 5 ba ile ba fuoa Kamora ho nka L-α-glycerophosphocholine (1200 mg/letsatsi) ka molomo ka likhoeli tse 3, li-electrode tse 16 li ile tsa sebelisoa ho rekota maqhubu a boko metsotso e 5 ha batho ba ntse ba falimehile 'me ba phomotse. Liphetho li bontšitse hore ha li bapisoa le placebo, L-alpha-glycerophosphocholine e ekelitse karolo ea maqhubu a boko a potlakileng haholo ha e ntse e e-na le tšekamelo ea ho fokotsa maqhubu a liehang ka ho fetisisa. Ke hore, e ka ntlafatsa matla a boko a batho ba lilemo tse mahareng le ho liehisa botsofali ba 'mele.
Ea bone ke ho laola maikutlo. Dopamine e ka etsa hore batho ba ikutloe ba thabile, 'me serotonin le gamma-aminobutyric acid li ka laola maikutlo a' mele. L-α-glycerophosphocholine e ka khothalletsa ho lokolloa ha dopamine, ea ntlafatsa tlhahiso ea li-transporter tsa dopamine, ea ntlafatsa phetisetso ea dopamine bokong, 'me ea eketsa maemo a serotonin ho striatum le prefrontal cortex; e ka boela ea khothalletsa haholo endogenous. Ho lokolloa ha γ-aminobutyric acid liseleng tsa cortical tsa thobalano ho imolla boroko, kahoo ho sebelisa litlamorao tsa eona tse khahlanong le khatello ea maikutlo, tse imollang matšoenyeho le tse tiisang maikutlo.
Ea bohlano ke ho ntlafatsa ts'ebetso ea lipapali. Nakong ea boikoetliso, L-alpha-glycerophosphocholine e boetse e ntlafatsa sebopeho sa 'mele ka ho eketsa boima ba mesifa le ho ntlafatsa ts'ebetso ea metabolism ka kakaretso ka ho eketsa tlhahiso ea lihormone tsa kholo e matla le tlhahiso ea matla. Ho feta moo, L-α-glycerophosphocholine e ka boela ea potlakisa phetiso ea li-neurotransmitter, ea ntlafatsa katleho ea likhokahano tsa methapo ea kutlo, ea eketsa ho koaleha le mamello ea mesifa ea masapo, ka hona ea ntlafatsa matla a boikoetliso ba 'mele, e thibela mokhathala,' me ea sebelisa tšusumetso e ntle kholong ea mesifa.
Joale batho ba ka fumana phepo ena hokae ka melemo e mengata hakaale? Ha e le hantle, L-α-glycerophosphocholine e fumaneha lijong tse ngata tse kang mahe, khoho le rainbow trout, empa ka kakaretso dikahare tsa yona di nyane. Ho ya ka "Khatiso ya Bobedi ya US General Food Choline Content Database" e phatlaladitsweng ke Lefapha la Temo la United States, dikahare tsa L-α-glycerophosphocholine dijong tse 630 ka kakaretso dihlopheng tse 22 di bontshitse hore L-α-glycerophosphocholine ka digrama tse 100 tsa dijo Dikahare tsa glycerophosphocholine di tloha ho 0 ho isa ho 190 mg. Ka hona, e le ho fihlela ditlhoko tsa kgolo ya mmele wa motho, ntshetsopele le metabolism, ditlatsetso tse ding di ka etswa ka nepo.
Ho kopanya lik'hemik'hale ke e 'ngoe ea mekhoa e meholo ea tlhahiso ea L-α-glycerophosphocholine. Ka ho sebelisa polyphosphoric acid, choline chloride, R-3-chloro-1,2-propanediol, sodium hydroxide le metsi e le thepa e tala, kamora karabelo ea condensation le esterification, e fetoloa 'mala, litšila lia tlosoa, lia teba, lia hloekisoa le ho omisoa. L-α-glycerophosphocholine e entsoeng ke lits'ebetso tse ling e ka eketsoa lino tse bonolo, lino tsa lipapali, kofi, li-gummies, li-oatmeal energy bar, jj., 'me e ka sebelisa litlamorao tsa eona tsa phepo ka mokhoa o reriloeng ho fihlela tlhoko ea bophelo bo botle ba phepo bo fapaneng ba bareki.
United States, Japane, Canada le linaheng tse ling, L-α-glycerophosphocholine e sebelisitsoe haholo lijong. Lihlahisoa tse amanang le eona li akaretsa li-supplement tsa lijo, lino, li-gummies le lihlopha tse ling, 'me sehlahisoa se seng le se seng se na le Mesebetsi e hlakileng, tekanyo e khothaletsoang le lihlopha tse khothaletsoang.
Suzhou Myland Pharm & Nutrition Inc. ke moetsi ea ngolisitsoeng ke FDA ea fanang ka phofo ea Alpha GPC ea boleng bo holimo le e hloekileng haholo.
Ho Suzhou Myland Pharm re ikemiselitse ho fana ka lihlahisoa tsa boleng bo holimo ka litheko tse ntle ka ho fetisisa. Phofo ea rona ea Alpha GPC e lekoa ka thata bakeng sa bohloeki le matla, ho netefatsa hore u fumana tlatsetso ea boleng bo holimo eo u ka e tšepang. Hore na u batla ho tšehetsa bophelo bo botle ba lisele, ho matlafatsa sesole sa hau sa 'mele kapa ho ntlafatsa bophelo bo botle ka kakaretso, phofo ea rona ea Alpha GPC ke khetho e phethahetseng.
Ka boiphihlelo ba lilemo tse 30 le ho khannoa ke theknoloji e phahameng le maano a R&D a ntlafalitsoeng haholo, Suzhou Myland Pharm e ntlafalitse mefuta e fapaneng ea lihlahisoa tse hlōlisanang 'me e fetohile khamphani e ncha ea tlatsetso ea mahlale a bophelo, tlhahiso ea lintho tse ikhethileng le lits'ebeletso tsa tlhahiso.
Ho phaella moo, Suzhou Myland Pharm le yona ke moetsi ya ngodisitsweng ke FDA. Mehlodi ya R&D ya khamphani, dibaka tsa tlhahiso, le disebediswa tsa tlhahlobo ke tsa sejwalejwale mme di sebetsa ka bongata, mme di ka hlahisa dikhemikhale ho tloha ho dimiligrama ho isa ho ditone ka boholo, mme di latela maemo a ISO 9001 le ditlhaloso tsa tlhahiso GMP.
Tlhokomeliso: Sengoloa sena ke sa tlhahisoleseding e akaretsang feela mme ha sea lokela ho nkuwa e le keletso efe kapa efe ya bongaka. Tse ding tsa tlhahisoleseding ya poso ya blog di tswa Inthaneteng mme ha se tsa botsebi. Webosaete ena e ikarabella feela bakeng sa ho hlophisa, ho hlophisa le ho hlophisa dihlooho. Morero wa ho fetisa tlhahisoleseding e eketsehileng ha o bolele hore o dumellana le maikutlo a yona kapa o tiisa bonnete ba dikahare tsa yona. Kamehla buisana le setsebi sa tlhokomelo ya bophelo pele o sebedisa ditlatsetso dife kapa dife kapa o etsa diphetoho tsamaisong ya hao ya tlhokomelo ya bophelo.
Nako ea poso: Loetse-25-2024
