Seo u hlokang ho se tseba ka botsofali le mekhoa eo u ka e nkang ho e fokotsa

Ha batho ba ntse ba tsofala, ba bangata ba batla litsela tsa ho fokotsa ts'ebetso le ho boloka ponahalo ea bocha le matla. Ho na le mekhoa le mekhoa e fapaneng e ka sebelisoang ho thusa ho liehisa ts'ebetso ea botsofali le ho khothaletsa bophelo bo botle le bophelo bo botle ka kakaretso.

Lipatlisiso tsa morao-rao li bontša hore botsofali ha bo hlahe butle-butle feela, empa bo boetse bo hlaha ka nako e itseng pakeng tsa lilemo tse 44 le 60.

Ho tloha lilemong tsa bo-40, metabolism ea lipid le joala e fetoha, ha ts'ebetso ea liphio, metabolism ea lik'habohaedreite le taolo ea 'mele ea ho itšireletsa mafung e qala ho theoha ho pota lilemo tse 60. Bafuputsi ba ile ba boela ba hlokomela liphetoho tse kholo letlalong, mesifa le kotsi ea lefu la pelo pakeng tsa lilemo tse 40 le 60. khale.

Boithuto bona bo ne bo kenyelletsa batho ba California ba 108 feela ba lilemo tse 25 ho isa ho tse 75, mme lipatlisiso tse ling lia hlokahala ho netefatsa liphetho. Leha ho le joalo, liphuputso tsena li ka lebisa litekong tse ncha tsa tlhahlobo le mekhoa ea ho thibela mafu a amanang le botsofali.

Ho phela nako e telele ha ho bolele ho phela bophelo bo botle kapa ho phela bophelo bo mahlahahlaha. Ho ea ka sengoli se phahameng sa thuto Dr. Michael Snyder, motsamaisi oa Setsi sa Genomics le Personalized Medicine Univesithing ea Stanford, bakeng sa batho ba bangata, karolelano ea bona ea "bophelo bo botle" - nako eo ba e qetang ba phela hantle - e telele ho feta bophelo ba bona bo khutšoanyane. 11-15 lilemo.

Midlife e bohlokoa bakeng sa botsofali bo botle

Liphuputso tse fetileng li bontšitse hore bophelo bo botle ba hau nakong ea bohareng ba bophelo (hangata pakeng tsa lilemo tse 40 le 65) bo phetha karolo ea bohlokoa bophelong ba hau hamorao bophelong. Phuputso ea 2018 koranteng ea Nutrition e ile ea amahanya mekhoa e itseng ea bophelo bohareng ba bophelo bo botle, joalo ka boima ba 'mele, ho ba mahlahahlaha, ho ja lijo tse nepahetseng le ho se tsube, ho ntlafatsa bophelo bo botle nakong ea botsofali. 2

Tlaleho e phatlalalitsoeng koranteng ea 2020 e boetse e bonts'a hore midlife ke nako ea bohlokoa ea phetoho bakeng sa bophelo bo botle ba boko. Ho laola khatello ea mali le ho lula u le sechabeng, ho tseba le ho sebetsa ka matla nakong ena ea bophelo ho ka thusa ho fokotsa kotsi ea 'dementia' hamorao bophelong, tlaleho e boletse.

Boithuto bona bo bocha bo eketsa lebaleng la lipatlisiso tsa bophelo bo botle mme bo totobatsa bohlokoa ba ho hlaolela mekhoa e itseng ea bophelo qalong ea bophelo.

Kenneth Boockvar, MD, motsamaisi oa Setsi sa Lipatlisiso tse Kopanetsoeng mabapi le Botsofali Univesithing ea Alabama, o itse: "U phela hantle hakae ha u le 60, 70 kapa 80 ho itšetlehile ka seo u se entseng lilemong tse mashome pele ho uena." Birmingham. ” empa o ne a sa kopanele thutong.

O ile a phaella ka hore e ne e le mathoasong haholo ho etsa litlhahiso tse tobileng ho latela lipatlisiso tse ncha, empa batho ba batlang ho phela hantle lilemong tsa bo-60 ba lokela ho qala ho ela hloko lijo tsa bona le mokhoa oa bona oa bophelo lilemong tsa bo-40 le 50.

Botsofali ke ntho e ke keng ea qojoa, empa liphetoho tsa mokhoa oa bophelo li ka eketsa nako ea bophelo bo botle

Patlisiso e ncha e fumana hore limolek'hule le likokoana-hloko tse amanang le botsofali lia fokotseha nakong ea mekhahlelo e itseng ea potoloho ea bophelo, empa lipatlisiso tsa kamoso lia hlokahala ho fumana hore na liphetoho tse tšoanang tsa limolek'hule li etsahala lichabeng tse fapaneng.

"Re batla ho sekaseka batho ba bangata ho pholletsa le naha ho bona hore na maikutlo a rona a sebetsa ho motho e mong le e mong - eseng feela batho ba Bay Area," Snyder o itse. "Re batla ho sekaseka phapang pakeng tsa banna le basali. Basali ba phela nako e telele 'me re batla ho utloisisa hore na ke hobane'ng."

Botsofali ke ntho e ke keng ea qojoa, empa liphetoho tse itseng tsa bophelo li ka thusa ho fokotsa kotsi ea mafu a amanang le botsofali. Leha ho le joalo, lintlha tse ling tse ngata tse kang tikoloho, botsitso ba lichelete, tlhokomelo ea bophelo bo botle le menyetla ea thuto le tsona li susumetsa liphello tsa botsofali tse phetseng hantle 'me ho thata hore batho ba li laole.

Batho ba ka etsa liphetoho tse nyenyane tsa bophelo bo kang ho lula ba le metsi ho boloka bophelo bo botle ba liphio, ho haha ​​mesifa ea mesifa ka koetliso ea boima ba 'mele le ho noa meriana ea k'holeseterole haeba LDL cholesterol e phahame, Snyder o itse.

O boetse a re: "Sena se ka 'na sa se ke sa emisa ho tsofala, empa se tla fokotsa mathata ao re a bonang le ho thusa ho lelefatsa bophelo ba batho ba phetseng hantle."

Ke eng se ka etsoang ho lieha ho tsofala?

E 'ngoe ea lintlha tsa bohlokoa ka ho fetisisa tse fokotsang botsofali ke ho boloka bophelo bo botle. Sena se kenyelletsa ho ja lijo tse leka-lekaneng tse nang le litholoana, meroho, lijo-thollo le protheine e se nang mafura. Ho qoba lijo tse entsoeng, tsoekere e feteletseng, le mafura a sa pheleng hantle ho ka thusa ho fokotsa ho ruruha 'meleng le ho tšehetsa bophelo bo botle ka kakaretso. Ho lula u le metsi ka ho noa metsi a mangata ho bohlokoa hape ho boloka letlalo le litho tsa 'mele tse phetseng hantle.

Ho ikoetlisa kamehla ke karolo e 'ngoe ea bohlokoa ea bophelo bo botle 'me ho ka thusa ho fokotsa botsofali. Boikoetliso ba 'mele bo thusa ho ntlafatsa bophelo bo botle ba pelo, ho boloka boima ba mesifa, le ho tšehetsa ho sisinyeha ka kakaretso le ho feto-fetoha ha maemo. Ho kenya letsoho mesebetsing e kang ho tsamaea, ho sesa, yoga kapa koetliso ea matla ho ka thusa 'mele oa hau hore o shebahale o le monyenyane le o matla haholoanyane.

Ntle le lijo le boikoetliso, ho laola khatello ea kelello ke habohlokoa ho fokotsa botsofali. Khatello ea maikutlo e sa feleng e ka ba le liphello tse mpe 'meleng, e leng se lebisang ho eketseha ho ruruha le ho fokolisa sesole sa' mele. Ho itloaetsa mekhoa ea ho fokotsa khatello ea kelello e kang ho thuisa, ho phefumoloha ho tebileng, kapa ho ba le kelello ho ka thusa ho khothalletsa ho phomola le ho phela hantle ka kakaretso.

Karolo e ’ngoe ea bohlokoa ea ho fokotsa ho tsofala butle ke ho robala ka ho lekaneng. Boroko ke ba bohlokoa bakeng sa hore 'mele o lokisoe le hore o tsosolose, 'me ho se robale hantle ho ka etsa hore motho a tsofale pele ho nako. Ho theha kemiso ea kamehla ea ho robala le ho etsa nako ea ho robala e khathollang ho ka thusa ho ntlafatsa boleng ba boroko le ho tšehetsa bophelo bo botle ka kakaretso.

Ntle le mekhoa ea bophelo, ho na le mekhoa e fapaneng ea phekolo e ka thusang ho fokotsa ho tsofala. Tsena li ka kenyelletsa mekhoa ea ho hlokomela letlalo, mekhoa ea litlolo le mehato ea bongaka. Ho sebelisa setlolo se sireletsang letlalo letsatsing le ho nosetsa letlalo la hao ho ka thusa ho thibela tšenyo ea letsatsi le ho boloka ponahalo ea bocha. Mekhoa ea litlolo e kang Botox, li-fillers, le litlhare tsa laser le tsona li ka thusa ho fokotsa ponahalo ea wrinkles le mela e metle.

Ho feta moo, ho na le li-supplement tse thibelang botsofali tse fumanehang tse ka tšehetsang bophelo bo botle le mahlahahlaha ka kakaretso. Har'a litlatsetso tse nang le bopaki bo bongata ba mahlale bo tšehetsang karolo ea bona ho ntlafatseng bophelo ba mitochondrial le ho lieha ho tsofala ke li-precursors tsa NAD+ le urolithin A.

NAD + tlatsetso

Moo ho nang le mitochondria, ho na le NAD+ (nicotinamide adenine dinucleotide), molek'hule e hlokahalang bakeng sa ho eketsa tlhahiso ea matla. NAD+ ka tlhaho e fokotseha ka lilemo, e shebahalang e lumellana le ho fokotseha ho amanang le lilemo ts'ebetsong ea mitochondrial.

Lipatlisiso li bontša hore ka ho matlafatsa NAD +, o ka ntlafatsa tlhahiso ea matla a mitochondrial le ho thibela khatello ea kelello e amanang le lilemo. Lisebelisoa tsa NAD + precursor li ka ntlafatsa ts'ebetso ea mesifa, bophelo bo botle ba boko, le metabolism ha li ntse li ka loants'a mafu a neurodegenerative. Ho feta moo, ba fokotsa boima ba 'mele, ba ntlafatsa kutloisiso ea insulin,' me ba etsa hore maemo a lipid a tloaelehe, joalo ka ho theola LDL cholesterol.

Coenzyme Q10

Joalo ka NAD +, coenzyme Q10 (CoQ10) e bapala karolo e tobileng le ea bohlokoa tlhahisong ea matla a mitochondrial. Joalo ka astaxanthin, CoQ10 e fokotsa khatello ea oxidative, sehlahisoa sa tlhahiso ea matla ea mitochondrial e mpefalang ha mitochondria e sa phele hantle. Ho tlatsetsa ka CoQ10 ho fokotsa kotsi ea lefu la pelo, stroke le lefu. Ha re nahana hore CoQ10 e fokotseha ka lilemo, ho tlatselletsa le CoQ10 ho ka fana ka melemo ea nako e telele ho batho ba baholo.

Urolithin A

Urolithin A (UA) e hlahisoa ke libaktheria tsa rona tsa mala ka mor'a ho ja li-polyphenols tse fumanoang lijong tse kang likharenate, fragole le walnuts. Tlatsetso ea UA ho litoeba tsa lilemo tse mahareng e kenya tšebetsong li-sirtuin mme e eketsa NAD + le maemo a matla a cellular. Habohlokoa, UA e bontšitsoe ho hlakola mitochondria e senyehileng mesifa ea motho, ka tsela eo e ntlafatsa matla, ho hanyetsa mokhathala le ts'ebetso ea liatleletiki. Ka hona, tlatsetso ea UA e ka eketsa nako ea bophelo ka ho hanyetsa botsofali ba mesifa.

Spermidine

Joalo ka NAD+ le CoQ10, spermidine ke molek'hule ea tlhaho e fokotsehang ka lilemo. Ho tšoana le UA, spermidine e hlahisoa ke libaktheria tsa rona tsa mala 'me e baka mitophagy - ho tlosoa ha mitochondria e sa pheleng, e senyehileng. Liphuputso tsa litoeba li bontša hore tlatsetso ea spermidine e ka sireletsa khahlanong le lefu la pelo le botsofali ba basali. Ho feta moo, spermidine ea lijo (e fumanehang lijong tse fapaneng ho kenyelletsa soya le lijo-thollo) e ntlafalitse mohopolo ho litoeba. Ho hlokahala lipatlisiso tse eketsehileng ho fumana hore na liphuputso tsena li ka phetoa ho batho.

Suzhou Myland Pharm & Nutrition Inc. ke moetsi ea ngolisitsoeng ke FDA ea fanang ka phofo ea boleng bo holimo le bohloeki ba urolithin A.

Ho Suzhou Myland Pharm re ikemiselitse ho fana ka lihlahisoa tsa boleng bo holimo ka litheko tse ntle. Urolithin ea rona ea phofo e lekoa ka matla bakeng sa bohloeki le potency, ho netefatsa hore u fumana tlatsetso ea boleng bo phahameng eo u ka e tšepang. Hore na o batla ho ts'ehetsa bophelo bo botle ba cellular, ho matlafatsa sesole sa hau sa 'mele kapa ho ntlafatsa bophelo bo botle ka kakaretso, phofo ea rona ea Urolithin A ke khetho e phethahetseng.

Ka boiphihlelo ba lilemo tse 30 'me e susumetsoa ke thekenoloji e phahameng le maano a R&D a ntlafalitsoeng haholo, Suzhou Myland Pharm e hlahisitse lihlahisoa tse ngata tsa tlholisano mme e fetohile tlatsetso e ncha ea mahlale a bophelo, ho kopanya tloaelo le k'hamphani ea lits'ebeletso tsa tlhahiso.

Ntle le moo, Suzhou Myland Pharm le eona ke moetsi ea ngolisitsoeng ke FDA. Lisebelisoa tsa R&D tsa k'hamphani, lisebelisoa tsa tlhahiso, le lisebelisoa tsa tlhahlobo ke tsa sejoale-joale ebile li na le mesebetsi e mengata, 'me li ka hlahisa lik'hemik'hale ho tloha ho limiligrama ho isa ho lithane ka tekanyo,' me li latela litekanyetso tsa ISO 9001 le litlhaloso tsa tlhahiso ea GMP.