Setlolo sa botona ke eng? Tataiso e bonolo ea setlolo sa botona

Spermidineke mofuta oa polyamine. Li-polyamine ke li-biomolecule tse nyane, tse mafura, tse nang le polycationic (-NH3+). Ho na le li-polyamine tse 'ne tse ka sehloohong ho liphoofolo tse anyesang: spermine, spermidine, putrescine le cadaverine. Spermine ke ea tetramine, spermidine ke ea triamine, putrescine le cadaverine ke ea diamine. Palo e fapaneng ea lihlopha tsa amino e li fa thepa e fapaneng ea 'mele.

Spermidine ho batho

Spermidine ha e fumanehe feela ka peong ea botona, empa e boetse e ajoa haholo liseleng tse ling le liseleng tsa 'mele oa motho. Bongata ba spermidine ka hare ho sele bo itšetlehile haholo ka lintlha tse 'ne:

①Ho kopanngoa ha lisele:

Arginine → putrescine → spermidine ← spermine. Arginine ke thepa e ka sehloohong e tala bakeng sa ho kopanya spermidine liseleng. E susumetsoa ke arginase ho hlahisa ornithine le urea. Ornithine e ntan'o sebelisoa ho hlahisa putrescine tlas'a ketso ea ornithine decarboxylase (ODC1). Ena ke mohato o fokotsang sekhahla), putrescine e hlahisa spermidine tlas'a ketso ea spermidine synthase (SPDS). Spermidine e ka boela ea hlahisoa ke ho senyeha ha spermine.

②Ho monya ka ntle ho sele:

E arotsoe ka ho ja lijo le ho kopanya likokoana-hloko mala. Lijo tse nang le spermidine e ngata li kenyelletsa koro ea koro, natto, soya, li-mushroom, jj. Peō ea botona le spermidine tse jeoang lijong li monngoa ka potlako mala 'me li ajoa ntle le ho senyeha, kahoo mahloriso a spermidine maling a fapane haholo. Libaktheria tsa probiotic ka har'a microbiota ea mala tse kang Bifidobacterium le tsona li ka kopanya spermidine.

③Katabolism:

Peō ea botona 'meleng e bolisoa butle-butle hore e be spermidine le putrescine ke N1-acetyltransferase (SSAT), polyamine oxidase (PAO) le li-amine oxidase tse ling, ha putrescine e fetoloa aminobutyric acid ke li-oxidase. Qetellong, li-ion tsa amine le carbon dioxide li hlahisoa 'me li ntšoa' meleng.

④Lilemo:

Ho phahama ha spermidine hoa fetoha ha lilemo li ntse li feta. Bafuputsi ba lekanyelitse ho phahama ha polyamine liseleng le lithong tse fapaneng tsa litoeba tse libeke li 3, libeke li 10 le libeke li 26 'me ba fumana hore e ne e bolokiloe ka har'a manyeme, bokong le popelong. Liphetoho maleng lia fokotseha hanyane ha lilemo li ntse li feta, 'me li fokotseha haholo ka har'a thymus, spleen, ovary, sebete, mpa, matšoafo, liphio, pelo le mesifa. Ha ho thata hore re nahane hore mabaka a phetoho ena a kenyelletsa liphetoho tsa lijo, liphetoho sebopehong sa limela tsa mala, ho fokotseha ha ts'ebetso ea polyamine synthase, jj.

Sepheo sa tlhaho sa spermidine

Ke hobane'ng ha molek'hule e nyane e bonolo hakana e le ntho ea bohlokoa bakeng sa 'mele oa motho? Sephiri se lutse sebopehong sa eona: Spermidine ke molek'hule e nyane ea amine ea polycationic (-NH3+) e fumanehang ka sebopeho se nang le liprotheine tse ngata tlas'a maemo a pH ea 'mele, ka li-ion tse ntle tse ajoang ho pholletsa le ketane ea khabone. Tefiso ea motlakase, e na le ts'ebetso e matla ea 'mele.

Ka hona, ebang ke nucleic acids, phospholipids, liprotheine tse nang le asiti tse nang le masala a asiti, pectic polysaccharides tse nang le lihlopha tsa carboxyl le sulfates, kapa li-neurotransmitters le lihormone (dopamine, epinephrine, serotonin, thyroid hormone, jj.) tse nang le meaho e tšoanang, E ka ba sepheo sa ho tlama spermidine. Tse bohlokoa ka ho fetisisa ke:

① Asiti ea nyutlelie:

Lithuto li fumane hore boholo ba li-polyamine li teng ka mokhoa oa li-complex tsa polyamine-RNA ka har'a lisele, tse nang le litekanyo tse 1-4 tsa polyamine tse tlamiloeng ka likarolo tse 100 tsa metsoako ea phosphate. Ka hona, karolo e ka sehloohong ea spermidine e amana le liphetoho tsa sebopeho le phetolelo ea RNA, joalo ka ho ama mekhahlelo e fapaneng ea tlhahiso ea protheine ka ho ama sebopeho sa bobeli sa mRNA, tRNA le rRNA. Spermidine e ka boela ea theha "marokho" a tsitsitseng pakeng tsa likhoele tsa DNA tse habeli tse helical, e fokotsang phihlello ea li-free radical kapa lintho tse ling tse senyang DNA, le ho sireletsa DNA ho tloha ho denaturation ea mocheso le mahlaseli a X-ray.

②Protheine:

Spermidine e ka tlama liprotheine tse jereng litefiso tse kholo tse mpe 'me ea fetola sebopeho sa sebaka sa protheine, ka hona ea ama ts'ebetso ea eona ea 'mele. Mehlala e kenyelletsa li-protein kinases/phosphatases (khokahano ea bohlokoa litseleng tse ngata tsa phetisetso ea matšoao), li-enzyme tse amehang ho methylation ea histone le acetylation (e amang tlhahiso ea liphatsa tsa lefutso ka ho fetola epigenetics), acetylcholinesterase (karolo ea bohlokoa ea mafu a neurodegenerative). e 'ngoe ea meriana ea phekolo), li-receptor tsa ion channel (tse kang AMPA, li-receptor tsa AMDA), jj.

Suzhou Myland ke moetsi ea ngolisitsoeng oa FDA ea fanang ka phofo ea Spermidine ea boleng bo holimo le bo hloekileng bo phahameng.

Ho Suzhou Myland, re ikemiselitse ho fana ka lihlahisoa tsa boleng bo holimo ka litheko tse ntle ka ho fetisisa. Phofo ea rona ea Spermidine e lekoa ka thata bakeng sa bohloeki le matla, ho netefatsa hore u fumana tlatsetso ea boleng bo holimo eo u ka e tšepang. Hore na u batla ho tšehetsa bophelo bo botle ba lisele, ho matlafatsa sesole sa hau sa 'mele kapa ho ntlafatsa bophelo bo botle ka kakaretso, phofo ea rona ea Spermidine ke khetho e phethahetseng.

Ka boiphihlelo ba lilemo tse 30 le ho khannoa ke theknoloji e phahameng le leano le ntlafalitsoeng haholo la R&D, Spermidine e hlahisitse mefuta e fapaneng ea lihlahisoa tse hlōlisanang ho ba tlatsetso e ncha ea mahlale a bophelo, k'hamphani ea lits'ebeletso tsa tlhahiso le tsa tlhahiso.

Ho phaella moo, Suzhou Myland le yona ke moetsi ya ngodisitsweng ke FDA. Mehlodi ya R&D ya khamphani, dibaka tsa tlhahiso, le disebediswa tsa tlhahlobo ke tsa sejwalejwale mme di sebetsa ka bongata, mme di kgona ho hlahisa dikhemikhale ho tloha ho dimiligrama ho isa ho ditone ka boholo, mme di latela maemo a ISO 9001 le ditlhaloso tsa tlhahiso GMP.