7,8-Dihydroxyflavone (7,8-DHF) ke flavonoid e hlahang ka tlhaho e bontšang tšepiso likarolong tse fapaneng tsa bophelo bo botle. Haeba u thahasella litlatsetso tsa tlhaho kapa metsoako ea lijo e ka tšehetsang bophelo bo botle ba boko, maikutlo, le bophelo bo botle ka kakaretso, 7,8-DHF e ka ba ea bohlokoa ho hlahloba. 7,8-Dihydroxyflavone Powder e fanoeng ke Suzhou Myland e na le nomoro ea CAS ea 38183-03-8 le bohloeki bo fihlang ho 98%. Sehlahisoa se bile le taolo e tiileng ea boleng mme se lumellana le maemo a machaba, ho netefatsa katleho le polokeho ea sehlahisoa. , e loketseng lipatlisiso tsa saense, nts'etsopele ea lithethefatsi, tlhahiso ea lihlahisoa tsa tlhokomelo ea bophelo le likarolo tse ling, ho u fa khetho e tšepahalang.
7,8-Dihydroxyflavone (7,8-DHF)ke motsoako o batlang o sa tloaeleha oa flavonoid o hlahang ka tlhaho. E fumanwe ho Astragalus pumila, Primula grandifolia le Hubei crabapple. e hlahile e le motsoako o tšepisang oa nootropic. E bonts'itse mefuta e mengata ea litlamorao tsa neuropharmacological lithutong tsa preclinical,
Li-Flavonoids ke sehlopha sa metsoako ea polyphenolic e fumanehang mefuteng e fapaneng ea litholoana, meroho le mehloli e meng ea limela. Lilemong tsa morao tjena, ba fumane tlhokomelo e kholo ka lebaka la thepa ea bona ea antioxidant, anti-inflammatory le neuroprotective.
Metsoako ena e bontšitsoe e na le litlamorao tse ntle bokong, ho kenyelletsa le ho matlafatsa ts'ebetso ea kelello le ho thibela mafu a neurodegenerative. 7,8-DHF ke e 'ngoe ea metsoako e tsebahalang haholo ea polyphenolic e amohelang tlhokomelo e ntseng e eketseha joalo ka nootropic. E 'nile ea ithutoa ka liphello tsa eona tse ka bang teng maikutlong, mohopolong, ho ithuta, ho tšoenyeha le mesebetsi e meng ea kelello.
Liphello tsa methapo ea 7,8-DHF ho nahanoa hore li kena lipakeng ka ho sebelisana ha eona le li-receptor tse itseng. E fumanoe e le TrkA, mokelikeli o amehang pontšong ea ho hōla ha methapo le ea bohlokoa bakeng sa ho phela ha neuronal le polasetiki.
7,8-DHF e sebetsa ka ho laola polelo ea li-receptor tse fapaneng, ho kenyelletsa le li-subunits tsa glutamate receptor le BDNF. E boetse e ama sebopeho sa synapse, metabolism ea matla, le ho lokolloa ha acetylcholine libakeng tse itseng tsa boko.
Ho phaella moo, lefu la ho fokola ha masapo le tsejoa e le "'molai ea khutsitseng" oa' mele oa motho, o sokelang bophelo bo botle ba batho ba lilemong tse bohareng le ba hōlileng, haholo-holo basali ba postmenopausal. Tlas'a maemo a tloaelehileng a 'mele, ho tsosolosoa ha masapo ho boemong bo leka-lekaneng; empa ha ho e-na le ho se leka-lekane pakeng tsa ho thehoa ha masapo a osteoblast-mediated le osteoclast-mediated bone resorption, 'me palo ea lesapo le entsoeng ha e lekane ho tlatsetsa lesapo le kenngoa, masapo a tla fokotseha. , microstructure ea lisele tsa masapo ea senyeha, e bakang osteoporosis.
7,8-Dihydroxyflavone (7,8-DHF) ke flavonoid e entsoeng ke semela e ka etsisang mosebetsi oa boko bo entsoeng ke neurotrophic factor (BDNF), e etsa hore ho be le dimerization ea li-receptor tsa TrkB le ho kenya tšebetsong limolek'hule tsa eona tse tlaase. Liphuputso li bontšitse hore BDNF e ka khothaletsa phapang ea osteoblast le ho falla le ho potlakisa pholiso ea fracture.
7,8-DHF e ka khothalletsa ho ata le ho arohana ha li-osteoblasts ka ho sebelisana le TrkB le ho kenya tšebetsong tsela ea pontšo ea Wnt / β-catenin, 'me e ka thibela ho hlahisa li-osteoclasts ka ho fokotsa mokhoa oa ho ngola oa c-fos; ho phaella moo, 7,8-DHF e ka ntlafatsa phenotype ea osteoporosis ho likhoto tse nang le ovariectomized.
Sebopeho sa lik'hemik'hale le thepa ea 7,8-dihydroxyflavone
E na le lihlopha tse peli tsa hydroxyl lesale la benzene le sehlopha se le seng sa hydroxyl lesale la pyrrolone. Ha re shebisiseng sebopeho sa lik'hemik'hale tsa 7,8-dihydroxyflavone:
Foromo ea molek'hule ea 7,8-DHF ke C15H10O5, e bontšang hore e na le liathomo tsa carbon tse 15, liathomo tsa hydrogen tse 10 le liathomo tse 5 tsa oksijene.
7,8-Dihydroxyflavone ke kristale e mosehla e tiileng e nang le boima ba molek'hule ea 286.24 g/mol. E qhibiliha hanyane ka metsing ka lebaka la lihlopha tse ngata tsa hydroxyl tse ka kopanyang hydrogen le limolek'hule tsa metsi.
7,8-DHF mokhoa oa ts'ebetso: taolo ea BDNF le ts'ebetso ea Trkb receptor
Mabapi le mokhoa oa ts'ebetso, 7,8-DHF e tsejoa ho khothalletsa tlhahiso ea BDNF (brain-derived neurotrophic factor) ka ho tlama le ho kenya ts'ebetsong ea eona ea ho amohela TrkB. Ntle le ho sebelisa tekheniki haholo, sena se lebisa ho phokotseho ea mesebetsi ea cellular e molemo ho boloka tšebetso e nepahetseng ea methapo ea kutlo le ho khothaletsa neurogenesis.
Ha re shebeng ka botebo mokhoa oa mantlha oa ts'ebetso oa 7,8-DHF ka tlase.
"Brain-derived neurotrophic factor (BDNF) le karolo ea eona ho neuroplasticity
Ka ho sibolloa hore polelo ea boko-derived neurotrophic factor (BDNF) e fokotsehile mafung a neurodegenerative, haholo-holo lefu la Alzheimer's (AD), bohlokoa ba eona ba ho boloka le ho ntlafatsa bophelo bo botle ba boko bo ntse bo bonahala haholoanyane. .
BDNF e bohlokoa bakeng sa mesebetsi e sa tšoaneng ea neuronal kaha e khothalletsa phetiso ea synaptic, synaptogenesis, le synaptic plasticity ka ho fana ka lipontšo le li-receptor tsa TrkB. Sena se etsa hore BDNF-TrkB e be sepheo se ts'episang bakeng sa nts'etsopele ea mehato ea phekolo e reretsoeng ho loantša mafu a neurodegenerative.
Liphuputso tsa morao-rao li batlisitse melemo e ka bang teng ea molek'hule e nyenyane ea TrkB agonist 7,8-dihydroxyflavone (7,8-DHF) ho fokotsa liphello tsa pele tsa lefutso le amanang le AD. Phuputsong ea mohlala oa 5xFAD mouse ea AD, litoeba li ile tsa phekoloa ka 7,8-DHF ka likhoeli tse peli ho qala ka khoeli e le 'ngoe.
Liphello tsa phuputso ena li senola bokhoni ba phekolo ea 7,8-DHF ho sebetsana le liphetoho tsa methapo ea methapo e amanang le AD le matšoao a pathological. Ka ho hlakileng, phekolo ea 7,8-DHF e ile ea fella ka ho fokotseha ha cortical Aβ plaque, letšoao le leholo la AD.
Ho feta moo, e sireletsa li-neurons tsa cortical phokotsong ea dendritic arbor complexity, e thusang ho boloka sebopeho sa neuronal ka kakaretso. Leha ho le joalo, ha ea ka ea ama haholo dendritic spine density.
Ho ea ka Aytan, Nurgul le ba bang, phekolo e boetse e bontšitse liphello tsa neuroprotective ho hippocampus, ho thibela maemo a phahameng a metsoako e nang le choline le ho fokotsa tahlehelo ea glutamate.
Tropomyosin receptor kinase B (Trkb) receptor signaling pathway
Ka 2010, sehlopha sa Moprofesa Ye Keqiang oa Univesithi ea Emory se tlalehile ka lekhetlo la pele ho Proceedings of the National Academy of Sciences (PNAS) hore 7,8-DHF e ka sebelisoa e le molek'hule e khethehileng ea agonist ea tropomyosin receptor kinase B ( TrkB), e ka etsisang Ts'ebetso ea boko-derived neurotrophic factor (BDNF) e tsoela pele ho kenya tšebetsong litsela tsa matšoao a tlase ho TrkB, joalo ka MAPK/ERK, PI3K/Akt le PKC. Ho feta moo, liphuputso tse latelang li fumane hore 7,8-DHF e ka fokotsa botenya bo bakoang ke lijo tse nang le mafura a mangata ho litoeba tsa basali ka ho kenya ts'ebetso ea mesifa ea masapo ea TrkB, e bontšang phapang e khōlō ea bong.
Brain-derived neurotrophic factor (BDNF) e ka khothaletsa phapang ea osteoblast, ho falla le ho fola ha fracture. BDNF ke setho sa lelapa la neurotrophic factor mme e laola mekhoa e fapaneng ea likokoana-hloko haholo-holo ka ho tlama ho transmembrane receptor tyrosine kinase B (TrkB). Leha ho le joalo, lets'oao la TrkB le hlahisitsoeng ke BDNF le ne le le nakoana ho 10 min mme la fihla tlhōrōng ea 60 min. Leha ho le joalo, BDNF e na le halofo ea bophelo bo khutšoanyane 'me ha e khone ho tšela mokoallo oa mali-boko habonolo.
7,8-dihydroxyflavone (7,8-DHF) ke flavonoid e entsoeng ke semela e khonang ho hlōla mefokolo e ka holimo ea BDNF 'me e ile ea tsejoa e le BDNF mimetic e sebetsang' me hona joale e sebelisoa mefuteng e sa tšoaneng ea lik'hemik'hale le lisele tsa cellular Ho netefalitsoe hore e ka kenya TrkB dimerization le ho kenya tšebetsong limolek'hule tsa eona tse tlase.
The tropomyosin receptor kinase B (TrkB) receptor e phetha karolo ea bohlokoa ho kopanyelletsa liphello tsa BDNF ho li-neurons. Joaloka receptor ea transmembrane tyrosine kinase, TrkB ke mokelikeli oa mantlha oa BDNF mme e qala letoto la liketsahalo tsa matšoao a intracellular holim'a tlamahano le lintlha tsa neurotrophic.
BDNF e kenya ts'ebetsong TrkB ho qala litsela tse 'maloa tsa bohlokoa tsa intracellular, ho akarelletsa phosphatidylinositol 3-kinase (PI3K) -Akt, mitogen-activated protein kinase (MAPK) -extracellular signal-regulated kinase (ERK), le phospholipase Cγ (PLCγ) -protein kinase C. PKC) tsela. E 'ngoe le e' ngoe ea litsela tsena e kenya letsoho karolong e fapaneng ea ts'ebetso ea neuronal le bophelo bo botle.
Tsela ea PI3K-Akt e bohlokoa bakeng sa ho khothaletsa ho phela ha neuronal le ho thibela apoptosis. Letšoao la BDNF-TrkB le kenya tšebetsong tsela ena ea ho eketsa bophelo ba lisele ka ho thibela lintlha tsa pro-apoptotic le ho susumetsa lintho tse khahlanong le apoptotic, ka hona ho netefatsa ho bolokoa ha li-neurone tse phetseng hantle.
Ka lehlakoreng le leng, tsela ea MAPK-ERK e phetha karolo ea bohlokoa ho khethollang le ho ata ha neuronal. Letšoao la BDNF-TrkB le khothalletsa ts'ebetso ea tsela ea MAPK-ERK, eo le eona e tšehetsang kholo ea methapo ea kutlo le phapang le ho kopanngoa ha tsona ho marang-rang a teng a neuronal.
Tsela ea PLCγ-PKC e bohlokoa bakeng sa ho laola polasetiki ea synaptic, mokhoa oa motheo oa ho ithuta le ho hopola. Letšoao la BDNF-TrkB le hlophisa mosebetsi oa tsela ena, e qetellang e lebisa liphetohong tsa matla a synaptic le khokahanyo.
Mokhoa ona oa ho feto-fetoha o khothalletsa ho ikamahanya le maemo le ho hlophisoa bocha ha li-circuits tsa neural ho arabela liphihlelo tse ncha le tšusumetso ea tikoloho.
Lintho tsa neuroprotective
Lipatlisiso li bontša hore flavonoid ena e sireletsa li-neurone khatellong ea oxidative le apoptosis (lefu la sele e hlophisitsoeng). Khatello ea oxidative ke ntlha ea bohlokoa ho mafu a neurodegenerative joalo ka lefu la Alzheimer's le Parkinson. Ka ho senya li-radicals tsa mahala le ho fokotsa tšenyo ea oxidative, 7,8-DHF e ka thusa ho sireletsa botšepehi ba neuronal le mosebetsi.
Lithutong tsa liphoofolo, 7,8-DHF e bontšitsoe ho ntlafatsa ts'ebetso ea kelello le mohopolo. Mohlala, mefuteng ea lefu la Alzheimer, 7,8-DHF e bonts'itsoe hore e matlafatsa polasetiki ea synaptic, e leng bohlokoa bakeng sa ho ithuta le mohopolo. Mokhoa oa ts'ebetso
Phello e khahlanong le ho ruruha
Ntle le lisebelisoa tsa eona tsa neuroprotective, 7,8-dihydroxyflavone e boetse e na le liphello tse khahlanong le ho ruruha. Ho ruruha ho sa foleng ke tšobotsi e tloaelehileng ea mafu a mangata, ho akarelletsa le mafu a neurodegenerative. Ka ho fetola litsela tsa ho ruruha, 7,8-DHF e ka thusa ho fokotsa neuroinflammation, eo hangata e amanang le ho fokotseha ha kelello.
Antioxidant thepa: ROS scavenging le lipid peroxidation
7,8-DHF e na le thepa ea antioxidant joalokaha ho pakoa ke bokhoni ba eona ba ho senya mefuta ea oksijene e sebetsang (ROS) le ho fokotsa lipid peroxidation. Litlamorao tsena li kenya letsoho litlamorao tsa eona tsa "neuroprotective" ka ho fokotsa tšenyo ea neuronal e bakoang ke oxidative le ho se sebetse hantle.
Liphuputso li bontšitse hore 7,8-DHF e thibela tlhahiso ea li-cytokine tsa pro-inflammatory le ho fokotsa ts'ebetso ea microglia, lisele tsa 'mele tsa ho itšireletsa mafung tsamaisong ea methapo e bohareng. Tšusumetso ena e khahlanong le ho ruruha ha e sireletse li-neurone feela empa e boetse e theha tikoloho e ntle bakeng sa ts'ebetso ea kelello.
Ka lebaka la litlamorao tsa eona tse molemo ho bophelo bo botle ba boko, 7,8-dihydroxyflavone e na le ts'ebeliso e ka bang teng libakeng tse fapaneng tsa bophelo bo botle le meriana. Tse ling tsa lisebelisoa tse tsebahalang haholo li kenyelletsa:
Ho kopanya le ho khutlisa mohopolo
7,8-DHF e fumanoe e matlafatsa khokahanyo ea memori le ho khutlisa mesebetsing e fapaneng e itšetlehileng ka hippocampal le memori mefuteng ea litoeba. Liphuputso tsena li fana ka maikutlo a hore 7,8-DHF e ka 'na ea e-ba nootropic e tšepisang bakeng sa ho ntlafatsa ts'ebetso ea mohopolo ho batho ba phetseng hantle le ba nang le bothata ba ho hopola.
Synaptic plasticity: bokhoni ba nako e telele le khatello ea maikutlo
Joalokaha ho boletsoe pejana, 7,8-DHF e bonts'itsoe ho fetola polasetiki ea synaptic ka ho khothaletsa LTP le ho fokotsa LTD ka har'a hippocampus. Liphello tsena ho nahanoa hore li na le matla a ho kenya tšebetsong li-receptor tsa TrkB ebe ka mor'a moo li ntlafatsa tsela ea matšoao ea BDNF.
Phetoho ena ea polasetiki ea synaptic e kenya letsoho ntlafatsong ea ts'ebetso ea kelello e hlokometsoeng kamora tsamaiso ea 7,8-DHF.
Ntlafatso ea kelello
Joalokaha ho boletsoe pejana, 7,8-DHF e bonts'a bokhoni ba ho ntlafatsa ts'ebetso ea kelello le mohopolo. Sena se etsa hore e be mokhethoa oa li-supplement tse reretsoeng ho ntlafatsa ts'ebetso ea kelello, haholo-holo ho batho ba tsofetseng kapa batho ba nang le bokooa bo fokolang.
Ho monya, Phatlalatso, Metabolism, le Excretion (ADME): 7,8-DHF e bonts'a thepa e ntle ea pharmacokinetic, ho kenyelletsa ho monya ka potlako, kabo e pharaletseng, le ho kenella hantle ha boko. Haholo-holo e tšeloa ka har'a sebete, 'me boholo ba motsoako o ntšoa ka har'a mantle 'me chelete e nyenyane e ntšoa ka har'a moroto.
Mali-boko mokoallo permeability le boko ba lisele permeability. E 'ngoe ea litšobotsi tsa bohlokoa tsa 7,8-DHFKe bokhoni ba eona ba ho tšela mokoallo oa mali-bokong (BBB) le ho kenella ka har'a lisele tsa boko, tse bohlokoa molemong oa ts'ebetso ea eona joalo ka nootropic.
Preclinical Safety Profile - Lithuto tse Hloahloa le tse sa Feleng: Lithuto tsa polokeho ea pele ho kliniki li bonts'itse hore 7,8-DHF e na le boemo bo botle ba polokeho, ntle le litlamorao tse mpe tse bonoang lithutong tsa chefo e matla le e sa foleng ho litoeba. Leha ho le joalo, tlhahlobo e eketsehileng ea polokeho, ho kenyeletsoa le lithuto tsa liphoofolo tse phahameng le batho, e ea hlokahala ho fumana polokeho ea eona bakeng sa ts'ebeliso ea bongaka.
Le hoja liphuputso tsa pele ho kliniki li bontšitse hore 7,8-DHF e na le boemo bo botle ba tšireletso, litla-morao tse ka bang teng litabeng tsa batho li ntse li sa tsejoe haholo. Joalo ka motsoako o mong le o mong oa lipale, ho tlameha ho be le tlhokomeliso 'me ho shejoe litlamorao tse ka bang teng ha ho hlahlojoa tšebeliso ea eona ho batho.
Ho latela mokhoa oa ts'ebetso oa 7,8-DHF le litlamorao ho li-receptor tsa TrkB, litlamorao tse ling tse ka amahanngoang le 7,8-DHF li ka kenyelletsa:
Hlooho ea hlooho: BDNF le TrkB receptor activation li laola mosebetsi oa neuronal le thabo; tsamaiso ea 7,8-DHF e ka baka hlooho ho batho ba bang.
Insomnia: Keketseho ea tšebetso ea methapo ea kutlo le polasetiki ea synaptic e ka ama mekhoa ea boroko, e ka lebisang ho hlobaeleng kapa ho sitisoa ke boroko.
Mathata a mala: Joaloka metsoako e mengata ea bioactive, 7,8-DHF e ka ’na ea baka litla-morao tsa mala, tse kang ho nyekeloa ke pelo, ho hlatsa, kapa letšollo ho batho ba bang.
Ho bohlokoa ho hlokomela hore litla-morao tsena tse ka bang teng li tlameha ho tsoela pele ho ithutoa litekong tsa bongaka. Kaha e na le bokhoni ba ho fetola pontšo ea BDNF le ts'ebetso ea TrkB receptor, tlhokomeliso e boetse e lokela ho sebelisoa ha ho kopanya 7,8-DHF le lithethefatsi tse ling tse lebisang litsela tsena kapa ho ba le mekhoa e tšoanang ea liketso.
Joaloka motsoako oa bohlokoa, 7,8-Dihydroxyflavone e hohetse tlhokomelo e ngata ka lebaka la mesebetsi ea eona e ikhethang ea likokoana-hloko. Bakeng sa bafuputsi ba saense le likhoebo, ho bohlokoa ho fumana 7,8-Dihydroxyflavone Powder ea boleng bo holimo. 7,8-Dihydroxyflavone Powder e fanoeng ke Suzhou Myland e na le nomoro ea CAS ea 38183-03-8 le bohloeki bo fihlang ho 98%. Sehlahisoa se bile le taolo e tiileng ea boleng mme se lumellana le maemo a machaba, ho netefatsa katleho le polokeho ea sehlahisoa. , e loketseng lipatlisiso tsa saense, nts'etsopele ea lithethefatsi, tlhahiso ea lihlahisoa tsa tlhokomelo ea bophelo le likarolo tse ling, ho u fa khetho e tšepahalang.
Netefaletso ea boleng
Rea tseba hore boleng ba lihlahisoa tsa rona bo ama ka kotloloho lipatlisiso tsa bareki ba rona le liphetho tsa ts'ebeliso. Ka hona, Suzhou Myland e latela ka tieo GMP (Ts'ebetso e Ntle ea Tlhahiso) le litekanyetso tsa setifikeiti sa ISO nakong ea ts'ebetso ea tlhahiso ho netefatsa botsitso le botsitso ba sehlopha ka seng sa lihlahisoa. Ho feta moo, sehlopha sa rona sa R&D se ntse se tsoela pele ho etsa boqapi ba theknoloji mme se ikitlaelletsa ho tsoela pele ho ntlafatsa boleng ba sehlahisoa le ts'ebetso.
Tšebeletso ea bareki
Suzhou Myland ha e fane feela ka lihlahisoa tsa boleng bo holimo, empa hape e ela hloko litlhoko tsa bareki. Re na le sehlopha sa profeshenale sa ts'ehetso ea tekheniki se ka fang bareki litlhahiso tsa tšebeliso ea sehlahisoa le tataiso ea botekgeniki ho thusa bareki ho fumana liphetho tse ntle ho lipatlisiso le ts'ebeliso. Ebang ke tlhahlobo e nyenyane kapa tlhahiso e kholo, re ka fana ka litharollo tse feto-fetohang ho finyella litlhoko tsa bareki ba fapaneng.
Mokhoa oa ho Fumana Phofo ea 7,8-Dihydroxyflavone
Haeba u batla Powder ea boleng bo holimo ea 7,8-Dihydroxyflavone, Suzhou Myland ke khetho ea hau e nepahetseng. O ka ikopanya le rona ka:
Webosaete ea semmuso: Etela webosaete ea semmuso ea Suzhou Myland ho ithuta haholoanyane ka tlhaiso-leseling ea sehlahisoa le tšehetso ea tekheniki.
Litherisano tsa Marang-rang: Buisana ka kotloloho le sehlopha sa rona sa litšebeletso tsa bareki ka ts'ebetso ea therisano ea Marang-rang e fanoeng ke sebaka sa Marang-rang ho fumana leseli la sehlahisoa le mantsoe a qotsitsoeng ao u a hlokang.
Khokahano ea mohala: Letsetsa nomoro ea rona ea puisano ho buisana le basebetsi ba porofeshenale ba thekiso le ho fumana lintlha tse qaqileng tsa sehlahisoa le litlhahiso tsa ho reka.
Tlhahlobo ea lengolo-tsoibila: U ka boela ua re kopa tlhahisoleseling ka lengolo-tsoibila, 'me re tla u araba kapele kamoo ho ka khonehang.
Ha re phethela
Joaloka motsoako oa bohlokoa o nang le mefuta e mengata ea mesebetsi ea likokoana-hloko, 7,8-Dihydroxyflavone butle-butle e fetoha karolo ea bohlokoa lipatlisisong tsa saense le likopo tsa indasteri. Phofo e phahameng ea 7,8-Dihydroxyflavone e fanoeng ke Suzhou Myland e tla fana ka tšehetso e matla bakeng sa lipatlisiso tsa hau le nts'etsopele ea lihlahisoa ka boleng ba eona bo botle le tšebeletso e tšepahalang. Re labalabela ho sebetsa le uena ho hlahloba menyetla e mengata ea ts'ebeliso ea 7,8-Dihydroxyflavone.
Q: 7,8-dihydroxyflavone ke eng?
A:7,8-Dihydroxyflavone ke flavonoid ea tlhaho e tsebahalang ka bokhoni ba eona ba ho sireletsa methapo ea kutlo 'me e ntse e ithutoa bakeng sa litlamorao tsa eona tšebetsong ea kelello le ntlafatso ea maikutlo.
P: Melemo e ka bang teng ea 7,8-dihydroxyflavone ke efe?
A: Lipatlisiso li bontša hore 7,8-dihydroxyflavone e ka thusa ho ntlafatsa mohopolo, ho fokotsa ho tšoenyeha, le ho thibela mafu a neurodegenerative. Thepa ea eona ea antioxidant e ka boela ea khothalletsa bophelo bo botle ka kakaretso ka ho loantša khatello ea kelello ea oxidative.
Q: bioavailability ea 7,8-DHF ke eng?
A: The bioavailability ea 7,8-dihydroxyflavone (7,8-DHF) lithutong tsa liphoofolo e batla e le 5% (ka litoeba) ka lebaka la ho fokola ha eona le metabolism e potlakileng. Ho sa tsotellehe bioavailability ea eona e tlaase, 7,8-DHF e ntse e ka tšela mokoallo oa mali le boko 'me ea ama boko. Lipatlisiso tse ling lia hlokahala ho fumana hore na bioavailability ea eona e teng bathong le ho hlahloba mekhoa ea ho e ntlafatsa.
P: 7,8-DHF e etsa hore u ikutloe joang?
A: Joaloka nootropic, 7,8-dihydroxyflavone (7,8-DHF) e na le liphello tse ntle mosebetsing oa kelello le maikutlo. Batho ba khona ho hopola lintho hantle, ba tsepamisa mohopolo haholoanyane le bokhoni ba ho ithuta bo ntlafetseng.
Boitlhotlhollo: Sengoloa sena ke sa tlhaiso-leseling e akaretsang feela 'me ha ea lokela ho nkuoa e le keletso efe kapa efe ea bongaka. Tse ling tsa litaba tsa poso ea blog li tsoa Marang-rang mme ha se setsebi. Sebaka sena sa marang-rang se na le boikarabello ba ho hlophisa, ho hlophisa le ho hlophisa lingoliloeng. Sepheo sa ho fetisa boitsebiso bo bongata ha se bolele hore u lumellana le maikutlo a eona kapa u tiisa bonnete ba litaba tsa eona. Kamehla buisana le setsebi sa tlhokomelo ea bophelo pele u sebelisa li-supplement leha e le life kapa u etsa liphetoho tsamaisong ea tlhokomelo ea bophelo.
Nako ea poso: Oct-14-2024
