spermidine ke eng? Tataiso e bonolo ea spermidine

Spermidineke mofuta oa polyamine. Polyamine ke li-biomolecules tse nyane, tse mafura, tse polycationic (-NH3+). Ho na le li-poliamine tse ka sehloohong liphoofolong tse anyesang: spermine, spermidine, putrescine le cadaverine. Spermine ke ea tetramines, spermidine ke ea triamines, putrescine le cadaverine ke tsa diamines. Lipalo tse fapaneng tsa lihlopha tsa amino li li fa litšobotsi tse fapaneng tsa 'mele.

Spermidine ho batho

Spermidine ha e fumanehe feela ka peō ea botona, empa e boetse e ajoa haholo ka lisele tse ling le lisele tsa 'mele oa motho. Intracellular spermidine concentrations haholo-holo e itšetlehile ka lintlha tse 'nè:

①Intracellular synthesis:

Arginine → putrescine → spermidine ← peō ea botona. Arginine ke ntho e ka sehloohong e tala bakeng sa tlhahiso ea spermidine liseleng. E hlahisoa ke arginase ho hlahisa ornithine le urea. Joale Ornithine e sebelisoa ho hlahisa putrescine tlas'a ketso ea ornithine decarboxylase (ODC1). Ena ke mohato oa ho fokotsa sekhahla), putrescine e hlahisa spermidine tlas'a ketso ea spermidine synthase (SPDS). Spermidine e ka boela ea hlahisoa ke ho senyeha ha spermine.

②Ho amoheloa ka bongata:

E arotsoe ka ho kenngoa ha lijo le intestinal microbial synthesis. Lijo tse nang le spermidine li kenyelletsa kokoana ea koro, natto, soya, li-mushroom, joalo-joalo Spermine le spermidine tse kenngoa lijong li kenngoa ka potlako ho tloha mala 'me li ajoa ntle le ho senyeha, kahoo mahloriso a spermidine maling a Concentrations a fapane haholo. Libaktheria tsa probiotic ka har'a mala a microbiota joalo ka Bifidobacterium le tsona li ka kopanya spermidine.

③ catabolism:

Spermine 'meleng e senyeha butle-butle hore e be spermidine le putrescine ke N1-acetyltransferase (SSAT), polyamine oxidase (PAO) le li-amine oxidase tse ling, ha putrescine e ntse e fetoloa aminobutyric acid ka li-oxidase. Qetellong, li-ion tsa amine le carbon dioxide lia hlahisoa ebe li ntšoa 'meleng.

④Lilemo:

Bongata ba spermidine bo fetoha le lilemo. Bafuputsi ba ile ba lekanya mahloriso a polyamine ka har'a lisele tse fapaneng le litho tsa litoeba tsa libeke tse 3, tse 10 le tse 26 'me ba fumana hore li ne li bolokiloe ka har'a manyeme, boko le popelo. Liphetoho tsa mala li fokotseha hanyane ka lilemo, 'me li fokotseha haholo ho thymus, spleen, ovary, sebete, mpa, matšoafo, liphio, pelo le mesifa. Ha ho thata ho rona ho nahana hore mabaka a phetoho ena a kenyelletsa liphetoho tsa lijo, liphetoho tsa sebopeho sa mala a mala, mosebetsi o fokotsehileng oa polyamine synthase, joalo-joalo.

Sepheo sa tlhaho sa spermidine

Ke hobane’ng ha molek’hule e nyenyane hakaale e le ntho ea bohlokoahali ’meleng oa motho? Sephiri se hlile se le sebopeho sa eona: Spermidine ke polycationic (-NH3 +) molek'hule e nyenyane ea mafura a amine e teng ka mefuta e mengata ea protonated tlas'a maemo a physiological pH, e nang le li-ion tse ntle tse ajoang ho pholletsa le ketane ea carbon. Tefiso ea motlakase, e na le ts'ebetso e matla ea 'mele.

Ka hona, ebang ke li-nucleic acid, phospholipids, liprotheine tse nang le acidic tse nang le masala a acidic, pectic polysaccharides e nang le lihlopha tsa carboxyl le sulfates, kapa li-neurotransmitters le li-hormone (dopamine, epinephrine, serotonin, hormone ea qoqotho, joalo-joalo) e nang le mehaho e tšoanang, e ka 'nang ea e-ba sepheo sa spermidine. tlamang. Tse mahlonoko haholo ke tsena:

① Asiti ea Nucleic:

Liphuputso li fumane hore li-polyamine tse ngata li teng ka mokhoa oa polyamine-RNA complexes ka har'a lisele, tse nang le 1-4 e lekanang le polyamine e tlanngoeng ka 100 e lekanang le metsoako ea phosphate. Ka hona, karolo e ka sehloohong ea spermidine e amana le liphetoho tsa moralo le phetolelo ea RNA, e kang ho ama mekhahlelo e sa tšoaneng ea protheine synthesis ka ho ama sebopeho sa bobeli sa mRNA, tRNA le rRNA. Spermidine e ka boela ea theha "marokho" a tsitsitseng pakeng tsa likhoele tsa DNA tse peli-helical, ho fokotsa ho fumaneha ha li-radicals tsa mahala kapa lisebelisoa tse ling tse senyang DNA, le ho sireletsa DNA ho tloha mocheso oa mocheso le mahlaseli a X-ray.

②Protheine:

Spermidine e ka tlama liprotheine tse jereng liqoso tse kholo tse mpe le ho fetola conformation ea sebaka sa protheine, kahoo e ama ts'ebetso ea eona ea 'mele. Mehlala e kenyelletsa protheine kinases/phosphatases (sehokelo sa bohlokoa litseleng tse ngata tsa ho fetisetsa lipontšo), li-enzyme tse amehang ho histone methylation le acetylation (e amang liphatsa tsa lefutso ka ho fetola epigenetics), acetylcholinesterase (karolo ea bohlokoa ea mafu a neurodegenerative). e 'ngoe ea litlhare tsa kalafo), li-receptor tsa ion channel (tse kang AMPA, AMDA receptors), joalo-joalo.

Suzhou Myland ke moetsi ea ngolisitsoeng oa FDA ea fanang ka phofo ea Spermidine ea boleng bo holimo le bohloeki bo phahameng.

Ho Suzhou Myland, re ikemiselitse ho fana ka lihlahisoa tsa boleng bo holimo ka litheko tse ntle. Phofo ea rona ea Spermidine e lekoa ka matla bakeng sa bohloeki le potency, ho netefatsa hore u fumana tlatsetso ea boleng bo phahameng eo u ka e tšepang. Ho sa tsotellehe hore na u batla ho tšehetsa bophelo bo botle ba lisele, ho matlafatsa sesole sa hau sa 'mele kapa ho ntlafatsa bophelo bo botle ka kakaretso, phofo ea rona ea Spermidine ke khetho e phethahetseng.

Ka phihlelo ea lilemo tse 30 'me e khannoa ke theknoloji e phahameng le leano la R&D le ntlafalitsoeng haholo, Spermidine e hlahisitse lihlahisoa tse ngata tsa tlholisano hore e be tlatsetso e ncha ea mahlale a bophelo, tlhahiso ea moetlo le k'hamphani ea lits'ebeletso tsa tlhahiso.

Ntle le moo, Suzhou Myland le eona ke moetsi ea ngolisitsoeng ke FDA. Lisebelisoa tsa R&D tsa k'hamphani, lisebelisoa tsa tlhahiso, le lisebelisoa tsa tlhahlobo ke tsa sejoale-joale ebile li na le mesebetsi e mengata, 'me li khona ho hlahisa lik'hemik'hale ho tloha ho limiligrama ho isa ho lithane ka tekanyo,' me li latela litekanyetso tsa ISO 9001 le litlhaloso tsa tlhahiso ea GMP.